Okawara Tatsuya 大川原辰也

… Alternative Names

Ohkawara Tatsuya 大川原辰也

OHKAWARA Tatsuya 大川原辰也

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Researcher Number	00374257
Other IDs
Affiliation (Current)	2025: 北海道大学, 薬学研究院, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2020: 北海道大学, 薬学研究院, 研究員 2015: 北海道大学, 薬学研究科(研究院), 研究員 2013 – 2014: 北海道大学, 薬学研究科(研究院), その他 2012: 北海道大学, 大学院・薬学研究院, 研究員 2012: 北海道大学, 薬学研究科(研究院), 研究員 … More 2010 – 2011: 北海道大学, 大学院・医学研究科, 客員研究員 2007: Hokkaido University, Graduate School of Medicine, Visiting researcher 2006: 北海道大学, 大学院医学研究科, 客員研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 38050:Food sciences-related
Keywords	Principal Investigator マクロファージ遊走阻止因子 / ワクチン治療 / 大腸癌 / 大腸炎 / 炎症性発癌 / 大腸腫瘍 / 炎症 / クロロゲン酸 / コーヒーポリフェノール / vaccination … More / Macrophaga migration inhibitory factor / Inflammatory bowel disease / Heat shock protein / Dextran sulfate sodium-induced colitis / Chemokine / MIF DNAワクチン / デキストラン硫酸誘導大腸炎 / 熱ショックタンパク / ケモカイン / 炎症性腸疾患 / 肝線維化 / 非アルコール性脂肪肝炎 / アセトアミノフェン / コリン・メチオニン欠損食 / 薬剤性肝障害 / 非アルコール性脂肪性肝炎 / MIF活性阻害剤 / 食道腫瘍 / 好酸球 / 食道炎 / 逆流性食道炎 / 好酸球性食道炎 Less

Does coffee polyphenol inhibit the level of MIF and the development of inflammatory carcinogenesis.Principal Investigator
- Principal Investigator
  
  Ohkawara Tatsuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Hokkaido University
Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitisPrincipal Investigator
- Principal Investigator
  
  OHKAWARA Tatsuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
Role of macrophage migration inhibitory factor in esophagitis and esophageal tumorPrincipal Investigator
- Principal Investigator
  
  OHKAWARA Tatsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University
The role of macrophage migration inhibitory factor in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  OHKAWARA Tatsuya
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hokkaido University

All 2021 2018 2012 2011 2007 2006 Other

All Journal Article Presentation

[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021
- Author(s)
  Ohkawara Tatsuya、Okubo Naoto、Maehara Osamu、Nishihira Jun、Takeda Hiroshi
- Journal Title
  
  Toxicology Letters
  
  Volume: 339 Pages: 51-59
- DOI
  10.1016/j.toxlet.2020.12.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18H02997
[Journal Article] The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.2018
- Author(s)
  Tanaka H, Watanabe A, Konishi M, Nakai Y, Yoshioka H, Ohkawara T, Takeda H, Harashima H, Akita H.
- Journal Title
  
  Heliyon
  
  Volume: 4 Issue: 12 Pages: e00959-e00959
- DOI
  10.1016/j.heliyon.2018.e00959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05500, KAKENHI-PROJECT-18K18377, KAKENHI-PROJECT-17K19473
[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.2011
- Author(s)
  Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, AsakaM.
- Journal Title
  
  International Immunopharmacology
  
  Volume: 11 Pages: 418-423
- NAID
  120003025340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590675
[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.2011
- Author(s)
  Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, Asaka M.
- Journal Title
  
  IntImmunopharmacol.
  
  Volume: 11 Pages: 418-23
- NAID
  120003025340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590675
[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidl anti-inflanunatory drugs-induced gastric injury in mice2011
- Author(s)
  Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, Asaka M
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 11 Issue: 4 Pages: 418-423
- DOI
  10.1016/j.intimp.2010.12.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249065, KAKENHI-PROJECT-22590675
[Journal Article] DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis.2011
- Author(s)
  Ohkawara T, Koyama Y, Onodera S, Takeda H, Kato M, Asaka M, Nishihira J.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: 163 Pages: 113-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590675
[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007
- Author(s)
  Ohkawara T, Saito M, Nakagawa S, Ohizumi H, Tamaki T, Yonekawa M, Takeda H, Asaka M, Nishihira J, Kawamura A.
- Journal Title
  
  Therapeutic Aphresis and Dialyasis 11
  
  Pages: 159-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis.2007
- Author(s)
  Ohkawara T, Nishihira J, Kato M, Takeda H, Sugiyama T, Asaka M.
- Journal Title
  
  Internal Medicine 46
  
  Pages: 1821-1822
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007
- Author(s)
  Ohkawara T, Saito M, et. al.
- Journal Title
  
  Therapeutic Apheresis and Dialysis 11
  
  Pages: 159-162
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis.2007
- Author(s)
  Ohkawara T, Nishihira J, Kato M, Takeda H, Sugiyama T, As-aka M.
- Journal Title
  
  Internal Medicine 46
  
  Pages: 1821-1822
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007
- Author(s)
  Ohkawara T, Saito M, Nakaga-wa S, Ohizumi H, Tamaki T, Yonekawa M, Takeda H, Asaka M, Nishihira J, Kawamura A
- Journal Title
  
  Therapeutic Apheresis and Dialysis 11
  
  Pages: 159-162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis.2007
- Author(s)
  Ohkawara T, Nishihira J, et. al.
- Journal Title
  
  Internal Medicine 46
  
  Pages: 1821-1822
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis.2006
- Author(s)
  Ishiguro Y, Ohkawara T, Sakuraba H, Yamagata K, Hiraga H, Yamaguchi S, Fukuda S, Munakata A, Nakane A, Nishihira J.
- Journal Title
  
  Clinical Immunology 120
  
  Pages: 353-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice.2006
- Author(s)
  Ohkawara T, Nishihira J, Ishiguro Y, Otsubo E, Nagai K, Takeda H, Kato M, Yoshiki T, Iwanaga T, Asaka M.
- Journal Title
  
  Immunology Letters 107・2
  
  Pages: 148-154
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Macrophage migration inhibitory factor has a proinflammatory a ctivity via the p38 pathway in glucocorticoid-resistant ulcerative colitis.2006
- Author(s)
  Ishiguro Y, Ohkawara T, et. al.
- Journal Title
  
  Clinical Immunology 120
  
  Pages: 353-341
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice.2006
- Author(s)
  Ohkawara T, Nishihira J, et. al.
- Journal Title
  
  Immunology Letters 107
  
  Pages: 148-154
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Macrophage migration inhibitory factor has a proinflammatory activity via the p38 pathway in glucocorticoid-resistant ulcerative colitis.2006
- Author(s)
  Ishiguro Y, Ohkawara T, Sakuraba H, Yamagata K, Hiraga H, Yamaguchi S, Fukuda S, Munakata A, Nakane A, Nishihira J.
- Journal Title
  
  Clinical Immunology 120・3
  
  Pages: 353-341
- Data Source
  KAKENHI-PROJECT-18590665
[Journal Article] Resistance to experimental colitis depends on cytoprotective heat shock proteins in macrophage migration inhibitory factor null mice.2006
- Author(s)
  Ohkawara T, Nishihira J, Ishiguro Y, Otsubo E, Nagai K, Takeda H, Kato M, Yoshiki T, Iwanaga T, Asaka M.
- Journal Title
  
  Immunology Letters 107
  
  Pages: 148-154
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590665
[Presentation] 消化管炎症におけるHeat shock protein と macrophage migration inhibitory factorの関係.2012
- Author(s)
  大川原辰也,中川宏治,大西礼造,大西俊介,西平順,浅香正博,武田宏司.
- Organizer
  第13回GGA-HSP勉強会
- Place of Presentation
  東京丸ビルホール&コンファレンススクェア
- Year and Date
  2012-08-04
- Data Source
  KAKENHI-PROJECT-22590675
[Presentation] 消化管炎症におけるHeat shock protein とmacrophage migration inhibitory factorの関係
- Author(s)
  大川原辰也（代表者）、中川宏治、大西礼造、大西俊介、西平順、浅香正博、武田宏司
- Organizer
  第13回GGA-HSP勉強会
- Place of Presentation
  丸ビルホール＆ｺﾝﾌｱﾚﾝｽスクェア（東京都）
- Data Source
  KAKENHI-PROJECT-22590675

1. TAKEDA Hiroshi (60261294)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. OHNISHI Shunsuke (10443475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KATO Fumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 加藤元嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okawara Tatsuya 大川原 辰也

Ohkawara Tatsuya 大川原 辰也

OHKAWARA Tatsuya 大川原 辰也

Research Projects

Research Products

Co-Researchers

Does coffee polyphenol inhibit the level of MIF and the development of inflammatory carcinogenesis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Macrophage migration inhibitory factor in non-alcoholic steatohepatitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of macrophage migration inhibitory factor in esophagitis and esophageal tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of macrophage migration inhibitory factor in inflammatory bowel diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The delivery of mRNA to colon inflammatory lesions by lipid-nano-particles containing environmentally-sensitive lipid-like materials with oleic acid scaffolds.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Macrophage migration inhibitory factor contributes to development of nonsteroidl anti-inflanunatory drugs-induced gastric injury in mice2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA vaccination targeting macrophage migration inhibitory factor prevents murine experimental colitis.2011

Author(s)

Journal Title

Data Source

[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Changes in the plasma level of macrophage migration inhibitory factor in ulcerative colitis patients treated with selective granulocyte and monocyte apheresis.2007

Author(s)

Journal Title

Data Source

[Journal Article] A case report of the therapeutic effect of cryofiltration in a patient with glucocorticoid-resistant ulcerative colitis.2007

Author(s)

Okawara Tatsuya 大川原辰也

Ohkawara Tatsuya 大川原辰也

OHKAWARA Tatsuya 大川原辰也