Sasajima Hitoshi 笹島仁

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SASAJIMA Hitoshi 笹島仁

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Researcher Number	00374562
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 旭川医科大学, 医学部, 講師 2019 – 2023: 旭川医科大学, 医学部, 講師 2018: 北海道大学, 医学研究院, 助教 2014 – 2017: 旭川医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Pharmacology in pharmacy Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Pharmacology in pharmacy
Keywords	Principal Investigator ミトコンドリアストレス / ドパミン / 神経変性 / モノアミン / 活性酸素 / 鉄代謝 / フェロトーシス / ロテノン / パーキンソン病 / 神経科学 … More / 薬学 / 抗酸化物質 / ドパミン代謝 / 神経保護 / オートファジー / ミトコンドリア / 黒質緻密部 / 嗅球 / 嗅覚障害 / 嗅覚輸送 / 環境毒物 / ドパミン神経 … More Except Principal Investigator 嗅覚障害 / 神経変性疾患 / 呼吸 / 嗅覚 / 嗅球 / マウス / 匂い嗅ぎ / 感覚運動 / パーキンソン病 / 嗅覚運動系 / ドパミン / 鼻腔内投与 / シヌクレイノパシー / ロテノン / 非運動症状 / 嗅神経 / 嗅覚情報処理 / 神経興奮 / 体性感覚野 / Fos陽性細胞 / 固形飼料摂餌 / 絶食 / 抑制性後シナプス電流 / 僧帽細胞 / 粉末飼料摂餌 / GABA / 介在神経 / 神経回路 / 神経新生 / 咀嚼 Less

多点ゲノム編集ドパミン代謝強化細胞を用いた鉄依存性神経変性の予防薬スクリーニングPrincipal Investigator
- Principal Investigator
  
  笹島仁
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Asahikawa Medical College
中枢性嗅覚障害における嗅球ドパミン神経細胞死と匂い嗅ぎ呼吸調節の因果関係
- Principal Investigator
  
  野口智弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
A study for therapeutic approach of dopaminergic neurodegeneration through ferroptosisPrincipal Investigator
- Principal Investigator
  
  笹島仁
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Asahikawa Medical College
Spatiotemporal control of synapse formation on dopaminergic interneurons in mouse olfactory bulbs during recovery from olfactory impairments.
- Principal Investigator
  
  野口智弘
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Mechanism of reciprocal enhancement of dopamine metabolism and mitochondrial stress-induced neurotoxicityPrincipal Investigator
- Principal Investigator
  
  SASAJIMA Hitoshi
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Asahikawa Medical College
  Hokkaido University
Elucidation of neural and molecular mechanisms regulating brain function by oral sensation
- Principal Investigator
  
  Kashiwayanagi Makoto
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Asahikawa Medical College
The vulnerability of dopaminergic neurons via olfactory transport pathwayPrincipal Investigator
- Principal Investigator
  
  SASAJIMA Hitoshi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Asahikawa Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation2023
- Author(s)
  Satoh Aya O.、Fujioka Yoichiro、Kashiwagi Sayaka、Yoshida Aiko、Fujioka Mari、Sasajima Hitoshi、Nanbo Asuka、Amano Maho、Ohba Yusuke
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112229-112229
- DOI
  10.1016/j.celrep.2023.112229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15436, KAKENHI-PLANNED-20H05872, KAKENHI-PROJECT-17K08302, KAKENHI-PROJECT-21K19347, KAKENHI-PROJECT-20K16115, KAKENHI-PUBLICLY-21H00413
[Journal Article] Localization of BCR-ABL to Stress Granules Contributes to Its Oncogenic Function2019
- Author(s)
  Sayaka Kashiwagi, Yoichiro Fujioka, Takeshi Kondo, Aya O. Satoh, Aiko Yoshida, Mari Fujioka, Hitoshi Sasajima, Maho Amano, Takanori Teshima, Yusuke Ohba
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 44 Issue: 2 Pages: 195-204
- DOI
  10.1247/csf.19033
- NAID
  130007775561
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08302, KAKENHI-PROJECT-19K22506, KAKENHI-PROJECT-19KK0198, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-18H04850, KAKENHI-PUBLICLY-19H04823, KAKENHI-PUBLICLY-19H05411, KAKENHI-PROJECT-17H04016, KAKENHI-PROJECT-16H06227, KAKENHI-PROJECT-17J07984
[Journal Article] Folding Latency of Fluorescent Proteins Affects the Mitochondrial Localization of Fusion Proteins2019
- Author(s)
  Sayaka Kashiwagi, Yoichiro Fujioka, Aya O. Satoh, Aiko Yoshida, Mari Fujioka, Prabha Nepal, Atsushi Tsuzuki, Ozora Aoki, Sarad Paudel, Hitoshi Sasajima, Yusuke Ohba
- Journal Title
  
  Cell Struct. Funct.
  
  Volume: 44 Issue: 2 Pages: 183-194
- DOI
  10.1247/csf.19028
- NAID
  130007775556
- ISSN
  0386-7196, 1347-3700
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08302, KAKENHI-PROJECT-19K22506, KAKENHI-PROJECT-19KK0198, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PUBLICLY-18H04850, KAKENHI-PUBLICLY-19H04823, KAKENHI-PUBLICLY-19H05411, KAKENHI-PROJECT-17H04016, KAKENHI-PROJECT-16H06227, KAKENHI-PROJECT-17J07984
[Journal Article] Parallel Processing by Two Olfactory Systems2017
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 柏柳誠
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 57 Issue: 1 Pages: 023-025
- DOI
  10.2142/biophys.57.023
- NAID
  130005296465
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860053
[Journal Article] Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra2017
- Author(s)
  Sasajima H, Miyazono S, Noguchi T, Kashiwayanagi M
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 1 Pages: 108-112
- DOI
  10.1248/bpb.b16-00654
- NAID
  130005188896
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860053, KAKENHI-PROJECT-17K07481, KAKENHI-PROJECT-15K18573
[Journal Article] Intranasal administration of rotenone in mice attenuated olfactory functions through the lesion of dopaminergic neurons in the olfactory bulb2015
- Author(s)
  Sasajima H, Miyazono S, Noguchi T, Kashiwayanagi M
- Journal Title
  
  NeuroToxicology
  
  Volume: 51 Pages: 106-115
- DOI
  10.1016/j.neuro.2015.10.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18573, KAKENHI-PROJECT-26860053
[Presentation] 匂い嗅ぎ中のマウス呼吸波形の特徴量抽出2024
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 高橋未来, 佐藤元, 志賀英明, 高草木薫
- Organizer
  第101回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-23K08904
[Presentation] 匂い刺激下における呼吸波形の特徴量抽出の試み2023
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 高橋未来, 高草木薫
- Organizer
  第103回北海道医学大会生理系分科会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] 嗅覚運動系によって制御される呼吸波形パラメータの探索2023
- Author(s)
  野口智弘、笹島仁、宮園貞治、高橋未来、佐藤元、志賀英明、高草木薫
- Organizer
  日本味と匂学会第57回大会
- Data Source
  KAKENHI-PROJECT-23K08904
[Presentation] ロテノン鼻腔内投与によって惹起されるマウス嗅球シナプス可塑性2023
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 高草木薫
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] マウス嗅神経における刺激周期に依存した発火抑制機構2022
- Author(s)
  野口智弘、笹島仁、宮園貞治、高橋未来、高草木薫
- Organizer
  第102回北海道医学大会生理系分科会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] Intrinsic ion channels regulating information transfer in mouse olfactory sensory neurons.2022
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 髙橋未来, 千葉龍介, 高草木薫
- Organizer
  Neuro2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K11848
[Presentation] マウス嗅神経の符号化を制御するイオンチャネル機構2022
- Author(s)
  野口智弘、笹島仁、宮園貞治、高橋未来、千葉龍介、高草木薫
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] Complementary information transfer on stimulus dynamics by olfactory and vomeronasal sensory neurons2022
- Author(s)
  Tomohiro Noguchi, Hitoshi Sasajima, Sadaharu Miyazono, Kaoru Takakusaki
- Organizer
  日本味と匂学会第56回大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] マウス嗅神経の符号化を制御する固有の興奮性2022
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 高草木薫
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] ドパミン介在神経の特異的減少によって生じる嗅球シナプス応答の代償性振幅増加2021
- Author(s)
  野口智弘, 笹島仁, 宮園貞治, 高草木薫
- Organizer
  第101回北海道医学大会生理系分科会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] マウスにおける２つの嗅覚系を介した天敵臭ピラジン化合物刺激に対する恐怖反応の制御2021
- Author(s)
  宮園貞治, 野口智弘, 笹島仁, 長田和実
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] 変化の速い刺激ほど正確に検出するマウス嗅神経のイオンチャネル機構2021
- Author(s)
  野口智弘、笹島仁、宮園貞治、志賀英明、三輪高喜、高草木薫
- Organizer
  日本味と匂学会第55回大会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] 嗅覚障害の発生機序の違いによって異なる嗅球シナプスの可塑性2020
- Author(s)
  野口　智弘、笹島　仁、宮園　貞治、志賀　英明、三輪　高喜
- Organizer
  日本味と匂学会第54回大会
- Data Source
  KAKENHI-PROJECT-20K09683
[Presentation] Analysis of non-apoptotic cell death mediated by dopamine catabolism under inhibition of mitochondrial respiration2018
- Author(s)
  Sasajima H, Fujioka Y, Sato A, Nepal P, Kashiwagi S, Tsuzuki A, Aoki O, Fujioka M, Yoshida A, Paudel S, Nanbo A, Ohba Y
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08302
[Presentation] ドパミン代謝とミトコンドリア機能障害の合成神経毒性に対するハーブ由来抗酸化成分カルノシン酸、ロズマリン酸の効果.2017
- Author(s)
  笹島仁, 野口智弘, 宮園貞治, 柏柳誠
- Organizer
  日本味と匂学会第51回大会
- Data Source
  KAKENHI-PROJECT-17K08302
[Presentation] The main olfactory and vomeronasal systems modulate fear of predator wolf odor, pyrazine analogs.2016
- Author(s)
  Miyazono S, Osada K, Sasajima H, Noguchi T, Kashiwayanagi M
- Organizer
  International Symposium on Olfaction and Taste
- Place of Presentation
  横浜市
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860053
[Presentation] Ion-channel mechanisms specializing firing patterns of olfactory and vomeronasal sensory neurons.2016
- Author(s)
  Noguchi T, Sasajima H, Miyazono S, Kashiwayanagi M
- Organizer
  International Symposium on Olfaction and Taste
- Place of Presentation
  横浜市
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860053
[Presentation] Intranasal rotenone administration to mice induces the degeneration of dopaminergic neurons in the olfactory bulb and the substantia nigra.2016
- Author(s)
  Sasajima H, Miyazono S, Noguchi T, Kashiwayanagi M
- Organizer
  International Symposium on Olfaction and Taste
- Place of Presentation
  横浜市
- Year and Date
  2016-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860053
[Presentation] マウス鼻腔内へのロテノン投与による嗅球・黒質ドパミン神経への影響2015
- Author(s)
  笹島仁, 宮園貞治, 野口智弘, 柏柳誠
- Organizer
  第7回北海道味覚嗅覚研究会
- Place of Presentation
  北海道
- Year and Date
  2015-04-02
- Data Source
  KAKENHI-PROJECT-26860053
[Presentation] マウス鼻腔内へのロテノン投与による嗅球内ドパミン神経および黒質緻密部ドパミン神経への影響
- Author(s)
  笹島仁
- Organizer
  日本味と匂学会
- Place of Presentation
  静岡
- Year and Date
  2014-10-02 – 2014-10-04
- Data Source
  KAKENHI-PROJECT-26860053

1. 野口智弘 (10466500)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
2. 宮園貞治 (50618379)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. 志賀英明 (80436823)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. Kashiwayanagi Makoto (20169436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 佐藤元 (10432452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 吉田藍子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasajima Hitoshi 笹島 仁

SASAJIMA Hitoshi 笹島 仁

Research Projects

Research Products

Co-Researchers

多点ゲノム編集ドパミン代謝強化細胞を用いた鉄依存性神経変性の予防薬スクリーニングPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

中枢性嗅覚障害における嗅球ドパミン神経細胞死と匂い嗅ぎ呼吸調節の因果関係

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study for therapeutic approach of dopaminergic neurodegeneration through ferroptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatiotemporal control of synapse formation on dopaminergic interneurons in mouse olfactory bulbs during recovery from olfactory impairments.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of reciprocal enhancement of dopamine metabolism and mitochondrial stress-induced neurotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of neural and molecular mechanisms regulating brain function by oral sensation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The vulnerability of dopaminergic neurons via olfactory transport pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Localization of BCR-ABL to Stress Granules Contributes to Its Oncogenic Function2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Folding Latency of Fluorescent Proteins Affects the Mitochondrial Localization of Fusion Proteins2019

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Parallel Processing by Two Olfactory Systems2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Intranasal Administration of Rotenone to Mice Induces Dopaminergic Neurite Degeneration of Dopaminergic Neurons in the Substantia Nigra2017

Author(s)

Journal Title

DOI

Sasajima Hitoshi 笹島仁

SASAJIMA Hitoshi 笹島仁