Mizukami Hiroki 水上浩哉

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MIZUKAMI Hiroki 水上浩哉

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Researcher Number	00374819
Other IDs
Affiliation (Current)	2025: 弘前大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 弘前大学, 医学研究科, 教授 2015: 弘前大学, 医学(系)研究科(研究院), 教授 2011 – 2013: 弘前大学, 医学(系)研究科(研究院), 講師 2010: Hirosaki University, 大学院・医学研究科, 講師 2007 – 2009: Hirosaki University, Departments of pathology, Assistant Professor 2004 – 2006: 弘前大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 50010:Tumor biology-related / General physiology / Metabolomics / Experimental pathology / Experimental pathology
Keywords	Principal Investigator 2型糖尿病 / β細胞 / 膵島 / β細胞減少 / ２型糖尿病 / β細胞容積 / 腺房細胞 / Carbonic anhydrase IX / 膵島病理 / SNPs … More / 膵β細胞 / 遺伝 / ALDH1A3 / 1塩基多型 / 一塩基多型 / 膵臓 / 動脈硬化 / 急性心筋梗塞 / アミロイド / 膵島アミロイド / 老人発症糖尿病 / 大血管障害 / 膵島アミロイド沈着 / β細胞容量 / 細胞増殖 / DNAメチル化 / DNAメチル化亢進 / 加齢 / 細胞容積 / インスリン分泌 / β細胞増殖 / 膵島移植 / β細胞アポトーシス / Gi / G蛋白共役受容体 / 1型糖尿病 / ベータ細胞 / S1P1 / G蛋白共益受容体 / スフィンゴ脂質 / 膵ベータ細胞 / Cre-loxP / ラットインスリンプロモーター / ガングリオシド / セラミド / グルコシルトランスフェラーゼ / cell death / diabetes / beta-cell / hypoxia / GKラット / 炎症反応 / PPAR-γ / チアゾリン誘導体 / 進行性β細胞脱落 / 低酸素 / 食後過血糖 … More Except Principal Investigator 糖尿病 / アルドース還元酵素 / ポリオール代謝 / ERK / CAMP / 合併症 / RAGE / AGE / セレトニン / 妊産婦死亡 / β細胞 / ランゲルハンス島 / アミロイド / ソマトスタチン / インスリン / 病理解剖 / 妊娠 / 妊娠糖尿病 / 癌微小環境 / 硫黄代謝 / 膵癌 / 微小血管 / 自律神経 / 膵島病理 / 病理変化 / 膵島神経 / 膵島血管 / インスリン抵抗性 / 2型糖尿病 / Gi-protein / Insulin secretion / S1P_1 receptor / Islet: β-cells / Gi / インスリン分泌 / Giタンパク / インスリン受容体 / S1P_1受容体 / 膵ラ島β細胞 / diabetic neuropathy / aldose reductase inhibitor / protein kinase C / aldose reductase / knockout mice / transgenic mice / polyol pathway / ノックアウトマウス / トランスジェニックマウス / 神経障害 / Diabetic complications / Target therapy / Neuropathy / Glycation / Aldose reductase / Polyol pathway / ニューロパチー / 血管障害 / 細胞傷害機構 / 遺伝子改変動物 / 標的治療 / 末梢神経障害 / グリケーション / 新規治療法 / 酸化ストレス / 急性腎不全 / 全身性炎症反応症候群(SIRS) / 虚血・再灌流 / アルドース還元酵素阻害薬 Less

マクロファージ制御による進行期糖尿病性神経障害新規病態の解明、治療法の確立Principal Investigator
- Principal Investigator
  
  水上浩哉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hirosaki University
Diabetes mellitus promotes sulfur metabolism in the pancreatic ductal adenocarcinoma and worsens the cancer prognosis
- Principal Investigator
  
  山田貴大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Hirosaki University
Pathophysiological analysis of the beta cell volume change elicited by pregnancy and gestational diabetes mellitus in Japanese pregnant women
- Principal Investigator
  
  若狹朋子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kindai University
膵島、腺房細胞クロストークを利用した2型糖尿病β細胞容積改善の試みPrincipal Investigator
- Principal Investigator
  
  水上浩哉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hirosaki University
Altered neurovascular network in type 2 diabetes and its repair
- Principal Investigator
  
  Yagihashi Soroku
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Toho University
Pancreatic islet pathological changes, clinical course, and prognostic prediction based on type 2 diabetes susceptibility gene polymorphismPrincipal Investigator
- Principal Investigator
  
  Mizukami Hiroki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Hirosaki University
Exploration of new therapy for type 2 diabetes regulating epigenetic state evoked by islet amyloid depositionPrincipal Investigator
- Principal Investigator
  
  Mizukami Hiroki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Exploration into the role of progesteron reseptor in islet beta cells of Japanese type 2 diabetic subjectsPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Development of new therapy for type 2 diabetes targeting sphingolipid receptor on pancreatic beta cellPrincipal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Analysis of new animal type 2 diabetic model, pancreatic beta cell specific deleted glucosyltransferase mouse.Principal Investigator
- Principal Investigator
  
  MIZUKAMI Hiroki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
全身性炎症反応症候群(SIRS)におけるポリオール代謝の役割と新規治寮法の開発
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University
Impaired insulin secretion in pancreatic β-cells lacking the sphingosine-1-phosphate_1 receptor
- Principal Investigator
  
  SUGA Sechiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Hirosaki University
2型糖尿病でみられる膵β細胞脱落への低酸素の関与とその制御Principal Investigator
- Principal Investigator
  
  水上浩哉
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Diabetic complications in mice transgenic and knockout for human aldose reductase.
- Principal Investigator
  
  WADA Ryuichi, 山岸晋一朗
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Hirosaki University
Exploration of pathogenesis of diabetic complications using transgenic mice and attempts of gene therapy
- Principal Investigator
  
  YAGIHASHI Soroku
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Hirosaki University

[Journal Article] Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease2024
- Author(s)
  Matsumoto Mika、Rokunohe Daiki、Sasaki Takanori、Matsuzaki Yasushi、Nakano Hajime、Mizukami Hiroki、Akasaka Eijiro、Sawamura Daisuke
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 27 Issue: 5 Pages: 228-228
- DOI
  10.3892/etm.2024.12516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Diabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma2024
- Author(s)
  Midorikawa Shin、Mizukami Hiroki、Kudoh Kazuhiro、Takeuchi Yuki、Sasaki Takanori、Kushibiki Hanae、Wang Zhenchao、Itakura Yuko、Murakami Kotaro、Kudo Naomi、Nagaki Takahiko、Wakasa Tomoko、Nakamura Yasuhiro、Matsubara Atsushi
- Journal Title
  
  Pathology
  
  Volume: 56 Issue: 1 Pages: 65-74
- DOI
  10.1016/j.pathol.2023.09.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Tryptophan metabolism and small fibre neuropathy: a correlation study2024
- Author(s)
  Kushibiki Hanae、Mizukami Hiroki、Osonoi Sho、Takeuchi Yuki、Sasaki Takanori、Ogasawara Saori、Wada Kanichiro、Midorikawa Shin、Ryuzaki Masaki、Wang Zhenchao、Yamada Takahiro、Yamazaki Keisuke、Tarusawa Takefusa、Tanba Taiyo、Mikami Tatsuya、Matsubara Atsushi、Ishibashi Yasuyuki、Hakamada Kenichi、Nakaji Shigeyuki
- Journal Title
  
  Brain Communications
  
  Volume: 6 Issue: 2
- DOI
  10.1093/braincomms/fcae103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Diabetes mellitus impacts on expression of DNA mismatch repair protein PMS2 and tumor microenvironment in pancreatic ductal adenocarcinoma2023
- Author(s)
  Pan X, Mizukami H, Hara Y, Yamada T, Yamazaki K, Kudoh K, Takeuchi Y, Sasaki T, Kushibiki H, Igawa A, Hakamada K.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 14 Issue: 1 Pages: 132-144
- DOI
  10.1111/jdi.13929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08746, KAKENHI-PROJECT-20K17636, KAKENHI-PROJECT-23K08020
[Journal Article] Oxytocin Receptor-Expressing Neurons in the Medial Preoptic Area Are Essential for Lactation, whereas Those in the Lateral Septum Are Not Critical for Maternal Behavior2023
- Author(s)
  Hidema Shizu、Sato Keisuke、Mizukami Hiroaki、Takahashi Yumi、Maejima Yuko、Shimomura Kenju、Nishimori Katsuhiko
- Journal Title
  
  Neuroendocrinology
  
  Volume: ahead Issue: 6 Pages: 517-537
- DOI
  10.1159/000535362
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08012, KAKENHI-PROJECT-23K08020, KAKENHI-PROJECT-21K11726
[Journal Article] Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response?Toward an Actionable Strategy for Anti-Aging2023
- Author(s)
  Kasai Shuya、Kokubu Daichi、Mizukami Hiroki、Itoh Ken
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 10 Pages: 1544-1544
- DOI
  10.3390/biom13101544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Protocol for producing an adeno-associated virus vector by controlling capsid expression timing2023
- Author(s)
  Ohba Kenji、Mizukami Hiroaki
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 4 Pages: 102542-102542
- DOI
  10.1016/j.xpro.2023.102542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Serine supplementation: Is it a new option for the treatment of diabetic polyneuropathy?2023
- Author(s)
  Mizukami Hiroki
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 14 Issue: 10 Pages: 1157-1159
- DOI
  10.1111/jdi.14047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08020
[Journal Article] Dual epigenetic changes in diabetes mellitus‐associated pancreatic ductal adenocarcinoma correlate with downregulation of E‐cadherin and worsened prognosis2023
- Author(s)
  Hara Yutaro、Mizukami Hiroki、Yamazaki Keisuke、Yamada Takahiro、Igawa Akiko、Takeuchi Yuki、Sasaki Takanori、Kushibiki Hanae、Murakami Kotaro、Kudoh Kazuhiro、Ishido Keinosuke、Hakamada Kenichi
- Journal Title
  
  The Journal of Pathology: Clinical Research
  
  Volume: 9 Issue: 5 Pages: 354-366
- DOI
  10.1002/cjp2.326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08020, KAKENHI-PROJECT-21K08746, KAKENHI-PROJECT-20K17636
[Journal Article] RAGE activation in macrophages and development of experimental diabetic polyneuropathy2022
- Author(s)
  Osonoi Sho、Mizukami Hiroki、Takeuchi Yuki、Sugawa Hikari、Ogasawara Saori、Takaku Shizuka、Sasaki Takanori、Kudoh Kazuhiro、Ito Koichi、Sango Kazunori、Nagai Ryoji、Yamamoto Yasuhiko、Daimon Makoto、Yamamoto Hiroshi、Yagihashi Soroku
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 23
- DOI
  10.1172/jci.insight.160555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-20K07027, KAKENHI-PROJECT-22K08682, KAKENHI-PROJECT-21H02695, KAKENHI-PROJECT-20K07773
[Journal Article] Diabetes in humans activates pancreatic stellate cells via RAGE in pancreatic ductal adenocarcinoma.2022
- Author(s)
  Uchida C, Mizukami H, Hara Y, Saito T, Umetsu S, Igawa A, Osonoi S, Kudoh K, Yamamoto H, Yagihashi S, Hakamada K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 21 Pages: 11716-11716
- DOI
  10.3390/ijms222111716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546, KAKENHI-PROJECT-21K08746, KAKENHI-PROJECT-21H02695
[Journal Article] The diversity and abundance of gut microbiota are associated with the pain sensation threshold in the Japanese population2022
- Author(s)
  Takeuchi Yuki、Mizukami Hiroki、Kudoh Kazuhiro、Osonoi Sho、Sasaki Takanori、Kushibiki Hanae、Ogasawara Saori、Hara Yutaro、Igawa Akiko、Pan Xuekai、Yamada Takahiro、Yamazaki Keisuke、Mikami Tatsuya、Daimon Makoto、Yagihashi Soroku、Hakamada Kenichi、Nakaji Shigeyuki
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 173 Pages: 105839-105839
- DOI
  10.1016/j.nbd.2022.105839
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546, KAKENHI-PROJECT-22K08682
[Journal Article] Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice2021
- Author(s)
  Takhashi K, Mizukami H, Osonoi S, Ogasawara S, Hara Y, Kudoh K, Takeuchi Y, Sasaki T, Daimon M, Yagihashi S
- Journal Title
  
  Neurobiol Dis
  
  Volume: 155 Pages: 105392-105392
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Islet microangiopathy and augmented be-ta cell loss in Japanese non-obese type 2 diabetes patients who died of acute myocardial infarction2021
- Author(s)
  Takahashi K, Mizukami H, Sho Osonoi, Takeuchi Y, Kudoh K, Sasaki T, Daimon M, Yagihashi S
- Journal Title
  
  J Diabetes Investigation
  
  Volume: 12 Issue: 12 Pages: 2149-2161
- DOI
  10.1111/jdi.13601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036, KAKENHI-PROJECT-21K08546
[Journal Article] Diabetes, an independent poor prognostic factor of non-B non-C hepatocellular carcinoma, correlates with dihydropyrimidinase-like 3 promoter methylation.2020
- Author(s)
  Umetsu S, Mizukami H, Saito T, Uchida C, Igawa A, Kudo K, Itabashi C, Osonoi S, Danyang G, Sasaki T, Yagihashi S, Hakamada K.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 1156-1156
- DOI
  10.1038/s41598-020-57883-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10587, KAKENHI-PROJECT-18K16220, KAKENHI-PROJECT-19K09036
[Journal Article] Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway.2020
- Author(s)
  Mizukami H, Osonoi S, Takaku S, Yamagishi SI, Ogasawara S, Sango K, Chung S, Yagihashi S
- Journal Title
  
  Brain Commun
  
  Volume: 2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Beneficial effects of combination therapy of canagliflozin and teneligliptin on diabetic polyneuropathy and beta-cell volume density in spontaneously type 2 diabeteic Goto-Kakizaki rats.2020
- Author(s)
  Guo D, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Kudo K, Sasaki T, Yagihashi S
- Journal Title
  
  Metabolism
  
  Volume: 107 Pages: 154232-154232
- DOI
  10.1016/j.metabol.2020.154232
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09036
[Journal Article] Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide2019
- Author(s)
  Hara A, Nakagawa Y, Nakao K, Tamaki M, Ikemoto T, Shimada M, Matsuhisa M, Mizukami H, Maruyama N, Watada H, Fujitani Y.
- Journal Title
  
  Endocr J
  
  Volume: 66 Issue: 5 Pages: 459-468
- DOI
  10.1507/endocrj.EJ18-0441
- NAID
  130007655243
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-16K10429, KAKENHI-PROJECT-18K08462
[Journal Article] Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes.2017
- Author(s)
  Xin A, Mizukami H, Inaba W, Yoshida T, Takeuchi YK, Yagihashi S.
- Journal Title
  
  J Clin Endocrinol Metab. 2017 102:3162-3171
  
  Volume: 102 Pages: 3162-3171
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09374
[Journal Article] Quo vadis: Where have the β-cells gone?2015
- Author(s)
  Yagihashi S, Mizukami H, Inaba W.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 6 Issue: 4 Pages: 393-395
- DOI
  10.1111/jdi.12287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09374
[Journal Article] Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese2014
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
- Journal Title
  
  J Diabetes Invest
  
  Volume: 5 Issue: 1 Pages: 38-47
- DOI
  10.1111/jdi.12118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591292, KAKENHI-PROJECT-24659158
[Journal Article] Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese2014
- Author(s)
  Mizukami H, Takahashi K, Inaba W, Osonoi S, Kamata K, Tsuboi K, Yagihashi S
- Journal Title
  
  J Diabetes Investig
  
  Volume: 5 Pages: 38-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591292
[Journal Article] 基礎の面からーインクレチン関連薬のβ細胞保護作用2013
- Author(s)
  水上浩哉
- Journal Title
  
  糖尿病診療マスター
  
  Volume: 11 Pages: 44-49
- Data Source
  KAKENHI-PROJECT-23591292
[Journal Article] 基礎の面から-インクレチン関連薬のβ細胞保護作用2013
- Author(s)
  水上浩哉
- Journal Title
  
  糖尿病診療マスター
  
  Volume: 11 Pages: 44-49
- Data Source
  KAKENHI-PROJECT-23591292
[Journal Article] 糖尿病発症・進展におけるグルカゴンの重要性糖尿病におけるα細胞の相対的・絶対的な量の変化2012
- Author(s)
  水上浩哉
- Journal Title
  
  糖尿病
  
  Volume: 55 Pages: 845-848
- Data Source
  KAKENHI-PROJECT-23591292
[Journal Article] 糖尿病におけるα細胞の相対的・絶対的な量の変化2012
- Author(s)
  水上浩哉
- Journal Title
  
  糖尿病
  
  Volume: 55 Pages: 845-848
- NAID
  10031136868
- Data Source
  KAKENHI-PROJECT-23591292
[Journal Article] Correction of protein kinase C activity and macrophage migration in peripheral nerve by pioglitazone, peroxisome proliferator activate-gamma-ligand, in insulin-deficient diabetic rats2008
- Author(s)
  Yamagishi SI, Ogasawara S, Mizukami H, Yajima N, Wada RI, Sugawara A, Yagihashi S.
- Journal Title
  
  J Neurochem 104
  
  Pages: 491-499
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] 2型糖尿病の膵病理2006
- Author(s)
  八木橋操六, 和田龍一, 水上浩哉, 矢嶋信久
- Journal Title
  
  病理と臨床 24・7
  
  Pages: 698-706
- Data Source
  KAKENHI-PROJECT-18659106
[Journal Article] Novel mechanism of chronic exposure of oleic acid-induced insulin release impairment in rat pancreatic beta-cells.2006
- Author(s)
  Kudo T, Wu J, Ogawa Y, Suga S, Hasegawa N, Suda T, Mizukami H, Yagihashi S, Wakui M
- Journal Title
  
  J Pharmacol Exp Ther 318・3
  
  Pages: 1203-1210
- Data Source
  KAKENHI-PROJECT-18659106
[Presentation] FFPE組織を用いたプロテオミクス解析による2型糖尿病長期罹患に関連した膵癌予後増悪因子の探索 Proteomic analysis to identify aggravating factor of PDAC in patients with long term type 2 diabetes2023
- Author(s)
  丹場　太陽1、水上　浩哉2、山崎　慶介1、山田　貴大1、佐々木　嵩矩2、王　朕超2、櫛引　英恵2、龍崎　正樹2、竹内　祐貴2、袴田　健一1
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 膵部分切除により膵α細胞容積が増加する2023
- Author(s)
  竹内　祐貴、遅野井　祥、工藤　和洋、佐々木崇矩、村上光太郎、櫛引　英恵、八木橋操六、水上　浩哉
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] マクロファージRAGEシグナルは糖尿病性神経障害を進展させる2023
- Author(s)
  水上　浩哉、村上光太郎、遅野井　祥、竹内　祐貴、小笠原早織、佐々木崇矩、工藤　和洋、八木橋操六
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] サイトメガロウイルスリンパ節炎に節性辺縁帯リンパ腫を合併した一例2023
- Author(s)
  櫛引　英恵、龍崎　正樹、竹内　祐貴、王　朕超、山田　貴大、山崎　慶介、丹場　太陽、高畑　武功、中村　直哉、水上　浩哉
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 糖尿病がEBV関連上咽頭癌の予後に与える影響2023
- Author(s)
  緑川　　伸、工藤　直美、工藤　和洋、水上　浩哉、松原　　篤
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 期糖尿病の罹患は膵導管癌間質の硫黄代謝を促進し予後を増悪させる2023
- Author(s)
  山田　貴大、水上　浩哉、石戸　圭之輔、原　裕太郎、山崎　慶介、櫛引　英恵、龍崎　正樹、王　朕超、佐々木　崇矩、袴田　健一
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 糖尿病の成因および合併症病態の病理学的解析2023
- Author(s)
  水上　浩哉
- Organizer
  第69回日本病理学会秋期特別総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 甲状腺未分化癌と副甲状腺癌の衝突癌の1例2023
- Author(s)
  龍崎　正樹、矢嶋　信久、板橋　智映子、高橋　淑郎、櫛引　英恵、水上　浩哉
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 非肥満型２型糖尿病モデルGoto-Kakizakiラットではインスリン・ソマトスタチン2重陽性細胞が増加する2023
- Author(s)
  王　朕超、竹内　祐貴、櫛引　英恵、龍崎　正樹、佐々木　崇矩、小笠原　早織、水上　浩哉
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] Whole slide imagingによる 2 型糖尿病全膵の病理学解析 Pathological analysis of the whole pancreas in type 2 diabetes mellitus with whole slide imaging2023
- Author(s)
  佐々木　崇矩、竹内　祐貴、小笠原　早織、櫛引　英恵、龍崎　正樹、王　朕超、水上　浩哉
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 実験的糖尿病性神経傷害における脊髄後根神経節ニューロンの3次元的解析2023
- Author(s)
  佐々木崇矩、竹内　祐貴、小笠原早織、櫛引　英恵、村上光太朗、王　　朕超、工藤　和洋、水上　浩哉
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] 長期2型糖尿病合併浸潤性膵管癌における網羅的タンパク発現解析 Pancreatic cancer comprehensive protein expression associated with long-term type-2 diabetes2023
- Author(s)
  山崎　慶介1,2、水上　浩哉1、竹内　祐貴1、山田　貴大2、王　朕超1、石戸　圭之輔2、木村　憲央2、長瀬　勇人2、若狭　悠介2、袴田　健一2
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-23K08020
[Presentation] ２型糖尿病膵臓における低酸素関連分子Carbonic Anhydrase-9の発現の意義2022
- Author(s)
  水上浩哉
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K08521
[Presentation] Implication of cyclin D2 in beta cell proliferation of human perinatal islet2021
- Author(s)
  Osonoi S, Sasaki T, Kudo K, Yagihashi S, Mizukami H
- Organizer
  80th American Diabetes Association meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] SD10-2　糖尿病の病態解析の進展2021
- Author(s)
  水上浩哉
- Organizer
  第110回　日本病理学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 臨床医が知っておくべき糖尿病の基礎５　膵内分泌細胞の可塑性と２型糖尿病2021
- Author(s)
  水上浩哉
- Organizer
  第55回　糖尿病学の進歩
- Invited
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] Activated xanthine oxidase in serum is a potent therapeutic target for experimental diabetic polyneuropathy2021
- Author(s)
  Ichinohe H, Mizukami H, Osonoi S, Takahashi K, Ogasawara S, Yagihashi S
- Organizer
  80th American Diabetes Association meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] Type 2 diabetes is a prognostic factor of non-B nonC hepatocellular carcinoma with increasing DPYSL3 promoter hypermethylation2021
- Author(s)
  Mizukami H, Umetsu S, Uchida C, Igawa A, Kudoh K, Osonoi S, Sasaki T, Yagihashi S
- Organizer
  80th American Diabetes Association meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] Possible Implication of Cyclin D2 in β Cell Proliferation of Human Perinatal Islet2020
- Author(s)
  Sho Osonoi, Takanori Sasaki, Kazuhiro Kudo, Soroku Yagihashi, Hiroki Mizukami
- Organizer
  80th american diabetes association scientific sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 膵島アミロイド沈着と低酸素関連分子の発現について2019
- Author(s)
  新井仁、遅野井祥、高橋和久、工藤和洋、板橋智映子、八木橋操六、水上浩哉
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 急性心筋梗塞合併2型糖尿病は膵島病理学的所見により亜分類される2019
- Author(s)
  水上浩哉、高橋和久、遅野井祥、郭丹陽、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第108回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] 新しい２型糖尿病亜分類の膵島病理学的所見に基づく検証2019
- Author(s)
  水上浩哉、高橋和久、遅野井　祥、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第62回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] Islet cell plasticity and its significance in diabetes Plasticity of human beta cells in type 2 diabetes of Japanese subjects2019
- Author(s)
  Hiroki Mizukami
- Organizer
  American Diabetes Association The 79th Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 急性心筋梗塞合併2型糖尿病は膵島病理学的所見により亜分類される2019
- Author(s)
  水上浩哉、高橋和久、遅野井祥、郭丹やん、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 胎生期から学童期の膵島内分泌細胞は各細胞独自の容積、増殖能を示す2019
- Author(s)
  一戸寛、遅野井祥、郭丹陽、工藤和洋、水上浩哉、八木橋操六
- Organizer
  第108回日本病理学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] 新しい2型糖尿病亜分類の膵島病理学的所見に基づく検討2019
- Author(s)
  水上浩哉、高橋和久、遅野井祥、工藤和洋、板橋智映子、八木橋操六
- Organizer
  第62回日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-19K09036
[Presentation] Symposium 2 How far have we learned the role of glucagon? Pathological alteration of alpha and beta cells in human type 2 diabetes2018
- Author(s)
  Hiroki Mizukami
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 2型糖尿病を病理学的に研究する2018
- Author(s)
  水上浩哉
- Organizer
  第80回　病理診断学講座 Seminar in Diagnostic Pathology
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] Augmented b-Cell Loss in Japanese Patients with Type 2 Diabetes Complicated with Acute Myocardial Infarction2018
- Author(s)
  Hiroki Mizukami, Kazuhisa Takahashi, Tetsuyuki Tateda, Wataru Inaba, Soroku Yagihashi
- Organizer
  American Diabetes association 78th Scientific Sessions
- Data Source
  KAKENHI-PROJECT-18K08462
[Presentation] 2型糖尿病における膵β細胞脱落機序の解明－ヒト剖検膵臓を用いた検討ー2017
- Author(s)
  水上浩哉
- Organizer
  Islet Biology’17
- Invited
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 急性心筋梗塞と2型糖尿病膵島病理学的変化について2017
- Author(s)
  水上浩哉、稲葉渉、高橋和久、阿部信、八木橋操六
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] Severe cardiac pathology correlates with marked islet amyloid deposition in patients2017
- Author(s)
  Kazuhisa Takahashi, Hiroki Mizukami, Tetsuyuki Tateda, Wataru Inaba, Soroku Yagihashi
- Organizer
  77th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] Loss of beta-cell mass in human type 2 diabetes: cell death vs. dedifferentiation2017
- Author(s)
  Hiroki Mizukami
- Organizer
  2017 Asia Islet Biology and Incretin Research Association
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 2型糖尿病における膵島アミロイド沈着と急性心筋梗塞の相関について2017
- Author(s)
  水上浩哉、稲葉渉、高橋和久、阿部信、八木橋操六
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 糖尿病膵島の病理～DPP-4阻害薬による新しいβ細胞保護機構の探求～2016
- Author(s)
  水上浩哉
- Organizer
  第105回日本病理学会
- Place of Presentation
  仙台国際会議場(宮城県、仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 大血管障害を有する2型糖尿病膵島の病理学的検討2016
- Author(s)
  水上浩哉、稲葉渉、高橋和久、阿部信、八木橋操六
- Organizer
  第105回日本病理学会
- Place of Presentation
  仙台国際会議場(宮城県、仙台市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 2型糖尿病の病態の解明をめざして～膵島病理学的解析を中心に～2016
- Author(s)
  水上浩哉
- Organizer
  第83回日本病理学会　東北支部学術集会
- Place of Presentation
  福島　コラッセ福島(福島県、福島市)
- Invited
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] Augmented b-Cell Loss in Japanese Patients with Type 2 Diabetes Complicated with Acute Myocardial Infarction2016
- Author(s)
  Kazuhisa Takahashi, Hiroki Mizukami, Tetsuyuki Tateda, Wataru Inaba, Soroku Yagihashi
- Organizer
  American Diabetes Association, 76th Scientific Sessions.
- Place of Presentation
  New Orleans（USA）
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] Molecular mechanisms of pancreatic b cell failure　Mechanism of b cell reduction in type 2 diabetes - from pathological investigation of human pancreas -2016
- Author(s)
  Hiroki Mizukami
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都都メッセ(京都府、京都市）
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 大血管障害を有する2型糖尿病症例における膵島変化の検討2015
- Author(s)
  舘田哲幸、稲葉渉、安欣、八木橋操六、水上浩哉
- Organizer
  第104回　日本病理学会総会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2015-04-30
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 膵β細胞病理UpDate2015
- Author(s)
  水上浩哉
- Organizer
  第51回弘前糖尿病研究会
- Place of Presentation
  ナクア弘前（青森県、弘前市）
- Year and Date
  2015-07-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] 膵島病理から考える2型糖尿病2015
- Author(s)
  水上浩哉
- Organizer
  弘前糖尿病カンファレンス
- Place of Presentation
  ナクア弘前（青森県、弘前市）
- Year and Date
  2015-04-24
- Invited
- Data Source
  KAKENHI-PROJECT-15K09374
[Presentation] Age-related changes of βcell volume and mass in non-diabetic Japanese subjects2013
- Author(s)
  Kohsuke Kamata, Hiroki Mizukami, Kazunori Takahashi, Wataru Inaba, Kentarou Tsuboi, Soroku Yagihashi
- Organizer
  第56回日本糖尿病学会年次集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Can incretin therapy improve the volume density of b cell in Japanese subjects?2013
- Author(s)
  Hiroki Mizukami
- Organizer
  Round Table Discussion in EASD 2013
- Place of Presentation
  バルセロナ（スペイン）
- Invited
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Slow and minimal decline of beta cell mass associated with aging 　　in non-diabetic Japanese and lack of compensatory islet hyperplasia in obesity.2013
- Author(s)
  Hiroki Mizukami, Kazunori Takahashi, Wataru Inaba, Kosuke Kamata, Osamu Uehara, Kentaro Tsuboi, Soroku Yagihashi
- Organizer
  Association for the Study of Diabetes 49th Annual Meeting
- Place of Presentation
  バルセロナ（スペイン）
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Molecular biology of the incretin in human and animalsインクレチンとβ細胞2013
- Author(s)
  水上浩哉
- Organizer
  糖尿病動物・肥満学会
- Place of Presentation
  JA共済ビルカンファレンスホール
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Slow and minimal decline of beta cell mass associated with aging in non-diabetic Japanese and lack of compensatory islet hyperplasia in obesity2013
- Author(s)
  Hiroki Mizukami, Kazunori Takahashi, Wataru Inaba, Kousuke Kamata, Osamu Uehara, kentaro Tsuboi, Soroku Yagihashi
- Organizer
  EASD 49^<th> annual meeting 2013
- Place of Presentation
  Barcelona
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Slow and progressive age-related decline of beta cell mass and proliferation activity 　of beta cells in non-diabetic Japanese subjects2012
- Author(s)
  Hiroki Mizukami, Kazunori Takahashi, Wataru Inaba, Kohsuke Kamata, Kentarou Tsuboi, Soroku Yagihashi
- Organizer
  ADA 72nd Scientific Sessions
- Place of Presentation
  Philadephia, USA
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Slow and progressive age-related decline of beta cell mass and proliferation activity of beta cells in non-diabetic Japanese subjects2012
- Author(s)
  Hiroki Mizukami, Kazunori Takahashi, Wataru Inaba, Kohsuke Kamata, Kentarou Tsuboi, Soroku Yagihashi
- Organizer
  ADA 72nd Scientific Sessions
- Place of Presentation
  Philadelphia, USA
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012
- Author(s)
  水上　浩哉、高橋一徳、稲葉渉、鎌田耕輔、小笠原早織、八木橋操六
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  京王プラザホテル
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012
- Author(s)
  水上浩哉、高橋一徳、稲葉渉、鎌田耕輔、小笠原早織、八木橋操六
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  京王プラザホテル、東京
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012
- Author(s)
  遅野井祥、水上浩哉、高橋一徳、稲葉渉、鎌田耕輔、小笠原早織、八木橋操六
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜パシフィコ
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] 加齢、肥満によるヒト膵島容量変化の検討2012
- Author(s)
  水上　浩哉
- Organizer
  第101回日本病理学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] Islet Beta Cell Mass in Human Type 2 Diabetic Patientsシンポジウム17膵β細胞の再生を目指して2011
- Author(s)
  Hiroki Mizukami and Soroku Yagihashi
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591292
[Presentation] 八木橋操六膵島移植における膵β細胞S1P1の役割について
- Author(s)
  水上浩哉、春日加奈子
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  於金沢
- Data Source
  KAKENHI-PROJECT-21790858

1. YAGIHASHI Soroku (40111231)

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2. WADA Ryuichi (20260408)

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16. SHIMOMURA Kenju

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17. KUDO Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 若狭朋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Mizukami Hiroki 水上 浩哉

MIZUKAMI Hiroki 水上 浩哉

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マクロファージ制御による進行期糖尿病性神経障害新規病態の解明、治療法の確立Principal Investigator

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Diabetes mellitus promotes sulfur metabolism in the pancreatic ductal adenocarcinoma and worsens the cancer prognosis

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Pathophysiological analysis of the beta cell volume change elicited by pregnancy and gestational diabetes mellitus in Japanese pregnant women

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膵島、腺房細胞クロストークを利用した2型糖尿病β細胞容積改善の試みPrincipal Investigator

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Altered neurovascular network in type 2 diabetes and its repair

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Pancreatic islet pathological changes, clinical course, and prognostic prediction based on type 2 diabetes susceptibility gene polymorphismPrincipal Investigator

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Exploration of new therapy for type 2 diabetes regulating epigenetic state evoked by islet amyloid depositionPrincipal Investigator

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Exploration into the role of progesteron reseptor in islet beta cells of Japanese type 2 diabetic subjectsPrincipal Investigator

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Development of new therapy for type 2 diabetes targeting sphingolipid receptor on pancreatic beta cellPrincipal Investigator

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Analysis of new animal type 2 diabetic model, pancreatic beta cell specific deleted glucosyltransferase mouse.Principal Investigator

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全身性炎症反応症候群(SIRS)におけるポリオール代謝の役割と新規治寮法の開発

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Impaired insulin secretion in pancreatic β-cells lacking the sphingosine-1-phosphate_1 receptor

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2型糖尿病でみられる膵β細胞脱落への低酸素の関与とその制御Principal Investigator

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Mizukami Hiroki 水上浩哉

MIZUKAMI Hiroki 水上浩哉