SAKAI Hiromichi 堺弘道

Researcher Number	00375255
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院医学・看護学系, 助教
Affiliation (based on the past Project Information) *help	2018 – 2023: 島根大学, 学術研究院医学・看護学系, 助教 2015 – 2017: 島根大学, 総合科学研究支援センター, 助教 2013 – 2014: 千葉大学, 理学(系)研究科(研究院), 特任研究員
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Functional biochemistry / Basic Section 90130:Medical systems-related
Keywords	Principal Investigator ジアシルグリセロールキナーゼ / 2型糖尿病 / 筋再生 / 褐色脂肪組織 / 筋形成 / 骨格筋 / 筋分化 / 脂肪酸 / 脂質代謝 / 脂質代謝経路 … More / β-tubulin / 骨格筋形成 / ミリスチン酸 / 細胞外マトリックス / 増殖 / 関節 / 細胞増殖 / 筋肉 / 坐骨神経 / テネイシンX / 慢性疼痛 / エーラス・ダンロス症候群 / グルコース / プロテインキナーゼC / サイクリンD1 / ホスファチジン酸 / 食餌療法 / 薬物療法 … More Except Principal Investigator ジアシルグリセロールキナーゼ / 認知症リスク検査 / 脳卒中 / 口腔内細菌 / リピドミクス / MRI / 認知症予防 / AI / 認知症予知 / アポトーシス / 歯状回 / ホスホリパーゼC / ホスファチジルコリン / ホスファチジルイノシトール / 神経細胞分化 / シグナル伝達 / ミリスチン酸 / モノアシルグリセロール / シヌクレイン / 糖尿病 / 強迫性障害 / 双極性障害 / がん / 活性制御 / リン酸化 / ジアシルグリセロール / 脂質 / 細胞情報伝達機構 / プレクストリン相同ドメイン / coiled-coil structure / sterile α motif domain / PH domain / 液体クロマトグラフィー/質量分析 / 相互作用 / Coiled-coil structure / ホスファチジルコリン特異的ホスホリパーゼC / 動脈硬化 / 生体膜 / ホスファチジルコリン-特異的ホスホリパーゼC Less

新規2型糖尿病治療法開発のためのDGKδの骨格筋・褐色脂肪組織形成機構の解明Principal Investigator
- Principal Investigator
  
  堺弘道
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Shimane University
認知症発症を予測するAI画像診断の多因子拡張による認知症予防システムの開発
- Principal Investigator
  
  長井篤
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90130:Medical systems-related
- Research Institution
  Shimane University
Regulation mechanisms of diacylglycerol kinase delta in differentiation and development of skeletal muscle to prevent exaggeration of type 2 diabetesPrincipal Investigator
- Principal Investigator
  
  Sakai Hiromichi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Shimane University
The mechanism of chronic pain in Ehlers-Danlos syndrome caused by tenascin-X deficiencyPrincipal Investigator
- Principal Investigator
  
  Sakai Hiromichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shimane University
Elucidation of the regulatory mechanisms of myogenesis by diacylglycerol kinase delta for improvement of insulin resistancePrincipal Investigator
- Principal Investigator
  
  Hiromichi Sakai
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shimane University
Identification of phosphatidylcholine-specifc phospholipase C
- Principal Investigator
  
  Sakane Fumio
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Chiba University
Identification of novel pathways consist of DGK isozymes using new analyzing methods and regulation of their functions
- Principal Investigator
  
  Sakane Fumio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Chiba University
Basic studies for development of type 2 diabetes therapy targeting diacylglycerol kinase deltaPrincipal Investigator
- Principal Investigator
  
  SAKAI Hiromichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Chiba University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Other

[Journal Article] Analysis of the time-dependent changes of phospholipids in the brain regions of a mouse model of Alzheimer’s disease2023
- Author(s)
  Ahsanul Haque Md.、Omori Naoki、Md. Sheikh Abdullah、Yano Shozo、Osago Harumi、Mitaki Shingo、Kalam Azad Abul、Sakai Hiromichi、Michikawa Makoto、Nagai Atsushi
- Journal Title
  
  Brain Research
  
  Volume: 1800 Pages: 148197-148197
- DOI
  10.1016/j.brainres.2022.148197
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07049, KAKENHI-PROJECT-20K07861
[Journal Article] Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated2023
- Author(s)
  Tobita Hiroshi、Sakai Hiromichi、Yamaguchi Akane、Notsu Yoshitomo、Kataoka Masatoshi、Yazaki Tomotaka、Nabika Toru、Ishihara Shunji、Kobayashi Hironori
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 73 Issue: 3 Pages: 255-261
- DOI
  10.3164/jcbn.23-58
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06096, KAKENHI-PROJECT-23K21628
[Journal Article] Myristic acid selectively augments β‐tubulin levels in C2C12 myotubes via diacylglycerol kinase δ2022
- Author(s)
  Sakai Hiromichi、Matsumoto Ken‐ichi、Urano Takeshi、Sakane Fumio
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 10 Pages: 1788-1796
- DOI
  10.1002/2211-5463.13466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19747, KAKENHI-PROJECT-20K07049, KAKENHI-PROJECT-20H03205
[Journal Article] Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry2021
- Author(s)
  Azad Abul Kalam、Kobayashi Hironori、Md. Sheikh Abdullah、Osago Harumi、Sakai Hiromichi、Ahsanul Haque Md.、Yano Shozo、Nagai Atsushi
- Journal Title
  
  Journal of Mass Spectrometry and Advances in the Clinical Lab
  
  Volume: 22 Pages: 26-33
- DOI
  10.1016/j.jmsacl.2021.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07049
[Journal Article] Time-Dependent Analysis of Plasmalogens in the Hippocampus of an Alzheimer’s Disease Mouse Model: A Role of Ethanolamine Plasmalogen2021
- Author(s)
  Azad Abul Kalam、Sheikh Abdullah Md.、Haque Md. Ahsanul、Osago Harumi、Sakai Hiromichi、Shibly Abu Zaffar、Yano Shozo、Michikawa Makoto、Hossain Shahdat、Tabassum Shatera、A. Garu、Zhou Xiaojing、Zhang Yuchi、Nagai Atsushi
- Journal Title
  
  Brain Sciences
  
  Volume: 11 Issue: 12 Pages: 1603-1603
- DOI
  10.3390/brainsci11121603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07049
[Journal Article] The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis2021
- Author(s)
  Sakane Fumio、Hoshino Fumi、Ebina Masayuki、Sakai Hiromichi、Takahashi Daisuke
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 20 Pages: 5190-5190
- DOI
  10.3390/cancers13205190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03205, KAKENHI-PROJECT-20J21133, KAKENHI-PROJECT-20K07049
[Journal Article] Diacylglycerol kinase eta regulates C2C12 myoblast proliferation through mTOR signaling pathway.2020
- Author(s)
  Hiromichi Sakai, Chiaki Murakami, Qiang Lu, Ken-ichi Matsumoto, Takeshi Urano and Fumio Sakane.
- Journal Title
  
  Biochimie
  
  Volume: 177 Pages: 13-24
- DOI
  10.1016/j.biochi.2020.07.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08470, KAKENHI-PROJECT-20K07049, KAKENHI-PROJECT-18J20003, KAKENHI-PROJECT-20H03205
[Journal Article] Myristic acid specifically stabilizes diacylglycerol kinase delta protein in C2C12 skeletal muscle cells.2019
- Author(s)
  Iwata, K., Sakai, H., Takahashi, D. and Sakane F.
- Journal Title
  
  Biochim Biophys Acta - Mol Cell Biol Lipids
  
  Volume: In press Issue: 7 Pages: 1031-1038
- DOI
  10.1016/j.bbalip.2019.04.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15444, KAKENHI-PROJECT-19K06527, KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-17K08271
[Journal Article] Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids2019
- Author(s)
  Hoshino Fumi、Murakami Chiaki、Sakai Hiromichi、Satoh Mamoru、Sakane Fumio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 513 Issue: 4 Pages: 1035-1040
- DOI
  10.1016/j.bbrc.2019.04.097
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-18J20003, KAKENHI-PROJECT-17K08271, KAKENHI-PROJECT-18K07462
[Journal Article] Diacylglycerol kinase β induces filopodium formation via its C1, catalytic and carboxy-terminal domains and interacts with the Rac1-GTPase-activating protein, β2-chimaerin2018
- Author(s)
  Maeda Yuki、Shibata Kosuke、Akiyama Rino、Murakami Yuki、Takao Saki、Murakami Chiaki、Takahashi Daisuke、Sakai Hiromichi、Sakane Fumio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 1 Pages: 54-60
- DOI
  10.1016/j.bbrc.2018.08.119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08271, KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-18J20003, KAKENHI-PROJECT-17K15444
[Journal Article] Diacylglycerol kinase δ controls down-regulation of cyclin D1 for C2C12 myogenic differentiation2018
- Author(s)
  Sakai Hiromichi、Murakami Chiaki、Matsumoto Ken-ichi、Urano Takeshi、Sakane Fumio
- Journal Title
  
  Biochimie
  
  Volume: 151 Pages: 45-53
- DOI
  10.1016/j.biochi.2018.05.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08271, KAKENHI-PROJECT-17K08983, KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-18J20003
[Journal Article] Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways.2018
- Author(s)
  Sakane, F., Mizuno, S., Takahashi, D., Sakai, H.
- Journal Title
  
  Adv. Biol. Regul.
  
  Volume: 67 Pages: 101-108
- DOI
  10.1016/j.jbior.2017.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08271, KAKENHI-PROJECT-17K15444, KAKENHI-PROJECT-17H03650
[Journal Article] A potential contribution of tenascin-X to blood vessel formation in peripheral nerves.2017
- Author(s)
  Sakai, H., Yokota, S., Kajitani, N., Yoneyama, T., Kawakami, K., Yasui, Y., Matsumoto, KI.
- Journal Title
  
  Neurosci. Res.
  
  Volume: 124 Pages: 1-7
- DOI
  10.1016/j.neures.2017.06.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08271
[Journal Article] Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behaviors.2016
- Author(s)
  Isozaki, T., Komenoi, S., Lu Q., Usuki, T., Tomokata, S., T., Matsutomo, D., Sakai, H. Bando, K., Kiyonari, H. and Sakane, F.
- Journal Title
  
  J. Neurochem.
  
  Volume: 137
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K14470
[Journal Article] Deficiency of diacylglycerol kinase η induces lithium-sensitive mania-like behaviors.2016
- Author(s)
  Isozaki, T., Komenoi, S., Lu Q., Usuki, T., Tomokata, S., T., Matsutomo, D., Sakai, H. Bando, K., Kiyonari, H. and Sakane, F.
- Journal Title
  
  J. Neurochem.
  
  Volume: 137
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26291017
[Journal Article] Distinct 1- and 2-monoacylglycerol kinase activities of diacylglycerol kinase isozymes.2016
- Author(s)
  Sato, Y., Murakami, C., Yamaki, A., Mizuno, S., Sakai, H. and Sakane, F.
- Journal Title
  
  Biochim. Biophys. Acta - Proteins Proteomics
  
  Volume: 1864 Issue: 9 Pages: 1170-1176
- DOI
  10.1016/j.bbapap.2016.06.012
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] The pleckstrin homology domain of diacylglycerol kinase η strongly and selectively binds to phosphatidylinositol 4,5-bisphosphate.2016
- Author(s)
  Kume, A., Kawase, K., Komenoi, S., Usuki, T., Takeshita, E., Sakai, H. and Sakane, F.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 15 Pages: 8150-8161
- DOI
  10.1074/jbc.m115.648717
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-16J06865, KAKENHI-PROJECT-15K18859
[Journal Article] Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species.2016
- Author(s)
  Kamiya, Y., Mizuno, S., Komenoi, S., Sakai, H., Sakane, F.
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 7 Pages: 361-366
- DOI
  10.1016/j.bbrep.2016.07.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J06865, KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] Myristic acid enhances diacylglycerol kinase δ-dependent glucose uptake in myotubes.2016
- Author(s)
  Wada, Y., Sakiyama, S., Sakai, H. and Sakane, F.
- Journal Title
  
  Lipids
  
  Volume: 51 Issue: 8 Pages: 897-903
- DOI
  10.1007/s11745-016-4162-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] Behavioral and pharmacological phenotypes of brain-specific diacylglycerol kinase δ-knockout mice.2016
- Author(s)
  Usuki, T., Takato, T., Lu Q., Sakai, H., Bando, K., Kiyonari, H. and Sakane, F.
- Journal Title
  
  Brain Res.
  
  Volume: 1648 Pages: 193-201
- DOI
  10.1016/j.brainres.2016.07.017
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] “Deficiency of diacylglycerol kinase h induces lithium-sensitive mania-like behavior.2016
- Author(s)
  Isozaki T., Komenoi S., Lu Q., Usuki T., Tomokata S., Usuki T., Tomokata S., Matsutomo D., Sakai H., Bando K., Kiyonari H., Sakane F.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 138 Issue: 3 Pages: 448-456
- DOI
  10.1111/jnc.13661
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16J06865, KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] Distinct expression and localization of type II diacylglycerol kinase isozymes δ, η and κ in mouse reproductive organs2015
- Author(s)
  Shionoya, T., Usuki, T., Komenoi, S., Isozaki, T., Sakai, H. and Sakane, F.
- Journal Title
  
  BMC Dev. Biol.
  
  Volume: 15 Issue: 1
- DOI
  10.1186/s12861-015-0055-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-26291017
[Journal Article] A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response2015
- Author(s)
  1)Lui K, Kunii N, Sakuma M, Yamaki A, Mizuno S, Sato M, Sakai H, Kado S, Kumagai K, Kojima H, Okabe T, Nagano T, Shirai Y. and Sakane F
- Journal Title
  
  J lipid res
  
  Volume: ５７ Issue: 3 Pages: 368-379
- DOI
  10.1194/jlr.m062794
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07002, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859, KAKENHI-PROJECT-26291017
[Journal Article] Expression and localization of type II diacylglycerol kinase isozymes δ and η in developing mouse brain2015
- Author(s)
  Usuki, T., Sakai, H., Shionoya, T., Sato, N. and Sakane, F.
- Journal Title
  
  J. Histochem. Cytochem.
  
  Volume: 63 Issue: 1 Pages: 57-68
- DOI
  10.1369/0022155414559130
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042, KAKENHI-PROJECT-26291017
[Journal Article] Diacylglycerol kinases η1 is a high affinity isozyme for diacylglycerol2015
- Author(s)
  Komenoi, S., Takemura, F., Sakai, H. and Sakane, F.
- Journal Title
  
  FEBS Lett.
  
  Volume: in press Issue: 11 Pages: 1272-1277
- DOI
  10.1016/j.febslet.2015.03.032
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-26291017, KAKENHI-PROJECT-15K14470, KAKENHI-PROJECT-15K18859
[Journal Article] Distinct expression and localization of type II diacylglycerol kinase isozymes δ, η and κ in mouse reproductive organs.2015
- Author(s)
  Shionoya, T., Usuki, T., Komenoi, S., Isozaki, T., Sakai, H., and Sakane, F.
- Journal Title
  
  BMC Dev. Biol.
  
  Volume: 15 Pages: 6-6
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860042
[Journal Article] Diacylglycerol kinase γ is a novel anionic phospholipid binding protein with a selective binding preference2014
- Author(s)
  Takeshita, E., Kume, I., Maeda, Y., Sakai, H. and Sakane, F.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 444 Issue: 4 Pages: 617-621
- DOI
  10.1016/j.bbrc.2014.01.116
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042
[Journal Article] EF-hand motifs of diacylglycerol kinase α interact intra-molecularly with its C1 domains2014
- Author(s)
  Yamamoto, T., Sakai, H. and Sakane, F.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 4 Issue: 1 Pages: 387-392
- DOI
  10.1016/j.fob.2014.04.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042, KAKENHI-PROJECT-26291017
[Journal Article] Regulation of diacylglycerol kinase δ expression in C2C12 skeletal muscle cells by free fatty acids2014
- Author(s)
  Sakiyama, S., Usuki, T., Sakai, H. and Sakane, F.
- Journal Title
  
  Lipids
  
  Volume: 49 Issue: 7 Pages: 633-640
- DOI
  10.1007/s11745-014-3912-9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042, KAKENHI-PROJECT-26291017
[Journal Article] Diacylglycerol kinase δ phosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels2014
- Author(s)
  Sakai, H., Kado, S., Taketomi, A. and Sakane, F.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 289 Issue: 38 Pages: 26607-26617
- DOI
  10.1074/jbc.m114.590950
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042, KAKENHI-PROJECT-26291017
[Journal Article] Osmotic shock-dependent redistribution of diacylglycerol kinase η1 to non-ionic detergent-resistant membrane via the pleckstrin homology and C1 domains2013
- Author(s)
  Matsutomo, D.
- Journal Title
  
  J. Biochem.
  
  Volume: 153 Issue: 2 Pages: 179-190
- DOI
  10.1093/jb/mvs130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370047, KAKENHI-PROJECT-25860042, KAKENHI-PUBLICLY-23116505
[Journal Article] Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method2013
- Author(s)
  Sato, M., Liu, K., Sasaki, S., Kunii, N., Sakai, H., Mizuno, H., Saga, H. and Sakane, F.
- Journal Title
  
  Pharmacology
  
  Volume: 92 Issue: 1-2 Pages: 99-107
- DOI
  10.1159/000351849
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116704, KAKENHI-PROJECT-25860042
[Journal Article] nduction of filopodia-like protrusions by diacylglycerol kinase γ independent of its enzymatic activity in N1E-115 neuroblastoma cells: potential novel function of the catalytic domain of diacylglycerol kinase γ2013
- Author(s)
  Tanino, F.
- Journal Title
  
  Mol. Cell. Biochem.
  
  Volume: 373 Issue: 1-2 Pages: 85-93
- DOI
  10.1007/s11010-012-1477-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370047, KAKENHI-PROJECT-25860042, KAKENHI-PUBLICLY-23116505
[Presentation] 脳ドック受診者における血中リゾリン脂質と脳委縮の関連性2023
- Author(s)
  大森直樹，石田学，高村真広，堺弘道，長井篤
- Organizer
  第32回日本脳ドック学会総会
- Data Source
  KAKENHI-PROJECT-23K06096
[Presentation] 脳ドック受診者における血中リゾリン脂質と脳委縮の関連性2023
- Author(s)
  大森直樹，石田　学，高村真広，堺　弘道，長井　篤
- Organizer
  第32回日本脳ドック学会総会
- Data Source
  KAKENHI-PROJECT-22K12864
[Presentation] PHOSPHO1はホスファチジルコリンとホスファチジルエタノールアミンのホスホリパーゼC活性を持つ2023
- Author(s)
  村上千明，堺弘道，坂根郁夫
- Organizer
  日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-23K06096
[Presentation] HOSPHO1はホスファチジルコリンとホスファチジルエタノールアミンに対するホスホリパーゼC活性を持つ2023
- Author(s)
  村上千明，堺弘道，角田（熱田）京子，Kamila Dilimulati，川合巧真，猪俣翔，坂根郁夫
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06096
[Presentation] PHOSPHO1はホスファチジルコリンとホスファチジルエタノールアミンのホスホリパーゼC活性を持つ2023
- Author(s)
  村上千明，堺弘道，坂根郁夫
- Organizer
  日本脂質生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06096
[Presentation] 保存期間がD型及びL型βアミノイソ酪酸の血漿濃度に及ぼす影響2022
- Author(s)
  外山雄大，野津吉友, 小林弘典, 堺弘道, 國澤研大, 渡辺淳, 矢野彰三, 金崎啓造, 並河徹
- Organizer
  第47回医用マススペクトル学会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ミリスチン酸はC2C12筋管細胞におけるβ-tubulin量を選択的かつジアシルグリセロールキナーゼδ依存的に増大させる2022
- Author(s)
  堺弘道，坂根郁夫
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] LC-MS/MSによるβアミノイソ酪酸（β-aminoisobutyric acid）鏡像異性体を識別する測定法の検討2021
- Author(s)
  外山雄大，野津吉友，田中美砂，小林弘典，堺弘道，國澤研大，渡辺淳，並河徹
- Organizer
  第46回日本医用マススペクトル学会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ミリスチン酸はC2C12細胞の筋分化過程におけるβ-tubulinの発現量を増大させる2021
- Author(s)
  堺弘道，坂根郁夫
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ジアシルグリセロールキナーゼηはmTOR－raptor－脂肪酸合成酵素経路を介してC2C12筋芽細胞の増殖を制御する2020
- Author(s)
  堺弘道，村上千明，坂根郁夫
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ジアシルグリセロールキナーゼηはmTORシグナル経路を介してC2C12筋芽細胞の増殖を制御する2020
- Author(s)
  堺弘道，村上千明，坂根郁夫
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ジアシルグリセロールキナーゼδとスフィンゴミエリン合成酵素関連タンパク質は機能的に連関する2020
- Author(s)
  村上千明，星野史規，堺弘道，林康広，山下純，坂根郁夫
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] Functional relationship between sphingomyelin synthase-related protein and diacylglycerol kinase δ2020
- Author(s)
  Chiaki Murakami, Fumi Hoshino, Hiromichi Sakai, Yasuhiro Hayashi, Atsushi Yamashita, Fumio Sakane
- Organizer
  Annual Meeting of the American Society for Biochemistry and Molecular Biology at Experimental Biology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] スフィンゴミエリン合成酵素関連タンパク質とジアシルグリセロールキナーゼδはsterile α motif domainを介して機能的に連関する2020
- Author(s)
  村上千明，星野史規，堺弘道，林康広，山下純，坂根郁夫
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] Functional relationship between sphingomyelin synthase- related protein and diacylglycerol kinase δ2020
- Author(s)
  Chiaki Murakami, Fumi Hoshino, Hiromichi Sakai, Yasuhiro Hayashi, Atsushi Yamashita and Fumio Sakane
- Organizer
  ASBMB 2020 Annual Meeting Virtual Spotlight Series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07049
[Presentation] ジアシルグリセロールキナーゼδとスフィンゴミエリン合成酵素関連タンパク質の相互作用および機能連関2019
- Author(s)
  村上千明，堺弘道，林康広，山下純，坂根郁夫
- Organizer
  2019年度生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] C2C12筋芽細胞におけるジアシルグリセロールキナーゼηによるmTORタンパク量の制御2019
- Author(s)
  堺弘道，坂根郁夫
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] Time-course analysis of ether lipids and ROS in Alzheimer’s disease model mouse2019
- Author(s)
  Abul Kalam Azad, Abdullah Md Sheikh, Harumi Osago, Hiromichi Sakai, Shozo Yano, Makoto Michikawa, Atsushi Nagai
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] ジアシルグリセロールキナーゼδとスフィンゴミエリン合成酵素関連タンパク質の相互作用および機能連関2019
- Author(s)
  村上千明，堺弘道，林康広，山下純，坂根郁夫
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] ジアシルグリセロールキナーゼηはC2C12筋芽細胞においてmTORタンパク量を調節する2019
- Author(s)
  堺弘道, 坂根郁夫
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] Analysis of phospholipid species in AD model mouse brain by LC-MS/MS2018
- Author(s)
  Haque Ahsanul，Sheikh Abdullah，長子　晴美，堺　弘道，土屋　美加子，道川　誠，長井　篤
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] ジアシルグリセロールキナーゼδによるC2C12筋芽細胞の筋分化制御機構2018
- Author(s)
  堺　弘道, 坂根　郁夫
- Organizer
  第91回日本生化学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] The role of diacylglycerol kinase δ in skeletal muscle glucose metabolism and myogenic differentiation2018
- Author(s)
  Hiromichi Sakai and Fumio Sakane
- Organizer
  1st International Symposium of Soft Molecular Activation Research Center (SMARC)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] 脂質代謝酵素ジアシルグリセロールキナーゼδの骨格筋グルコース代謝と分化における役割とその制御機構2018
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  第123回日本解剖学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] ジアシルグリセロールキナーゼδはC2C12筋芽細胞の筋分化誘導のためにcyclin D1の発現を制御する2017
- Author(s)
  堺　弘道, 松本　健一，坂根　郁夫
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] 細胞外マトリックス・テネイシンXは末梢神経の血管形成に関与する2017
- Author(s)
  堺　弘道, 松本　健一
- Organizer
  第90回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08271
[Presentation] ジアシルグリセロールキナーゼδはC2C12筋芽細胞の筋分化誘導のためにcyclin D1の発現を制御する2017
- Author(s)
  堺　弘道, 松本　健一，坂根　郁夫
- Organizer
  第59回日本脂質生化学会
- Place of Presentation
  京都（京都大学百周年時計台記念館）
- Year and Date
  2017-06-15
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] C2C12筋芽細胞の筋分化におけるジアシルグリセロールキナーゼδの機能2016
- Author(s)
  堺弘道，松本健一，坂根郁夫
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田・秋田
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] C2C12筋芽細胞の筋分化におけるジアシルグリセロールキナーゼδの機能2016
- Author(s)
  堺　弘道, 松本　健一，坂根　郁夫
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田（にぎわい交流館AU）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] C2C12筋芽細胞の筋分化におけるジアシルグリセロールキナーゼδの機能2016
- Author(s)
  堺弘道，松本健一，坂根郁夫
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田・秋田
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] ミリスチン酸は筋管細胞のジアシルグリセロールキナーゼδの発現とグルコース取り込み能を亢進する2015
- Author(s)
  和田　祐子，堺　弘道，崎山　静花，坂根　郁夫
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸（神戸ポートピアホテル、神戸国際会議場、神戸国際展示場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] ミリスチン酸は筋管細胞のジアシルグリセロールキナーゼδの発現とグルコース取り込み能を亢進する2015
- Author(s)
  和田祐子，堺弘道, 崎山静花，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] Diacylglycerol kinase η is a high affinity isozyme for diacylglycerol.2015
- Author(s)
  Komenoi, S., Sakai, H. and Sakane, F.
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼによって代謝されるジアシルグリセロール分子種のプロテインキナーゼC活性化能2015
- Author(s)
  神谷侑那, 水野悟, 堺弘道, 坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都・千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼによって代謝されるジアシルグリセロール分子種のプロテインキナーゼC活性化能2015
- Author(s)
  神谷侑那, 水野悟, 堺弘道, 坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] 発達中マウスの脳におけるdiacylglycerol kinase δの発現とその脳特異的欠損マウスの表現型解析2015
- Author(s)
  臼木　貴子, 高戸　珠恵, 堺　弘道, 坂根　郁夫
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸（神戸ポートピアホテル、神戸国際会議場、神戸国際展示場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都・千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井　優，堺　弘道，坂根　郁夫
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸（神戸ポートピアホテル、神戸国際会議場、神戸国際展示場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] Diacylglycerol kinase η is a high affinity isozyme for diacylglycerol.2015
- Author(s)
  Komenoi, S., Sakai, H. and Sakane, F.
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases.
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] 発達中マウスの脳におけるdiacylglycerol kinase δの発現とその脳特異的欠損マウスの表現型解析2015
- Author(s)
  臼木貴子，高戸珠恵，堺弘道，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである2015
- Author(s)
  米野井　優，堺　弘道，坂根　郁夫
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  東京（一橋大学一橋講堂）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] ミリスチン酸は筋管細胞のジアシルグリセロールキナーゼδの発現とグルコース取り込み能を亢進する2015
- Author(s)
  和田祐子，堺弘道, 崎山静花，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K14470
[Presentation] 発達中マウスの脳におけるdiacylglycerol kinase δの発現とその脳特異的欠損マウスの表現型解析2015
- Author(s)
  臼木貴子，高戸珠恵，堺弘道，坂根郁夫
- Organizer
  Biochemistry and Molecular Biology 2015（第88回日本生化学会大会・第38回日本分子生物学会年会）
- Place of Presentation
  神戸コンベンションセンター（兵庫県・神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼによって代謝されるジアシルグリセロール分子種のプロテインキナーゼC活性化能2015
- Author(s)
  神谷　侑那, 水野　悟, 堺　弘道, 坂根　郁夫
- Organizer
  第88回日本生化学会
- Place of Presentation
  神戸（神戸ポートピアホテル、神戸国際会議場、神戸国際展示場）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] Diacylglycerol kinases η1 is a high affinity isozyme for diacylglycerol2015
- Author(s)
  Suguru Komenoi, Hiromichi Sakai, and Fumio Sakane
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
- Place of Presentation
  Budapest（ハンガリー）
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] Expression and localization of diacylglycerol kinase δ in the developing mouse brain and phenotype of its brain-specific knockout mice2015
- Author(s)
  Takako Usuki, Hiromichi Sakai, and Fumio Sakane
- Organizer
  14th International Conference on Bioactive Lipids in Cancer, Inflammation, and Related Diseases
- Place of Presentation
  Budapest（ハンガリー）
- Year and Date
  2015-07-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18859
[Presentation] 脂質代謝酵素ジアシルグリセロールキナーゼδ、ηの酵素学的性質解析2014
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] Overlay法によるジアシルグリセロールキナーゼδのプレクストリン相同ドメインとリン脂質の相互作用の解析2013
- Author(s)
  久米　愛子，竹下　依那，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼαのCa2+に応答した分子内相互作用解析2013
- Author(s)
  山本　達也，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] Cell stimulation-dependent phosphorylation/consumption of various diacylglycerol sepecies by diacylglycerol kinase isozymes2013
- Author(s)
  Fumio Sakane and Hiromichi Sakai
- Organizer
  The 86th Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] グルコース刺激時にジアシルグリセロールキナーゼδが代謝するジアシルグリセロール分子種2013
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼη-ノックアウトマウスの表現型の解析2013
- Author(s)
  磯崎　丈志，臼木　貴子，米野井　優，松友　大介，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼδの脂肪酸による発現制御2013
- Author(s)
  崎山　静花，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] インスリン抵抗性を制御するDGKδによる糖応答性DG分子種選択的代謝2013
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  新学術領域「自然炎症」+「脂質マシナリー」合同若手ワークショップ
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] インターロイキン-2に応答したジアシルグリセロールキナーゼαの基質選択性の解析2013
- Author(s)
  水野　悟，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] LC/ESI-MSを用いたホスファチジン酸分子種の定量的分析法の確立とジアシルグリセロールキナーゼαの基質選択性の解析2013
- Author(s)
  水野　悟，堺　弘道，坂根　郁夫
- Organizer
  日本脂質生化学会
- Place of Presentation
  宮城
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 脂質代謝酵素ジアシルグリセロールキナーゼδ，ηの大腸菌を利用した大量発現・精製・性質解析2013
- Author(s)
  米野井　優，斎藤　雅文，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 脳におけるジアシルグリセロールキナーゼδの発現部位の解明及び脳特異的な本酵素ノックアウトマウスの表現型解析2013
- Author(s)
  臼木　貴子，堺　弘道，坂根　郁夫
- Organizer
  日本生化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼδはホスファチジルコリンに由来するパルミチン酸含有ジアシルグリセロール分子種を選択的にリン酸化する
- Author(s)
  堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] 脂質代謝酵素ジアシルグリセロールキナーゼδ，ηの酵素学的性質解析
- Author(s)
  米野井　優，堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] Diacylglycerol kinase η is a high affinity isozyme for diacylglycerol
- Author(s)
  Suguru Komenoi, Hiromichi Sakai, and Fumio Sakane
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 発達中マウスの脳におけるII型diacylglycerol kinaseアイソザイムδ及びηの発現と局在
- Author(s)
  臼木　貴子，堺　弘道，塩谷　貴生，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼηはジアシルグリセロール高親和性のアイソザイムである
- Author(s)
  米野井優，堺弘道，坂根郁夫
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  東京
- Year and Date
  2015-05-28 – 2015-05-29
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] 雌雄生殖器における II型ジアシルグリセロールキナーゼアイソザイム, δ, η, κの発現部位の同定と組織内発現分布の解析
- Author(s)
  塩谷貴生，臼木貴子，堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] 雌雄生殖器におけるII型ジアシルグリセロールキナーゼアイソザイム, δ, η, κの発現部位の同定と組織内発現分布の解析
- Author(s)
  塩谷　貴生，臼木　貴子，堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] グルコース刺激時におけるジアシルグリセロールキナーゼδのパルミチン酸含有ジアシルグリセロール分子種の選択的代謝
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 発達中マウスの脳におけるII型diacylglycerol kinaseアイソザイムδ及びηの発現と局在
- Author(s)
  臼木貴子，堺弘道，塩谷貴生，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼδはホスファチジルコリンに由来するパルミチン酸含有ジアシルグリセロール分子種を選択的にリン酸化する
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 神経分化誘導時に産生されるホスファチジン酸およびリゾホスファチジン酸分子種の解析
- Author(s)
  水野悟，堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ルコース刺激時におけるジアシルグリセロールキナーゼδのパルミチン酸含有ジアシルグリセロール分子種の選択的代謝
- Author(s)
  堺弘道，坂根郁夫
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  東大阪
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] 神経分化誘導時に産生されるホスファチジン酸およびリゾホスファチジン酸分子種の解析
- Author(s)
  水野　悟，堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] Expression and localization of diacylglycerol kinase δ in the developing mouse brain and phenotype of its brain-specific knockout mice
- Author(s)
  Takako Usuki, Hiromichi Sakai, and Fumio Sakane
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] II型ジアシルグリセロールキナーゼのプレクストリン相同ドメインとリン脂質の相互作用
- Author(s)
  久米愛子，竹下依那，堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] ジアシルグリセロールキナーゼδのモノアシルグリセロールキナーゼ活性
- Author(s)
  佐藤　優里子，堺　弘道，水野　悟，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] II型ジアシルグリセロールキナーゼのプレクストリン相同ドメインとリン脂質の相互作用
- Author(s)
  久米　愛子，竹下　依那，堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] 糖代謝に関わる脂質代謝酵素ジアシルグリセロールキナーゼδの基質選択性の同定
- Author(s)
  堺　弘道，坂根　郁夫
- Organizer
  千葉疾患プロテオミクス研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] Diacylglycerol kinase δ phosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels
- Author(s)
  Sakai, H. and Sakane, F.
- Organizer
  6th International Conference on PLA2 and Lipid Mediators (PLM2015)
- Place of Presentation
  Tokyo
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] Cold shock-trigger factor系を用いたジアシルグリセロールキナーゼα, δ, ηの発現・精製と活性測定
- Author(s)
  竹村　文花，米野井　優，佐藤　優里子，堺　弘道，坂根　郁夫
- Organizer
  第87回日本生化学会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] Cold shock-trigger factor系を用いたジアシルグリセロールキナーゼα, δ, ηの発現・精製と活性測定
- Author(s)
  竹村文花，米野井優，佐藤優里子，堺弘道，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[Presentation] Diacylglycerol kinase δ phosphorylates phosphatidylcholine-specific phospholipase C-dependent, palmitic acid-containing diacylglycerol species in response to high glucose levels
- Author(s)
  Hiromichi Sakai and Fumio Sakane
- Organizer
  6th international conference on Phospholipase A2 and Lipid Mediators
- Place of Presentation
  Tokyo
- Year and Date
  2015-02-10 – 2015-02-12
- Data Source
  KAKENHI-PROJECT-25860042
[Presentation] ジアシルグリセロールキナーゼδのモノアシルグリセロールキナーゼ活性
- Author(s)
  藤優理子，堺弘道，水野悟，坂根郁夫
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26291017
[]

1. SAKANE Fumio (10183815)

# of Collaborated Projects: 4 results

# of Collaborated Products: 77 results
2. 長井篤 (40273940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SK.A bdullahMD (30403447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 和田孝一郎 (90263467)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 白井康仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 高橋大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 松本健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAI Hiromichi 堺 弘道

Research Projects

Research Products

Co-Researchers

新規2型糖尿病治療法開発のためのDGKδの骨格筋・褐色脂肪組織形成機構の解明Principal Investigator

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認知症発症を予測するAI画像診断の多因子拡張による認知症予防システムの開発

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Regulation mechanisms of diacylglycerol kinase delta in differentiation and development of skeletal muscle to prevent exaggeration of type 2 diabetesPrincipal Investigator

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The mechanism of chronic pain in Ehlers-Danlos syndrome caused by tenascin-X deficiencyPrincipal Investigator

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Elucidation of the regulatory mechanisms of myogenesis by diacylglycerol kinase delta for improvement of insulin resistancePrincipal Investigator

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Identification of phosphatidylcholine-specifc phospholipase C

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Identification of novel pathways consist of DGK isozymes using new analyzing methods and regulation of their functions

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Basic studies for development of type 2 diabetes therapy targeting diacylglycerol kinase deltaPrincipal Investigator

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[Journal Article] Analysis of the time-dependent changes of phospholipids in the brain regions of a mouse model of Alzheimer’s disease2023

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[Journal Article] Association of lysophosphatidic acid molecules with liver fibrosis: different roles indicated2023

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[Journal Article] Myristic acid selectively augments β‐tubulin levels in C2C12 myotubes via diacylglycerol kinase δ2022

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[Journal Article] Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry2021

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[Journal Article] Time-Dependent Analysis of Plasmalogens in the Hippocampus of an Alzheimer’s Disease Mouse Model: A Role of Ethanolamine Plasmalogen2021

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[Journal Article] The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis2021

SAKAI Hiromichi 堺弘道