Yamamoto Takehito 山本武人

… Alternative Names

YAMAMOTO Takehito 山本武人

山本武人ヤマモトタケヒト

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Researcher Number	00376469
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 副薬剤部長
Affiliation (based on the past Project Information) *help	2016 – 2022: 東京大学, 大学院薬学系研究科(薬学部), 講師 2015: 東京大学, 薬学研究科(研究院), 講師 2014: 東京大学, 医学部附属病院, 薬剤主任 2010 – 2012: 東京大学, 医学部附属病院, 助教 2005 – 2006: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Infectious disease medicine Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator クリアランス / 血液透析 / PK/PD理論 / 抗菌薬 / 動的PK/PDモデル / PKPD理論 / シミュレーション / モデル解析 / 数理モデル / 慢性腎不全 … More / タンパク結合 / 尿毒素 / 蛋白質結合性尿毒素 / タンパク結合性尿毒素 / 慢性腎臓病 / 透過性 / 定量的予測 / 透析性 / 投与設計 / 薬物動態学 / 個別化薬物療法 / TDM / 投与量設計 / 個別化投与量設計 / 感染症治療学 / セロトニン / 薬物受容体 / 遺伝薬理学 / 遺伝的多型 / 薬剤反応性 … More Except Principal Investigator 医療・福祉 / 臨床 / 薬剤反応性 / 蛋白質 / トランスレーショナルリサーチ / 療・福祉 / 炎症性サイトカイン / 薬剤性肝障害 / 医薬品化学 Less

Construction and evaluation of a mechanism-based dynamic PK/PD model for antimicrobial agents for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takehito
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  The University of Tokyo
Investigation of new blood purification therapy which enables efficient removal of protein-bound uremic toxinsPrincipal Investigator
- Principal Investigator
  
  Yamamoto Takehito
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Quantitative prediction of drug removal by hemodialysis based on permeation clearance of hemodialyzerPrincipal Investigator
- Principal Investigator
  
  YAMAMOTO Takehito
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo
Construction of the methodology to enable the rational dosage setting of various antibiotics based on the available TDM data.Principal Investigator
- Principal Investigator
  
  YAMAMOTO Takehito
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  The University of Tokyo
Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP
- Principal Investigator
  
  HISAKA Akihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
セロトニン受容体遺伝子多型のトリプタン系薬剤の有効性に対する影響に関する研究Principal Investigator
- Principal Investigator
  
  山本武人
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  The University of Tokyo

[Book] 腎不全と薬の使い方Q&A 第2版2020
- Author(s)
  平田純生, 竹内裕紀, 古久保拓, 大野能之, 山本武人
- Total Pages
  899
- Publisher
  株式会社じほう
- ISBN
  9784840752817
- Data Source
  KAKENHI-PROJECT-17K08437
[Journal Article] Teicoplanin and vancomycin as treatment for glycopeptide-susceptible Enterococcus faecium bacteraemia: a propensity score-adjusted non-inferior comparative study2023
- Author(s)
  Ryo Yamaguchi, Takehito Yamamoto, Koh Okamoto, Sohei Harada, Miho Echizenya, Takeya Tsutsumi, Tappei Takada
- Journal Title
  
  Journal of Antimicrobial Chemotherapy
  
  Volume: - Issue: 5 Pages: 1231-1240
- DOI
  10.1093/jac/dkad079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04300, KAKENHI-PROJECT-20K07127
[Journal Article] Impact of targeted intervention using a collaborative approach for oral third-generation cephalosporins: An interrupted time-series analysis2022
- Author(s)
  Ryo Yamaguchi, Koh Okamoto, Takehito Yamamoto, Sohei Harada, Takehiro Tanaka, Hiroshi Suzuki, Kyoji Moriya
- Journal Title
  
  Antimicrobial Stewardship & Healthcare Epidemiology
  
  Volume: 2 Issue: 1
- DOI
  10.1017/ash.2022.251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07127
[Journal Article] History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer2021
- Author(s)
  Nara Katsuhiko、Taguchi Ayumi、Tojima Yuri、Miyamoto Yuichiro、Tanikawa Michihiro、Sone Kenbun、Mori Mayuyo、Tsuruga Tetsushi、Yamamoto Takehito、Takenaka Ryosuke、Takada Tappei、Osuga Yutaka、Suzuki Hiroshi
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 26 Issue: 9 Pages: 1759-1766
- DOI
  10.1007/s10147-021-01950-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07636, KAKENHI-PROJECT-20H03820, KAKENHI-PROJECT-20K07127, KAKENHI-PROJECT-20K18157
[Journal Article] Poor penetration of cefcapene into aqueous humor after oral administration of cefcapene pivoxil to patients undergoing cataract surgery2020
- Author(s)
  Okamoto Koh、Asano Shotaro、Yamamoto Takehito、Toyono Tetsuya、Yamaguchi Ryo、Okada Yuta、Okugawa Shu、Suzuki Hiroshi、Moriya Kyoji、Aihara Makoto
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 26 Issue: 2 Pages: 312-315
- DOI
  10.1016/j.jiac.2019.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08949, KAKENHI-PROJECT-17K08437
[Journal Article] Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.2018
- Author(s)
  Takada T, Yamamoto T, Matsuo H, Tan JK, Ooyama K, Sakiyama M, Miyata H, Yamanashi Y, Toyoda Y, Higashino T, Nakayama A, Nakashima A, Shinomiya N, Ichida K, Ooyama H, Fujimori S, Suzuki H
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 11147-11147
- DOI
  10.1038/s41598-018-29208-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08437, KAKENHI-PROJECT-18KK0247, KAKENHI-PROJECT-16H01808, KAKENHI-PROJECT-18H02685, KAKENHI-PROJECT-15H05610, KAKENHI-PROJECT-16H06219
[Journal Article] Bayesian Estimation of Pharmacokinetic Parameters of Vancomycin in Patients with Decreasing Renal Function2012
- Author(s)
  Yamamoto Takehito, Terakawa Hirokazu, Hisaka Akihiro, Suzuki Hiroshi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 101巻 Pages: 2968-2975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791133
[Journal Article] Proposal of a pharmacokinetically optimized dosage regimen of antibiotics in patients receiving continuous hemodiafiltration.2011
- Author(s)
  Yamamoto Takehito, Yasuno Nobuhiro, Katada Shoichi, Hisaka Akihiro, Hanafusa Norio, Noiri Eisei, Yahagi Naoki, Fujita Toshiro, Suzuki Hiroshi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 55 Pages: 5804-5812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791133
[Journal Article] Proposal of a pharmacokinetically optimized dosage regimen of antibiotics in patients receiving continuous hemodiafiltration2011
- Author(s)
  Yamamoto Takehito, Yasuno Nobuhiro, Katada Shoichi, Hisaka Akihiro, Hanafusa Norio, Noiri Eisei, Yahagi Naoki, Fujita Toshiro, Suzuki Hiroshi
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 55巻 Pages: 5804-5812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791133
[Journal Article] Theoretical considerations on quantitative prediction of drug-drug Interactions.2010
- Author(s)
  Hisaka A, Ohno Y, Yamamoto T, Suzuki H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 25 Pages: 48-61
- NAID
  10027581845
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] 腸管と腎・尿細管のクロストーク:吸収から物質輸送まで　腸管・腎尿細管の尿酸輸送と高尿酸血症2019
- Author(s)
  高田龍平, 宮田大資, 豊田優, 山梨義英, 山本武人, 鈴木洋史
- Organizer
  第50回日本消化吸収学会総会
- Data Source
  KAKENHI-PROJECT-17K08437
[Presentation] Quantitative prediction of drug removal rate by hemodialysis based on the permeation clearance of hemodialyzer.2017
- Author(s)
  Yamamoto T, Ogiue N, Miyata Y, Suzuki H
- Organizer
  15th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08437
[Presentation] 透析膜透過クリアランスに着目した透析除去率の定量的予測2016
- Author(s)
  荻上尚樹、宮田優希、山本武人、鈴木洋史
- Organizer
  第10回日本腎臓病薬物療法学会
- Place of Presentation
  横浜
- Year and Date
  2016-11-19
- Data Source
  KAKENHI-PROJECT-26460191
[Presentation] Therapeutic Drug Monitoring guidelines of JSTDM2015
- Author(s)
  Takehito Yamamoto
- Organizer
  14th International Congress of Therapeutic Drug. Monitoring & Clinical Toxicology
- Place of Presentation
  Rotterdam, Netherlands
- Year and Date
  2015-10-11
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460191
[Presentation] よくわかる透析による薬物除去の考え方－クリアランスに着目して理解しよう－2015
- Author(s)
  山本武人
- Organizer
  第9回　日本腎臓病薬物療法学会
- Place of Presentation
  仙台国際センター（宮城県・仙台市）
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-26460191
[Presentation] CRRT施行中の薬物投与のポイント（教育セミナー）2013
- Author(s)
  山本武人
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] CRRT施行中の薬物投与のポイント2013
- Author(s)
  山本武人
- Organizer
  第40回日本集中治療医学会学術集会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 腹膜透析導入患者におけるバンコマイシンの体内動態解析と投与量設計への応用2012
- Author(s)
  山本武人、樋坂章博、鈴木洋史
- Organizer
  第６回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 持続血液浄化療法施行時の抗菌薬の投与量設計－薬物動態学的解析を用いたアプローチ－2012
- Author(s)
  山本武人、安野伸浩、樋坂章博、花房規男、片田正一、矢作直樹、鈴木洋史
- Organizer
  第6回日本腎臓病薬物療法学会学術集会・総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 腹膜透析導入患者におけるバンコマイシンの体内動態解析と投与量設計への応用2012
- Author(s)
  山本武人,樋坂章博,鈴木洋史
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] Construction of the Mutabale Covariates Model which enables the pharmacokinetic analysis with unstable drug clearance and its application for the patients receiving vancomycin therapy2012
- Author(s)
  Yamamoto Takehito, Terakawa Hirokazu, Hisaka Akihiro, Suzuki Hiroshi
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] Estimation of Optimal Dosages for Patients Receiving Continuous Renal Replacement Therapy: A Proposal for the Description of Pharmacokinetic Data in Product Labeling2012
- Author(s)
  Yamamoto Takehito, Hisaka Akihiro, Suzuki Hiroshi
- Organizer
  World Conference on Pharmacometrics 2012
- Place of Presentation
  ソウル（韓国）
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 持続血液浄化療法施行時の抗菌薬の投与量設計-薬物動態学的解析を用いたアプローチ-2012
- Author(s)
  山本武人,安野伸浩,樋坂章博,花房規男,片田正一,矢作直樹,鈴木洋史
- Organizer
  第6回日本腎臓病薬物療法学会学術集会・総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] Construction of the Mutable Covariates Model which enables the pharmacokinetic analysis with unstable drug clearance and its application for the patients receivingvancomycin therapy2012
- Author(s)
  Yamamoto Takehito, Terakawa Hirokazu, Hisaka Akihiro, Suzuki Hiroshi
- Organizer
  日本薬物動態学会第27回年回
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] Estimation of Optimal Dosages for Patients Receiving Continuous Renal Replacement Therapy: A Proposal for the Description of Pharmacokinetic Data in Product Labeling2012
- Author(s)
  Yamamoto Takehito, Hisaka Akihiro, Suzuki Hiroshi
- Organizer
  World Conference onPharmacometrics 2012
- Place of Presentation
  ソウル(韓国)
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 患者の疾患背景に基づいた薬物誘発性肝障害の発症リスク評価2012
- Author(s)
  池淵祐樹、伊藤晃成、本間雅、山本武人、鈴木洋史
- Organizer
  第12回東京大学生命科学シンポジウム
- Place of Presentation
  東京(東京大学）
- Data Source
  KAKENHI-PROJECT-22390020
[Presentation] Pharmacokinetic optimization of dosing regimen of aminosides and vancomycin in critically ill patients receiving continuous renal replacement.2011
- Author(s)
  Yamamoto Takehito, Yasuno Nobuhiro, Hisaka Akihiro, Katada Shoichi,
- Organizer
  12th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  シュツッツガルト（ドイツ）
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] Pharmacokinetic optimization of dosing regimen of aminosides and vancomycin in critically ill patients receiving continuous renal replacement2011
- Author(s)
  Yamamoto Takehito, Yasuno Nobuhiro, Hisaka Akihiro, Katada Shoichi, Hanafusa Norio, Suzuki Hiroshi
- Organizer
  12th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Place of Presentation
  シュツッツガルト(ドイツ)
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 経時的なクリアランス変動を考慮した薬物動態モデルの構築とベイズ推定に基づくバンコマイシンのTDMへの応用2011
- Author(s)
  山本武人,寺川央一,樋坂章博,鈴木洋史
- Organizer
  第28回日本TDM学会・学術集会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 経時的なクリアランス変動を考慮した薬物動態モデルの構築とベイズ推定に基づくバンコマイシンのTDMへの応用2011
- Author(s)
  山本武人、寺川央一、樋坂章博、鈴木洋史
- Organizer
  第28回日本TDM学会・学術大会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23791133
[Presentation] 血液浄化法による薬物除去について徹底討論する　この薬物は除去されるのか、どれだけ補充すればよいのか? 持続的血液浄化法(CAPD、CRRT)施行時の薬物除去を科学する
- Author(s)
  山本武人
- Organizer
  第59回日本透析医学会学術集会・総会
- Place of Presentation
  神戸
- Year and Date
  2014-06-12 – 2014-06-15
- Data Source
  KAKENHI-PROJECT-26460191
[Presentation] 急性血液浄化療法中の薬物動態変化と投与設計の考え方
- Author(s)
  山本武人、鈴木洋史
- Organizer
  第25回日本急性血液浄化療法学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2014-10-10 – 2014-10-11
- Data Source
  KAKENHI-PROJECT-26460191
[]

1. HISAKA Akihiro (80420206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. ITO Kousei (30323405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. HONMA Masashi (60401072)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. IKEBUCHI Yuki (20645725)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 鈴木洋史 (80206523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. MORI Mayuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. Yamaguchi Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 奥川周

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 田口歩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamamoto Takehito 山本 武人

YAMAMOTO Takehito 山本 武人

山本 武人 ヤマモト タケヒト

Research Projects

Research Products

Co-Researchers

Construction and evaluation of a mechanism-based dynamic PK/PD model for antimicrobial agents for clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of new blood purification therapy which enables efficient removal of protein-bound uremic toxinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Quantitative prediction of drug removal by hemodialysis based on permeation clearance of hemodialyzerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of the methodology to enable the rational dosage setting of various antibiotics based on the available TDM data.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on Drug-Induced Liver Injury Associated with MetabolicActivation by CYP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

セロトニン受容体遺伝子多型のトリプタン系薬剤の有効性に対する影響に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 腎不全と薬の使い方Q&A 第2版2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Teicoplanin and vancomycin as treatment for glycopeptide-susceptible Enterococcus faecium bacteraemia: a propensity score-adjusted non-inferior comparative study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of targeted intervention using a collaborative approach for oral third-generation cephalosporins: An interrupted time-series analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Poor penetration of cefcapene into aqueous humor after oral administration of cefcapene pivoxil to patients undergoing cataract surgery2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bayesian Estimation of Pharmacokinetic Parameters of Vancomycin in Patients with Decreasing Renal Function2012

Author(s)

Journal Title

Data Source

[Journal Article] Proposal of a pharmacokinetically optimized dosage regimen of antibiotics in patients receiving continuous hemodiafiltration.2011

Author(s)

Journal Title

Yamamoto Takehito 山本武人

YAMAMOTO Takehito 山本武人

山本武人ヤマモトタケヒト

[Presentation] 腸管と腎・尿細管のクロストーク:吸収から物質輸送まで　腸管・腎尿細管の尿酸輸送と高尿酸血症2019

[Presentation] よくわかる透析による薬物除去の考え方－クリアランスに着目して理解しよう－2015