SONE Takefumi 曽根岳史

Researcher Number	00379091
Other IDs
Affiliation (based on the past Project Information) *help	2017: 慶應義塾大学, 医学部(信濃町), 訪問研究員 2016: 慶應義塾大学, 医学部(信濃町), 特任助教 2015: 慶應義塾大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator System genome science
Keywords	Principal Investigator ウイルスベクター / 疾患研究 / 相同組換え / 遺伝子治療 / TALEN / ノックイン / CRISPR / iPS細胞 / ゲノム編集

Development of genome editing technology with low off-target risk and high efficiency in human pluripotent stem cellsPrincipal Investigator
- Principal Investigator
  
  SONE Takefumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  System genome science
- Research Institution
  Keio University

All 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction.2018
- Author(s)
  Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M.
- Journal Title
  
  Mol Brain.
  
  Volume: 11 Issue: 1 Pages: 6-6
- DOI
  10.1186/s13041-018-0349-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07070, KAKENHI-PROJECT-16K08280, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-15K06924, KAKENHI-PUBLICLY-17H05706
[Journal Article] Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene2018
- Author(s)
  Tanaka Yasuyoshi、Sone Takefumi、Higurashi Norimichi、Sakuma Tetsushi、Suzuki Sadafumi、Ishikawa Mitsuru、Yamamoto Takashi、Mitsui Jun、Tsuji Hitomi、Okano Hideyuki、Hirose Shinichi
- Journal Title
  
  Stem Cell Research
  
  Volume: 28 Pages: 100-104
- DOI
  10.1016/j.scr.2018.01.036
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-26461552, KAKENHI-PROJECT-16K18478, KAKENHI-PROJECT-26860833, KAKENHI-PROJECT-18K07802, KAKENHI-PROJECT-15H02548, KAKENHI-PROJECT-16K15532
[Journal Article] Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss2017
- Author(s)
  Makoto Hosoya, Masato Fujioka, Takefumi Sone, Satoshi Okamoto, Wado Akamatsu, Hideki Ukai, Hiroki R. Ueda, Kaoru Ogawa, Tatsuo Matsunaga, Hideyuki Okano
- Journal Title
  
  Cell Reports
  
  Volume: 18 Issue: 1 Pages: 68-81
- DOI
  10.1016/j.celrep.2016.12.020
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-15K15624, KAKENHI-PROJECT-26670748, KAKENHI-PROJECT-15H04991
[Journal Article] Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons.2017
- Author(s)
  Suzuki S, Akamatsu W, Kisa F, Sone T, Ishikawa KI, Kuzumaki N, Katayama H, Miyawaki A, Hattori N, Okano H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 489 Issue: 1 Pages: 88-93
- DOI
  10.1016/j.bbrc.2016.12.188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-16K09677, KAKENHI-PROJECT-16K19524, KAKENHI-PROJECT-16K08280
[Journal Article] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells.2016
- Author(s)
  Naoki Ichiyanagi, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa, Yoshinori Nishimoto, Yasuharu Ishihara, Tetsushi Sakuma, Takashi Yamamoto, Hitomi Tsuiji, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Hideyuki Okano
- Journal Title
  
  Stem Cell Reports
  
  Volume: 6 Issue: 4 Pages: 496-510
- DOI
  10.1016/j.stemcr.2016.02.011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924, KAKENHI-PROJECT-25430055, KAKENHI-PROJECT-26830018, KAKENHI-PROJECT-15H04278, KAKENHI-PROJECT-15H05667, KAKENHI-PROJECT-25293199, KAKENHI-PLANNED-26117007, KAKENHI-PUBLICLY-15H01568, KAKENHI-PROJECT-25640038, KAKENHI-PROJECT-16K07247
[Journal Article] 2. iPS細胞技術とゲノム編集技術を駆使した筋萎縮性側索硬化症病態モデルの創成と治療への展望2016
- Author(s)
  曽根岳史、一柳直希、藤森康希、岡野栄之
- Journal Title
  
  実験医学(増刊)
  
  Volume: 34 Pages: 146-157
- Data Source
  KAKENHI-PROJECT-15K06924
[Journal Article] Controlling the regional identity of hPSC-derived neurons to uncover neuronal subtype specificity of neurological disease phenotypes.2015
- Author(s)
  Kent Imaizumi, Takefumi Sone, Keiji Ibata, Koki Fujimori, Michisuke Yuzaki, Wado Akamatsu, Hideyuki Okano
- Journal Title
  
  Stem Cell Reports
  
  Volume: 5 Issue: 6 Pages: 1010-1022
- DOI
  10.1016/j.stemcr.2015.10.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924, KAKENHI-PLANNED-26117007
[Presentation] Generation of gene-corrected iPSC from patient-derived iPSC with familial Parkinson's disease2017
- Author(s)
  Etsuro Ohta, Takefumi Sone, Yuri Obinata, Hideki Ukai, Tomoko Hisamatsu, Tokiko Kitagawa, Mitsuru Ishikawa, Hajime Komano, Hiroki R. Ueda, Fumiya Obata, Hideyuki Okano
- Organizer
  ISSCR 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Pathophysiological analysis of skeletal muscles in spinal bulbar muscular atrophy (SBMA) by genome editing of CAG repeats.2017
- Author(s)
  Satoshi Tanaka, Takuji Ito, Akinobu Ota, Takefumi Sone, Daisuke Shimojo, Shiro Imagama, Yoshitaka Hosokawa, Manabu Doyu, Hideyuki Okano, Yohei Okada
- Organizer
  Neuroscience 2017 (SfN’s 47th Annual Meeting)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Functional analysis of synaptic gene expression and morphologies in Angelman syndrome patient-derived neurons2017
- Author(s)
  Mitsuru Ishikawa, Ryotaro Okochi, Hironobu Okuno, Shoma Tanaka, Takefumi Sone
- Organizer
  CDB Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Multisite Gatewayクローニング技術に立脚した汎用ヒトiPS細胞ゲノム編集ツールボックス2017
- Author(s)
  曽根岳史, 吉松祥, 塩澤誠司, 大河内遼太郎, 石川充, 木下実結, 藤森康希, 川嶋志保子, 大多茂樹, 鐘ヶ江裕美, 三好浩之, 岡野栄之
- Organizer
  日本ゲノム編集学会第2回大会
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] iPS細胞におけるAngelman症候群原因遺伝子UBE3Aノックアウトの作製と神経細胞の表現型探索2017
- Author(s)
  大河内遼太郎, 曽根岳史, 石川充, 奥野博庸, 中武悠樹, 洪実, 小崎健次郎, 岡野栄之
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター, 仙台
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2017
- Author(s)
  太田悦朗, 曽根岳史, 大日方友理, 鵜飼英樹, 久松知子, 北川季子, 石川充, 駒野肇, 上田泰己, 小幡文弥, 岡野栄之
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台国際センター, 仙台
- Year and Date
  2017-03-07
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] ゲノム編集による筋委縮性側索硬化症(ALS)の病態モデル細胞の創成と遺伝子治療2016
- Author(s)
  曽根岳史*, 一柳直希, 藤森康希, 岡野栄之
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場, 広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells2016
- Author(s)
  Naoki Ichiyanagi*, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa, Yoshinori Nishimoto, Yasuharu Ishihara, Tetsushi Sakuma, Takashi Yamamoto, Hitomi Tsuiji, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Hideyuki Okano
- Organizer
  ISSCR 2016 Annual Meeting
- Place of Presentation
  San Francisco, CA
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] mt-Keimaを用いたパーキンソン病iPS細胞におけるマイトファジー解析システムの構築2016
- Author(s)
  鈴木禎史*, 赤松和土, 木佐文彦, 曽根岳史, 石川景一, 服部信孝, 岡野栄之
- Organizer
  第38回日本生物学的精神医学会・第59回日本神経化学会大会合同年会
- Place of Presentation
  福岡国際会議場, 福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Generation of specific neuronal subtypes from human pluripotent stem cells2016
- Author(s)
  Kent Imaizumi*, Takefumi Sone, Wado Akamatsu, Hideyuki Okano
- Organizer
  ISSCR 2016 Annual Meeting
- Place of Presentation
  San Francisco, CA
- Year and Date
  2016-06-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] ゲノム編集によるポリグルタミン病の病態解析と治療開発の可能性2016
- Author(s)
  田中智史, 伊藤卓治, 太田明伸, 曽根岳史, 下門大祐, 小野寺一成, 今釜史郎, 細川好孝, 道勇学, 勝野雅央, 祖父江元, 岡野栄之, 岡田洋平
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜, 横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞のゲノム編集および病態解析2016
- Author(s)
  太田悦朗*, 曽根岳史, 大日方友理, 鵜飼英樹, 久松知子, 北川季子, 石川充, 駒野肇, 上田泰己, 小幡文弥, 岡野栄之
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜, 横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2016
- Author(s)
  大日方友理*, 太田悦朗, 曽根岳史, 鵜飼英樹, 久松知子, 石川充, 駒野肇, 上田泰己, 小幡文弥, 岡野栄之
- Organizer
  第11回日本臨床検査教育学会学術大会
- Place of Presentation
  神戸常盤大学・神戸国際展示場, 神戸
- Year and Date
  2016-08-31
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] ゲノム編集によるポリグルタミン病の病態解析と治療開発の可能性2016
- Author(s)
  田中智史, 伊藤卓治, 太田明伸, 曽根岳史, 今釜史郎, 細川好孝, 道勇学, 岡野栄之, 岡田洋平
- Organizer
  日本ゲノム編集学会第1回大会
- Place of Presentation
  広島国際会議場, 広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] PENDRED症候群疾患特異的iPS細胞由来内耳細胞を用いた薬剤スクリーニング2015
- Author(s)
  細谷誠*, 藤岡正人, 岡本理志, 曽根岳史, 松永達雄, 赤松和土, 小川郁, 岡野栄之
- Organizer
  第36回日本炎症・再生医学会
- Place of Presentation
  虎ノ門ヒルズフォーラム (東京都港区)
- Year and Date
  2015-07-21
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] Genome editing of SCN1A in induced pluripotent stem cells to study the pathomechanisms of Dravet syndrome.2015
- Author(s)
  Yasuyoshi Tanaka*, Taku Uchida, Takefumi Sone, Norimichi Higurashi, Mitsuru Ishikawa, Hideyuki Okano, Shinichi Hirose
- Organizer
  The 13th Asian and Oceanian Congress of Child Neurology
- Place of Presentation
  台北 (台湾)
- Year and Date
  2015-05-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] ゲノム編集した患者由来疾患iPS細胞の全ゲノム解析によって明らかになったこと2015
- Author(s)
  曽根岳史*、朴聖俊、田中泰圭、太田悦朗、日暮憲道、中井謙太、廣瀬伸一、岡野栄之
- Organizer
  BMB2015 （第38回日本分子生物学会年会、第88回日本生化学会大会合同大会）
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] A mutated PENDRIN formed intracellular aggregations in the inner ear cells induced from Pendred syndrome patients-specific iPS cells.2015
- Author(s)
  細谷誠*, 藤岡正人, 渡部孝太郎, 岡本理志, 曽根岳史, 松永達雄, 赤松和土, 小川郁, 岡野栄之
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸国際会議場・神戸国際展示場 (兵庫県神戸市)
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K06924
[Presentation] TALEN-mediated genome editing of patient-derived iPSCs for disease model studies.2015
- Author(s)
  Takefumi Sone*, Yasuyoshi Tanaka, Etsuro Ohta, Makoto Hosoya、Naoki Ichiyanagi, Tetsuya Akiyama, Norimichi Higurashi, Shinichi Hirose, Hideyuki Okano
- Organizer
  TGE2015: Conference on Transposition and Genome Engineering 2015
- Place of Presentation
  奈良春日野国際フォーラム甍～I・RA・KA～ (奈良県奈良市)
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06924

1. SHIBASAKI Masahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 岡野栄之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SONE Takefumi 曽根 岳史

Research Projects

Research Products

Co-Researchers

Development of genome editing technology with low off-target risk and high efficiency in human pluripotent stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of D1-1 TALEN isogenic control cell line from Dravet syndrome patient iPSCs using TALEN-mediated editing of the SCN1A gene2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient induction of dopaminergic neuron differentiation from induced pluripotent stem cells reveals impaired mitophagy in PARK2 neurons.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 2. iPS細胞技術とゲノム編集技術を駆使した筋萎縮性側索硬化症病態モデルの創成と治療への展望2016

Author(s)

Journal Title

Data Source

[Journal Article] Controlling the regional identity of hPSC-derived neurons to uncover neuronal subtype specificity of neurological disease phenotypes.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Generation of gene-corrected iPSC from patient-derived iPSC with familial Parkinson's disease2017

Author(s)

Organizer

Data Source

[Presentation] Pathophysiological analysis of skeletal muscles in spinal bulbar muscular atrophy (SBMA) by genome editing of CAG repeats.2017

Author(s)

Organizer

Data Source

[Presentation] Functional analysis of synaptic gene expression and morphologies in Angelman syndrome patient-derived neurons2017

Author(s)

Organizer

Data Source

[Presentation] Multisite Gatewayクローニング技術に立脚した汎用ヒトiPS細胞ゲノム編集ツールボックス2017

Author(s)

Organizer

Data Source

[Presentation] iPS細胞におけるAngelman症候群原因遺伝子UBE3Aノックアウトの作製と神経細胞の表現型探索2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 遺伝性パーキンソン病患者由来iPS細胞におけるゲノム編集iPS細胞の樹立2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] ゲノム編集による筋委縮性側索硬化症(ALS)の病態モデル細胞の創成と遺伝子治療2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Establishment of in vitro FUS-associated familial amyotrophic lateral sclerosis model using human induced pluripotent stem cells2016

Author(s)

SONE Takefumi 曽根岳史