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FUJIMOTO Minoru  藤本 穣

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… Alternative Names

藤本 穣  フジモト ミノル

FUJIMOTO MINORU  藤本 穣

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Researcher Number 00379190
Other IDs
Affiliation (Current) 2025: 岩手医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2025: 岩手医科大学, 医学部, 准教授
2023: 岩手医科大学, 医学部, 准教授
2021: 岩手医科大学, 医学部, 准教授
2017 – 2020: 高知大学, 教育研究部医療学系臨床医学部門, 准教授
2017: 高知大学, 教育研究部・医療学系臨床医学部門, 准教授 … More
2016: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 免疫シグナルプロジェクト, 客員研究員
2015: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 免疫シグナルプロジェクト, 主任研究員
2011: 独立行政法人医薬基盤研究所, 創薬基盤推進研究部, 主任研究員
2011: 独立行政法人医薬基盤研究所, 創薬基盤研究事業部, 主任研究員
2010: 独立行政法人医薬基盤研究所, 創薬基盤研究部・免疫シグナルプロジェクト, 主任研究員
2009: National Institute of Biomedical Innovation, 基盤的研究部免疫シグナルプロジェクト, 主任研究員
2006: 独立行政法人医薬基盤研究所, 免疫シグナルプロジェクト, 主任研究員
2005: 阪大, 医学部附属病院 Less
Review Section/Research Field
Principal Investigator
膠原病・アレルギー・感染症内科学 / Basic Section 52010:General internal medicine-related / Basic Section 53010:Gastroenterology-related / Collagenous pathology/Allergology
Except Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Dermatology / Tumor therapeutics / Collagenous pathology/Allergology
Keywords
Principal Investigator
サイトカイン / バイオマーカー / 膠原病学 / LRG / マーカー / 炎症性腸疾患 / 内科 / 免疫学 / 尿細管障害 / ループス腎炎 … More / 尿蛋白 / 尿検査 / 生物単的製剤 / 難病モデル動物 / モデルマウス / 生物学的製剤 / 自己免疫疾患 / IL-17 / ノックアウトマウス / IL-2 / 制御性T細胞 / SOCS … More
Except Principal Investigator
重症気管支肺異形成 / バイオマーカー / 絨毛膜羊膜炎 / プロテオーム解析 / LRG / 蛋白質 / 抗体医薬 / 悪性黒色腫 / 抗体 / タンパク質 / プロテオーム / 癌 / 抗体療法 / LSR / 癌幹細胞 / 卵巣癌 / シグナル伝達 / 免疫学 / 難病 / リウマチ学 Less
  • Research Projects

    (9 results)
  • Research Products

    (79 results)
  • Co-Researchers

    (14 People)
  •  新規炎症マーカーLRGの膠原病診療への応用Principal Investigator

    • Principal Investigator
      藤本 穣
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Iwate Medical University
  •  プロテオーム解析による、重症気管支肺異形成を予測する新規バイオマーカーの同定

    • Principal Investigator
      外舘 玄一朗
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Iwate Medical University
  •  Application of a new biomarker LRG to real-world clinical practice of inflammatory bowel diseasePrincipal Investigator

    • Principal Investigator
      FUJIMOTO MINORU
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Iwate Medical University
      Kochi University
  •  Investigation of the mechanism of LRG, a novel inflammatory molecule, in modulating TGF-beta signaling for the development of therapy in rheumatic diseases

    • Principal Investigator
      Naka Tetsuji
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Kochi University
  •  Investigation of the clinical significance of a new inflammatory molecule LRG in lupus nephritisPrincipal Investigator

    • Principal Investigator
      FUJIMOTO MINORU
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Kochi University
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Functional analysis of LSR and development of innovative therapy for ovarian cancer stem cells.

    • Principal Investigator
      NAKA TETSUJI
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor therapeutics
    • Research Institution
      Kochi University
  •  Proteomic screening for malignant melanoma antigen and development of antibody-based medicine for metastasis.

    • Principal Investigator
      NAKA TETSUJI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Dermatology
    • Research Institution
      National Institutes of Biomedical Innovation, Health and Nutrition
  •  Analysis on the mechanism of action of biologic agents using mouse models of autoimmune disordersPrincipal Investigator

    • Principal Investigator
      FUJIMOTO Minoru
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      National Institute of Biomedical Innovation
  •  生体における免疫制御機構の解明Principal Investigator

    • Principal Investigator
      藤本 穣
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      独立行政法人医薬基盤研究所
      Osaka University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2006 Other

All Journal Article Presentation Other

  • [Journal Article] Leucine-rich alpha 2 glycoprotein is a new marker for active disease of tuberculosis2020

    • Author(s)
      Fujimoto Minoru、Matsumoto Tomoshige、Serada Satoshi、Tsujimura Yusuke、Hashimoto Shoji、Yasutomi Yasuhiro、Naka Tetsuji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 3384-3384

    • DOI

      10.1038/s41598-020-60450-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08371, KAKENHI-PROJECT-17H04215, KAKENHI-PROJECT-17H04079
  • [Journal Article] Evaluation of leucine-rich alpha-2 glycoprotein as a biomarker of fetal infection2020

    • Author(s)
      Kajimoto Etsuko、Endo Masayuki、Fujimoto Minoru、Matsuzaki Shinya、Fujii Makoto、Yagi Kazunobu、Kakigano Aiko、Mimura Kazuya、Tomimatsu Takuji、Serada Satoshi、Takeuchi Makoto、Yoshino Kiyoshi、Ueda Yutaka、Kimura Tadashi、Naka Tetsuji
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: 0242076-0242076

    • DOI

      10.1371/journal.pone.0242076

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08371, KAKENHI-PROJECT-18K09228
  • [Journal Article] 採血で知る炎症性腸疾患の活動性 新規血清マーカーLRG2019

    • Author(s)
      藤本 穣, 仲 哲治
    • Journal Title

      医学のあゆみ

      Volume: 270 Pages: 1215-1216

    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Journal Article] 血液検査による炎症性腸疾患(IBD)の疾患活動性の測定 ロイシンリッチα2グリコプロテイン(LRG)2019

    • Author(s)
      伊藤 いづみ, 藤本 穣, 仲 哲治
    • Journal Title

      臨床栄養

      Volume: 135 Pages: 748-750

    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Journal Article] LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake2018

    • Author(s)
      Hiramatsu K, Serada S, Enomoto T, Takahashi Y, Nakagawa S, Nojima S, Morimoto A, Matsuzaki S, Yokoyama T, Takahashi T, Fujimoto M, Takemori H, Ueda Y, Yoshino K, Morii E, Kimura T, Naka T
    • Journal Title

      Cancer Res

      Volume: 78 Issue: 2 Pages: 516-27

    • DOI

      10.1158/0008-5472.can-17-0910

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11137, KAKENHI-PROJECT-17K11278, KAKENHI-PROJECT-17H04336, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-16K14637
  • [Journal Article] Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury2018

    • Author(s)
      Lee Hyun、Fujimoto Minoru、Ohkawara Tomoharu、Honda Hiromi、Serada Satoshi、Terada Yoshio、Naka Tetsuji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 498 Issue: 4 Pages: 1045-1051

    • DOI

      10.1016/j.bbrc.2018.03.111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04215, KAKENHI-PROJECT-16K09916
  • [Journal Article] Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in na?ve helper T cells2017

    • Author(s)
      Urushima Hayato、Fujimoto Minoru、Mishima Takashi、Ohkawara Tomoharu、Honda Hiromi、Lee Hyun、Kawahata Hirohisa、Serada Satoshi、Naka Tetsuji
    • Journal Title

      Arthritis Research & Therapy

      Volume: 19 Issue: 1 Pages: 137-137

    • DOI

      10.1186/s13075-017-1349-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Journal Article] Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts2017

    • Author(s)
      Honda Hiromi、Fujimoto Minoru、Serada Satoshi、Urushima Hayato、Mishima Takashi、Lee Hyun、Ohkawara Tomoharu、Kohno Nobuoki、Hattori Noboru、Yokoyama Akihito、Naka Tetsuji
    • Journal Title

      Physiological Reports

      Volume: 5 Issue: 24 Pages: e13556-e13556

    • DOI

      10.14814/phy2.13556

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Journal Article] 新規急性期蛋白LRG(leucine-rich alpha-2 glycoprotein)の炎症マーカーとしての評価2016

    • Author(s)
      藤本穣, 世良田聡, 仲哲治
    • Journal Title

      リウマチ科

      Volume: 56(1) Pages: 111-116

    • Data Source
      KAKENHI-PROJECT-16K09916
  • [Journal Article] CpG ODN potentiates the anti-tumor activity of anti-BST2 antibody.2015

    • Author(s)
      Hiramatsu, K., Serada, S., Kobiyama, K., Nakagawa, S., Morimoto, A., Matsuzaki, S., Ueda,Y., Fujimoto, M., Yoshino, K., Ishii, K., Enomoto, T., Kimura, T., Naka, T.
    • Journal Title

      Cancer Science

      Volume: 106(10) Issue: 10 Pages: 474-82

    • DOI

      10.1111/cas.12738

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15598, KAKENHI-PROJECT-25670508, KAKENHI-PROJECT-25860575, KAKENHI-PROJECT-25293338
  • [Journal Article] Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells.2015

    • Author(s)
      Tagami-Nagata N, Serada S, Fujimoto M, Tanemura A, Nakatsuka R, Ohkawara T, Murota H, Kishimoto T, Katayama I, Naka T.
    • Journal Title

      Exp Dermatol.

      Volume: 24 Issue: 11 Pages: 864-71

    • DOI

      10.1111/exd.12802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15418, KAKENHI-PROJECT-25670508, KAKENHI-PROJECT-25860575
  • [Journal Article] Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines.2015

    • Author(s)
      Takemoto N, Serada S, Fujimoto M, Honda H, Ohkawara T, Takahashi T, Nomura S, Inohara H, Naka T.
    • Journal Title

      Oncotarget

      Volume: In Press

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670508
  • [Journal Article] Gene therapy with SOCS1 for gastric cancer induces G2/M arrest and has an anti-tumor effect on peritoneal carcinomatosis.2015

    • Author(s)
      Natatsuka R, Takahashi T, Serada S, Fujimoto M, Ookawara T, Nishida T, Hara H,  Nishigaki T,  Harada E, Murakami T, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.
    • Journal Title

      Br J Cancer

      Volume: 113(3) Issue: 3 Pages: 433-442

    • DOI

      10.1038/bjc.2015.229

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461700, KAKENHI-PROJECT-25670508, KAKENHI-PROJECT-25860575
  • [Journal Article] Proteomic identification of heterogeneous nuclear ribonucleoprotein K as a novel cold-associated autoantigen in patients with secondary Raynaud's phenomenon.2015

    • Author(s)
      Yang L, Fujimoto M, Murota H, Serada S, Fujimoto M, Honda H, Yamada K, Suzuki K, Nishikawa A, Hosono Y, Yoneda Y, Takehara K, Imura Y, Mimori T, Takeuchi T, Katayama I, Naka T.
    • Journal Title

      Rheumatology (Oxford).

      Volume: 54 Issue: 2 Pages: 349-58

    • DOI

      10.1093/rheumatology/keu325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24247036, KAKENHI-PLANNED-25116008, KAKENHI-PROJECT-25670508
  • [Journal Article] Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner.2014

    • Author(s)
      Morimoto A, Serada S, Enomoto T, Kim A, Matsuzaki S, Takahashi T, Ueda Y, Yoshino K, Fujita M, Fujimoto M, Kimura T, Naka T.
    • Journal Title

      Oncotarget

      Volume: 5 Pages: 7776-87

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670508
  • [Journal Article] Periostin accelerates human malignant melanoma progression by modificating the melanoma microenvironment2014

    • Author(s)
      Kotobuki Y, Tanemura A, Serada S, Yang L, Nomura S, Kudo A, Izuhara K, Murota H, Fujimoto M, Katayama I, Naka T
    • Journal Title

      Pigment Cell Melanoma Res

      Volume: 27 Issue: 4 Pages: 630-639

    • DOI

      10.1111/pcmr.12245

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293224, KAKENHI-PROJECT-25670508
  • [Journal Article] Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells.2013

    • Author(s)
      Shimada K, Serada S, Fujimoto M, Nomura S, Nakatsuka R, Harada E, Iwahori K, Tachibana I, Takahashi T, Kumanogoh A, Kishimoto T, Naka T.
    • Journal Title

      Cancer Sci.

      Volume: 104 Issue: 11 Pages: 1483-91

    • DOI

      10.1111/cas.12266

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670508, KAKENHI-PROJECT-25860575
  • [Journal Article] New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis.2013

    • Author(s)
      Takahashi T, Serada S, Ako M, Fujimoto M, Miyazaki Y, Nakatsuka R, Ikezoe T, Yokoyama A, Taguchi T, Shimada K, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Doki Y, Naka T, Nishida T.
    • Journal Title

      Int J Cancer

      Volume: 133(11) Pages: 2737-2743

    • DOI

      10.1002/ijc.28282

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22130005, KAKENHI-PROJECT-25670508, KAKENHI-PROJECT-25860575
  • [Journal Article] IL-6によるレギュラトリーT細胞の抑制:nTregとiTregの相違2012

    • Author(s)
      藤本穣、寺部文隆、仲哲治
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 57(1) Pages: 79-86

    • NAID

      40019192523

    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis2012

    • Author(s)
      Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T
    • Journal Title

      Inflamm Bowel Dis

      Volume: (in press) Issue: 11 Pages: 2169-79

    • DOI

      10.1002/ibd.22936

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22790643
  • [Journal Article] Dysregulation of melanocyte function by Th17-related cytokines : significance of Th17 cell infiltration in autoimmune vitiligo vulgaris2012

    • Author(s)
      Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I
    • Journal Title

      Pigment Cell Melanoma Res

      Volume: 25(2) Issue: 2 Pages: 219-230

    • DOI

      10.1111/j.1755-148x.2011.00945.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591219, KAKENHI-PROJECT-24659529
  • [Journal Article] Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma2012

    • Author(s)
      Kitaba S, Murota H, Terao M, Azukizawa H, Terabe F, Shima Y, Fujimoto M, Tanaka T, Naka T, Kishimoto T, Katayama I
    • Journal Title

      Am J Pathol

      Volume: 180(1) Issue: 1 Pages: 165-176

    • DOI

      10.1016/j.ajpath.2011.09.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22791069, KAKENHI-PROJECT-24591444
  • [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis2011

    • Author(s)
      Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 17 Pages: 491-502

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] The influence of excessive IL-6 production in vivo on the development and function of Foxp3+regulatory T cells2011

    • Author(s)
      Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T
    • Journal Title

      J Immunol

      Volume: 186(1) Issue: 1 Pages: 32-40

    • DOI

      10.4049/jimmunol.0903314

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells2011

    • Author(s)
      Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T
    • Journal Title

      Int J Cancer

      Volume: (in press) Issue: 6 Pages: 1287-96

    • DOI

      10.1002/ijc.27350

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22790775
  • [Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma2011

    • Author(s)
      Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T
    • Journal Title

      Int J Cancer

      Volume: 129(4) Issue: 4 Pages: 993-1005

    • DOI

      10.1002/ijc.25716

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101, KAKENHI-PROJECT-22790775
  • [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+T-cell responses in murine colitis2011

    • Author(s)
      Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Jang MH, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T
    • Journal Title

      Inflamm Bowel Dis

      Volume: 17(2) Issue: 2 Pages: 491-502

    • DOI

      10.1002/ibd.21384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells.2011

    • Author(s)
      Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T.
    • Journal Title

      The Journal of Immunology

      Volume: 186 Pages: 32-40

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis2011

    • Author(s)
      Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(6) Issue: 6 Pages: 3264-3271

    • DOI

      10.1167/iovs.10-6272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis2011

    • Author(s)
      Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio
    • Journal Title

      Cardiovasc Res

      Volume: 91(4) Pages: 640-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] IL-6-mediated Th17 differentiation through ROR{gamma} t is essential for the initiation of experimental autoimmune myocarditis2011

    • Author(s)
      Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y
    • Journal Title

      Cardiovasc Res

      Volume: 91(4) Issue: 4 Pages: 640-648

    • DOI

      10.1093/cvr/cvr148

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] Thl7細胞とレギュラトリーT細胞のバランスを決定する要因2010

    • Author(s)
      藤本穣
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53 Pages: 413-418

    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses2010

    • Author(s)
      Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T
    • Journal Title

      Exp Eye Res

      Volume: 91(2) Issue: 2 Pages: 162-170

    • DOI

      10.1016/j.exer.2010.04.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases2010

    • Author(s)
      Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T
    • Journal Title

      Ann Rheum Dis

      Volume: 69(4) Issue: 4 Pages: 770-774

    • DOI

      10.1136/ard.2009.118919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] Th17細胞とレギュラトリーT細胞のバランスを決定する要因2010

    • Author(s)
      藤本穣
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 53巻 Pages: 413-418

    • NAID

      40017125278

    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases2010

    • Author(s)
      Fujimoto M, Naka T
    • Journal Title

      Gastroenterol Res Pract

      Volume: 2010 Pages: 470468-470468

    • DOI

      10.1155/2010/470468

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression2010

    • Author(s)
      Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T
    • Journal Title

      Int Immunol

      Volume: 22(5) Issue: 5 Pages: 359-366

    • DOI

      10.1093/intimm/dxq015

    • NAID

      10027579870

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276, KAKENHI-PROJECT-22591101
  • [Journal Article] Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Thl7 Responses.2010

    • Author(s)
      Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T.
    • Journal Title

      Experimental Eye Research.

      Volume: 91 Pages: 162-170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] SOCS1, a Negative Regulator of Cytokine Signals and TLR Respouses, in Human Liver Diseases.2010

    • Author(s)
      Fujimoto M, Naka T.
    • Journal Title

      Gastroenterology Research Practice

      Volume: On line

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] IL-6阻害による自己免疫性関節炎治療効果はTh17抑制を介している2010

    • Author(s)
      大河原知治、藤本穣、仲哲治
    • Journal Title

      リウマチ科 43

      Pages: 62-67

    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] iTRAQ-based proteomic identification of leucine-rich alpha-2 glycoprotein as a novel inflammatory biomarker in autoimmune diseases2010

    • Author(s)
      Serada S, Fujimoto M, et. al.
    • Journal Title

      Annals of the Rheumatic Diseases 69

      Pages: 770-774

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] IL-6阻害による自己免疫性関節炎治療効果はTh17抑制を介している2010

    • Author(s)
      大河原知治、藤本穣、仲哲治
    • Journal Title

      リウマチ科

      Volume: 43巻 Pages: 62-67

    • Data Source
      KAKENHI-PROJECT-21591276
  • [Journal Article] SOCS-2 interferes with myotube formation and potentiates osteoblast differentiation through upregulation of JunB in C2C12 cells2006

    • Author(s)
      Ouyang X, Fujimoto M, Nakagawa R, Serada S, Tanaka T, Nomura S, Kawase I, Kishimoto T, Naka T.
    • Journal Title

      J Cell Physiol. 207・5

      Pages: 428-436

    • Data Source
      KAKENHI-PROJECT-17790673
  • [Journal Article] Osteoblast differentiation is impaired in SOCS-1-deficient mice.2006

    • Author(s)
      Abe T, Nomura S, Nakagawa R, Fujimoto M, Kawase I, Naka T.
    • Journal Title

      J Bone Miner Metab. 24・4

      Pages: 283-290

    • Data Source
      KAKENHI-PROJECT-17790673
  • [Journal Article] Comparative Analysis of the Effects of Anti-IL-6 Receptor mAb and Anti-TNF mAb Treatment on CD4+ T Cell Responses in Murine Colitis.

    • Author(s)
      Terabe F, Fujimoto M, et. al.
    • Journal Title

      Inflammatory Bowel Diseases (Accepted)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] ロイシンリッチα2グリコプロテイン (LRG) 測定試薬「ナノピアLRG」の分析性能および臨床的有用性の評価2020

    • Author(s)
      星野将規, 藤本穰,一森俊樹,沖裕昌,久原太助,出間智行, 荒井紀光, 徳弘慎治,横山彰仁,仲哲治
    • Organizer
      第60回日本臨床化学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Presentation] IL-6阻害薬とバイオマーカー2019

    • Author(s)
      藤本 穣
    • Organizer
      第34回日本臨床リウマチ学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Presentation] 関節リウマチおよび炎症性疾患におけるLRGの意義2019

    • Author(s)
      仲哲治,藤本穣,世良田聡
    • Organizer
      第71回日本皮膚科学会西部支部学術集会
    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Presentation] 関節リウマチおよび炎症性疾患におけるLRGの意義2019

    • Author(s)
      仲哲治,藤本穣,世良田聡
    • Organizer
      第71回日本皮膚科学会西部支部学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Presentation] ロイシンリッチα2グリコプロテイン(LRG)測定キット「ナノピアLRG」の分析性能及び臨床性能の評価2019

    • Author(s)
      徳弘慎治,亀山智代,藤本穰,一森俊樹,沖裕昌,久原太助,山中茂雄,上岡樹生,荒井紀光,横山彰仁,仲哲治
    • Organizer
      日本臨床検査自動化学会第51回大会
    • Data Source
      KAKENHI-PROJECT-19K08371
  • [Presentation] 新規炎症マーカー分子LRG(Leucine rich α2 glycoprotein)の腎疾患における尿検査マーカーとしての可能性2018

    • Author(s)
      藤本 穣、大河原知治、李 賢、世良田聡、三森経世、寺田典生、仲 哲治
    • Organizer
      第46回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-16K09916
  • [Presentation] 疾患活動性評価の正確化(新しいバイオマーカーの可能性)2018

    • Author(s)
      藤本 穣
    • Organizer
      第33回日本臨床リウマチ学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09916
  • [Presentation] 新規炎症マーカーLRGの同定からIBD バイオマーカーとしての実用化まで2018

    • Author(s)
      仲 哲治、金井隆典、松岡克善、世良田聡、藤本 穣、飯島英樹、新崎信一郎、水野慎大
    • Organizer
      第46回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Presentation] 新規炎症マーカー分子LRG(Leucine rich α2 glycoprotein)の腎疾患における尿検査マーカーとしての可能性2018

    • Author(s)
      藤本 穣、大河原知治、李 賢、世良田聡、三森経世、寺田典生、仲 哲治
    • Organizer
      第46回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Presentation] 新規炎症マーカーLRGの自己免疫性関節炎の病態進行における役割の検討2017

    • Author(s)
      藤本穣、宇留島隼人、川畑浩久、大河原知治、李賢、本田宏美、世良田聡、仲哲治
    • Organizer
      第45回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-17H04215
  • [Presentation] 新規急性期蛋白LRG(Leucine-rich α-2 glycoprotein)のループス腎炎のマーカーとしての検討2017

    • Author(s)
      李賢、藤本穣、本田宏美、大河原智冶、世良田聡、谷口義典、堀野太郎、寺田典生、仲哲治
    • Organizer
      第45回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-16K09916
  • [Presentation] LSR promotes ovarian cancer cell growth following the activation of β-oxidation and its antibody inhibits lipid catabolism. ポスター発表(英語)2017

    • Author(s)
      Hiramatsu K, Serada S, Enomoto T, Yokoyama T, Takahashi Y, Fujimoto M, Yoshino K, Kimura T, Naka T.
    • Organizer
      AACR Annual Meeting 2017 in Washington, D.C
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K14637
  • [Presentation] LSR promotes beta-oxidation via lipid uptake and subsequent tumor growth in ovarian cancer.口頭発表(英語)2017

    • Author(s)
      Hiramatsu K, Serada S, Fujimoto M, Matsuzaki S, Ueda Y, Yoshino K, Kimura T, Naka T.
    • Organizer
      第76回日本癌学会学術総会 パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-16K14637
  • [Presentation] 新たな急性期蛋白LRG(Leucine-rich α-2 glycoprotein)のループス腎炎マーカーとしての検討2016

    • Author(s)
      李賢、藤本穣、本田宏美、宇留島隼人、仲哲治
    • Organizer
      第60回日本リウマチ学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-16K09916
  • [Presentation] SOCS-1, -3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of JAK/STAT and P38 MAPK signaling pathways2011

    • Author(s)
      Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka
    • Organizer
      AACR
    • Place of Presentation
      アメリカ(オーランド)
    • Year and Date
      2011-04-04
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] TGFbeta1 promotes bleomycin induced murine dermal sclerosis via its downstream molecule of periostin2011

    • Author(s)
      Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T
    • Organizer
      9th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      イタリア(フィレンツェ)
    • Year and Date
      2011-10-11
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis2011

    • Author(s)
      Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Tregの分化、機能におけるIL-6の作用2011

    • Author(s)
      藤本穣、仲哲治
    • Organizer
      第31回日本臨床免疫学会総会(招待講演)
    • Place of Presentation
      京王プラザ(東京)
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Quantitative proteomic analysis of cell-surface membrane proteins : Biomarker discovery in endometrial cancer2011

    • Author(s)
      Takuhei Yokoyama, Takayuki Enomoto, Satoshi Serada, Shinya Matsuzaki, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Kiyoshi Yoshino, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka
    • Organizer
      AACR
    • Place of Presentation
      アメリカ(オーランド)
    • Year and Date
      2011-04-06
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] MYD88 GENE KNOCKOUT INHIBITS THE DEVELOPMENT OF LUPUS-LIKE DISEASE IN NZB/W F1 MICE2011

    • Author(s)
      T. Ohkawara, B. Ripley, M. Fujimoto, T. Naka
    • Organizer
      EULAR
    • Place of Presentation
      イギリス(ロンドン)
    • Year and Date
      2011-05-28
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] SOCS-1,-3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of JAK/STAT and P38 MAPK signaling pathways2011

    • Author(s)
      Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka
    • Organizer
      AACR
    • Place of Presentation
      アメリカ(オーランド)
    • Year and Date
      2011-04-04
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Nuclear receptor PPAR-gamma interacts with IRF7 to negatively regulate TLR7/9-mediated type I interferon production and the development of murine lupus2011

    • Author(s)
      Ripley B, Fujimoto M, Han A, Millrine D, Lee S, Kawai T, Akira S, Naka T, Kishimoto T
    • Organizer
      9th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      イタリア(フィレンツェ)
    • Year and Date
      2011-10-10
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索2011

    • Author(s)
      Satoshi Serada, Takuhei Yokoyama, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka
    • Organizer
      第9回日本プロテオーム学会
    • Place of Presentation
      新潟市朱鷺メッセ
    • Year and Date
      2011-07-29
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Tregの分化、機能におけるIL-6の作用2011

    • Author(s)
      藤本穣、仲哲治
    • Organizer
      第31回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザ(東京)(招待講演)
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Leucine rich alpha 2 glycoprotein(LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis2011

    • Author(s)
      Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] PERIOSTIN GENE KNOCKOUT IS PROTECTIVE AGAINST THE DEVELOPMENT OF BLEOMYCIN-INDUCED MURINE SKIN SCLERODERMA2011

    • Author(s)
      L. Yang, M. Fujimoto, S. Serada, H. Murota, B. Ripley, S. Kitaba, Y. Kotobuki, T. Naka, I. Katayama
    • Organizer
      EULAR
    • Place of Presentation
      イギリス(ロンドン)
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] NUCLEAR RECEPTOR PPAR-GAMMA NEGATIVELY REGULATES TYPE I INTERFERON PRODUCTION VIA INTERACTION WITH IRF72011

    • Author(s)
      B. Ripley, M. Fujimoto, S. Serada, L.-L. Yang, F. Terabe, Y.-M. Han, T. Ohkawara, T. Nishikawa, T. Naka
    • Organizer
      EULAR
    • Place of Presentation
      イギリス(ロンドン)
    • Year and Date
      2011-05-27
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] TGFbeta1 promotes bleomycin-induced murine dermal sclerosis via its downstream molecule of periostin2011

    • Author(s)
      Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T
    • Organizer
      9th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
    • Place of Presentation
      イタリア(フィレンツェ)
    • Year and Date
      2011-10-11
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] The effect of IL-6 overproduction in vivo on wound healing, Cytokines in Infectious Diseases2010

    • Author(s)
      Fujimoto M, Kotobuki Y, Kitaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T
    • Organizer
      Autoimmune Disorders and Cancer(Cytokines 2010)
    • Place of Presentation
      アメリカ(シカゴ)
    • Year and Date
      2010-10-04
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] The effect of IL-6 overproduction on T helper cell differentiation in vivo2010

    • Author(s)
      Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] The effect of IL-6 overproduction on T helper cell differentiation in vivo2010

    • Author(s)
      Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      ポートピアホテル(神戸)
    • Year and Date
      2010-08-25
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Myd88 gene knockout inhibits the development of lupus-like disease in NZB/W F1 mice2009

    • Author(s)
      Ohkawara T, Fujimoto M and Naka T
    • Organizer
      Tri-Society Annual Conference
    • Place of Presentation
      ポルトガル(リスボン)
    • Year and Date
      2009-10-20
    • Data Source
      KAKENHI-PROJECT-21591276
  • [Presentation] Myd88 gene knockout inhibits the development of lupus-like disease in NZB/W F1 mice2009

    • Author(s)
      Ohkawara T, Fujimoto M, Naka T
    • Organizer
      Tri-Society Annual Conference 2009
    • Place of Presentation
      Lisbon, Portugal
    • Data Source
      KAKENHI-PROJECT-21591276
  • []

  • 1.  Naka Tetsuji (30303936)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 2.  SERADA SATOSHI (50463302)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 5 results
  • 3.  YOSHINO KIYOSHI (90362730)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  外舘 玄一朗 (70405819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  赤坂 真奈美 (00405797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  Lee Hyun
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  上田 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  松崎 慎哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  榎本 隆之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  森 正樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  片山 一朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  出原 賢治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  村上 孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  米田 悦啓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

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