YAMASHITA MAKIKO 山下万貴子

… Alternative Names

山下万貴子ヤマシタマキコ

YAMASHITA Makiko 山下万貴子

Less

Researcher Number	00380668
Affiliation (Current)	2025: 公益財団法人がん研究会, 有明病院先端医療開発科 , 研究員 2025: 国立研究開発法人国立がん研究センター, 研究所, 外来研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人がん研究会, 有明病院先端医療開発科, 研究員 2022: 公益財団法人がん研究会, 有明病院先進がん治療開発センター, 研究員 2020: 公益財団法人がん研究会, 有明病院がん免疫治療開発部, 研究員 2017 – 2019: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2014: 独立行政法人国立がん研究センター, 研究所, 研究員 … More 2013: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 2012: 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 2011: 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 研究員 2010: (財)東京都医学総合研究所, 東京都精神医学総合研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor diagnostics Except Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 免疫モニタリング / 腫瘍免疫 / 神経変性疾患 / TDP-43 / 有害事象 / 薬効評価・予測 / 抗体医薬 / 抗腫瘍免疫 / 神経細胞毒性 / FTLD-U / ALS / 凝集体形成 / 凝集体形成阻害薬 … More Except Principal Investigator … More B細胞 / 周術期治療 / 腫瘍免疫学 / 周術期 / 乳がん / TLS / 腫瘍免疫 Less

Antitumor B Cell Immune Responses in Perioperative Breast Cancer Patients
- Principal Investigator
  
  北野滋久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Japanese Foundation for Cancer Research
転移性乳癌患者における全身免疫病態の網羅的集団動態解析Principal Investigator
- Principal Investigator
  
  山下万貴子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research
Immune monitoring of circulating immune cells in the blood of patients with malignant solid tumors treated with checkpoint inhibitorsPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Makiko
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnostics
- Research Institution
  Japanese Foundation for Cancer Research
  National Cancer Center Japan
Distinct pathways leading to cellular dysfunction by TDP-43Principal Investigator
- Principal Investigator
  
  YAMASHITA Makiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  National Cancer Center Japan
  Tokyo Metropolitan Institute of Medical Science
The aggregation mechanisms of TDP-43 inclusion in neuronal cellPrincipal Investigator
- Principal Investigator
  
  YAMASHITA Makiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  財団法人東京都医学総合研究所
   Tokyo Metropolitan Organization for Medical Research

All 2024 2023 2021 2020 2018 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book Patent

[Book] 「すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患」(祖父江元先生責任編集)2013
- Author(s)
  山下万貴子、長谷川成人
- Total Pages
  6
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-24700370
[Journal Article] Pathological complete response to neoadjuvant chemotherapy may improve antitumor immune response via reduction of regulatory T cells in muscle-invasive bladder cancer2024
- Author(s)
  Ikarashi Daiki、Kitano Shigehisa、Tsuyukubo Takashi、Yamashita Makiko、Matsuura Tomohiko、Maekawa Shigekatsu、Kato Renpei、Kato Yoichiro、Kanehira Mitsugu、Takata Ryo、Sugai Tamotsu、Obara Wataru
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1442-1442
- DOI
  10.1038/s41598-024-51273-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16807, KAKENHI-PROJECT-21K09434, KAKENHI-PROJECT-22K07265, KAKENHI-PROJECT-23K08101
[Journal Article] Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment2024
- Author(s)
  Hanamura Toru、Yokoyama Kozue、Kitano Shigehisa、Kagamu Hiroshi、Yamashita Makiko、Terao Mayako、Okamura Takuho、Kumaki Nobue、Hozumi Katsuto、Iwamoto Takayuki、Honda Chikako、Kurozumi Sasagu、Richer Jennifer K.、Niikura Naoki
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 73 Issue: 3 Pages: 42-54
- DOI
  10.1007/s00262-024-03629-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07156, KAKENHI-PROJECT-22K07265
[Journal Article] <scp>Interleukin‐4 induced 1</scp>‐mediated resistance to an immune checkpoint inhibitor through suppression of <scp>CD8</scp><sup>+</sup> T cell infiltration in melanoma2024
- Author(s)
  Hirose Shiho、Mashima Tetsuo、Yuan Xunmei、Yamashita Makiko、Kitano Shigehisa、Torii Shinichi、Migita Toshiro、Seimiya Hiroyuki
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 3 Pages: 791-803
- DOI
  10.1111/cas.16073
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07265, KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23K24192
[Journal Article] Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations2023
- Author(s)
  Aoki Kazunori, Makiko Yamashita, et. al.
- Journal Title
  
  Cancer Research Communications
  
  Volume: 3 Issue: 6 Pages: 1026-1040
- DOI
  10.1158/2767-9764.crc-22-0415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07265, KAKENHI-PROJECT-23K08101
[Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.2021
- Author(s)
  Aoki H, Ueha S, Shichino S, Ogiwara H, Shitara K, Shimomura M, Suzuki T, Nakatsura T, Yamashita M, Kitano S, Kuroda S, Wakabayashi M, Kurachi M, Ito S, Doi T, Matsushima K.
- Journal Title
  
  Cancer Immunol Res.
  
  Volume: - Issue: 6 Pages: 624-636
- DOI
  10.1158/2326-6066.cir-20-0989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-17K07207, KAKENHI-PROJECT-19K07476, KAKENHI-PROJECT-20H03474
[Journal Article] Biomarkers for Immune Checkpoint Inhibitors in Melanoma2018
- Author(s)
  Kitano S, Nakayama T, Yamashita M.
- Journal Title
  
  Front Oncol.
  
  Volume: 8 Pages: 1-8
- DOI
  10.3389/fonc.2018.00270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07207, KAKENHI-PROJECT-17K07208
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions2014
- Author(s)
  Makiko Yamashita, Takashi Nonaka, Shinobu Hirai, Akiko Miwa, Haruo Okado, Tetsuaki Arai, Masato Hosokawa, Haruhiko Akiyama and Masato Hasegawa
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 23 Pages: 1-12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24700370
[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014
- Author(s)
  Yamashita M, Nonaka T, Hirai S, Miwa A, Okado H, Arai T, Hosokawa M, Akiyama H, Hasegawa M.
- Journal Title
  
  Hum Mol Genet.
  
  Volume: 23 Issue: 16 Pages: 4345-56
- DOI
  10.1093/hmg/ddu152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24500429, KAKENHI-PROJECT-24591738, KAKENHI-PROJECT-24700370, KAKENHI-PUBLICLY-25123726, KAKENHI-PUBLICLY-26111730, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26461733
[Journal Article] 家族性ALS～TDP-43の機能とALSにおける病態2011
- Author(s)
  山下万貴子、長谷川成人
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 29 Pages: 1022-1023
- Data Source
  KAKENHI-PROJECT-22700383
[Journal Article] シナプスの病態～TDP-43 proteinopathy2010
- Author(s)
  山下万貴子、長谷川成人
- Journal Title
  
  Clinical Neuroscience別冊
  
  Volume: 28 Pages: 904-905
- Data Source
  KAKENHI-PROJECT-22700383
[Journal Article] シナプスの病態～ TDP-43 proteinopathy2010
- Author(s)
  山下万貴子、長谷川成人
- Journal Title
  
  Clinical Neurosciencee
  
  Volume: 28 Pages: 904-905
- Data Source
  KAKENHI-PROJECT-22700383
[Journal Article] TDP-43 凝集体形成阻害化合物の検察2010
- Author(s)
  山下万貴子、野中隆、長谷川成人
- Journal Title
  
  最新医学
  
  Volume: 65
- Data Source
  KAKENHI-PROJECT-22700383
[Journal Article] TDP-43凝集体形成阻害化合物の検索2010
- Author(s)
  山下万貴子、野中隆、長谷川成人
- Journal Title
  
  最新医学
  
  Volume: 65 Pages: 53-58
- Data Source
  KAKENHI-PROJECT-22700383
[Patent] レチノイン酸等を含む神経変性疾患の治療及び／又は予防用医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-074114
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Patent] ニフェジピン等を含む神経変性疾患の治療及び／又は予防用医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-074065
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Patent] フルベストラントを含む神経変性疾患の治療又は予防のための医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-072977
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Patent] ミトタンを含む神経変性疾患の治療又は予防のための医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-072989
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Patent] アモジアキンを含む神経変性疾患の治療又は予防のための医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-072983
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Patent] ブロムヘキシン塩酸塩等を含む神経変性疾患の治療及び／又は予防用医薬組成物2013
- Inventor(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Holder
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-074155
- Filing Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-24700370
[Presentation] 3.Immune monitoring of blood in advanced gastroesophageal adenocarcinoma patients treated with an anti-MMP9 monoclonal antibody in combination with nivolumab.2020
- Author(s)
  Kitano, Makiko Yamashita, Kei Muro, Taroh Satoh, Kensei Yamaguchi, Shigenori Kadowaki, Daisuke Sakai, Takashi Ichimura, Seiichiro Mitani, Toshihiro Kudo, Keisho Chin, Masato Fukui, Pankaj Bhargava, Carrie Brachmann, Marianna Zavodovskaya
- Organizer
  ASCO-SITC2020
- Data Source
  KAKENHI-PROJECT-17K07207
[Presentation] Immunological analysis of the combination therapy of Nivolumab, Paclitaxel and Bevacizumab in patients with HER2-negative MBC in NEWBEAT trial (WJOG9917BTR)2020
- Author(s)
  Yukinori Ozaki, Shigehisa Kitano, Junji Tsurutani, Tsutomu Iwasa, Masato Takahashi, Toru Mukohara, Norikazu Masuda, Manabu Futamura, Hironobu Minami, Koji Matsumoto, Hidetaka Kawabata, Makiko Yamashita, Kenichi Yoshimura, Toshimi Takano
- Organizer
  SABCS2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07207
[Presentation] TDP-43 inclusions suppress proliferation of human neuroblastoma cell line SH-SY5Y and interfere with transcriptional regulation.2012
- Author(s)
  Makiko YAMASHITA, Takashi NONAKA, Haruhiko AKIYAMA, Masato HASEGAWA
- Organizer
  2012.09.05-07, The 8th International Conference on Frontotemporal Dementia (FTD2012) (Manchester, UK)
- Place of Presentation
  イギリス・マンチェスター
- Data Source
  KAKENHI-PROJECT-24700370
[Presentation] TDP-43 inclusions suppress proliferation of human neuroblastoma cell line SH-SY5Y and interfere with transcriptional regulation.2012
- Author(s)
  Makiko YAMASHITA, Takashi NONAKA, Haruhiko AKIYAMA, Masato HASEGAWA
- Organizer
  2012.12.11-15 第35回日本分子生物学会年会（福岡）
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24700370
[Presentation] C-terminal TDP-43 inclusion suppress proliferation mediated by transcriptional dysregulation2011
- Author(s)
  Makiko YAMASHITA, Takashi NONAKA, Haruhiko AKIYAMA, Masato HASEGAWA
- Organizer
  Alzheimer's Association International Conference
- Place of Presentation
  Paris, France
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22700383
[Presentation] TDP-43凝集体形成による神経細胞毒性の誘導2010
- Author(s)
  山下万貴子、野中隆、亀谷富由樹、細川雅人、秋山治彦、長谷川成人
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22700383
[Presentation] TDP-43凝集体形成による神経細胞毒性の誘導2010
- Author(s)
  山下万貴子、野中隆、亀谷富由樹、細川雅人、秋山治彦、長谷川成人
- Organizer
  第29回認知症学会
- Place of Presentation
  名古屋
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22700383
[Presentation] TDP-43凝集体形成による神経細胞毒性の誘導2010
- Author(s)
  山下万貴子
- Organizer
  第29回認知症学会
- Place of Presentation
  名古屋・ウインクあいち
- Year and Date
  2010-11-05
- Data Source
  KAKENHI-PROJECT-22700383
[Presentation] 全長TDP-43あるいはTDP-43C末断片凝集体による神経細胞毒性メカニズムの解明
- Author(s)
  山下万貴子、野中隆、秋山治彦、長谷川成人
- Organizer
  第５５回日本神経病理学会総会学術研究会
- Place of Presentation
  学術総合センター
- Year and Date
  2014-06-05 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-24700370
[Presentation] 全長TDP-4３あるいはC末断片凝集体により誘導される異なる神経細胞毒性メカニズムの解明
- Author(s)
  山下万貴子、野中隆
- Organizer
  脳内環境　H25年度冬の班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24700370

1. 北野滋久 (60402682)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 清谷一馬 (30433642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 上野貴之 (40452362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松島綱治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 五十嵐大樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 花村徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 平井宏和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 山下俊英

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 長谷川寿一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 岡戸晴生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 青木茂樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 長谷川成人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMASHITA MAKIKO 山下 万貴子

山下 万貴子 ヤマシタ マキコ

YAMASHITA Makiko 山下 万貴子

Research Projects

Research Products

Co-Researchers

Antitumor B Cell Immune Responses in Perioperative Breast Cancer Patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転移性乳癌患者における全身免疫病態の網羅的集団動態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Immune monitoring of circulating immune cells in the blood of patients with malignant solid tumors treated with checkpoint inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Distinct pathways leading to cellular dysfunction by TDP-43Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The aggregation mechanisms of TDP-43 inclusion in neuronal cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 「すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患」(祖父江元先生責任 編集)2013

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Pathological complete response to neoadjuvant chemotherapy may improve antitumor immune response via reduction of regulatory T cells in muscle-invasive bladder cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>Interleukin‐4 induced 1</scp>‐mediated resistance to an immune checkpoint inhibitor through suppression of <scp>CD8</scp><sup>+</sup> T cell infiltration in melanoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-infiltrating Leukocyte Profiling Defines Three Immune Subtypes of NSCLC with Distinct Signaling Pathways and Genetic Alterations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient Depletion of CD4 + Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biomarkers for Immune Checkpoint Inhibitors in Melanoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions2014

Author(s)

Journal Title

Data Source

[Journal Article] Distinct pathways leading to TDP-43-induced cellular dysfunctions.2014

Author(s)

Journal Title

DOI

Data Source

YAMASHITA MAKIKO 山下万貴子

山下万貴子ヤマシタマキコ

YAMASHITA Makiko 山下万貴子

[Book] 「すべてがわかる ALS(筋萎縮性側索硬化症)・運動ニューロン疾患」(祖父江元先生責任編集)2013