Chiba Tetsuhiro 千葉哲博

… Alternative Names

CHIBA Tetsuhiro 千葉哲博

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Researcher Number	00381583
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2023: 千葉大学, 大学院医学研究院, 講師 2016 – 2018: 千葉大学, 大学院医学研究院, 講師 2012 – 2015: 千葉大学, 医学(系)研究科(研究院), 講師 2009 – 2011: Chiba University, 医学部附属病院, 助教 2008: Chiba University, 大学院医学研究院, 助教 … More 2007 – 2008: Chiba University, Graduate School of Medicine, Assistant Professor 2006: 千葉大学, 大学院医学研究院, 助手 2005: 横浜市立大学, 大学院医学研究科, 客員研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related / General surgery Except Principal Investigator Biological Sciences / Basic Section 53010:Gastroenterology-related / Hematology
Keywords	Principal Investigator 癌幹細胞 / 肝臓癌 / 幹細胞 / 肝癌 / エピジェネティクス / DZNep / 自己複製能 / 肝細胞癌 / 免疫チェックポイント / 癌免疫逃避機構 … More / 腫瘍微小環境 / 癌 / ヒストンメチル化酵素 / 癌幹細胞特異的治療法 / ポリコーム遺伝子 / 肝臓 / EZH2 / BMI1 / ポリコーム群遺伝子 / SP細胞 / 自己複製 / フローサイトメトリー / CD90 / CD133 / Bmil / CD133, CD90 / Bmi1 / SCIDマウス / NOD / 階層性 / 幹細胞生物学 / FACS … More Except Principal Investigator Dmap1 / Bmil / ポリコーム遺伝子 / Bmi1 / 造血幹細胞 / 深達度診断 / 内視鏡 / 人工知能 / 大腸がん / AI / 大腸癌 / self-renewal / hematopoietic stem cell / polycomb group gene / 自己複製 / gene silencing / DNAメチル化 / Dnmt1 / NuA4 / DNA damage / STAT5 / 白血病幹細胞 Less

Development of an endoscopic diagnosis system for colorectal cancer using artificial intelligence
- Principal Investigator
  
  Matsumura Tomoaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Investigation of tumor immune escape mechanisms in liver cancer using allograft mouse modelPrincipal Investigator
- Principal Investigator
  
  Chiba Tetsuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Chiba University
Importance of loss-of-function of ARID family proteins in liver cancerPrincipal Investigator
- Principal Investigator
  
  Chiba Tetsuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
The regulatory machinery of histone methyltransferases ESET in normal liver and liver cancerPrincipal Investigator
- Principal Investigator
  
  Chiba Tetsuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Epigenetic regulation of liver cancer stem cells and establishment of a novel therapeutic approachPrincipal Investigator
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
Investigation of cancer stem cell system in hepatocellular carcinomaPrincipal Investigator
- Principal Investigator
  
  CHIBA Tetsuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Chiba University
白血病幹細胞の自己複製の分子基盤の解明
- Principal Investigator
  
  IWAMA Atsushi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
ポリコーム遺伝子Bmi-1によるエピジェネティクス制御
- Principal Investigator
  
  岩間厚志
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba University
Epigenetic regulation of hematopoietic stem cell self renewal
- Principal Investigator
  
  IWAMA Atsushi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
ヒト肝臓癌からの癌幹細胞の分離と特性解析Principal Investigator
- Principal Investigator
  
  千葉哲博
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Chiba University
  Yokohama City University

[Journal Article] Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.2023
- Author(s)
  Qiang N, Ao J, Nakamura M, Chiba T, Kusakabe Y, Kaneko T, Kurosugi A, Kogure T, Ma Y, Zhang J, Ogawa K, Kan M, Iwanaga T, Sakuma T, Kanayama K, Kanzaki H, Kojima R, Nakagawa R, Kondo T, Nakamoto S, Muroyama R, Kato J, Mimura N, Ma A, Jin J, Kato N.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 118 Pages: 110068-110068
- DOI
  10.1016/j.intimp.2023.110068
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-23K27577
[Journal Article] Miglustat, a glucosylceramide synthase inhibitor, mitigates liver fibrosis through TGF-β/Smad pathway suppression in hepatic stellate cells2023
- Author(s)
  Iwanaga T, Chiba T, Nakamura M, et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 642 Pages: 192-200
- DOI
  10.1016/j.bbrc.2022.12.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02631, KAKENHI-PROJECT-20K08276
[Journal Article] Successful Identification of a Novel Therapeutic Compound for Hepatocellular Carcinoma Through Screening of ADAM9 Inhibitors.2023
- Author(s)
  Ogawa K, Chiba T, Nakamura M, Arai J, Zhang J, et al.
- Journal Title
  
  Anticancer Res.
  
  Volume: 43 Issue: 3 Pages: 1043-1052
- DOI
  10.21873/anticanres.16249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Effect of Atezolizumab plus Bevacizumab in Patients with Hepatocellular Carcinoma Harboring CTNNB1 Mutation in Early Clinical Experience.2022
- Author(s)
  Ogawa K, Kanzaki H, Chiba T, Ao J, Qiang N, et al.
- Journal Title
  
  J Cancer
  
  Volume: 13 Issue: 8 Pages: 2656-2661
- DOI
  10.7150/jca.71494
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-23K24441
[Journal Article] Bile proteome analysis by high-precision mass spectrometry to examine novel biomarkers of primary sclerosing cholangitis.2022
- Author(s)
  Kan M, Chiba T, Konno R, Kouchi Y, Mishima T, Kawashima Y, Kishimoto T, Ohtsuka M, Ohara O, Kato N.
- Journal Title
  
  J Hepatobiliary Pancreat Sci.
  
  Volume: in press Issue: 7 Pages: 914-923
- DOI
  10.1002/jhbp.1299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] A diet-induced murine model for non-alcoholic fatty liver disease with obesity and insulin resistance that rapidly develops steatohepatitis and fibrosis.2022
- Author(s)
  Sakuma T, Nakamura M, Chiba T, Iwanaga T, Kan M, Kojima R, Ao J, Ma Y, Unozawa H, Fujita N, Kanayama K, Kanzaki H, Koroki K, Kobayashi K, Nakagawa R, Kanogawa N, Kiyono S, Kondo T, Saito T, Ogasawara S, Nakamoto S, Muroyama R, Kato J, Kishimoto T, Kato N.
- Journal Title
  
  Lab Invest.
  
  Volume: 102 Issue: 10 Pages: 1150-1157
- DOI
  10.1038/s41374-022-00807-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] The RNA-Binding Protein ELAVL1 Regulates Hepatitis B Virus Replication and Growth of Hepatocellular Carcinoma Cells.2022
- Author(s)
  Kanzaki H, Chiba T, Kaneko T, Ao J, Kan M, Muroyama R, Nakamoto S, Kanda T, Maruyama H, Kato J, Zen Y, Kotani A, Sekiba K, Otsuka M, Ohtsuka M, Kato N.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 23 Issue: 14 Pages: 7878-7878
- DOI
  10.3390/ijms23147878
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma2021
- Author(s)
  Kanzaki H、Chiba T、Ao J、Koroki K、Kanayama K、Maruta S、Maeda T、Kusakabe Y、Kobayashi K、Kanogawa N、Kiyono S、Nakamura M、Kondo T、Saito T、Nakagawa R、Ogasawara S、Suzuki E、Ooka Y、Muroyama R、Nakamoto S、Yasui S、Tawada A、Arai M、Kanda T、Maruyama H、Mimura N、Kato J、Zen Y、Ohtsuka M、Iwama A、Kato N
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 5303-5303
- DOI
  10.1038/s41598-021-84117-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-20K17041, KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08276
[Journal Article] The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.2021
- Author(s)
  Nagai Y, Mimura N, Nakaseko C et al
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 2074-2074
- DOI
  10.1038/s41598-021-81577-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-19K08807, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K19497
[Journal Article] Analysis of circulating cell-free DNA after endoscopic ultrasound-guided fine needle aspiration in pancreatic ductal adenocarcinoma.2021
- Author(s)
  Asano K, Mikata R, Chiba T, Kan M, Maruta S, Yamada T, Miura Y, Shima Y, Sensui M, Nagashima H, Yokoyama M, Ohyama H, Kusakabe Y, Yasui S, Sugiyama H, Ohno I, Kato J, Takano S, Ohtsuka M, Kato N.
- Journal Title
  
  Pancreatology
  
  Volume: - Issue: 6 Pages: 3903-3903
- DOI
  10.1016/j.pan.2021.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07707, KAKENHI-PROJECT-20K08276
[Journal Article] Acquisition of mesenchymal-like phenotypes and overproduction of angiogenic factors in lenvatinib-resistant hepatocellular carcinoma cells2021
- Author(s)
  Ao J, Chiba T, Shibata S, Kurosugi A, Qiang N, Ma Y, Kan M, Iwanaga T, Sakuma T, Kanzaki H, Kanayama K, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Kondo T, Ogasawara S, Suzuki E, Muroyama R, Kato J, Mimura N, Kanda T, Maruyama H, Kato N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 549 Pages: 171-178
- DOI
  10.1016/j.bbrc.2021.02.097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Comprehensive mutational analysis of background mucosa in patients with Lugol‐voiding lesions2021
- Author(s)
  Akizue Naoki、Okimoto Kenichiro、Arai Makoto、Hirotsu Yosuke、Amemiya Kenji、Oura Hirotaka、Kaneko Tatsuya et al
- Journal Title
  
  Cancer Medicine
  
  Volume: 10 Issue: 11 Pages: 3545-3555
- DOI
  10.1002/cam4.3905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K17012, KAKENHI-PROJECT-18K07408, KAKENHI-PROJECT-23K21402
[Journal Article] Serum Angiopoietin 2 acts as a diagnostic and prognostic biomarker in hepatocellular carcinoma2021
- Author(s)
  Ao Junjie、Tawada Akinobu、Kato Naoya et al
- Journal Title
  
  Journal of Cancer
  
  Volume: 12 Issue: 9 Pages: 2694-2701
- DOI
  10.7150/jca.56436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08412, KAKENHI-PROJECT-20K08276
[Journal Article] Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice2021
- Author(s)
  Kakizaki Masatoshi、Yamamoto Yuichiro、Nakayama Shunya、Kameda Kazuaki、Nagashima Etsuko、Ito Masatoshi、Suyama Takashi、Matsuzaki Yumi、Chiba Tetsuhiro、Sumiyoshi Hideaki、Inagaki Yutaka、Kotani Ai
- Journal Title
  
  Cell Death and Disease
  
  Volume: 12 Issue: 11 Pages: 1010-1010
- DOI
  10.1038/s41419-021-04204-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20K17064, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-20J14747, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K15420, KAKENHI-PROJECT-21H02907
[Journal Article] Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients2021
- Author(s)
  Tokunaga Mamoru、Okimoto Kenichiro、Akizue Naoki、Ishikawa Kentaro、Hirotsu Yosuke、Amemiya Kenji、Ota Masayuki、Matsusaka Keisuke、et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 17671-17671
- DOI
  10.1038/s41598-021-97249-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K17451, KAKENHI-PROJECT-20H03668, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K07956, KAKENHI-PROJECT-18K07408, KAKENHI-PROJECT-23K21402
[Journal Article] EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma2021
- Author(s)
  Kusakabe Y, Chiba T, Zen Y, Otsuka M, Kaneda A, Iwama A, Kato N, et al
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 21396-21396
- DOI
  10.1038/s41598-021-00889-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09113, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-19K17482, KAKENHI-PROJECT-20K08276
[Journal Article] Diagnostic value of IMP3 and p53 immunohistochemical staining in EUS-guided fine-needle aspiration for solid pancreatic tumors2021
- Author(s)
  Mikata R, Yasui S, Kishimoto T, Kouchi Y, Shingyoji A, Senoo J, Takahashi K, Nagashima H, Kusakabe Y, Ohyama H, Ohno I, Sugiyama H, Chiba T, Kato J, Kato N.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 17257-17257
- DOI
  10.1038/s41598-021-96492-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Free fatty acid-based low-impedance liver image: a characteristic appearance in nonalcoholic steatohepatitis (NASH).2020
- Author(s)
  Maruyama H, Kobayashi K, Kiyono S, Chiba T, Kato N, Ohtsuka M, Ito K, Yamaguchi T, Shiina S.
- Journal Title
  
  Eur Radiol Exp
  
  Volume: 4 Issue: 1 Pages: 3-3
- DOI
  10.1186/s41747-019-0137-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Long-term administration of Tolvaptan to patients with decompensated cirrhosis.2020
- Author(s)
  Kanayama K, Chiba T, Kobayashi K, Koroki K, Maruta S, Kanzaki H, Kusakabe Y, Saito T, Kiyono S, Nakamura M, Ogasawara S, Suzuki E, Ooka H, Yasui S, Nakamoto S, Kanda T, Maruyama H, Kato J, Kato N.
- Journal Title
  
  Int J Med Sci
  
  Volume: 17 Issue: 7 Pages: 874-880
- DOI
  10.7150/ijms.41454
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Potential of Lenvatinib for an Expanded Indication from the REFLECT Trial in Patients with Advanced Hepatocellular Carcinoma.2020
- Author(s)
  Maruta S, Ogasawara S, Ooka Y, Obu M, Inoue M, Itokawa N, Haga Y, Seki A, Okabe S, Azemoto R, Itobayashi E, Atsukawa M, Sugiura N, Mizumoto H, Koroki K, Kanayama K, Kanzaki H, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N.
- Journal Title
  
  Liver Cancer
  
  Volume: 9 Issue: 4 Pages: 382-396
- DOI
  10.1159/000507022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan.2020
- Author(s)
  Ogasawara S, Ooka Y, Itokawa N, Inoue M, Okabe S, Obu M, Atsukawa M, Itobayashi E, Mizumoto H, Sugiura N, Azemoto R, Kanayama K, Kanzaki H, Maruta S, Maeda T, Kusakabe Y, Yokoyama M, Kobayashi K, Kiyono S, Nakamura M, Saito T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato N
- Journal Title
  
  Invest New Drugs
  
  Volume: 38 Issue: 1 Pages: 172-180
- DOI
  10.1007/s10637-019-00801-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma.2020
- Author(s)
  Kudo M, Morimoto M, Moriguchi M, Izumi N, Takayama T, Yoshiji H, Hino K, Oikawa T, Chiba T, Motomura K, Kato J, Yasuchika K, Ido A, Sato T, Nakashima D, Ueshima K, Ikeda M, Okusaka T, Tamura K, Furuse J.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 10 Pages: 3759-3769
- DOI
  10.1111/cas.14582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] The efficacy of linked color imaging in the endoscopic diagnosis of Barrett’s esophagus and esophageal adenocarcinoma.2020
- Author(s)
  Tokunaga M, Matsumura T, Ishikawa K, Kaneko T, Oura H, Ishikawa T, Nagashima A, Shiratori W, Okimoto K, Akizue N, Maruoka D, Ohta Y, Saito K, Nakagawa T, Chiba T, Arai M, Kato J, Kato N.
- Journal Title
  
  Gastroenterol Res Pract
  
  Volume: 2020 Pages: 9604345-9604345
- DOI
  10.1155/2020/9604345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Analyses of intermediate-stage hepatocellular carcinoma patients receiving TACE prior to designing clinical trials.2020
- Author(s)
  Koroki K, Ogasawara S, Ooka Y, Kanzaki H, Kanayama K, Maruta S, Maeda T, Yokoyama M, Wakamatsu T, Inoue M, Kobayashi K, Kiyono S, Nakamura M, Kanogawa N, Saito T, Kondo T, Suzuki E, Nakamoto S, Yasui S, Tawada A, Chiba T, Arai M, Kanda T, Maruyama H, Kato J, Kuboki S, Ohtsuka Miyazaki M, Yokosuka O, Kato N.
- Journal Title
  
  Liver Cancer
  
  Volume: 9 Issue: 5 Pages: 596-612
- DOI
  10.1159/000508809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08276
[Journal Article] Interferon-γ induced PD-L1 expression and soluble PD-L1 production in gastric cancer.2020
- Author(s)
  Imai Y, Chiba T, Kondo T, Kanzaki H, Kanayama K, Ao J, Kojima R, Kusakabe Y, Nakamura M, Saito T, Nakagawa R, Suzuki E, Nakamoto S, Muroyama R, Tawada A, Matsumura T, Nakagawa T, Kato J, Kotani A, Matsubara H, Kato N.
- Journal Title
  
  Oncol Lett
  
  Volume: 20 Issue: 3 Pages: 2161-2168
- DOI
  10.3892/ol.2020.11757
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-20H03749
[Journal Article] PD-L1 is induced on hepatocyte surface via CKLF-like MARVEL transmembrane domain-containing protein 6 upregulation by the anti-HBV drug Entecavir2020
- Author(s)
  Yamamoto Yuichiro、Kakizaki Masatoshi、Shimizu Takayuki、Carreras Joaquim、Chiba Tetsuhiro、Chamoto Kenji、Kagawa Tatehiro、Aoki Taku、Nakamura Naoya、Ando Kiyoshi、Kotani Ai
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 8 Pages: 519-531
- DOI
  10.1093/intimm/dxaa018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15100, KAKENHI-PROJECT-18K15131, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20H03716
[Journal Article] Epigenetic dysregulation in hepatocellular carcinoma: an up-to-date review.2019
- Author(s)
  Nakamura M, Chiba T, Kanayama K, Kanzaki H, Saito T, Kusakabe Y, Kato N.
- Journal Title
  
  Hepatol Res.
  
  Volume: 49 Issue: 1 Pages: 3-13
- DOI
  10.1111/hepr.13250
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells2019
- Author(s)
  Kanayama K, Chiba T, Oshima Kanzaki H, Koide S, Saraya A, Miyagi S, Mimura N, Kusakabe Y, Saito T, Ogasawara S, Suzuki E, Ooka Yoshihiko, Maruyama H, Iwama A, Kato N.
- Journal Title
  
  Stem Cells Int
  
  Volume: 2019 Pages: 9789240-9789240
- DOI
  10.1155/2019/9789240
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-19K08865
[Journal Article] A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.2019
- Author(s)
  Tateishi R, Uchino K, Fujiwara N, Takehara T, Okanoue T, Seike M, Yoshiji H, Yatsuhashi H, Shimizu M, Torimura T, Moriyama M, Sakaida I, Okada H, Chiba T, Chuma M, Nakao K, Isomoto H, Sasaki Y, Kaneko S, Masaki T, Chayama K, Koike K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 4 Pages: 367-376
- DOI
  10.1007/s00535-018-1532-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09352, KAKENHI-PROJECT-18K07945, KAKENHI-PROJECT-19K08465, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-18H02798
[Journal Article] Transarterial chemoembolization as a substitute to radiofrequency ablation for treating barcelona clinic liver cancer stage 0/A hepatocellular carcinoma.2018
- Author(s)
  Ishikawa K, Chiba T, Ooka Y, Suzuki E, Ogasawara S, Maeda T, Yokoyama M, Inoue M, Wakamatsu T, Kusakabe Y, Saito T, Tawada A, Arai M, Kanda T, Maruyama H, Imazeki F, Kato N.
- Journal Title
  
  Oncotarget
  
  Volume: －
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Successful retreatment with sofosbuvir plus ledipasvir for cirrhotic patients with hepatitis C virus genotype 1b, who discontinued the prior treatment with asunaprevir plus daclatasvir: A case series and review of the literature.2018
- Author(s)
  Haga Y, Kanda T, Yasui S, Nakamura M, Ooka Y, Takahashi K, Wu S, Nakamoto S, Arai M, Chiba T, Maruyama H, Yokosuka O, Takada N, Moriyama M, Imazeki F, Kato N.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 5509-5513
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Application of transcutaneous ultrasonography for the diagnosis of muscle mass loss in patients with liver cirrhosis.2017
- Author(s)
  Kobayashi K, Maruyama H, Kiyono S, Ogasawara S, Suzuki E, Ooka Y, Chiba T, Kato N, Yamaguchi T.
- Journal Title
  
  J Gastroenterol
  
  Volume: － Issue: 5 Pages: 652-659
- DOI
  10.1007/s00535-017-1378-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] A randomized placebo-controlled trial of prophylactic dexamethasone for transcatheter arterial chemoembolization.2017
- Author(s)
  Ogasawara S, Chiba T, Ooka Y, Kanogawa N, Motoyama T, Suzuki E, Tawada A, Nagai K, Nakagawa T, Sugawara T, Hanaoka H, Kanai F, Yokosuka O
- Journal Title
  
  Hepatology
  
  Volume: － Issue: 2 Pages: 575-585
- DOI
  10.1002/hep.29403
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Characteristics of patients with sorafenib-treated advanced hepatocellular carcinoma eligible for second-line treatment.2017
- Author(s)
  Ogasawara S, Chiba T, Ooka Y, Suzuki E, Maeda T, Yokoyama M, Wakamatsu T, Inoue M, Saito T, Kobayashi K, Kiyono S, Nakamura M, Nakamoto S, Yasui S, Tawada A, Arai M, Kanda T, Maruyama H, Yokosuka O, Kato N.
- Journal Title
  
  Invest New Drugs
  
  Volume: － Issue: 2 Pages: 332-339
- DOI
  10.1007/s10637-017-0507-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Association of IFNL3 Genotype with Hepatic Steatosis in Chronic Hepatitis C Patients Treated with Peginterferon and Ribavirin Combination Therapy.2017
- Author(s)
  Nakamoto S, Imazeki F, Kanda T, Wu S, Nakamura M, Yasui S, Tawada A, Mikata R, Chiba T, Arai M, Yokosuka O, Shirasawa H.
- Journal Title
  
  Int J Med Sci
  
  Volume: 14 Pages: 1088-1093
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Presence of non-hypervascular hypointense nodules on Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging in patients with hepatocellular carcinoma.2017
- Author(s)
  Inoue M, Ogasawara S, Chiba T, Ooka Y, Wakamatsu T, Kobayashi K, Suzuki E, Tawada A, Yokosuka O.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 32 Issue: 4 Pages: 908-915
- DOI
  10.1111/jgh.13622
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma2017
- Author(s)
  Yokoyama M, Chiba T, Zen Y, Oshima M, Kusakabe Y, Noguchi Y, Yuki K, Koide S, Tara S, Saraya A, Aoyama K, Mimura N, Miyagi S, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 13 Pages: 21315-21326
- DOI
  10.18632/oncotarget.15528
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840
[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016
- Author(s)
  Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
- Journal Title
  
  Blood
  
  Volume: 128(5) Issue: 5 Pages: 638-649
- DOI
  10.1182/blood-2016-01-694810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Prognostic Significance of Concurrent Hypovascular and Hypervascular Nodules in Patients with Hepatocellular Carcinoma.2016
- Author(s)
  Ogasawara S, Chiba T, Motoyama T, Kanogawa N, Saito T, Shinozaki Y, Suzuki E, Ooka Y, Tawada A, Kato H, Okabe S, Kanai F, Yoshikawa M, Yokosuka O.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 9 Pages: e0163119-e0163119
- DOI
  10.1371/journal.pone.0163119
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09340
[Journal Article] Cancer stem cells in hepatocellular carcinoma: Therapeutic implications based on stem cell biology2016
- Author(s)
  Chiba T, Iwama A, Yokosuka O
- Journal Title
  
  Hepatol Res
  
  Volume: 46 Issue: 1 Pages: 50-57
- DOI
  10.1111/hepr.12548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460977
[Journal Article] Biological features and biomarkers in hepatocellular carcinoma2015
- Author(s)
  Chiba T, Suzuki E, Saito T, Ogasawara S, Ooka Y, Tawada A, Iwama A, Yokosuka O
- Journal Title
  
  World J Hepatol
  
  Volume: 7 Issue: 16 Pages: 2020-2028
- DOI
  10.4254/wjh.v7.i16.2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460977
[Journal Article] Histone lysine methyltransferase SUV39H1 is a potent target for epigenetic therapy of hepatocellular carcinoma.2015
- Author(s)
  Chiba T, Saito T, Yuki K, Zen Y, Koide S, Kanogawa N, Motoyama T, Ogasawara S, Suzuki E, Ooka Y, Tawada A, Otsuka M, Miyazaki M, Iwama A, Yokosuka O.
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Issue: 2 Pages: 289-298
- DOI
  10.1002/ijc.28985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460977
[Journal Article] The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells.2014
- Author(s)
  Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A.
- Journal Title
  
  Stem Cell Reports.
  
  Volume: 2 Issue: 2 Pages: 145-52
- DOI
  10.1016/j.stemcr.2013.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-25893049, KAKENHI-PROJECT-221S0002
[Journal Article] Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners2014
- Author(s)
  Chiba T, Suzuki E, Yuki K, Zen Y, Oshima M, Miyagi S, Saraya A, Koide S, Motoyama T, Ogasawara S, Ooka Y, Tawada A, Nakatsura T, Hayashi T, Yamashita T, Kaneko S, Miyazaki M, Iwama A, Yokosuka O
- Journal Title
  
  PLoS One
  
  Volume: 9(1) Issue: 1 Pages: e84807-e84807
- DOI
  10.1371/journal.pone.0084807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039, KAKENHI-PUBLICLY-25130702, KAKENHI-PROJECT-25460977
[Journal Article] Natural history of postvascular-phase iso-enhanced lesions on the sonogram in chronic liver diseases2014
- Author(s)
  Kondo T, Maruyama H, Sekimoto T, Shimada T, Takahashi M, Chiba T, Kanai F, Yokosuka O, Yamaguchi T
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 29(1) Issue: 1 Pages: 165-72
- DOI
  10.1111/jgh.12449
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Efficacy of transcatheter arterial chemoembolization with miriplatin-lipiodol water-soluble contrast agent emulsion in patients with hepatocellular carcinoma2013
- Author(s)
  Okimoto K, Ogasawara S, Chiba T, Ooka Y, Oobu M, Azemoto R, Kanogawa N, Motoyama T, Suzuki E, Tawada A, Yoshikawa M, Yokosuka O
- Journal Title
  
  Anticancer Res
  
  Volume: 33(12) Pages: 5603-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Gadoxetic acid-enhanced MRI compared with CT during angiography in the diagnosis of hepatocellular carcinoma2013
- Author(s)
  Ooka Y, Kanai F, Okabe S, Ueda T, Shimofusa R, Ogasawara S, Chiba T, Sato Y, Yoshikawa M, Yokosuka O
- Journal Title
  
  Magn Reson Imaging
  
  Volume: 31(5) Issue: 5 Pages: 748-54
- DOI
  10.1016/j.mri.2012.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Circulating cancer stem cells : a novel prognostic predictor of hepatocellular carcinoma2013
- Author(s)
  Chiba T, Kanai F, Iwama A, Yokosuka O
- Journal Title
  
  Hepatobiliary Surg Nutr
  
  Volume: 2(1) Pages: 4-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Metformin, a Diabetes Drug, Eliminates Tumor-Initiating Hepatocellular Carcinoma Cells.2013
- Author(s)
  Saito, T., Chiba, T., Yuki, K., Zen, Y., Oshima, M., Koide, S., Motoyama, T., Ogasawara, S., Suzuki, E., Ooka, Y., Tawada, A., Tada, M., Kanai, F., Takiguchi, Y., Iwama, A. and Yokosuka, O.
- Journal Title
  
  PloS one
  
  Volume: 8 Issue: 7 Pages: e70010-e70010
- DOI
  10.1371/journal.pone.0070010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-25460977
[Journal Article] Circulating cancer stem cells: a novel prognostic predictor of hepatocellular carcinoma.2013
- Author(s)
  Chiba T, Kanai F, Iwama A, Yokosuka O.
- Journal Title
  
  Hepatobiliary Surg Nutr.
  
  Volume: 2 Pages: 4-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Adherence to medication is a more important contributor to viral breakthrough in chronic hepatitis B patients treated with entecavir than in those with Lamivudine2013
- Author(s)
  Kamezaki H, Kanda T, Arai M, Wu S, Nakamoto S, Chiba T, Maruyama H, Fujiwara K, Kanai F, Imazeki F, Nomura F, Yokosuka O
- Journal Title
  
  Int J Med Sci
  
  Volume: 10(5) Issue: 5 Pages: 567-74
- DOI
  10.7150/ijms.5795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Effect of metformin on residual cells after chemotherapy in a human lung adenocarcinoma cell line.2013
- Author(s)
  Kitazono, S., Takiguchi, Y., Ashinuma, H., Saito-Kitazono, M., Kitamura, A., Chiba, T., Sakaida, E., Sekine, I., Tada, Y., Kurosu, K., Sakao, S., Tanabe, N., Iwama, A., Yokosuka, O. and Tatsumi, K.
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 43 Issue: 6 Pages: 1846-1854
- DOI
  10.3892/ijo.2013.2120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-23689039
[Journal Article] Antiproliferative action of metformin in human lung cancer cell lines2012
- Author(s)
  Ashinuma N, Chiba T, et al.
- Journal Title
  
  Oncol Rep
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells2012
- Author(s)
  Chiba T, Suzuki E, Negishi M, Saraya A, Miyagi S, Konuma T, Tanaka S, Tada M, Kanai F, Imazeki F, Iwama A, Yokosuka O
- Journal Title
  
  International Journal of Cancer
  
  Volume: 130(11) Issue: 11 Pages: 2557-2567
- DOI
  10.1002/ijc.26264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03550, KAKENHI-PROJECT-21390289, KAKENHI-PUBLICLY-23130502, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-23791071
[Journal Article] Ezh2 augments leukemogenecity by reinforcing differentiation blockage in acute myeloid leukemia2012
- Author(s)
  Tanaka S
- Journal Title
  
  Blood
  
  Volume: 120 Issue: 5 Pages: 1107-17
- DOI
  10.1182/blood-2011-11-394932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249015, KAKENHI-PROJECT-23591367, KAKENHI-PROJECT-23689039, KAKENHI-PROJECT-23791071, KAKENHI-PROJECT-24249054, KAKENHI-PROJECT-221S0002, KAKENHI-PUBLICLY-23130502
[Journal Article] 3-Deazaneplanocin A is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells2012
- Author(s)
  Chiba T, et al.
- Journal Title
  
  Int J Cancer
  
  Volume: 130 Pages: 2557-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Antiproliferative action of metformin in human lung cancer cell lines2012
- Author(s)
  Ashinuma H, Takiguchi Y, Sakaida E, Sekine I, et al
- Journal Title
  
  Oncology Reports
  
  Volume: 28(1) Pages: 8-14
- DOI
  10.3892/or.2012.1763
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590850, KAKENHI-PROJECT-23591136, KAKENHI-PROJECT-23689039
[Journal Article] Aldehyde dehydrogenase 1 is associated with recurrence free survival but notstem cell-like properties in hepatocellular carcinoma2012
- Author(s)
  Chiba T, et al.
- Journal Title
  
  Hepatol Res
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma2012
- Author(s)
  Suzuki E, Chiba T, Zen Y, Miyagi S, Tada M, Kanai F, Imazeki F, Miyazaki M, Iwama A, Yokosuka O
- Journal Title
  
  Hepatol Res
  
  Volume: 42(11) Issue: 11 Pages: 1100-11
- DOI
  10.1111/j.1872-034x.2012.01028.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3 K14 and required for fetal liver erythropoiesis2011
- Author(s)
  Mishima Y, Chiba T, et al.
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 2443-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23689039
[Journal Article] Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010
- Author(s)
  Chiba T, et al.
- Journal Title
  
  Hepatology
  
  Volume: 52 Pages: 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010
- Author(s)
  Chiba T, et al.
- Journal Title
  
  Journal of Hepatology
  
  Volume: 52 Pages: 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Bmil promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.2010
- Author(s)
  Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
- Journal Title
  
  Hepatology 52
  
  Pages: 1111-1123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.2010
- Author(s)
  Chiba T, Aoki R, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.
- Journal Title
  
  J Hepatol 52
  
  Pages: 854-863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Cancer stem cells in hepatocellular carcinoma : Recent progress and perspective.2009
- Author(s)
  Chiba T, Kamiya A, Yokosuka O, Iwama A.
- Journal Title
  
  Cancer Lett, 286
  
  Pages: 145-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Dmapl plays an essential role in the maintenance of genome integrity through the DNA repair process.2009
- Author(s)
  Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A.
- Journal Title
  
  Gene Cells, 14
  
  Pages: 1347-1357
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Cancer stem cells in hepatocellular carcinoma : Recent progress and perspective2009
- Author(s)
  Chiba T, et al.
- Journal Title
  
  Cancer Letters 286
  
  Pages: 145-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790649
[Journal Article] Stem cells and cancer in the liver.2008
- Author(s)
  Taniguchi H, Chiba T.
- Journal Title
  
  Dis Markers 24
  
  Pages: 223-229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumorinitiating side population cells in hepatocellular carcinoma2008
- Author(s)
  Chiba T.
- Journal Title
  
  Cancer Research 68
  
  Pages: 7742-7749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.2008
- Author(s)
  Chiba T, Miyagi S, Saraya A, Ryutaro Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H,Iwama A.
- Journal Title
  
  Cancer Res 68
  
  Pages: 7742-7749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] Excessive self-renewal of hepatic stem/progenitor cells.drives cancer initiation2007
- Author(s)
  Chiba T.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390277
[Journal Article] Excessive self-renewal of hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390277
[Journal Article] Excessive self-renewal of hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18013008
[Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T, et. al.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] Excessive self-renewal of hepatic stem/progenitor cells drives cancer initiation2007
- Author(s)
  Chiba T.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390277
[Journal Article] Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi M, Nakano M, Nakauchi H, Iwama A, Taniguchi H.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Journal Article] Excessive self-renewal of hepatic stem/progenitor cells drives cancer initiation.2007
- Author(s)
  Chiba T.
- Journal Title
  
  Gastroenterology 133
  
  Pages: 937-950
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18055006
[Journal Article] Side Population Purified from Hepatocellular Carcinoma Cells Harbors Cancer Stem Cell-like Properties2006
- Author(s)
  Chiba T.
- Journal Title
  
  Hepatology 44・1
  
  Pages: 240-251
- Data Source
  KAKENHI-PROJECT-17659393
[Journal Article] Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.2006
- Author(s)
  Chiba T.
- Journal Title
  
  Hepatology 44
  
  Pages: 240-251
- Data Source
  KAKENHI-PROJECT-18055006
[Journal Article] Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.2006
- Author(s)
  Chiba T.
- Journal Title
  
  Hepatology 44
  
  Pages: 240-251
- Data Source
  KAKENHI-PROJECT-18013008
[Journal Article] Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.2006
- Author(s)
  Chiba T.
- Journal Title
  
  Hepatology 44
  
  Pages: 240-251
- Data Source
  KAKENHI-PROJECT-18390277
[Journal Article] Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.
- Author(s)
  Yonemitsu Y, Imazeki F, Chiba T, Fukai K, Nagai Y, Miyagi S, Arai M, Aoki R, Miyazaki M, Nakatani Y, Iwama A, Yokosuka O.
- Journal Title
  
  Hum Pathol (in press.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790468
[Patent] 肝がん幹細胞阻害剤2013
- Inventor(s)
  千葉哲博、鈴木英一郎、金井文彦、横須賀收
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-224722
- Acquisition Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-23689039
[Patent] 肝がん幹細胞阻害剤2012
- Inventor(s)
  千葉哲博、他3名
- Industrial Property Rights Holder
  国立大学法人千葉大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-224722
- Filing Date
  2012-10-10
- Acquisition Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-23689039
[Patent] 肝がん幹細胞阻害剤2011
- Inventor(s)
  千葉哲博, ら
- Industrial Property Rights Holder
  千葉大学
- Industrial Property Number
  2011-223639
- Filing Date
  2011-10-11
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 肝細胞癌におけるCTNNB1遺伝子変異とアテゾリズマブ/ベバシズマブ併用療法の初期治療効果と末梢血CCL5濃度に関する検討2022
- Author(s)
  小川慶太、千葉哲博、加藤直也
- Organizer
  第59回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 高精度質量分析を用いた胆汁プロテオーム解析による原発性硬化性胆管炎の病態解明の試み2022
- Author(s)
  菅元康、千葉哲博、加藤直也
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Involvement of FGF and VEGF signaling in multi-kinase inhibitor resistance in hepatocellular carcinoma2021
- Author(s)
  Kanzaki H, Chiba T, Kato N.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Impacts of EZH2 inhibitor UNC1999 on tumor and tumor microenvironment in hepatocellular carcinoma2021
- Author(s)
  Ao J, Chiba T, Kaneko T et al.
- Organizer
  APASL Oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Effects of EZH2 inhibition on tumor and tumor microenvironment in hepatocellular carcinoma2021
- Author(s)
  Ao J, Chiba T, Kato N.
- Organizer
  AASLD The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 血清可溶型PD-L1のバイオマーカーとしての意義-アテゾリズマブ/ベバシズマブ併用症例を含めて-2021
- Author(s)
  神﨑洋彰, 千葉哲博, 加藤直也
- Organizer
  第57回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 血清FGF19値に基づいた肝細胞癌に対するレンバチニブの後方治療時の成績2021
- Author(s)
  千葉哲博, 神﨑洋彰, 敖俊杰, 他.
- Organizer
  第57回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] EZH2阻害剤の肝癌微小環境に与える影響の検討2021
- Author(s)
  敖俊杰, 千葉哲博, 加藤直也
- Organizer
  JDDW 2021
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 血清Angiopoietin 2の肝細胞癌新規バイオマーカーとしての有用性2021
- Author(s)
  強娜, 千葉哲博, 敖俊杰, 他.
- Organizer
  JDDW 2021
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] マルチキナーゼ阻害剤耐性化におけるFGFシグナルとVEGFシグナルの関わり2021
- Author(s)
  神﨑洋彰, 千葉哲博, 加藤直也
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 肝細胞癌におけるGas6と可溶型Axlのバイオマーカーとしての有用性の検証2021
- Author(s)
  佐久間崇文, 千葉哲博, 加藤直也
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Role of FGF19/FGFR4 Signaling and Potential of Serum FGF19 as a Biomarker in Hepatocellular Carcinoma.2021
- Author(s)
  Chiba T
- Organizer
  APASL Oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] The effect of glucosylceramide synthase inhibitor on liver fibrosis regression2021
- Author(s)
  Iwanaga T, Chiba T, Zhang J, et al.
- Organizer
  APASL Oncology 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 新規食餌誘導性非アルコール性脂肪性肝疾患マウスモデルの構築と病態解析2021
- Author(s)
  中村昌人, 千葉哲博, 加藤直也
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] グルコシルセラミド合成酵素阻害薬の肝線維化抑制効果の検討2021
- Author(s)
  岩永光巨, 千葉哲博, 加藤直也
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Serum angiopoietin 2 as a diagnostic and prognostic biomarkers in hepatocellular carcinoma.2020
- Author(s)
  Chiba T，Ao J，Kanzaki H，Shibata S，Kakiuchi R，Sakaue A，Qiang N，Ma Y，Kanayama K, Kojima R，Kusakabe Y，Nakamura M，Saito T，Nakagawa R，Kondo T，Ogasawara S，Suzuki E，Muroyama R，Kondo T，Maruyama H，Kato J，Kato N.
- Organizer
  米国肝臓学会議 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] An improved diet-induced murine model for nonalcoholic fatty liver disease with rapid progression of steatohepatitis and fibrosis.2020
- Author(s)
  Nakmaura M，Chiba T，Sakuma T，Iwanaga T，Fujita N，Ao J，Ma Y，Kanayama K， Kanzaki H，Koroki K，Kobayashi K，Nakagawa R，Kanogawa N，Kiyono S，Kondo T， Saito T，Ogasawara S，Ooka Y，Suzuki E，Nakamoto S，Muroyama R，Kato N.
- Organizer
  米国肝臓学会議 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 同種移植肝癌モデルマウスを用いたマルチキナーゼ阻害剤の肝癌微小環境への影響の検討2020
- Author(s)
  金山健剛，千葉哲博，加藤直也
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 肝細胞癌における可溶型PD-L1の特性および分泌機序の検討2020
- Author(s)
  神崎洋彰，千葉哲博，加藤直也
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] Potential as biomarkers of circulating cell-free DNA.2020
- Author(s)
  Kanzaki H，Chiba T，Unozawa H，Iwanaga T，Sakuma T，Fujita N，Koroki K，Kobayashi K，Kiyono S，Nakmaura M，Kanogawa N，Kondo T，Saito T，Nakagawa R，Ogasawara S，Suzuki E，Muroyama R，Nakamoto S，Tawada A，Kato N.
- Organizer
  米国肝臓学会議 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 肝癌のMKI治療におけるFG19及びVEGFの血清バイオマーカーとしての意義2020
- Author(s)
  千葉哲博，神崎洋彰，加藤直也
- Organizer
  第56回日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 血清FGF19・VEGF値からみた進行肝癌症例におけるソラフェニブ及びレンバチニブの治療反応性と病勢進行に伴う変化の検討2020
- Author(s)
  神崎洋彰，千葉哲博，加藤直也
- Organizer
  第43回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-20K08276
[Presentation] 胎生肝幹 / 前駆細胞の分化制御から見た新規肝癌治療法の可能性の検討.2018
- Author(s)
  千葉哲博, 日下部裕子, 加藤直也.
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] 肝癌におけるポリコーム群遺伝子EZH1およびEZH2の役割.2018
- Author(s)
  日下部裕子, 千葉哲博, 加藤直也.
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] 非アルコール性脂肪肝疾患における肝炎症及び肝線維化に対するmicroRNA-200bの重要性.2018
- Author(s)
  中村昌人, 千葉哲博, 加藤直也.
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] 肝癌に対する分子標的治療におけるFGF19/FGFR4シグナル制御の意義.2018
- Author(s)
  神崎洋彰, 千葉哲博, 加藤直也.
- Organizer
  第26回日本消化器病関連学会週間
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] 肝細胞癌におけるG9aの機能解析2017
- Author(s)
  横山昌幸, 千葉哲博
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] 肝細胞癌におけるEZH1/2の治療標的分子としての有用性2017
- Author(s)
  日下部裕子, 千葉哲博
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] Patient preferences regarding treatment for hepatocellular carcinoma (HCC) in Japan: A best-worst scaling approach2017
- Author(s)
  千葉哲博
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-16K09340
[Presentation] Cancer stem cells in hepatocellular carcinoma and epigenetic therapy2016
- Author(s)
  Tetsuhiro Chiba
- Organizer
  the Asian Pacific Association for the Study of the Liver (APASL)
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区)
- Year and Date
  2016-02-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460977
[Presentation] ヒストンメチル化による肝幹細胞の分化制御機構の検討2015
- Author(s)
  千葉哲博, 岩間厚志, 横須賀收
- Organizer
  日本消化器関連学会週間
- Place of Presentation
  グランドプリンスホテル新高輪（東京都港区)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460977
[Presentation] 肝癌幹細胞治療薬ジスルフィラムの有用性の検証2013
- Author(s)
  鈴木英一郎、千葉哲博、元山天佑、小笠原定久、大岡美彦、太和田暁之、金井文彦、岩間厚志、横須賀收
- Organizer
  第55回日本消化器病学会大会
- Place of Presentation
  東京
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] Prognosis of the hepatic nodules that show hypovascular in arterial phase and hypointense in hepatobiliary phase on gadoxetic acid enhanced MRI2013
- Author(s)
  Ooka Y, Kanai F, Motoyama T, Ogasawara S, Suzuki E, Tawada A, Chiba T, Yokosuka O
- Organizer
  2013年度米国肝臓学会総会(AASLD 2013)
- Place of Presentation
  米国
- Year and Date
  2013-11-02
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 当院における非B 非C 肝細胞癌の臨床像2013
- Author(s)
  叶川直哉、小笠原定久、元山天佑、鈴木英一郎、大岡美彦、太和田暁之、千葉哲博、金井文彦、横須賀收
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 高度血小板減少を伴う進行肝細胞癌患者における化学療法導入のための部分脾動脈塞栓術および肝動脈化学塞栓術併用療法の有効性と安全性2013
- Author(s)
  大岡美彦、金井文彦、元山天佑、小笠原定久、鈴木英一郎、太和田暁之、千葉哲博、横須賀收
- Organizer
  第99回日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2013-03-21
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] バルーン下閉塞下肝動脈化学塞栓術(B-TACE)を用いたTACE 不能症例に対する肝細胞癌治療の経験2013
- Author(s)
  中村昌人、大岡美彦、小笠原定久、元山天佑、鈴木英一郎、太和田暁之、千葉哲博、吉川正治、金井文彦、横須賀收
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] Intermediate stage におけるTACE 不応症例の治療戦略2013
- Author(s)
  小笠原定久、大岡美彦、元山天佑、鈴木英一郎、太和田暁之、千葉哲博、金井文彦、横須賀收
- Organizer
  第17回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] EOB 造影MRI 肝細胞相で低信号となる乏血性肝細胞性結節の予後2013
- Author(s)
  坂本大、大岡美彦、元山天佑、小笠原定久、鈴木英一郎、太和田暁之、千葉哲博、金井文彦、横須賀收
- Organizer
  第49回日本肝臓学会総会
- Place of Presentation
  東京
- Year and Date
  2013-06-06
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 進行肝細胞癌におけるソラフェニブPD後の治療戦略2012
- Author(s)
  小笠原定久、金井文彦、大岡美彦、元山天佑、太和田暁之、千葉哲博、横須賀收
- Organizer
  第16回日本肝臓学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] アルデヒド脱水素酵素1(ALDH1)の新規肝癌バイオマーカーとしての有用性の検討2012
- Author(s)
  鈴木英一郎、千葉哲博、横須賀收
- Organizer
  第48回日本肝癌研究会
- Place of Presentation
  金沢
- Year and Date
  2012-07-20
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] EZH2 ablation is a novel therapeutic target for the eradication of tumor-initiating hepatocellular carcinoma cells2012
- Author(s)
  千葉哲博, ら
- Organizer
  2012年度アジア太平洋肝臓学会議総会(APASL2012)
- Place of Presentation
  台北
- Year and Date
  2012-02-17
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] EZH2 ablation is a novel therapeutic target for the eradication of tumor-initiating hepatocellular carcinoma cells2012
- Author(s)
  Chiba T, Suzuki E, Motoyama T, Ogasawara S, Ooka Y, Tawada A, Kanai F, Iwama A, Yokosuka O
- Organizer
  2012年度アジア太平洋肝臓学会議総会(APASL 2012)
- Place of Presentation
  台湾
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 幹細胞マーカーアルデヒド脱水素酵素1(ALDH1)の肝癌における解析2012
- Author(s)
  鈴木英一郎、千葉哲博、横須賀收
- Organizer
  第54回日本消化器病学会大会
- Place of Presentation
  神戸
- Year and Date
  2012-10-10
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 肝癌幹細胞に対するエピジェネティック治療の可能性2011
- Author(s)
  千葉哲博, ら
- Organizer
  2011年度日本消化器関連学会週間(JDDW2011)
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 肝癌幹細胞に対するエピジェネティック治療の可能性2011
- Author(s)
  千葉哲博、岩間厚志、横須賀收
- Organizer
  第53回日本消化器病学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] Regulation of liver cancer stem cells by polycomb group proteins2011
- Author(s)
  千葉哲博
- Organizer
  The 3rd JCA-AACR Special Joint Conference
- Place of Presentation
  千葉
- Year and Date
  2011-03-03
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] Regulation of liver cancer stem cells by polycomb group proteins.2011
- Author(s)
  千葉哲博、岩間厚志、横須賀収
- Organizer
  第3回JCA-AACR Special Joint Conference
- Place of Presentation
  千葉県
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] ポリコーム群タンパクによる肝幹細胞の制御機構2010
- Author(s)
  千葉哲博、青木竜太郎、横須賀収
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟県
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] ポリコーム群タンパクによる肝幹細胞の制御機構2010
- Author(s)
  千葉哲博
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] 肝臓における癌幹細胞システムの制御機構2009
- Author(s)
  千葉哲博
- Organizer
  第27回日本ヒト細胞学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] Regulatory machinery of Bmil in both normal and cancer stem cells in liver2009
- Author(s)
  千葉哲博
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] Regulatory machinery of Bmil in both normal and cancer stem cells in liver2009
- Author(s)
  千葉哲博、青木竜太郎、横須賀収、岩間厚志
- Organizer
  第68回日本癌学会総会
- Place of Presentation
  神奈川県
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] 肝臓における正常幹細胞および癌幹細胞システムの制御機構2009
- Author(s)
  千葉哲博、岩間厚志
- Organizer
  第17回日本消化器病学会関連週間
- Place of Presentation
  京都府
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] 肝臓における正常幹細胞および癌幹細胞システムの制御機構2009
- Author(s)
  千葉哲博
- Organizer
  第51回日本消化器病学会大会
- Place of Presentation
  京都
- Year and Date
  2009-10-15
- Data Source
  KAKENHI-PROJECT-21790649
[Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system2008
- Author(s)
  千葉哲博
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] 肝臓における癌幹細胞システムの成立・維持メカニズム2008
- Author(s)
  千葉哲博、横須賀收、岩間厚志
- Organizer
  第16回日本消化器病学会関連週間
- Place of Presentation
  東京都
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] 肝臓における癌幹細胞システムの成立・維持メカニズム2008
- Author(s)
  千葉哲博
- Organizer
  第16回日本消化器病学会関連週間
- Place of Presentation
  グランドプリンスホテル高輪
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] Molecular machinery in the establishment and maintenance of liver cancer stem cell system.2008
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  愛知県
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] Investigation of cancer stem cell system in hepatocellular carcinoma.2007
- Author(s)
  Chiba T, Miyagi S, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
- Organizer
  17th APASL conference
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] ポリコーム遺伝子産物Bmi1は肝癌細胞の腫瘍形成能維持に必須である2007
- Author(s)
  千葉哲博
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] The polycomb gene product BMI1 is required for the tumor-initiating capacity of hepatocellular carcinoma cells.2007
- Author(s)
  千葉哲博、宮城聡、横須賀收、岩間厚志
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  神奈川県
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790468
[Presentation] 肝癌幹細胞治療薬としてのジスルフィラムの有用性の検証
- Author(s)
  鈴木英一郎、千葉哲博、金井文彦、斉藤朋子、叶川直哉、元山天佑、小笠原定久、大岡美彦、太和田暁之、岩間厚志、横須賀收
- Organizer
  第55回日本消化器病学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 肝癌幹細胞に対する糖尿病治療薬メトホルミンの作用機序の検討
- Author(s)
  斉藤朋子、千葉哲博、叶川直哉、元山天佑、小笠原定久、鈴木英一郎、大岡美彦、太和田暁之、岩間厚志、横須賀收
- Organizer
  第50回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23689039
[Presentation] 1 型アルデヒド脱水素酵素（ALDH1）の新規肝癌バイオマーカーとしての有用性の検討
- Author(s)
  鈴木英一郎、千葉哲博、金井文彦、元山天佑、小笠原定久、大岡美彦、太和田暁之、岩間厚志、横須賀收
- Organizer
  第48回日本肝癌研究会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-23689039
[]

1. IWAMA Atsushi (70244126)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
2. YOKOSUKA Osamu (90182691)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. MIYAGI Satoru (20400997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. Matsumura Tomoaki (00514530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 谷口英樹 (70292555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 金山健剛 (20835102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
7. 徳長鎮 (30866992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 沖元謙一郎 (30770739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤江舞 (90899337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 野村行弘 (60436491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KATO NAOYA

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. NAKASEKO Chiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. SAKAIDA Emiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. INAGAKI Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. NAKAMURA Hiroyukii

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. TADA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. CARRERAS Joaquim

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. SAKAO Seiichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. KATSUSHI Kurosu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 大塚将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 中内啓光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 三村尚也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 三方林太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 弘津陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 太和田暁之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 荒井潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 田辺信宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 巽浩一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Chiba Tetsuhiro 千葉 哲博

CHIBA Tetsuhiro 千葉 哲博

Research Projects

Research Products

Co-Researchers

Development of an endoscopic diagnosis system for colorectal cancer using artificial intelligence

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Investigation of tumor immune escape mechanisms in liver cancer using allograft mouse modelPrincipal Investigator

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Importance of loss-of-function of ARID family proteins in liver cancerPrincipal Investigator

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The regulatory machinery of histone methyltransferases ESET in normal liver and liver cancerPrincipal Investigator

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Epigenetic regulation of liver cancer stem cells and establishment of a novel therapeutic approachPrincipal Investigator

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Investigation of novel target genes regulated by polycomb group genes in hepatocellular carcinomaPrincipal Investigator

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Investigation of cancer stem cell system in hepatocellular carcinomaPrincipal Investigator

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白血病幹細胞の自己複製の分子基盤の解明

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ポリコーム遺伝子Bmi-1によるエピジェネティクス制御

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Epigenetic regulation of hematopoietic stem cell self renewal

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ヒト肝臓癌からの癌幹細胞の分離と特性解析Principal Investigator

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[Journal Article] Alteration of the tumor microenvironment by pharmacological inhibition of EZH2 in hepatocellular carcinoma.2023

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[Journal Article] Miglustat, a glucosylceramide synthase inhibitor, mitigates liver fibrosis through TGF-β/Smad pathway suppression in hepatic stellate cells2023

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DOI

Chiba Tetsuhiro 千葉哲博

CHIBA Tetsuhiro 千葉哲博