Oshima Tadayuki 大島忠之

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OSHIMA Tadayuki 大島忠之

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Researcher Number	00381814
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 研究員
Affiliation (based on the past Project Information) *help	2023: 名古屋市立大学, 医薬学総合研究院(医学), 研究員 2016 – 2022: 兵庫医科大学, 医学部, 准教授 2007 – 2015: Hyogo College of Medicine, 医学部, 講師 2006: 兵庫医科大学, 医学部, 助手 2005: 名古屋市立大学, 大学院医学研究科, 研究員
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Gastroenterology
Keywords	Principal Investigator タイト結合 / クローディン / 細胞間接着装置 / 機能性消化管疾患 / 機能性消化管障害 / 刷子細胞 / 粘膜バリア / 好酸球性消化管疾患 / クロディン / IL-33 … More / 非びらん性胃食道逆流症 / 機能性ディスペプシア / 胃癌 / 上部消化管学(食道,胃,十二指腸) / 逆流性食道炎 / 生体分子 / 遺伝子 / シグナル伝達 / 内科 / クローディング / MAPKホスファターゼ / 炎症性腸疾患 … More Except Principal Investigator 臨床 / 再生医学 / 遺伝子 / 免疫学 / 感染症 / 上部消化管学（食道、胃、十二指腸） / 非心臓性胸痛 / 機能性ディスペプシア / 内臓知覚過敏 / 過敏性腸症候群 / ホスホジエステラーゼ / 機能性消化管障害 / 電気刺激 / NERD / 非びらん性胃食道逆流症(NERD) / 食道知覚閾値 / CRH / 癌 / 感染 / サブスタンスP / ニューロキニン / 逆流性食道炎 / 上部消化管学(食道,胃,十二指腸) Less

Functional analysis and therapeutidc application targeting mucosal barrier and intestinal tuft cells in functional gastrointestinal disordersPrincipal Investigator
- Principal Investigator
  
  大島忠之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
  Hyogo Medical University
Development of new therapy for eosinophilic gastrointestinal diseases targeting the regulation of mucosal barrierPrincipal Investigator
- Principal Investigator
  
  Oshima Tadayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hyogo Medical University
Role of Reg protein on the mucosal barrier function in the inflammatory gastrointestinal diseases
- Principal Investigator
  
  Fukui Hirokazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
The development and application of in vivo evaluation of mucosal barrier function in functional gastrointestinal disordersPrincipal Investigator
- Principal Investigator
  
  OSHIMA Tadayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
A Factual Survey of Non-Cardiac Chest Pain (NCCP) in Japan
- Principal Investigator
  
  MIWA Hiroto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Phosphodiesterase 2A mediate visceral hypersensitivity in a rodent model of functional dyspepsia
- Principal Investigator
  
  Takashi Kondo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Role of Reg protein on the maintenance of mucosal homeostasis in the gastrointestinal tract
- Principal Investigator
  
  Fukui Hirokazu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Duodenal epithelial intercellular junction and IL-33 on the development of dyspepsiaPrincipal Investigator
- Principal Investigator
  
  OSHIMA TADAYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Effect of intra-venous corticotropin releasing hormone (CRH) on esophageal physiological changes in NERD patients.
- Principal Investigator
  
  Miwa Hiroto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Protective role of Reg protein on mucosal injury in the gastrointestinal tract
- Principal Investigator
  
  FUKUI Hirokazu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Functional analysis of tight junction protein: claudins on the development and progression of gastric cancerPrincipal Investigator
- Principal Investigator
  
  OSHIMA Tadayuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Mechanisms of abdominal symptom development-involvement of neural inflammation and mucosal permeability on esophageal symptoms-
- Principal Investigator
  
  MIWA Hiroto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
Esophageal mucosal defense mechanisms and a new pathophysiological classification by intercellular junctional complexPrincipal Investigator
- Principal Investigator
  
  OSHIMA Tadayuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo College of Medicine
MAPKホスファターゼによるタイト結合蛋白発現制御と炎症性腸疾患に対する効果Principal Investigator
- Principal Investigator
  
  大島忠之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Hyogo Medical University
  Nagoya City University

[Book] Functional dyspepsia2019
- Author(s)
  Oshima T, Miwa H
- Total Pages
  187
- Publisher
  Springer Nature
- ISBN
  9789811310737
- Data Source
  KAKENHI-PROJECT-16K09297
[Book] Role of acid in functional dyspepsia．2015
- Author(s)
  Tomita T，Oshima T, Fukui H, Watari J, Miwa H
- Total Pages
  7
- Publisher
  Nihon Rinsho
- Data Source
  KAKENHI-PROJECT-25460940
[Book] 医学と医療の最前線　機能性ディスペプシアの最近の話題．2015
- Author(s)
  大島忠之，三輪洋人
- Total Pages
  8
- Publisher
  日本内科学会
- Data Source
  KAKENHI-PROJECT-25460940
[Book] The effect of antianxiety and anti-depressive agents for the acid-related gastrointestinal diseases．2015
- Author(s)
  Oshima T，Miwa H
- Total Pages
  5
- Publisher
  Nihon Rinsho
- Data Source
  KAKENHI-PROJECT-25460940
[Book] ストレスと機能性消化管障害2015
- Author(s)
  大島忠之，三輪洋人
- Total Pages
  6
- Publisher
  日本職業・災害医学会
- Data Source
  KAKENHI-PROJECT-25460940
[Book] H.pylori除菌による早期胃癌内視鏡治療後の異時性発癌の抑制効果(解説/特集)消化器内科(1884-2895)54 巻 3号Page302-308(2012.03) H.pyloriと胃癌の基礎と臨床
- Author(s)
  渡二郎,盛一健太郎,田邊裕貴,藤谷幹浩,富田寿彦,大島忠之,福井広一,堀和敏,松本譽之,三輪洋人,高後裕.
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-22590691
[Journal Article] How should we interpret the data of eosinophilic esophagitis patients from an academic institution?2023
- Author(s)
  Oshima T
- Journal Title
  
  JGH Open
  
  Volume: 7 Issue: 8 Pages: 525-526
- DOI
  10.1002/jgh3.12962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08066
[Journal Article] 機能性ディスペプシア(FD)に対するPPI治療の注意点2023
- Author(s)
  大島忠之，新﨑信一郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 112 Pages: 25-31
- Data Source
  KAKENHI-PROJECT-22K08066
[Journal Article] 【機能性消化管障害の治療戦略】上部消化管機能性消化管障害と慢性胃炎・ピロリ菌感染の関わりはあるのか？2023
- Author(s)
  大島忠之
- Journal Title
  
  カレントテラピー
  
  Volume: 41 Pages: 518-422
- Data Source
  KAKENHI-PROJECT-22K08066
[Journal Article] Non-cardiac chest pain in Japan: prevalence, impact, and consultation behavior - a population-based study2023
- Author(s)
  Chen J, Oshima T, Kondo T, Tomita T, Fukui H, Shinzaki S, Miwa H.
- Journal Title
  
  J Neurogastroenterol Motil.
  
  Volume: 29 Issue: 4 Pages: 446-454
- DOI
  10.5056/jnm22184
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066, KAKENHI-PROJECT-21K08016
[Journal Article] Biologic Therapies Targeting Eosinophilic Gastrointestinal Diseases2023
- Author(s)
  Oshima T
- Journal Title
  
  Intern Med.
  
  Volume: 62 Pages: 3429-3430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08066
[Journal Article] Lubiprostone induces claudin-1 and protects intestinal barrier function2020
- Author(s)
  Nishii N, Oshima T, Li M, Eda H, Nakamura K, Tamura A, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Tomita T, Fukui H, Miwa H.
- Journal Title
  
  Pharmacology
  
  Volume: 105 Issue: 1-2 Pages: 102-108
- DOI
  10.1159/000503054
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Phosphorylated STAT3 expression linked to SOCS3 methylation is associated with proliferative ability of gastric mucosa in patients with early gastric cancer2020
- Author(s)
  Fukui H, Watari J, Zhang X, Ran Y, Tomita T, Oshima T, Hirota S, Miwa H.
- Journal Title
  
  Oncol Lett
  
  Volume: 19 Pages: 3542-3550
- DOI
  10.3892/ol.2020.11462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] DNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use2019
- Author(s)
  Watari J, Ito C, Shimoda T, Tomita T, Oshima T, Fukui H, Das KM, Miwa H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 12559-12559
- DOI
  10.1038/s41598-019-49069-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] The Link Between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues2019
- Author(s)
  Xin Xu , Hirokazu Fukui , Ying Ran , Xuan Wang , Yoshihito Inoue , Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita , Tadayuki Oshima , Jiro Watari , Hiroshi Kiyama , Hiroto Miwa
- Journal Title
  
  Mediators　Inflamm
  
  Volume: 6 Pages: 7859460-7859460
- DOI
  10.1155/2019/7859460
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07986, KAKENHI-PROJECT-17K09363
[Journal Article] Colonic M1 macrophage is associated with the prolongation of gastrointestinal motility and obesity in mice treated with vancomycin2019
- Author(s)
  Inoue Y, Fukui H, Xu X, Ran Y, Tomita T, Oshima T, Watari J, Miwa H.
- Journal Title
  
  Mol Med Rep
  
  Volume: 19 Pages: 2591-2598
- DOI
  10.3892/mmr.2019.9920
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Chenodeoxycholic acid releases proinflammatory cytokines from small intestinal epithelial cells through the farnesoid X receptor2019
- Author(s)
  Horikawa T, Oshima T, Li M, Kitayama Y, Eda H, Nakamura K, Tamura A, Ogawa T, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Tomita T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Digestion
  
  Volume: 100 Issue: 4 Pages: 286-294
- DOI
  10.1159/000496687
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Alteration of GLP-1/GPR43 expression and gastrointestinal motility in dysbiotic mice treated with vancomycin.2019
- Author(s)
  Xu X, Fukui H, Ran Y, Tomita T, Oshima T, Watari J, Miwa H.
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 4381-4381
- DOI
  10.1038/s41598-019-40978-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363, KAKENHI-PROJECT-18K07986
[Journal Article] A randomized double-blind placebo-controlled trial on the effect of magnesium oxide in patients with chronic constipation2019
- Author(s)
  Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 25 Issue: 4 Pages: 563-575
- DOI
  10.5056/jnm18194
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Duodenal low-grade inflammation and expression of tight junction proteins in functional dyspepsia2019
- Author(s)
  Taki M, Oshima T, Li M, Sei H, Tozawa K, Tomita T, Fukui H, Watari J, Miwa H
- Journal Title
  
  Neurogastroenterology & motility
  
  Volume: Epub ahead Issue: 10
- DOI
  10.1111/nmo.13576
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297, KAKENHI-PROJECT-17K09363
[Journal Article] Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center2019
- Author(s)
  Miwa H, Oshima T, Tomita T, Fukui H, Kondo T, Yamasaki T, Watari J
- Journal Title
  
  Journal of gastroenterology
  
  Volume: 54 Issue: 4 Pages: 305-311
- DOI
  10.1007/s00535-019-01550-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09297
[Journal Article] Functional Dyspepsia - A Revolution in Management2018
- Author(s)
  Oshima T, Miwa H
- Journal Title
  
  American journal of gastroenterology
  
  Volume: 113 Issue: 10 Pages: 1420-1422
- DOI
  10.1038/s41395-018-0264-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09297
[Journal Article] Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population2018
- Author(s)
  Nakai K, Watari J, Tozawa K, Tamura A, Hara K, Yamasaki T, Kondo T, Kono T, Tomita T, Ohda Y, Oshima T, Fukui H, Sakurai J, Kim Y, Hayakawa Y, Fujisawa T, Morimoto T, Miwa H.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 63 Issue: 2 Pages: 154-163
- DOI
  10.3164/jcbn.18-11
- NAID
  130007479962
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Filaggrin and tight junction proteins are crucial for IL-13-mediated esophageal barrier dysfunction2018
- Author(s)
  Wu L, Oshima T, Li M, Tomita T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 315 Issue: 3 Pages: G341-G350
- DOI
  10.1152/ajpgi.00404.2017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363, KAKENHI-PROJECT-16K09297
[Journal Article] Effect of probiotic Bifidobacterium bifidum G9-1 on the relationship between gut microbiota profile and stress sensitivity in maternally separated rats2018
- Author(s)
  Fukui H, Oshima T, Tanaka Y, Oikawa Y, Makizaki Y, Ohno H, Tomita T, Watari J, Miwa H.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 12384-12384
- DOI
  10.1038/s41598-018-30943-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Long-term effects of H. pylori eradication on epigenetic alterations related to gastric carcinogenesis2018
- Author(s)
  Michigami Y, Watari J, Ito C, Nakai K, Yamasaki T, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Fukui H, Morimoto T, Das KM, Miwa H.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 14369-14369
- DOI
  10.1038/s41598-018-32717-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS-induced colitis2018
- Author(s)
  Kodani M, Fukui H, Tomita T, Oshima T, Watari J, Miwa H.
- Journal Title
  
  Mol Med Rep
  
  Volume: 17 Pages: 8167-8172
- DOI
  10.3892/mmr.2018.8926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09363, KAKENHI-PROJECT-18K07986
[Journal Article] Magnitude and direction of the association between Clostridium difficile infection and proton pump inhibitors in adults and pediatric patients: a systematic review and meta-analysis.2018
- Author(s)
  Oshima T, Wu L, Li M, Fukui H, Watari J, Miwa H.
- Journal Title
  
  J Gastroenterol
  
  Volume: 53 Issue: 1 Pages: 84-94
- DOI
  10.1007/s00535-017-1369-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Adenosine triphosphate induces P2Y2 activation and IL-8 release in human esophageal epithelial cells2017
- Author(s)
  Wu L, Oshima T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 32 Issue: 7 Pages: 1341-1347
- DOI
  10.1111/jgh.13672
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] The Role of Esophageal Hypersensitivity in Functional Heartburn.2017
- Author(s)
  Hiroto Miwa, Takashi Kondo, Tadayuki Oshima
- Journal Title
  
  Curr Opin Gastroenterol.
  
  Volume: 51 Issue: 7 Pages: 571-578
- DOI
  10.1097/mcg.0000000000000885
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09298, KAKENHI-PROJECT-15K08961
[Journal Article] Involvement of gut microbiota in the association between gastrointestinal motility and 5-HT expression/M2 macrophage behavior in the gastrointestinal tract2017
- Author(s)
  Yang M, Fukui H, Eda H, Kitayama Y, Hara K, Kodani M, Tomita T, Oshima T, Watari J, Miwa H
- Journal Title
  
  Mol Med Rep
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Effect of long-term aspirin use on molecular alterations in precancerous gastric mucosa in patients with and without gastric cancer2017
- Author(s)
  Michigami Y, Watari J, Ito C, Hara K, Yamasaki T, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Fukui H, Morimoto T, Das KM, Miwa H.
- Journal Title
  
  Sci Rep
  
  Volume: 7 Issue: 1 Pages: 13384-13384
- DOI
  10.1038/s41598-017-13842-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Acotiamide improves stress-induced gastric accommodation2017
- Author(s)
  Ikeo K, Oshima T, Sei H, Kondo T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 29 Issue: 4
- DOI
  10.1111/nmo.12991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Effect of vonoprazan, a potassium-competitive acid blocker, on the 13C-urea breath test in Helicobacter pylori-positive patients2017
- Author(s)
  Takimoto M, Tomita T, Yamasaki T, Fukui S, Taki M, Okugawa T, Kondo T, Kono T, Tozawa K, Arai E, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Dig Dis Sci
  
  Volume: 62 Issue: 3 Pages: 739-745
- DOI
  10.1007/s10620-016-4439-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Intravenous corticotropin-releasing hormone administration increases esophageal electrical sensitivity in healthy individuals2017
- Author(s)
  Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 23 Issue: 4 Pages: 526-532
- DOI
  10.5056/jnm17067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial.2017
- Author(s)
  Kondo T, Sei H, Yamasaki T, Tomita T, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  J Gastroenterol
  
  Volume: 52 Issue: 10 Pages: 1081-1089
- DOI
  10.1007/s00535-017-1308-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] A double-blind placebo controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia2017
- Author(s)
  Nakamura K, Tomita T, Oshima T, Asano H, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Fukui H, Kazuhito F, Hirota S, Watari J, Miwa H.
- Journal Title
  
  J Gastroenterol
  
  Volume: 52 Issue: 5 Pages: 602-610
- DOI
  10.1007/s00535-016-1260-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Involvement of gut microbiota in the association between GLP-1/GLP-1 receptor expression and gastrointestinal motility2017
- Author(s)
  Yang M, Fukui H, Eda H, Xu X, Kitayama Y, Hara K, Kodani M, Tomita T, Oshima T, Watari J, Miwa H
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 312 Issue: 4 Pages: G367-G373
- DOI
  10.1152/ajpgi.00232.2016
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953, KAKENHI-PROJECT-17K09363
[Journal Article] Prevalence of gastric motility disorders in patients with functional dyspepsia2017
- Author(s)
  Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Fukushima K, Hirota S, Watari J, Miwa H.
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 23 Issue: 3 Pages: 392-399
- DOI
  10.5056/jnm16173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Effect of Helicobacter pylori infection on the link between GLP-1 expression and motility of the gastrointestinal tract2017
- Author(s)
  Eda H, Fukui H, Uchiyama R, Kitayama Y, Hara K, Yang M, Kodani M, Tomita T, Oshima T, Watari J, Tsutsui H, Miwa H
- Journal Title
  
  PLOS One
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Genetic instability, CpG island methylator phenotype and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum2017
- Author(s)
  Nando Y, Watari J, Hara K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Tomita T, Ohda Y, Oshima T, Fukui H, Matsubara N, Tomita N, Hirota S, Miwa H.
- Journal Title
  
  Hum Pathol
  
  Volume: 60 Pages: 37-45
- DOI
  10.1016/j.humpath.2016.09.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Involvement of gut microbiota in the association between gastrointestinal motility and 5-HT expression/M2 macrophage behavior in the gastrointestinal tract2017
- Author(s)
  Yang M, Fukui H, Eda H, Kitayama Y, Hara K, Kodani M, Tomita T, Oshima T, Watari J, Miwa H.
- Journal Title
  
  Mol Med Rep
  
  Volume: 16 Issue: 3 Pages: 3482-3488
- DOI
  10.3892/mmr.2017.6955
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Claudin-2 expression is upregulated in the ileum of diarrhea predominant irritable bowel syndrome patients2017
- Author(s)
  Ishimoto H, Oshima T, Sei H, Yamasaki T, Kondo T, Tozawa K, Tomita T, Ohda Y, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Journal of Clinical Biochemistry and Nutrition
  
  Volume: 60 Issue: 2 Pages: 146-150
- DOI
  10.3164/jcbn.16-92
- NAID
  130005398540
- ISSN
  0912-0009, 1880-5086
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Effect of Helicobacter pylori infection on the link between GLP-1 expression and motility of the gastrointestinal tract2017
- Author(s)
  Eda H, Fukui H, Uchiyama R, Kitayama Y, Hara K, Yang M, Kodani M, Tomita T, Oshima T, Watari J, Tsutsui H, Miwa H.
- Journal Title
  
  PLOS One
  
  Volume: 12 Issue: 5 Pages: e0177232-e0177232
- DOI
  10.1371/journal.pone.0177232
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Journal Article] Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn2016
- Author(s)
  Hiroo Sei, Tadayuki Oshima, Jing Shan, Liping Wu, Takahisa Yamasaki, Takuya Okugawa, Takashi Kondo, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 4 Pages: e0154234-e0154234
- DOI
  10.1371/journal.pone.0154234
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460939
[Journal Article] Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model2016
- Author(s)
  Liping Wu, Tadayuki Oshima, Toshihiko Tomita, Yoshio Ohda, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 未
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460939
[Journal Article] Role of regenerating gene I in claudin expression and barrier function in the small intestine2016
- Author(s)
  Kitayama Y, Fukui H, Hara K, Eda H, Kodani M, Yang M, Sun C, Yamagishi H, Tomita T, Oshima T, Watari J, Takasawa S, Miwa H.
- Journal Title
  
  Transl Res
  
  Volume: 173 Pages: 92-100
- DOI
  10.1016/j.trsl.2016.03.007
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Interferon gamma-induced nuclear interleukin-33 potentiates the release of esophageal epithelial derived cytokines2015
- Author(s)
  Jing Shan, Tadayuki Oshima, Liping Wu, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e0151701-e0151701
- DOI
  10.1371/journal.pone.0151701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460939
[Journal Article] Evidence-based clinical practice guidelines for functional dyspepsia.2015
- Author(s)
  Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, Suzuki H, Tominaga K, Nakada K, Nagahara A, Futagami S, Manabe N, Inui A, Haruma K, Higuchi K, Yakabi K, Hongo M, Uemura N, Kinoshita Y, Sugano K, Shimosegawa T
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 2 Pages: 125-39
- DOI
  10.1007/s00535-014-1022-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460940, KAKENHI-PROJECT-26670065, KAKENHI-PROJECT-25293178
[Journal Article] Epidemiology of functional gastrointestinal disorders in japan and in the world.2015
- Author(s)
  Oshima T, Miwa H
- Journal Title
  
  J Neurogastroenterol Motil
  
  Volume: 21 Issue: 3 Pages: 320-9
- DOI
  10.5056/jnm14165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460940
[Journal Article] FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells2015
- Author(s)
  Sun C, Fukui H, Hara K, Zhang X, Kitayama Y, Eda H, Tomita T, Oshima T, Kikuchi S, Watari J, Sasako M, Miwa H
- Journal Title
  
  BMC Cancer
  
  Volume: 15 Issue: 1 Pages: 333-333
- DOI
  10.1186/s12885-015-1353-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Effect of Effect of REG Ia protein on angiogenesis in gastric cancer tissuesREG I protein on angiogenesis in gastric cancer tissues2015
- Author(s)
  Hara K, Fukui H, Sun C, Kitayama Y, Eda H, Yamasaki T, Kondo T, Tomita T, Oshima T, Watari J, Fujimori T, Miwa H
- Journal Title
  
  Oncol Rep
  
  Volume: 33 Issue: 5 Pages: 2183-2189
- DOI
  10.3892/or.2015.3878
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Atypical symptoms and health-related quality of life of patients with asymptomatic reflux esophagitis.2015
- Author(s)
  Tomita T, Yasuda T, Oka H, Terao S, Arai E, Oshima T, Fukui H, Hori K, Watari J, Miwa H
- Journal Title
  
  J Gastroenterol Hepatorol
  
  Volume: 30 Issue: S1 Pages: 19-24
- DOI
  10.1111/jgh.12745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460940
[Journal Article] Childhood abuse history is associated with the development of dyspepsia: a population-based survey in Japan.2015
- Author(s)
  Oshima T, Fukui H, Watari J, Miwa H
- Journal Title
  
  J Gastroenterol
  
  Volume: 50 Issue: 7 Pages: 744-50
- DOI
  10.1007/s00535-014-1014-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460940
[Journal Article] Expression of Reg family genes in the gastrointestinal tract of mice treated with indomethacin2015
- Author(s)
  Sun C, Fukui H, Hara K, Kitayama Y, Eda H, Yang M, Yamagishi H, Tomita T, Oshima T, Watari J, Takasawa S, Chiba T, Miwa H
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 308 Issue: 9 Pages: G736-G744
- DOI
  10.1152/ajpgi.00362.2014
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] Epithelial-derived nuclear IL-33 aggravates inflammation in the pathogenesis of reflux esophagitis.2015
- Author(s)
  Shan J, Oshima T, Muto T, Yasuda K, Fukui H, Watari J, Nakanishi K, Miwa H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 40 Issue: 4 Pages: 414-423
- DOI
  10.1007/s00535-014-0988-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460521, KAKENHI-PROJECT-25460939
[Journal Article] Effect of rikkunshito on the expression of substance P and CGRP in dorsal root ganglion neurons and voluntary movement in rats with experimental reflux esophagitis.2014
- Author(s)
  Kondo T, Oshima T, Koseki J, Hattori T, Kase Y, Tomita T, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Neurogastroenterol Motility
  
  Volume: 26 Issue: 7 Pages: 913-921
- DOI
  10.1111/nmo.12342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460940
[Journal Article] IL-4 induces columnar like differentiation of esophageal squamous epithelium through JAK/PI3K pathway: possible role in pathogenesis of Barrett's esophagus.2014
- Author(s)
  Shan J, Oshima T, Farre R, Fukui H, Watari J, Miwa H.
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] IL-22 produced by cancer-associated fibroblasts promotes gastric cancer cell invasion via STAT3 and ERK signaling.2014
- Author(s)
  Fukui H, Zhang X, Sun C, Hara K, Kikuchi S, Yamasaki T, Kondo T, Tomita T, Oshima T, Watari J, Imura J, Fujimori T, Sasako M, Miwa H
- Journal Title
  
  Br J Cancer
  
  Volume: 111 Issue: 4 Pages: 183-490
- DOI
  10.1038/bjc.2014.336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460413, KAKENHI-PROJECT-25460466, KAKENHI-PROJECT-26460953
[Journal Article] A Randomized, double-blind, placebo-controlled study of rebamipide for gastric mucosal injury taking aspirin with or without clopidogrel.2014
- Author(s)
  Tozawa K, Oshima T, Okugawa T, Ogawa T, Ohda Y, Tomita T, Hida N, Fukui H, Hori K, Watari J, Nakamura S, Miwa H.
- Journal Title
  
  Dig Dis Sci
  
  Volume: 59 Pages: 1885-1890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460953
[Journal Article] REG Iα is a biomarker for predicting response to chemotherapy S-1 plus cisplatin in patients with unresectab le stage IV gastric cancer.2013
- Author(s)
  Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H.
- Journal Title
  
  Br J Cancer.
  
  Volume: 108(2) Issue: 2 Pages: 395-401
- DOI
  10.1038/bjc.2012.572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22590691, KAKENHI-PROJECT-23590929, KAKENHI-PROJECT-24229005
[Journal Article] Acidic deoxycholic acid and chenodeoxycholic acid induce IL-8 production through p38 MAPK and PKA in a squamous epithelial model2013
- Author(s)
  Shan J, Oshima T, Fukui H, Watari J, Miwa
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 28 Pages: 823-828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer at the invasive front2013
- Author(s)
  Oshima T, Shan J, Okugawa T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Miwa H
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] REG Iαis a biomarker for predicting response to chemotherapy with S-1 puls cisplatin in patients with unresectable stage IV gastric cancer2013
- Author(s)
  Sekikawa A, Fukui H, Zhang X, Maruo T, Tsumura T, Okabe Y, Wakasa T, Osaki Y, Chiba T, Tomita T, Oshima T, Watari J, Miwa H
- Journal Title
  
  Br J Cancer
  
  Volume: 108 Pages: 395-401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers2012
- Author(s)
  Okugawa T, Oshima T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Miwa H
- Journal Title
  
  Dig Dis Sci
  
  Volume: 57 Pages: 1562-1567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins2012
- Author(s)
  Chen X, Oshima T, Shan J, Fukui H, Watari J, Miwa H
- Journal Title
  
  Am J Physiol
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Acid modulates the squamous epithelial barrier function by modulating the localization of claudins in the superficial layers2012
- Author(s)
  Oshima T, Miwa H, et al(5名5番目)
- Journal Title
  
  Lab Invest
  
  Volume: 92 Issue: 1 Pages: 22-31
- DOI
  10.1038/labinvest.2011.139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Trypsin impaired epithelial barrier function and induced IL-8 secretion through basolateral PAR-2: a lesson from a stratified squamous epithelial model2012
- Author(s)
  Shan J, Oshima T, Chen X, Fukui H, Watari J, Miwa H
- Journal Title
  
  Am J Physiol
  
  Volume: 303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers.2012
- Author(s)
  Okugawa T, Oshima T, Chen X, Hori K, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H
- Journal Title
  
  Dig Dis Sci.
  
  Volume: 57(6) Issue: 6 Pages: 1562-7
- DOI
  10.1007/s10620-012-2043-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590691
[Journal Article] Biomarkers predicting development of metachronous gastric cancer after endoscopic resection: An analysis of molecular pathology of Helicobacter pylori eradication.2012
- Author(s)
  Watari J, Moriichi K, Tanabe H, Kashima S, Nomura Y, Fujiya M, Tomita T, Oshima T, Fukui H, Miwa H, Das KM, Kohgo Y.
- Journal Title
  
  Int J Cancer.
  
  Volume: 15;130(10) Issue: 10 Pages: 2349-58
- DOI
  10.1002/ijc.26275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590691, KAKENHI-PROJECT-22590692
[Journal Article] Acidic bile salts modulate the squamous epithelial barrier function bymodulating tight junction proteins2011
- Author(s)
  Chen X, Oshima T, Miwa H, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 301 Issue: 2 Pages: 203-9
- DOI
  10.1152/ajpgi.00096.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Current understanding of pathogenesis of functional dyspepsia2011
- Author(s)
  Miwa H, Oshima T, Sakurai J, et al
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: Suppl3 Issue: s3 Pages: 53-60
- DOI
  10.1111/j.1440-1746.2011.06633.x
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Establishment of esophageal like non-keratinized stratified epithelium using normal human bronchial epithelial cells2011
- Author(s)
  Oshima T, Miwa H, et al
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins2011
- Author(s)
  Chen X, Oshima T, Miwa H, et al
- Journal Title
  
  Am J Physiol Gastrointest Liver Physiol
  
  Volume: 301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Outcomes of Treatment of Argon Plasma Coagulation Therapy in Elderly or High-risk Patients With Early Gastric Cancer: A Comparison of Outcomes Among Experienced and Nonexperienced Endoscopists.2011
- Author(s)
  Tomita T, Arai E, Kohno T, Kondo T, Kim Y, Oshima T, Hori K, Watari J, Matsumoto T, Miwa H.
- Journal Title
  
  J Clin Gastroenterol.
  
  Volume: 45(6) Issue: 6 Pages: 54-9
- DOI
  10.1097/mcg.0b013e3181ef3612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590691
[Journal Article] Acidic bile salts modulate the squamous epithelial barrier function by modulating tight junction proteins2011
- Author(s)
  Chen X, Oshima T, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H
- Journal Title
  
  Am J Physiol
  
  Volume: 301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590929
[Journal Article] Establishment of esophageal like non-keratinized stratified epithelium using normal human bronchial epithelial cells.2011
- Author(s)
  Oshima T, Miwa H, et al.
- Journal Title
  
  Am J Physiol Cell Physiol.
  
  Volume: (Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Multiple gastric polypoid lesions with protein-losing enteropathy.2011
- Author(s)
  Sakurai J, Watari J, Oshima T, Miwa H.
- Journal Title
  
  Intern Med. 査読有
  
  Volume: 50(14) Pages: 1497-8
- NAID
  130000969429
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/21757837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590691
[Journal Article] Establishment of esophageal like non-keratinized stratified epithelium using normal human bronchial epithelial cells2011
- Author(s)
  Oshima T, Miwa H, et al(8名, 7番目)
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 300 Issue: 6 Pages: 1422-1429
- DOI
  10.1152/ajpcell.00376.2010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model.2010
- Author(s)
  Oshima T, Koseki J, Sakurai J, Watari J, Matsumoto T, Miwa H
- Journal Title
  
  Neurogastroenterol Motil. 22
  
  Pages: 579-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa.2010
- Author(s)
  Miwa H, Koseki J, Oshima T, Kondo T, Tomita T, Watari J, Matsumoto T, Hattori T, Kubota K, Iizuka S
- Journal Title
  
  J Gastroenterol. 45
  
  Pages: 478-487
- NAID
  10027215919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model2010
- Author(s)
  Oshima T, Koseki J, Sakurai J, Watari J, Matsumoto T, Miwa H
- Journal Title
  
  Neurogastroenterol Motil
  
  Volume: 22 Pages: 579-584
- DOI
  10.1111/j.1365-2982.2009.01450.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Rikkunshito a traditional Japanese medicine, may relieve abdominal symptoms in rats withexperimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa2010
- Author(s)
  Miwa H, Koseki J, Oshima T, Kondo T, Tomita T, Watari J, Matsumoto T, Hattori T, Kubota K, Iizuka S
- Journal Title
  
  J Gastroenterol
  
  Volume: 45 Issue: 5 Pages: 478-487
- DOI
  10.1007/s00535-009-0180-1
- NAID
  10027215919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590799
[Journal Article] Experimental oesophagitis in the rat is associated with decreased voluntary movement2009
- Author(s)
  Miwa H, Oshima T, Sakurai J, Tomita T, Matsumoto T, Iizuka S, Koseki J.
- Journal Title
  
  Neurogastroenterol Motil 21
  
  Pages: 296-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] 非びらん性胃食道逆流症(NERD)の病態と治療2009
- Author(s)
  大島忠之,三輪洋人
- Journal Title
  
  日本消化器病学会雑誌 106巻3号
  
  Pages: 327-334
- NAID
  130000444570
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Gastro-esophageal reflux disease: the recent trend in Japan2008
- Author(s)
  Miwa H, Oshima T, Tomita T, Kim Y, Hori K, Matsumoto T
- Journal Title
  
  Clin J Gastroenterol 1
  
  Pages: 133-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Changes in the expression of claudins in active ulcerative colitis2008
- Author(s)
  Oshima T, Miwa H, Joh T.
- Journal Title
  
  J Gastroenterol Hepatol 23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Oxidative stress induces gastric epithelial permeability through claudin-32008
- Author(s)
  Hashimoto K, Oshima T, Tomita T, Kim Y, Matsumoto T, Joh T, Miwa H
- Journal Title
  
  Biochem Biophys Res Commun 376
  
  Pages: 154-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Interobserver agreement in endoscopic evaluation of reflux esophagitis using a modified Los Angeles classification incorporating grades N and M: a validation study in a cohort of Japanese endoscopists2008
- Author(s)
  Miwa H, Yokoyama T, Hori K, Sakagami T, Oshima T, Tomita T, Fujiwara Y, Saita H, Itou T, Ogawa H, Nakamura Y, Kishi K, Murayama Y, Hayashi E, Kobayashi K, Tano N, Matsushita K, Kawamoto H, Sawada Y, Ohkawa A, Arai E, Nagao K, Hamamoto N, Sugiyasu Y, Sugimoto K, Hara H, Tanimura M, Honda Y, Isozaki K, Noda S, Kubota S, Himeno S
- Journal Title
  
  Dis Esophagus 21
  
  Pages: 355-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-72008
- Author(s)
  Oshima T, Miwa H, Joh T
- Journal Title
  
  Am J Physiol Cell Physiol 295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] 【生活習慣病と消化器疾患】生活習慣からみた消化器疾患胃食道逆流症と生活習慣2007
- Author(s)
  大島忠之, 三輪洋人
- Journal Title
  
  綜合臨床 56巻11号
  
  Pages: 3029-3032
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] 【胃食道逆流症(GERD)非びらん性逆流症(NERD)を含めて】GERDの病因論2007
- Author(s)
  大島忠之, 三輪洋人
- Journal Title
  
  日本臨床 65巻5号
  
  Pages: 797-801
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] Wip1 protects hydrogen peroxide-induced colonic epithelial barrier dysfunction2007
- Author(s)
  Oshima T, Sasaki M, Kataoka H, Miwa H, Takeuchi T, Joh T
- Journal Title
  
  Cel lMol Life Sci 64
  
  Pages: 3139-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790501
[Journal Article] 【NERDの病態と治療】内臓知覚からみたNERDの病態2007
- Author(s)
  大島忠之, 三輪洋人
- Journal Title
  
  G.I.Research 15巻3号
  
  Pages: 196-201
- Data Source
  KAKENHI-PROJECT-19790501
[Presentation] Impact of the COVID pandemic on gastroenterology.2023
- Author(s)
  Tadayuki Oshima
- Organizer
  Seoul International Digestive Disease Symposium (SIDDS) 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] Pharmacological management of Functional Dyspepsia: What is New. Functional Dyspepsia and Gastroparesis.2023
- Author(s)
  Tadayuki Oshima
- Organizer
  The 7th Biennial Congress of the Asian Neurogastroenterology and Motility Association (ANMA) in conjunction with the 7th Annual Meeting of Taiwan Neurogastroenterology and Motility Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] Functional dyspepsia: Current understanding and future directions.2023
- Author(s)
  Tadayuki Oshima
- Organizer
  GUT TALKS: Unravelling the Mysteries of FGID (DGBI)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] 機能性消化管障害における十二指腸の微小炎症2023
- Author(s)
  大島忠之，三輪洋人，新﨑信一郎
- Organizer
  第106回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] Pathophysiology of Functional Dyspepsia (FD): Duodenal inflammation.2023
- Author(s)
  Tadayuki Oshima
- Organizer
  Asian Pacific Digestive Week 2023 (APDW 2023)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] Updated pathophysiology of FD and gastroparesis2022
- Author(s)
  Tadayuki Oshima
- Organizer
  Korean Quality of Life in stomach cancer patient study group (KOQUSS) 2022 spring seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] 34.機能性ディスペプシアにおける十二指腸微小炎症とタフト細胞の関連2022
- Author(s)
  大島忠之，黄欣儀，三輪洋人
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-22K08066
[Presentation] Esophageal epithelial barrier function and inflammation in eosinophilic esophagitis before and after treatment2021
- Author(s)
  Junji Chen, Tadayuki Oshima, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
- Organizer
  第49回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-19K08480
[Presentation] Effect of treatment on esophageal epithelial barrier function and inflammation in eosinophilic esophagitis2021
- Author(s)
  Junji Chen, Tadayuki Oshima, Keisuke Nakai, Yoshitaka Kitayama, Ken Hara, Akio Tamura, Masashi Fukushima, Takuya Okugawa, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
- Organizer
  Asian Pacific Digestive Week (APDW) 2021
- Data Source
  KAKENHI-PROJECT-19K08480
[Presentation] 好酸球性食道炎における好酸球浸潤と食道粘膜透過性の関係2020
- Author(s)
  大島忠之，李敏，三輪洋人
- Organizer
  第16回日本消化管学会総会学術集会　ワークショップ１
- Data Source
  KAKENHI-PROJECT-19K08480
[Presentation] Relationship between bile acids and low-grade inflammation of small intestine in IBS2019
- Author(s)
  Horikawa T, Oshima T, Li M, Kondo T, Kono T, Tozawa K, Tomita T, Fukui H, Watari J, Miwa H
- Organizer
  The 12th International Gastrointestinal Consensus Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Alteration of colonic mucosal permeability under antibiotics-induced dysbiotic condition2019
- Author(s)
  Ran Y, Fukui H, Xu X, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Antibiotics treatment affects body metabolism and GI motility accompanied by the alteration of macrophage polarization in the colonic tissues2019
- Author(s)
  Fukui H, Inoue Y, Ran Y, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  nnual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] 公算急性食道炎における食道粘膜透過性と好酸球浸潤の検討2019
- Author(s)
  田村彰朗，大島忠之，李敏，三輪洋人
- Organizer
  日本消化器病学会近畿支部第111回例会
- Data Source
  KAKENHI-PROJECT-19K08480
[Presentation] 胃食道逆流症の病態と治療2019
- Author(s)
  大島忠之
- Organizer
  第15回日本消化管学会総会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Axis of Reg III/STAT3-associated cytokines in DSS-induced colitis in mice2019
- Author(s)
  Fukui H, Nishimura H, Ogawa T, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Miwa H.
- Organizer
  Asian Pacific Digestive Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Alteration of gut microbiota affects Reg IIIγ expression in the intestine2019
- Author(s)
  Nishimura H, Fukui H, Ogawa T, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Miwa H.
- Organizer
  Asian Pacific Digestive Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] 日本人の非心臓性胸痛の頻度とその特徴2019
- Author(s)
  近藤　隆、堀川知紀、道上祐己、江田裕嗣、中村久美子、北山嘉隆、田村彰朗、小川智広、山崎尊久、奥川卓也、河野友彰、戸澤勝之、富田寿彦、大島忠之、福井広一、渡　二郎、三輪洋人
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-16K09298
[Presentation] 機能性ディスペプシアにおける十二指腸微細炎症（Duodenal microinflammation in functional dyspepsia）2019
- Author(s)
  大島忠之，滝　正登，清　裕生，堀川知紀，Li Min，西井謙夫，富田寿彦，福井広一，渡　二郎，三輪洋人
- Organizer
  第15回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] DISRUPTION OF ESOPHAGEAL EPITHELIAL BARRIER FUNCTION AND ITS CORRELATION WITH EOSINOPHIL INFILTRATION IN EOSINOPHILIC ESOPHAGITIS2019
- Author(s)
  Min Li, Tadayuki Oshima, Hiroto Miwa
- Organizer
  Digestive Disease Week 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08480
[Presentation] Antibiotics treatment prolongs gastrointestinal transit time accompanied by increase of colonic GLP-1/GPR43 expression.2018
- Author(s)
  Inoue Y, Fukui H, Xu X, Kondo T, Kono T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Epithelial barrier dysfunction and immunomodulation in eosinophilic esophagitis2018
- Author(s)
  Oshima T
- Organizer
  The 7th Cross-strait Digestive Disease Forum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] ストレスを考慮した機能性ディスペプシア/胃食道逆流症合併患者の診療2018
- Author(s)
  大島忠之
- Organizer
  第20回日本神経消化器病学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Stress and impaired gastric accommodation in functional dyspepsia2018
- Author(s)
  Oshima T
- Organizer
  Summer School on Stress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] 母子分離ラットモデルにおける腸内細菌叢と消化管機能に関する検討2018
- Author(s)
  福井広一，大島忠之，三輪洋人.
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Functional GI disorders and microbiota2018
- Author(s)
  Oshima T
- Organizer
  The 2nd Seoul International Symposium on Helicobacter and Upper Gastrointestinal Diseases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] CDCA released proinflammatory cytokine from small intestinal epithelial cells2018
- Author(s)
  Horikawa T, Oshima T, Li M, Kondo T, Kono T, Tozawa K, Tomita T, Fukui H, Watari J, Miwa H
- Organizer
  3rd Meeting of the Federation of Neurogastroeterology and Motility Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Clinical outcome of patients after endoscopic resection for T1-stage colorectal cancer.2018
- Author(s)
  Eda H, Fukui H, Kono T, Kitayama Y, Nakamura K, Tamura A, Ogawa T, Yamasaki T, Kondo T, Tozawa K, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Asian Pacific Digestive Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] The Prevalence of Non-Cardiac Chest Pain (NCCP) in Japan2018
- Author(s)
  Takashi Kondo, Tomoki Horikawa, Akio Tamura, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Organizer
  FNM2018
- Data Source
  KAKENHI-PROJECT-16K09298
[Presentation] Capsule endoscopic observation of small intestine in patients with familial adenomatous polyposis.2018
- Author(s)
  Kono T, Fukui H, Katsuyuki T, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Asian Pacific Digestive Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Duodenal low-grade inflammation and tight junction proteins in functional dyspepsia.2017
- Author(s)
  Taki M, Oshima T, Takimoto M, Nakamura K, Tamura A, Hara K, Kobayashi M, Okugawa T, Kono T, Tozawa K, Tomita T, Taniguchi Y, Ohda Y, Fukui H, Watari J, Miwa H.
- Organizer
  Digestive Disease Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] 内視鏡陰性GERD患者の胸やけ症状とプロスタグランジンE2との関連2017
- Author(s)
  近藤　隆，岡田啓希, 河野友彰, 戸澤勝之，富田寿彦，應田義雄，大島忠之, 福井広一，渡　二郎，三輪洋人
- Organizer
  日本消化器病学会週間（JDDW2017)
- Data Source
  KAKENHI-PROJECT-16K09298
[Presentation] Effect of gut microbiota on Reg IIIr expression in relation to intestinal immunity.2017
- Author(s)
  Xin Xu, Fukui H, Eda H, Yamasaki T, Kondo T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  5th Biennial Congress of Asian Neurogastroenterology and Motility Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Effect of gut microbiota on GLP-1 receptor expression in relation to gastrointestinal motility.2017
- Author(s)
  Xin Xu, Fukui H, Eda H, Yamasaki T, Kondo T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] 過敏性腸症候群における内臓知覚過敏とホスホジエステラーゼとの関連2017
- Author(s)
  近藤隆、大島忠之、三輪洋人
- Organizer
  日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-15K08961
[Presentation] GERD症状に対する新規治療ターゲットとしてのプロスタグランジンE2の可能性2017
- Author(s)
  近藤隆，大島忠之，戸澤勝之，富田寿彦，應田義雄，福井広一，渡　二郎，三輪洋人
- Organizer
  第13回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-16K09298
[Presentation] Role of gut microbiota on GLP-1 receptor expression and gastrointestinal motility.2017
- Author(s)
  Xin Xu, Fukui H, Eda H, Yamasaki T, Kondo T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  5th Biennial Congress of Asian Neurogastroenterology and Motility Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Low-grade inflammation and epithelial junctional proteins of duodenal mucosa in functional dyspepsia2017
- Author(s)
  Masato Taki, Tadayuki Oshima, Kumiko Nakamura, Mayu Takimoto, Akio Tamura, Ken Hara, Masaya Kobayashi, Takuya Okugawa, Tomoaki Kono, Katsuyuki Tozawa, ToshihikoTomita, Yoshio Ohda, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  Osaka International Convention Center (大阪府大阪市)
- Year and Date
  2017-03-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Relationship between intestinal motility and small intestinal inflammation after acute colitis.2017
- Author(s)
  Fukui H, Kodani M, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] Effect of gut microbiota on Reg IIIr expression in relation to intestinal immunity2017
- Author(s)
  Xin Xu, Fukui H, Eda H, Yamasaki T, Kondo T, Tozawa K, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Biennial Congress of Asian Neurogastroenterology and Motility Association
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2017-03-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] The duodenum, a new target for research2017
- Author(s)
  Tadayuki Oshima, Masato Taki, Liping Wu, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Organizer
  ANMA & JSNM Joint Meeting 2017
- Place of Presentation
  Osaka International Convention Center (大阪府大阪市)
- Year and Date
  2017-03-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09297
[Presentation] Ratio of neutrophil to lymphocytes is useful to predict the prognosis of patients with paclitaxel plus ramucirumab treatment for unresectable advanced gastric cancer.2017
- Author(s)
  Hara K, Fukui H, Tozawa K, Takimoto M, Nakamura K, Tamura A, Okugawa T, Tomita T, Ohda Y, Oshima T, Watari J, Miwa H.
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09363
[Presentation] 胃食道逆流症における食道上皮細胞内IL-33の役割2016
- Author(s)
  大島忠之，清　裕生，三輪洋人
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル，東京
- Year and Date
  2016-04-23
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] Involvement of gut microbiota in the association between macrophage and gastrointestinal motility2016
- Author(s)
  Yang M, Fukui H, Eda H, Kodani M, Yamasaki T, Kondo T, Ikehara H, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] Effect of REG protein on the link between claudin expression and mucosal permeability in the small intestine2016
- Author(s)
  Fukui H, Kitayama Y, Hara K, Yamasaki T, Kondo T, Ikehara H, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-05-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] Alteration of gastrointestinal motility and mast cell behavior in mice after DSS-induced colitis2016
- Author(s)
  Kodani M, Fukui H, Tomita T, Oshima T, Watari J, Miwa H.
- Organizer
  Federation of Neurogastroenterology and Motility Meeting 2016
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-08-26
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] Serum Reg Ia is a marker to predict histological and clinical activity in ulcerative colitis2015
- Author(s)
  Tozawa K, Fukui H, Yamasaki T, Kondo T, Kono T, Toyoshima F, Ikehara H, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Place of Presentation
  Washington, USA
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] Effect of REG protein on mucosal permeability and adhesion molecule expression in the small intestine2015
- Author(s)
  Kitayama Y, Fukui H, Yamasaki T, Kondo T, Kono T, Toyoshima F, Ikehara H, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Annual Meetings of the American Gastroenterology Association and American Association for the Study of Liver Disease at the Digestive Disease Week
- Place of Presentation
  Washington, USA
- Year and Date
  2015-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] Upregulation and the regulation of esophageal epithelial-derived IL-33 in non-erosive reflux disease2015
- Author(s)
  Hiroo Sei, Tadayuki Oshima, Jing Shan, Liping Wu, Takashi Kondo, Tomoaki Kono, Fumihiko Toyoshima, Katsuyuki Tozawa, Hisatomo Ikehara, Yoshio Ohda, Toshihiko Tomita, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
- Organizer
  Digestive Disease Week 2015
- Place of Presentation
  Walter E. Washington Convention Center, Washington, DC
- Year and Date
  2015-05-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] 酸関連・非酸関連上腹部症状発現のメカニズム2015
- Author(s)
  大島忠之，ウ　リピン，清　裕生，近藤　隆，三輪洋人
- Organizer
  合同学術集会2015 第17回日本神経消化器病学会
- Place of Presentation
  沖縄科学技術大学院大学，沖縄
- Year and Date
  2015-11-13
- Invited
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] 食道上皮細胞内のIL-33は胃食道逆流症の増悪に関与する2015
- Author(s)
  大島忠之，単　晶，ウ　リピン，清　裕生，原　謙，小川智広，山崎尊久，奥川卓也，河野友彰，近藤　隆，池原久朝，上山茂充，谷口友佳子，富田寿彦，應田義雄，福井広一，渡　二郎，三輪洋人
- Organizer
  合同学術集会2015 第17回日本神経消化器病学会
- Place of Presentation
  沖縄科学技術大学院大学，沖縄
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] 非びらん性食道胃逆流症におけるIL-33の発現と炎症性サイトカインの産生に関する検討2015
- Author(s)
  清　裕生，大島忠之，L. Wu，山崎尊久，近藤　隆，河野友彰，豊島史彦，戸澤勝之，池原久朝，富田寿彦，應田義雄，福井広一，渡　二郎，三輪洋人
- Organizer
  第57回日本消化器病学会大会（JDDW 2015）
- Place of Presentation
  グランドプリンス新高輪，東京
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] 機能性ディスペプシアにおける十二指腸粘膜の炎症細胞浸潤2015
- Author(s)
  清　裕生，大島忠之，ウ　リピン，原　謙，小川智広，山崎尊久，奥川卓也，近藤　隆，河野友彰，戸澤勝之，池原久朝，谷口友佳子，上山茂充，富田寿彦，應田義雄，福井広一，渡　二郎，三輪洋人
- Organizer
  合同学術集会2015 第17回日本神経消化器病学会
- Place of Presentation
  沖縄科学技術大学院大学，沖縄
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] Effect of H. pylori infection on GLP-1 expression and gastrointestinal motility2015
- Author(s)
  Eda H, Fukui H, Kitayama Y, Hara K, Yamasaki T, Kondo T, Tozawa K, Ikehara H, Ohda Y, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Asia Pacific Digestive Week
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] 健常人のCRH負荷にともなう電気刺激に対する食道知覚閾値の検討2015
- Author(s)
  山崎尊久，瀧本真弓,　河野友彰,　近藤隆,　戸澤勝之,　池原久朝,　應田義雄,　富田寿彦,　大島忠之,　福井広一,　渡二郎,　三輪洋人
- Organizer
  日本消化器関連学会週間 (JDDW) 2015
- Place of Presentation
  グランドプリンスホテル新高輪（東京都，港区）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460940
[Presentation] Involvement of STAT3 activation in the development of early gastric cancer2014
- Author(s)
  Sakamoto H, Fukui H, Kono T, Ikehara H, Tomita T, Oshima T, Watari J, Miwa H
- Organizer
  Asia Pacific Digestive Week
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2014-11-25
- Data Source
  KAKENHI-PROJECT-26460953
[Presentation] 機能性ディスペプシアにおける十二指腸粘膜防御機構障害2014
- Author(s)
  大島忠之，単　晶，三輪洋人
- Organizer
  第88回日本消化器内視鏡学会総会（JDDW 2014）
- Place of Presentation
  神戸国際展示場
- Year and Date
  2014-10-24
- Data Source
  KAKENHI-PROJECT-25460939
[Presentation] Intra-venous Corticotropin Releaseing Hormone (CRH) administration increased esophageal electrical sensitivity in normal subjects.2014
- Author(s)
  Yamasaki T, Takimoto M, Kono T, Kondo T, Toyoshim F, Sakurai J, Tozawa K, Ikehara H, Tomita T, Oshima T, Fukui H, Watari J, Miwa H.
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-05-05
- Data Source
  KAKENHI-PROJECT-25460940
[Presentation] Watari J, Fujimori T, Miwa H. Groαpromotes invasion of gastric cancer cells.2013
- Author(s)
  Fukui H, Zhang X, Sun C, Yamasaki T, Kondo T, Ikehara H, Tomita T, Oshima T
- Organizer
  Sa1719 (Digestive Disease Week
- Place of Presentation
  Orlando, Florida, USA)
- Year and Date
  2013-05-18
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Involvement of IL-22 signaling in gastric cancer cell invasion.2012
- Author(s)
  Fukui H, Zhang X, Toyoshima F, TomitaT, Oshima T, Watari J, Imura J, Fujimori T, Matsumoto T, Miwa H.
- Organizer
  Su1840 (Digestive Disease Week
- Place of Presentation
  San Diego, California, USA)
- Year and Date
  2012-05-22
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Acidic bile salt modulates the squamous epithelial barrier function by modulating tight junction protein2011
- Author(s)
  Chen X, Oshima T, Miwa H, et al
- Organizer
  DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Establishment of a system measuring liquid meal-induced gastric accommodation in conscious guinea pigs2011
- Author(s)
  Okugawa T, Oshima T, Miwa H, et al
- Organizer
  DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Acid modulates the squamous epithelial barrier function by modulating the localization of claudins2011
- Author(s)
  Oshima T, Miwa H, et al
- Organizer
  DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Down-regulation of submucosal claudin-18 at the invasivefront is associated with proliferative potential of submucosal gastric cancer.2011
- Author(s)
  Okugawa T, Oshima T, Morita T, SakuraiJ, Tanaka J, Tomita T, Fukui H, Watari J, Matsumoto T, Miwa H.
- Organizer
  Sa1907 (Digestive Disease Week
- Place of Presentation
  Chicago, Illinois, USA)
- Year and Date
  2011-05-07
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Pathophysiology and Treatment of Functional Dyspepsia2011
- Author(s)
  Oshima T
- Organizer
  2011 National Intestinal Disease Congress & New Technique Forum of Digestive Endoscopy in Tianjin
- Place of Presentation
  Tianjin, China(招待講演)
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Down-regulation of submucosal claudin-18 at the invasive front is associated with proliferative potential of submucosal gastric cancer2011
- Author(s)
  Okugawa T, Oshima T, et al
- Organizer
  DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Visceral symptoms and dilated intercellular spaces in a rat chronic acid reflux esophagitis model are mediated by increased neuropeptides expression in dorsal root ganglion2011
- Author(s)
  Oshima T, Sakurai J, Miwa H, et al
- Organizer
  DDW2011
- Place of Presentation
  Chicago, USA
- Year and Date
  2011-05-09
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Implicationsin Gastrointestinal Diseases.(招聘講演)2011
- Author(s)
  Oshima T. Tight Junctions
- Organizer
  The Sino-Japan Symposium aboutDigestive Diseases in Tianjin.
- Place of Presentation
  Tianjin, China
- Year and Date
  2011-03-06
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Pathophysiology and Treatment of Functional Dyspepsia2011
- Author(s)
  Oshima T
- Organizer
  2011 National Intestinal Disease Congress & New Technique Forum of Digestive Endoscopy in Tianjin
- Place of Presentation
  Tianjin, China
- Year and Date
  2011-11-12
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Bile acids in acidic condition modulate the squamous epithelial barrier function2010
- Author(s)
  Oshima T, Miwa H, et al.
- Organizer
  The 12 World Congress of the International Society for Diseases of the Esophagus (ISDE2010)
- Place of Presentation
  Kagoshima
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Acid Modulates the Squamous Epithelial Barrier Function by Modulating the Localization of Claudins2010
- Author(s)
  Oshima T, Miwa H, et al
- Organizer
  Digestive Disease Week 2010
- Place of Presentation
  New Orleans
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Down-regulation of claudin-4 and up-regulation of claudin-18 are associated with proliferative potential of intramucosal gastric cancer2010
- Author(s)
  Chen X, Oshima T, et. al.
- Organizer
  DDW2010
- Place of Presentation
  New Orleans
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Down-regulation of claudin-4 and up-regulation of claudin-18 are associated with proliferative potential of intramucosal gastric cancer.2010
- Author(s)
  Chen X, Oshima T, Sakurai J, Tanaka J, Morita T, Tomita T, Kim Y, Hori K, Watari J, Matsumoto T, Miwa H.
- Organizer
  S1961 (Digestive Disease Week
- Place of Presentation
  New Orleans, Louisiana, USA)
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Acidic bile salts modulates the squamous epithelial barrier function by modulating tight junction proteins2010
- Author(s)
  Chen X, Oshima T, Miwa H, et al
- Organizer
  第38回日本潰瘍学会
- Place of Presentation
  大阪
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] 胃粘膜内癌におけるクローディンの発現と増殖能は相関する2010
- Author(s)
  奥川卓也, 大島忠之, ら
- Organizer
  JDDW2010
- Place of Presentation
  横浜
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-22590691
[Presentation] Bile acids in acidic condition modulate the squamous epithelial barrier function2010
- Author(s)
  Oshima T, Miwa H, et al
- Organizer
  The 12 World Congress of the International Society for Diseases of the Esophagus(ISDE2010)
- Place of Presentation
  Kagoshima
- Year and Date
  2010-09-05
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Involvement of NK1 receptor in the development of chronic dyspeptic symptoms in a rat chronic acid reflux esophagitis model2009
- Author(s)
  Oshima T, Koseki J, Sakurai J, Tomita T, Matsumoto T, Miwa H
- Organizer
  The 1st Biennial Congress of the Asian Neurogas troenterology and Motility Association
- Place of Presentation
  Seoul
- Year and Date
  2009-04-04
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] NK-1 receptor is involved in the development of chronic dyspeptic symptom in a rat chronic acid reflux esophagitis model2009
- Author(s)
  Oshima T, Koseki J, Sakurai J, Matsumoto T, Miwa H
- Organizer
  Digestive Disease Week 2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Involvement of NK1 receptor in the development of chronic dyspeptic symptoms in a rat chronic acid reflux esophagitis model2009
- Author(s)
  Oshima T, Koseki J, Sakurai J, Tomita T, Matsumoto T, Miwa H
- Organizer
  The 1st Biennial Congress of the Asian Neurogastroenterology and Motility Association
- Place of Presentation
  Seoul
- Year and Date
  2009-04-04
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] NK-1 receptor is involved in the development of chronic dyspeptic symptorn in a rat chronic acid reflux esonhagitis model2009
- Author(s)
  Oshima T, Koseki J, Sakurai J, Matsumoto T, Miwa H
- Organizer
  Digestive Disease Week 2009
- Place of Presentation
  Chicago
- Year and Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-21590799
[Presentation] Aspirin induced gastric epithelial barrier dysfunction and tight junction2008
- Author(s)
  Oshima T, Joh T, Miwa H.
- Organizer
  The 1st International Gastrointestinal Consensus Symposium (IGICS)
- Place of Presentation
  Osaka, Japan
- Year and Date
  2008-02-08
- Data Source
  KAKENHI-PROJECT-19790501
[Presentation] Proton pump inhibitor treatment ameliorates dilated intercellular space, decrease and dislocalization of esophageal mucosal tight junction proteins in a rat chronic acid reflux esophagitis model2008
- Author(s)
  Oshima T, Koseki J, Iizuka S, Tomita T, Matsumoto T, Sakurai J, Miwa H.
- Organizer
  Digestive Disease Week 2008
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19790501
[Presentation] Decreased rat voluntary movement as a measure of chronic visceral pain -a study using the rat chronic acid reflux esophagitis model2007
- Author(s)
  Miwa H, Oshima T, Tomita T, Sakurai J, Matsumoto T, Koseki J
- Organizer
  Digestive Disease Week 2007
- Place of Presentation
  Washington DC, USA
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19790501
[Presentation] Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAP kinase via claudin-72007
- Author(s)
  Oshima T, Joh T, Kataoka H, Sasaki M, Matsumoto T, Miwa H
- Organizer
  Digestive Disease Week2007
- Place of Presentation
  Washington DC, USA
- Year and Date
  2007-05-21
- Data Source
  KAKENHI-PROJECT-19790501
[Presentation] Recent trend of GERD in Japan2007
- Author(s)
  Miwa H, Hori K, Oshima T, Yamamoto N, Matsumoto T
- Organizer
  APDW 2007
- Place of Presentation
  Kobe, Japan
- Year and Date
  2007-10-18
- Data Source
  KAKENHI-PROJECT-19790501

1. MIWA Hiroto (80190833)

# of Collaborated Projects: 12 results

# of Collaborated Products: 138 results
2. FUKUI Hirokazu (60378742)

# of Collaborated Projects: 6 results

# of Collaborated Products: 78 results
3. WATARI Jiro (10311531)

# of Collaborated Projects: 5 results

# of Collaborated Products: 73 results
4. TOMITA Toshihiko (60388824)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
5. Takashi Kondo (90594870)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. SAKURAI Jun (30528998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. YAMASAKI Takahisa (80648791)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. IMURA Johji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YASUDA Koubun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oshima Tadayuki 大島 忠之

OSHIMA Tadayuki 大島 忠之

Research Projects

Research Products

Co-Researchers

Functional analysis and therapeutidc application targeting mucosal barrier and intestinal tuft cells in functional gastrointestinal disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Development of new therapy for eosinophilic gastrointestinal diseases targeting the regulation of mucosal barrierPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of Reg protein on the mucosal barrier function in the inflammatory gastrointestinal diseases

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

The development and application of in vivo evaluation of mucosal barrier function in functional gastrointestinal disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A Factual Survey of Non-Cardiac Chest Pain (NCCP) in Japan

Principal Investigator

Project Period (FY)

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Research Institution

Phosphodiesterase 2A mediate visceral hypersensitivity in a rodent model of functional dyspepsia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of Reg protein on the maintenance of mucosal homeostasis in the gastrointestinal tract

Principal Investigator

Project Period (FY)

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Research Institution

Duodenal epithelial intercellular junction and IL-33 on the development of dyspepsiaPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Effect of intra-venous corticotropin releasing hormone (CRH) on esophageal physiological changes in NERD patients.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Protective role of Reg protein on mucosal injury in the gastrointestinal tract

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of tight junction protein: claudins on the development and progression of gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of abdominal symptom development-involvement of neural inflammation and mucosal permeability on esophageal symptoms-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Esophageal mucosal defense mechanisms and a new pathophysiological classification by intercellular junctional complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Oshima Tadayuki 大島忠之

OSHIMA Tadayuki 大島忠之

[Book] 医学と医療の最前線　機能性ディスペプシアの最近の話題．2015

[Book] H.pylori除菌による早期胃癌内視鏡治療後の異時性発癌の抑制効果(解説/特集)消化器内科(1884-2895)54 巻 3号Page302-308(2012.03) H.pyloriと胃癌の基礎と臨床