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Suzuki Akari  鈴木 亜香里

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鈴木 亜香里  スズキ アカリ

SUZUKI Akari  鈴木 亜香里

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Researcher Number 00391996
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員
Affiliation (based on the past Project Information) *help 2018 – 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー
2016 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー
2008 – 2011: The Institute of Physical and Chemical Research, 自己免疫疾患研究チーム, 上級研究員
2008: The Institute of Physical and Chemical Research, ゲノム医科学研究センター, 自己免疫疾患研究チーム
2007: The Institute of Physical and Chemical Research, 関節リウマチ関連遺伝子研究チーム, 研究員
Review Section/Research Field
Principal Investigator
膠原病・アレルギー・感染症内科学 / Pathological medical chemistry
Except Principal Investigator
Broad Section I
Keywords
Principal Investigator
関節リウマチ / ぺプチジルアルギニンデイミナーゼ / モデルマウス / ペプチジルアルギニンデイミナーゼ / ノックアウトマウス / シトルリン化 / 遺伝子発現 / 遺伝子 / 全ゲノム関連解析法 / 効シトルリン化抗体 … More / 疾患モデルマウス / 全ゲノム関連解析 / ダブルノックアウトマウス / シトルリンか / リスク遺伝子 / GWAS / 関節炎マウス / 抗シトルリン化抗体 / petidylarginine deiminase type 4 / citrullination / collagen-induced arthritis / Knock-out mouse / rheumatoid arthritis / peptidylarginine deiminase / フィブリノーゲン … More
Except Principal Investigator
エピゲノム解析 / オミックス / ホールトランスクリプトーム解析 / 一塩基多型 / 多因子性疾患 / クロマチンステイタス解析 / クロマチン構造解析 / eQTL解析 / マルチオミクス解析 / 遺伝子多型 / シングルセル解析 / オープンクロマチン解析 / エンハンサー / プロモーター / 遺伝子発現量 / エピゲノム / ゲノム / プロモーターエンハンサー解析 / 遺伝子発現量解析 / 疾患関連遺伝子多型 / 免疫細胞分画 / QTL解析 / 量的形質遺伝子座 / 疾患感受性遺伝子変異 / ゲノムワイド関連解析 / ヒト免疫 / 免疫疾患 / 多因子疾患 Less
  • Research Projects

    (4 results)
  • Research Products

    (36 results)
  • Co-Researchers

    (10 People)
  •  Establishment of a novel strategy for pathological analysis of multifactorial diseases using genetic risk variants

    • Principal Investigator
      Yamamoto Kazuhiko
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of new drug target for rheumatoid arthritis based on GWASPrincipal Investigator

    • Principal Investigator
      Suzuki Akari
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Study of Peptidylarginine deiminase type 4(PADI4) as a susceptibility gene of rheumatoid arthritis(RA)Principal Investigator

    • Principal Investigator
      SUZUKI Akari
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Study of Peptidylariginine deiminase type 4 as susceptibility gene of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      SUZUKI Akari
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      The Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2018 2017 2016 2011 2008 2007 Other

All Journal Article Presentation Book

  • [Book] 関節リウマチ滑膜におけるPAD-2, PAD-4発現2008

    • Author(s)
      鈴木亜香里,山田亮,山本一彦
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-19790702
  • [Book] RAにおけるPADI4遺伝子2007

    • Author(s)
      鈴木亜香里,山田亮,山本一彦
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-19790702
  • [Book] Citrullination of peptidylarginine deiminase in rheumatoid arthritis2007

    • Author(s)
      Suzuki A, Yamada R, Yamamoto K
    • Publisher
      the New York Academy of Sciences
    • Data Source
      KAKENHI-PROJECT-19790702
  • [Book] 関節リウマチ滑膜におけるPAD-2, PA D-4発現リウマチ科40巻4号

    • Author(s)
      鈴木亜香里、山田亮、山本一彦
    • Data Source
      KAKENHI-PROJECT-21689028
  • [Journal Article] Splicing QTL analysis focusing on coding sequences reveals mechanisms for disease susceptibility loci2022

    • Author(s)
      Yamaguchi Kensuke、Ishigaki Kazuyoshi、Suzuki Akari、Tsuchida Yumi、Tsuchiya Haruka、Sumitomo Shuji、Nagafuchi Yasuo、Miya Fuyuki、Tsunoda Tatsuhiko、Shoda Hirofumi、Fujio Keishi、Yamamoto Kazuhiko、Kochi Yuta
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4659-4659

    • DOI

      10.1038/s41467-022-32358-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-20K08800, KAKENHI-PROJECT-21K19501, KAKENHI-PROJECT-21K20647, KAKENHI-PROJECT-23K23860, KAKENHI-PROJECT-23K24373
  • [Journal Article] Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus2022

    • Author(s)
      Takeshima Yusuke、Iwasaki Yukiko、Nakano Masahiro、Narushima Yuta、Ota Mineto、Nagafuchi Yasuo、Sumitomo Shuji、Okamura Tomohisa、Elkon Keith、Ishigaki Kazuyoshi、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: - Issue: 6 Pages: 845-853

    • DOI

      10.1136/annrheumdis-2021-221464

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02849, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-21H02960, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-21K19501
  • [Journal Article] Functional genomics of autoimmune diseases2021

    • Author(s)
      Suzuki Akari、Guerrini Matteo Maurizio、Yamamoto Kazuhiko
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 無 Issue: 6 Pages: 689-697

    • DOI

      10.1136/annrheumdis-2019-216794

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020

    • Author(s)
      Terao Chikashi、Suzuki Akari、Momozawa Yukihide、Akiyama Masato、Ishigaki Kazuyoshi、Yamamoto Kazuhiko、Matsuda Koichi、Murakami Yoshinori、McCarroll Steven A.、Kubo Michiaki、Loh Po-Ru、Kamatani Yoichiro
    • Journal Title

      Nature

      Volume: 584 Issue: 7819 Pages: 130-135

    • DOI

      10.1038/s41586-020-2426-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676
  • [Journal Article] Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis2020

    • Author(s)
      Tsuchiya Haruka、Ota Mineto、Sumitomo Shuji、Ishigaki Kazuyoshi、Suzuki Akari、Sakata Toyonori、Tsuchida Yumi、Inui Hiroshi、Hirose Jun、Kochi Yuta、Kadono Yuho、Shirahige Katsuhiko、Tanaka Sakae、Yamamoto Kazuhiko、Fujio Keishi
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 80 Issue: 4 Pages: 440-450

    • DOI

      10.1136/annrheumdis-2020-218189

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16275, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02846
  • [Journal Article] Linking of genetic risk variants to disease-specific gene expression via multi-omics studies in rheumatoid arthritis2019

    • Author(s)
      Suzuki Akari、Terao Chikashi、Yamamoto Kazuhiko
    • Journal Title

      Seminars in Arthritis and Rheumatism

      Volume: 49 Issue: 3 Pages: S49-S53

    • DOI

      10.1016/j.semarthrit.2019.09.007

    • Open Access
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16K08634
  • [Journal Article] Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians2019

    • Author(s)
      Molineros Julio E.、Looger Loren L.、Kim Kwangwoo、Okada Yukinori、Terao Chikashi、Sun Celi、Zhou Xu-jie、Raj Prithvi、Kochi Yuta、Suzuki Akari et al.
    • Journal Title

      PLOS Genetics

      Volume: 15 Issue: 4 Pages: 1008092-1008092

    • DOI

      10.1371/journal.pgen.1008092

    • NAID

      120006885404

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02849
  • [Journal Article] PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes2019

    • Author(s)
      Akizuki S, Ishigaki K, Kochi Y, Law SM, Matsuo K, Ohmura K, Suzuki A, Nakayama M, Iizuka Y, Koseki H, Ohara O, Hirata J, Kamatani Y, Matsuda F, Sumida T, Yamamoto K, Okada Y, Mimori T, Terao C.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 4 Pages: 509-518

    • DOI

      10.1136/annrheumdis-2018-214116

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-16K09891, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-18H02849
  • [Journal Article] Reduction of CD83 Expression on B Cells and the Genetic Basis for Rheumatoid Arthritis: Comment on the Article by Thalayasingam et al2018

    • Author(s)
      Tsuchida Yumi、Sumitomo Shuji、Ota Mineto、Tsuchiya Haruka、Nagafuchi Yasuo、Shoda Hirofumi、Fujio Keishi、Ishigaki Kazuyoshi、Yamaguchi Kensuke、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
    • Journal Title

      Arthritis & Rheumatology

      Volume: 70 Issue: 10 Pages: 1695-1696

    • DOI

      10.1002/art.40652

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18K16140, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285
  • [Journal Article] Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility2018

    • Author(s)
      Tanikawa Chizu、Ueda Koji、Suzuki Akari、Iida Aritoshi、Nakamura Ryoichi、Atsuta Naoki、Tohnai Genki、Sobue Gen、Saichi Naomi、Momozawa Yukihide、Kamatani Yoichiro、Kubo Michiaki、Yamamoto Kazuhiko、Nakamura Yusuke、Matsuda Koichi
    • Journal Title

      Cell Reports

      Volume: 22 Issue: 6 Pages: 1473-1483

    • DOI

      10.1016/j.celrep.2018.01.031

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16KT0116, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-17K09778, KAKENHI-PROJECT-17K16116, KAKENHI-PROJECT-26710007, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676
  • [Journal Article] A gene module associated with dysregulated TCR signaling pathways in CD4 + T cell subsets in rheumatoid arthritis2018

    • Author(s)
      Sumitomo Shuji、Nagafuchi Yasuo、Tsuchida Yumi、Tsuchiya Haruka、Ota Mineto、Ishigaki Kazuyoshi、Nakachi Shinichiro、Kato Rika、Sakurai Keiichi、Hanata Norio、Tateishi Shoko、Kanda Hiroko、Suzuki Akari、Kochi Yuta、Fujio Keishi、Yamamoto Kazuhiko
    • Journal Title

      Journal of Autoimmunity

      Volume: 89 Pages: 21-29

    • DOI

      10.1016/j.jaut.2017.11.001

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09972, KAKENHI-PROJECT-18H05285
  • [Journal Article] Genetics of rheumatoid arthritis: 2018 status2018

    • Author(s)
      Okada Yukinori、Eyre Stephen、Suzuki Akari、Kochi Yuta、Yamamoto Kazuhiko
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 78 Issue: 4 Pages: 446-453

    • DOI

      10.1136/annrheumdis-2018-213678

    • Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-18H05285
  • [Journal Article] Macrophage extracellular chromatin release induced by Mac-1 mediated platelet-macrophage interactions triggers acute kidney injury in rhabdomyolysis.2018

    • Author(s)
      Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J.
    • Journal Title

      Nat. Med.

      Volume: 24 Issue: 2 Pages: 232-238

    • DOI

      10.1038/nm.4462

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0055, KAKENHI-PROJECT-16K08634, KAKENHI-PROJECT-16H02606, KAKENHI-PROJECT-17H04089, KAKENHI-PROJECT-15K09459, KAKENHI-PROJECT-16K15294, KAKENHI-PROJECT-16K19497, KAKENHI-PUBLICLY-16H01369
  • [Journal Article] Decreased Severity of Experimental Autoimmune Arthritis in Peptidylarginine Deiminase Type 4 Knockout Mice.2016

    • Author(s)
      Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Yu Seri, Keishi Fujio, Tetsuji Sawada, Ryo Yamada and Kazuhiko Yamamoto
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 17 Issue: 1 Pages: 205-205

    • DOI

      10.1186/s12891-016-1055-2

    • NAID

      120006338049

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Journal Article] Insight from Genome-Wide Association Studies in Rheumatoid Arthritis and Multiple Sclerosis2011

    • Author(s)
      Suzuki A., Kochi Y., Okada Y., and Yamamoto K
    • Journal Title

      FEBS letters

      Volume: 585(23) Pages: 3627-3632

    • Data Source
      KAKENHI-PROJECT-21689028
  • [Journal Article] Citrullinated fibrinogen inhibits thrombin-catalyzed fibrin polymerization2008

    • Author(s)
      Nakayama-Hamada M*, Akari Suzuki* et.al (*equal contributed)
    • Journal Title

      J. Biochem 144

      Pages: 393-397

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790702
  • [Journal Article] 関節リウマチ滑膜におけるPAD-2, PAD-4発現2008

    • Author(s)
      鈴木亜香里, ら
    • Journal Title

      リウマチ科 40

      Pages: 422-426

    • Data Source
      KAKENHI-PROJECT-19790702
  • [Journal Article] RAにおけるPADI4遺伝子2007

    • Author(s)
      鈴木 亜香里, 山田 亮, 山本 一彦
    • Journal Title

      リウマチ科 37

      Pages: 251-255

    • Data Source
      KAKENHI-PROJECT-19790702
  • [Journal Article] Citrullination of peptidylarginine deiminase in rheumatoid art hritis.2007

    • Author(s)
      Suzuki A, Yamada R, Yamamoto K.
    • Journal Title

      Annals of the New York Academy of Sciences. 1108

      Pages: 323-339

    • Data Source
      KAKENHI-PROJECT-19790702
  • [Journal Article] Regulation of histone modification and chromatin structure by the p53-PADI4 pathway

    • Author(s)
      Tanigawa C., Espinosa M., Suzuki A., Matsuda K., et al
    • Journal Title

      Nature Communications

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21689028
  • [Presentation] 統合オミックス解析による関節リウマチ関連遺伝子の同定2019

    • Author(s)
      鈴木亜香里、高地雄太、石垣和慶、山本一彦
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18H05285
  • [Presentation] Reduced Severity of Collagen-induced Arthritis in Peptidylarginine Deiminase Knockout Mice2019

    • Author(s)
      Akari Suzuki
    • Organizer
      European Society of Human Genetics(2019, 52nd)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] 統合オミックス解析による関節リウマチ関連遺伝子の同定2019

    • Author(s)
      鈴木 亜香里
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Functional study of Peptidylarginine Deiminase genes in arthritis model mice2018

    • Author(s)
      Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Keishi Fujio, and Kazuhiko Yamamoto
    • Organizer
      ASHG 68th Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Phenotypic analysis of Peptidylarginine deiminase type 4 knock-out mice2018

    • Author(s)
      Akari Suzuki
    • Organizer
      Human Genome Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Functional study of Peptidylarginine Deiminase genes in arthritis model mice2018

    • Author(s)
      Akari Suzuki, Yuta Kochi, Hirofumi Shoda, Keishi Fujio, and Kazuhiko Yamamoto
    • Organizer
      ESHG 51th Annual Meeting 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Reduced Severity of Collagen-induced Arthritis in Peptidylarginine Deiminase Type 4 Knockout Mice2017

    • Author(s)
      Akari Suzuki
    • Organizer
      American Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Decreased Severity of Experimental Arthritis in Peptidylarginine Deiminase Type 4 Knockout Mice2017

    • Author(s)
      Akari Suzuki
    • Organizer
      European Society of Human Genetics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Decreased Severity of Experimental Autoimmune Arthritis in Peptidylarginine Deiminase Type 4 Knockout Mice2016

    • Author(s)
      鈴木 亜香里
    • Organizer
      ASHG2016, Vancouver, Canada
    • Place of Presentation
      Vancouver
    • Year and Date
      2016-10-18
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Decreased Severity of Experimental Autoimmune Arthritis in Peptidylarginine Deiminase Type 4 Knockout Mice2016

    • Author(s)
      鈴木 亜香里
    • Organizer
      ESHG 49th Annual Meeting 2016, Barcelona, Spain
    • Place of Presentation
      Barcelona
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-16K08634
  • [Presentation] Functional study of Peptidylarginine deiminase type 4 as genetic risk factor for RA2011

    • Author(s)
      A. Suzuki
    • Organizer
      61st American Society of Human Genetics
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-21689028
  • [Presentation] RAとPADI4遺伝子2007

    • Author(s)
      鈴木亜香里
    • Organizer
      第51回日本リウマチ学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2007-02-26
    • Data Source
      KAKENHI-PROJECT-19790702
  • 1.  Yamamoto Kazuhiko (80191394)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 2.  庄田 宏文 (20529036)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  尾崎 浩一 (50373288)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  寺尾 知可史 (60610459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  UEDA Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  住友 秀次
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  土屋 遥香
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  住田 孝之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  高地 雄太
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  長谷 耕二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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