SENBA Kei 仙波圭

Researcher Number	00398190
Other IDs
Affiliation (based on the past Project Information) *help	2015: 熊本大学, 学内共同利用施設等, 研究員 2015: 熊本大学, 熊本大学生命資源・研究支援センター, 研究員 2014: 熊本大学, 生命資源・研究支援センター, 研究員 2013: 熊本大学, 生命資源研究・支援センター, 助教 2012: 熊本大学, 生命資源研究支援センター, 特定事業研究員 2011 – 2012: 熊本大学, 生命資源研究・支援センター, 特定事業研究員 2006 – 2010: 熊本大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator Sd変異マウス / Ptf1a / キメラマウス / 臓器欠損 / 椎間板髄核欠損 / 椎間板線維輪 / 椎間板髄核 / 霊長類ES細胞 / 霊長類iPS / 細胞間ネットワーク … More / 細胞移植 / 霊長類 / マウス / 椎間板線維輪マーカー分子 / 椎間板髄核マーカー分子 / CRISPR-Cas9 / チンパンジーiPS / 霊長類化椎間板キメラ / 椎間板 / 分子メカニズム / ノックアウト / 発生異常 / lacZ / ノックイン / ノックアウ / ES細胞 / 脊椎欠損 / 変異 ES 細胞 / 遺伝子破壊 / 脊索 / transposon / Sd 変異マウス / Danforth's short tail … More Except Principal Investigator 小胞体ストレス / ER stress / autoohaey / cell-death / growth plate / chondrocyte / articular cartilage / osteoarthritis / オートファジー / 細胞死 / 成長軟骨板細胞死 / 軟骨細胞 / 関節軟骨 / 変形性関節症 / 小胞体 / ストレス / シグナル伝達 / 細胞・組織 / アポトーシス / 糖化最終産物 Less

Establishment of chimeric mice having a primatized intervertebral discs and comprehensive research of the primatized intervertebral disc.Principal Investigator
- Principal Investigator
  
  SEMBA KEI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University
Elucidation for molecular etiology of Danforth's short tail (Sd)mutant, a caudal regression model mousePrincipal Investigator
- Principal Investigator
  
  SEMBA Kei
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University
Pathogenesis and pathological role of endoplasmic reticulum stress in cartilage degeneration
- Principal Investigator
  
  MIZUTA Hiroshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University
Analyses of induction of autophagic response related to the chondrocyte cell-death in osteroarthritis.
- Principal Investigator
  
  MIZUTA Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University

All 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 脊椎・脊髄-up todate, 「脊椎と脊髄の発生」2012
- Author(s)
  仙波圭,他
- Publisher
  ClinicalNeuroscience
- Data Source
  KAKENHI-PROJECT-22791388
[Book] 論文ができてしまう!疾患モデルマウス表現型解析指南,「脊椎」2011
- Author(s)
  仙波圭,他
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22791388
[Journal Article] GNAS and Kras cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.2016
- Author(s)
  Taki, K., Ohmuraya, M., Tanji, E., Komatsu, H., Hashimoto, D., Semba, K., Araki, K., Kawaguchi, Y., Baba, H. and Furukawa, T.
- Journal Title
  
  Oncogene
  
  Volume: in press Issue: 18 Pages: 1-6
- DOI
  10.1038/onc.2015.294
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0001, KAKENHI-PLANNED-26110003, KAKENHI-PUBLICLY-26111516, KAKENHI-PROJECT-25640052, KAKENHI-PROJECT-25670653
[Journal Article] Etiology of caudal regression syndrome.2013
- Author(s)
  Semba K. & Yamamura, K.
- Journal Title
  
  Human Genet. Embryol.
  
  Volume: 3 Issue: 02 Pages: 1-7
- DOI
  10.4172/2161-0436.1000107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670653
[Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012
- Author(s)
  Abe, K. et al.
- Journal Title
  
  Genesis
  
  Volume: 50 Issue: 10 Pages: 758-765
- DOI
  10.1002/dvg.22035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22500392, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-24592213, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-24115712
[Journal Article] 脊椎・脊髄―up to date, 「脊椎と脊髄の発生」2012
- Author(s)
  仙波圭
- Journal Title
  
  Clinical Neuroscience.
  
  Volume: 30 Pages: 1094-7
- Data Source
  KAKENHI-PROJECT-22791388
[Journal Article] Ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.2012
- Author(s)
  Semba, K., Araki, K., Matsumoto, K.-I., Suda, H., Ando, T. Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, Y., Araki, M., Abe, K. and Yamamura, K.
- Journal Title
  
  PLoS Genet.
  
  Volume: Vol.9 Issue: 2 Pages: 1-17
- DOI
  10.1371/journal.pgen.1003204
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20062013, KAKENHI-PROJECT-21220010, KAKENHI-PLANNED-22132006, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23651189, KAKENHI-PUBLICLY-24115712, KAKENHI-PROJECT-25670653, KAKENHI-PROJECT-221S0001
[Journal Article] The Skt gene, required for anorectaldevelopment, is a candidate for a molecularmarker of the cloacal plate.2011
- Author(s)
  Suda H, Lee KJ, Semba K, et al
- Journal Title
  
  Pediatr SurgInt.
  
  Volume: 27 Pages: 269-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791388
[Journal Article] The floor plate is sufficient fordevelopment of the sclerotome and spinewithout the notochord.2011
- Author(s)
  Ando T, Semba K, et al.
- Journal Title
  
  Mech Dev
  
  Volume: 128 Pages: 129-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 椎間板線維輪細胞・髄核細胞のマーカー分子になり得るPax1・Sktの変性椎間板・発生異常椎間板における発現動態の解析2015
- Author(s)
  仙波圭
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山国際会議場
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] 発生期の脊索・中腎・総排泄腔でのPtf1a異所性発現が尾部退行症候群を発症させる2015
- Author(s)
  仙波圭
- Organizer
  第31回日本糖尿病・妊娠学会
- Place of Presentation
  リーガロイヤルホテル東京
- Year and Date
  2015-11-20
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] Ptf1a遺伝子の脊索細胞での異所性発現が脊椎欠損・椎間板変性を発症させる2015
- Author(s)
  仙波圭
- Organizer
  第88回日本整形外科学会総会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] 脊索欠損から椎間板変性を引き起こすPtf1a異所性発現の機能解析2014
- Author(s)
  仙波圭
- Organizer
  第27回日本軟骨代謝学会
- Place of Presentation
  京都府医師会館, 京都市
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth’s short tail mice.2013
- Author(s)
  Kei Semba
- Organizer
  The 26th annual Mouse Molecular Genetics meeting
- Place of Presentation
  Wellcome Trust Genome Campus, Cambridge, UK
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] 尾部退行症候群の疾患モデル動物であるDanforth’s short tail変異マウスの解析2013
- Author(s)
  仙波圭
- Organizer
  第60回日本実験動物学会
- Place of Presentation
  つくば国際会議場, つくば市
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] Caudal regression in Danforth'sshort tail is caused by the ectopicexpression of Ptf1a.2013
- Author(s)
  仙波圭
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば国際会議場(つくば市)
- Year and Date
  2013-05-15
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] Caudal regression in Danforth’s short tail is caused by the ectopic expression of Ptf1a induced by the insertion of a transposon.2013
- Author(s)
  Kei Semba
- Organizer
  The 27th International Mammalian Genome Conference
- Place of Presentation
  Colegio Fonseca, Salamanca, Spain
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] Danforth's short tail (Sd)マウスのゲノム変異と原因遺伝子領域の決定2012
- Author(s)
  仙波圭
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場(福岡市)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 仙椎形成異常の発生メカニズムに関する解析2011
- Author(s)
  仙波圭
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  ベイシア文化ホール(前橋市)
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 第2回DBELSワークショップ2011
- Author(s)
  仙波圭
- Organizer
  第2回DBELSワークショップ
- Place of Presentation
  雲仙観光ホテル(雲仙市)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 尾部退行症候群を示すDanforth's short tail (Sd)変異マウスの解析2011
- Author(s)
  仙波圭
- Organizer
  第2回 DBELS ワークショップ in 雲仙・普賢岳
- Place of Presentation
  雲仙観光ホテル(雲仙市
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 変性椎間板における Pax1 発現の検討2010
- Author(s)
  仙波圭、加齢
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 加齢、変性椎間板におけるPax1発現の検討2010
- Author(s)
  仙波圭
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 軟骨変性において軟骨細胞内の糖化最終産物は小胞体ストレスを惹起する2009
- Author(s)
  高田興志、廣瀬隼、仙波圭、山部聡一郎、水田博志
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-20591784
[Presentation] 糖化最終産物の軟骨細胞内蓄積は小胞体ストレスを誘導する2008
- Author(s)
  高田興志、水田博志、廣瀬隼、仙波圭
- Organizer
  第23回日本整形外科学会基礎学術集会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-20591784
[Presentation] 変性軟骨細胞内の小胞体ストレスに関する解析2007
- Author(s)
  仙波圭
- Organizer
  第22回日本整形外科学会基礎学術集会
- Place of Presentation
  浜松市
- Year and Date
  2007-10-26
- Data Source
  KAKENHI-PROJECT-18591667
[Presentation] Analyses of endoplasmic reticulum stress in chondrocytes of osteoarthritis2007
- Author(s)
  Semba, K
- Organizer
  The 22nd Annual Research Meeting of the Japanese Orthopaedic Association
- Place of Presentation
  Hamamatsu
- Year and Date
  2007-10-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591667
[Presentation] 変性軟骨細胞内の小胞体ストレスに関する解析2007
- Author(s)
  仙波圭(代表者)
- Organizer
  第22回日本整形外科学会基礎学術集会
- Place of Presentation
  浜松
- Year and Date
  2007-10-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591667
[Presentation] 変性軟骨細胞における蛋白分解システムの検討2007
- Author(s)
  仙波圭(代表者)
- Organizer
  第20回日本軟骨代謝学会
- Place of Presentation
  岡山
- Year and Date
  2007-03-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591667
[Presentation] Examination of protein degradation systems in chondrocytes of the osteoarthritis.2007
- Author(s)
  Semba, K
- Organizer
  The 20th Annual Meeting of the Japanese Society of Cartilage Metabolism
- Place of Presentation
  Okayama
- Year and Date
  2007-03-02
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591667
[Presentation] Danforth’s short tail (Sd)マウスのゲノム変異と原因遺伝子領域の決定
- Author(s)
  仙波圭
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市、福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] Caudal regression in Danforth’s short tail is caused by the ectopic expression of Ptf1a.
- Author(s)
  仙波圭
- Organizer
  第60回日本実験動物学会総会
- Place of Presentation
  つくば市、つくば国際会議場
- Data Source
  KAKENHI-PROJECT-22791388
[Presentation] 椎間板髄核細胞・線維輪細胞のマーカ分子になり得る Skt・Pax1 の加齢における発現動態の解析
- Author(s)
  仙波圭
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  東京医科歯科大学鈴木章夫記念講堂(東京都)
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] 軟骨細胞内のオートファジー発生とその病態解析
- Author(s)
  仙波圭
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島市城山観光ホテル(鹿児島市)
- Year and Date
  2014-10-09 – 2014-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-25670653
[Presentation] 椎間板変性モデルマウス(Danforth’s short tail)の発症原因の解明
- Author(s)
  仙波圭
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島市城山観光ホテル(鹿児島市)
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-25670653

1. MIZUTA Hiroshi (60174025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. ARAKI Kimi (90211705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. HIROSE Jun (40433007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. YAMAMURA Ken-ichi (90115197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAMURA Eiichi (70274719)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. HASHIMOTO Syuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 井本正哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 阿部訓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SENBA Kei 仙波 圭

Research Projects

Research Products

Co-Researchers

Establishment of chimeric mice having a primatized intervertebral discs and comprehensive research of the primatized intervertebral disc.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation for molecular etiology of Danforth's short tail (Sd)mutant, a caudal regression model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis and pathological role of endoplasmic reticulum stress in cartilage degeneration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of induction of autophagic response related to the chondrocyte cell-death in osteroarthritis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 脊椎 ・ 脊髄-up todate, 「脊椎と脊髄の発生」2012

Author(s)

Publisher

Data Source

[Book] 論文ができてしまう!疾患モデルマウス表現型解析指南,「脊椎」2011

Author(s)

Publisher

Data Source

[Journal Article] GNAS and Kras cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Etiology of caudal regression syndrome.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 脊椎・脊髄―up to date, 「脊椎と脊髄の発生」2012

Author(s)

Journal Title

Data Source

[Journal Article] Ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Skt gene, required for anorectaldevelopment, is a candidate for a molecularmarker of the cloacal plate.2011

Author(s)

Journal Title

Data Source

[Journal Article] The floor plate is sufficient fordevelopment of the sclerotome and spinewithout the notochord.2011

Author(s)

Journal Title

Data Source

[Presentation] 椎間板線維輪細胞・髄核細胞のマーカー分子になり得るPax1・Sktの変性椎間板・発生異常椎間板における発現動態の解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 発生期の脊索・中腎・総排泄腔でのPtf1a異所性発現が尾部退行症候群を発症させる2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

SENBA Kei 仙波圭

[Book] 脊椎・脊髄-up todate, 「脊椎と脊髄の発生」2012