HISAOKA Tomoko 久岡朋子

Researcher Number	00398463
Affiliation (Current)	2019: 和歌山県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2014 – 2018: 和歌山県立医科大学, 医学部, 助教 2007 – 2012: Wakayama Medical University, 医学部, 助教 2007: Wakayama Medical Univ., Medical School, Assistant Prof. 2005 – 2006: 和歌山県立医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Nerve anatomy/Neuropathology / Otorhinolaryngology / Cerebral neurosurgery / Orthopaedic surgery / Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator General anatomy (including Histology/Embryology) / General internal medicine(including psychosomatic medicine) / Nerve anatomy/Neuropathology / Applied health science / Metabolomics
Keywords	Principal Investigator サイトカイン / 自閉症スペクトラム障害 / 注意欠如・多動性障害 / 発生 / 脊髄 / 運動ニューロン / 転写因子 / 内耳 / 蝸牛 / アストロサイト … More Except Principal Investigator 脳 / 脳・神経 / 発生・分化 / 視床下部 / サイトカイン / TNF receptor superfamily / TROY / 細胞接着因子 / 免疫グロブリンスーパーファミリー / 神経細胞 / シナプス / 発現制御 / 細胞接着分子 / 組胞接着因子 / 神経発生 / シナプス形成 / 小脳 / 海馬 / 大脳皮質 / 嗅球 / Klotho / FGF23 / 絶食 / マウス / 神経幹細胞 / アストロサイト / 血液-脳関門 / 腫瘍壊死因子 / 受容体 / スーパーファミリー / 星状膠細胞 / 血管透過性 / 血液・脳関門 / cytokine / brain / mice / neural stem cells / astrocytes / blood-brain barrier / 糖尿病 / 非アルコール性脂肪肝 / 運動 / AFF4 / 転写因子 / FGF21 / メタボリック症候群 / 摂食調節 / 糖・脂質代謝 / エネルギー代謝 Less

ADHDを伴う自閉症の小脳シナプス病態の解明とそれに基づく治療法についての検討Principal InvestigatorOngoing
- Principal Investigator
  
  久岡朋子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Wakayama Medical University
Establishment and analysis of a mouse model of treatment-resistant autism comorbid with ADHDPrincipal Investigator
- Principal Investigator
  
  HISAOKA TOMOKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Wakayama Medical University
Role of exercise-induced oncostatin M in the treatment of NASH
- Principal Investigator
  
  Morikawa Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Wakayama Medical University
Roles of AFF4, a member of the AF4 family of transcription factors, in FGF21 resistance
- Principal Investigator
  
  Komori Tadasuke
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Wakayama Medical University
Role of alpha-Klotho, an anti-aging gene, and its ligand , FGF23, in the regulation of food intake in the hypothalamus
- Principal Investigator
  
  MORIKAWA Yoshihiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Wakayama Medical University
The role of TROY after the spinal cord injury and application ofTROY for the treatment of injuries of the central nervous system.Principal Investigator
- Principal Investigator
  
  HISAOKA Tomoko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Wakayama Medical University
The kirrel family regulates neural circuits formation and higher brain functions.
- Principal Investigator
  
  MORIKAWA Yoshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Wakayama Medical University
The role of orphan receptor, TROY, in the proliferation and differentiation of glioma stem cellsPrincipal Investigator
- Principal Investigator
  
  HISAOKA Tomoko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Wakayama Medical University
The role of TROY in inner ear developmentPrincipal Investigator
- Principal Investigator
  
  HISAOKA Tomoko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Wakayama Medical University
Roles of TROY in the development, differentiation and functions of astroglial lineage cells in the mouse brain
- Principal Investigator
  
  SENBA Emiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical University
フォークヘッド型転写因子Foxp1の神経系における役割の解析Principal Investigator
- Principal Investigator
  
  久岡朋子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Wakayama Medical University

All 2019 2018 2017 2016 2012 2011 2010 2007 2006 Other

All Journal Article Presentation

[Journal Article] Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice2018
- Author(s)
  Hisaoka T, Komori T, Kitamura T, Morikawa Y
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 1408-1408
- DOI
  10.1038/s41598-018-19844-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09873
[Journal Article] Characterization of TROY-expressing cells in the developing and postnatal CNS : the possible role in neuronal and glial cell development2006
- Author(s)
  Hisaoka T, Morikawa Y, Komori T, Sugiyama T, Kitamura T, Senba, E
- Journal Title
  
  Eur. J. Neurosci 23(12)
  
  Pages: 3149-3160
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Journal Article] Characterization of TROY-expressing cells in the developing and postnatal CNS:the possible role in neuronal and glial cell development2006
- Author(s)
  Hisaoka T, et. al.
- Journal Title
  
  European Journal of Neuroscience 23(12)
  
  Pages: 3149-3160
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300116
[Journal Article] Characterization of TROY/ TNFRSF 19/TAJ-expressing cells in the adult mouse forebrain2006
- Author(s)
  Hisaoka T, Morikawa Y, Senba, E
- Journal Title
  
  Brain Res 1110(1)
  
  Pages: 81-94
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Journal Article] Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain2006
- Author(s)
  Hisaoka T, et. al.
- Journal Title
  
  Brain Research 1110(1)
  
  Pages: 81-94
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300116
[Journal Article] Novel tumor ncrosis factor receptor superfamily(TNFRSF), TROY, in the central nervous system2006
- Author(s)
  Morikawa Y, Hisaoka T, Kitamura T, Senba, E
- Journal Title
  
  Ann NY Acad Sci 1088
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Journal Article] Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain.2006
- Author(s)
  Hisaoka T, Morikawa Y, Senba E
- Journal Title
  
  Brain Research 1110・1
  
  Pages: 81-94
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] 自閉症関連遺伝子Kirrel3の小脳における発現と小脳ピンスー構造形成における役割2019
- Author(s)
  久岡朋子、小森忠祐、北村俊雄、森川吉博
- Organizer
  第124回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-18K07610
[Presentation] Abnormal synapse formation of cerebellar pinceau in Kirrel3-knockout mice2018
- Author(s)
  Tomoko Hisaoka, Tadasuke Komori, Toshio Kitamura, Yoshihiro Morikawa
- Organizer
  48th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07610
[Presentation] シナプス形成期の脳におけるKirrel3の発現とその欠損マウスにおける発達期のコミュニケーション異常2018
- Author(s)
  久岡朋子、小森忠祐、北村俊雄、森川吉博
- Organizer
  第１２３回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] Abnormal organization of pinceau in the cerebellum of Kirrel3-deficient mice2018
- Author(s)
  Tomoko Hisaoka, Tadasuke Komori, Toshio Kitamura, Yoshihiro Morikawa
- Organizer
  第61回日本神経化学会大会・第40回日本生物学的精神医学会合同年会
- Data Source
  KAKENHI-PROJECT-18K07610
[Presentation] Autistic-like behaviors in postnatal and adult Kirrel3-knockout mice2018
- Author(s)
  Yoshihiro Morikawa, Tomoko Hisaoka, Tadasuke Komori, Toshio Kitamura
- Organizer
  48th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07610
[Presentation] Characterization of Kirrel3-expressing cells in the mouse substantia nigra and ventral tegmental area2018
- Author(s)
  Yuki Shikaze, Tadasuke Komori, Tomoko Hisaoka, Toshio Kitamura, Yoshihiro Morikawa
- Organizer
  48th Annual Meeting of Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07610
[Presentation] 脳におけるkirrel3の局在とその欠損による行動異常2017
- Author(s)
  久岡朋子、小森忠祐、形部裕昭、北村俊雄、森川吉博
- Organizer
  第122回日本解剖学会
- Place of Presentation
  長崎大学坂本キャンパス(長崎県、長崎市)
- Year and Date
  2017-03-30
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] Further characterization of autistic-like behaviors in kirrel3-knockout mice2017
- Author(s)
  Hisaoka T, Komori T, Gyobu H, Kitamura T, Morikawa Y
- Organizer
  第６０回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] Deficiency of kirrel3, a synaptic cell adhesion molecule, results in behaviors relevant to ASD with ADHD2017
- Author(s)
  Tomoko Hisaoka, Tadasuke Komori, Hiroaki Gyobu, Toshio Kitamura, Yoshihiro Morikawa
- Organizer
  A Keystone Symposium (Synapses and Circuits joint with the conference on Connectomics))
- Place of Presentation
  Santa Fe, New Mexico, USA
- Year and Date
  2017-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] kirrel3遺伝子欠損マウスは注意欠陥・多動性障害(ADHD)を伴う自閉症様行動を示す2016
- Author(s)
  久岡朋子、小森忠祐、形部裕昭、北村俊雄、森川吉博
- Organizer
  第59回日本神経化学会大会（第38回日本生物学的精神医学会との合同大会）
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] Autistic-like behaviors with hyperactivity in mice lacking kirrel32016
- Author(s)
  Tomoko Hisaoka, Tadasuke Komori, Hiroaki Gyobu, Toshio Kitamura, Yoshihiro Morikawa
- Organizer
  The 46th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09873
[Presentation] マウスの中枢神経系におけるkirrel3の時空間的発現解析2012
- Author(s)
  久岡朋子、形部裕昭、藤本幸太、北村俊雄、仙波恵美子、森川吉博
- Organizer
  第117回解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス(山梨県)
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 成獣、及び発達過程のマウス後根神経節におけるkirrel3の発現パターンの解析2012
- Author(s)
  森川吉博、形部裕昭、久岡朋子、小森忠祐、北村俊雄、仙波恵美子
- Organizer
  第117回解剖学会総会
- Place of Presentation
  甲府
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] マウスの中枢神経系におけるkirrel3の時空間的発現解析2012
- Author(s)
  久岡朋子、形部裕昭、藤本幸太、北村俊雄、仙波恵美子、森川吉博
- Organizer
  第117回解剖学会総会
- Place of Presentation
  甲府
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 成獣、及び発達過程のマウス後根神経節におけるkirrel3の発現パターンの解析2012
- Author(s)
  森川吉博、形部裕昭、久岡朋子、小森忠祐、北村俊雄、仙波恵美子
- Organizer
  第117回解剖学会総会・全国学術集会
- Place of Presentation
  山梨大学甲府キャンパス(山梨県)
- Year and Date
  2012-03-26
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] Developmental expression pattern of kirrel3 in the hippocampus2012
- Author(s)
  久岡朋子、形部裕昭、小森忠祐、板東高功、北村俊雄、仙波恵美子、森川吉博
- Organizer
  第55回日本神経化学会・第11回アジア・太平洋神経化学合同大会
- Place of Presentation
  神戸
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 発達過程の海馬歯状回におけるkirrel3発現細胞の同定2012
- Author(s)
  久岡朋子、小森忠祐、北村俊雄、仙波恵美子、森川吉博
- Organizer
  第118回解剖学会総会
- Place of Presentation
  高松
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 成獣マウスの中枢神経系におけるkirrel3の発現パターン2011
- Author(s)
  久岡朋子、形部裕昭、小森忠祐、藤本幸太、北村俊雄、仙波恵美子、森川吉博
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 発達過程の後根神経節におけるkirrel3の発現2011
- Author(s)
  森川吉博、形部裕昭、久岡朋子、小森忠祐、北村俊雄、仙波恵美子
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 成獣マウスの中枢神経系におけるkirrel3発現細胞の詳細な解析2011
- Author(s)
  久岡朋子、森川吉博、小森忠祐、北村俊雄、仙波恵美子
- Organizer
  第116回解剖学会総会・全国学術集会
- Place of Presentation
  Journal of Physiological Science(紙上開催(震災のため))
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 成獣マウスの中枢神経系におけるkirrel3発現細胞の詳細な解析2011
- Author(s)
  久岡朋子、森川吉博、小森忠祐、北村俊雄、仙波恵美子
- Organizer
  第116回解剖学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] Identification of Kirrel3-expressing cells in the central nervous system of adult mice.2010
- Author(s)
  Hisaoka T, Komori T, Kitamura T, Senba E, Morikawa Y
- Organizer
  40th Annual Meeting of Society for Neuroscience.
- Place of Presentation
  米国サンディエゴ
- Year and Date
  2010-11-13
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] Identification of Kirrel3-expressing cells in the central nervous system of adult mice2010
- Author(s)
  Hisaoka T, Komori T, Kitamura T, Senba E, Morikawa Y
- Organizer
  40th Annual Meeting of Society for Neuroscience
- Place of Presentation
  San Diego, CA
- Year and Date
  2010-11-06
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] マウス中枢神経発生過程におけるアストロサイトへの分化とTROYシグナリング2007
- Author(s)
  森川吉博, 仙波恵美子, 久岡朋子, 小森忠祐
- Organizer
  第9回ORIGIN神経科学研究会夏のワークショップ
- Place of Presentation
  浜松
- Year and Date
  2007-09-01
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] 発達過程の中枢神経系におけるTROYの役割2007
- Author(s)
  久岡朋子, 森川吉博, 小森忠祐, 仙波恵美子
- Organizer
  第44回日本臨床分子医学会学術集会
- Place of Presentation
  和歌山
- Year and Date
  2007-07-20
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] 発達過程の中枢神経系におけるTROYの役割2007
- Author(s)
  久岡朋子, ら
- Organizer
  第44回日本臨床分子医学会学術集会
- Place of Presentation
  和歌山市、和歌山県
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] Negative regulation of neuronal differentiation through TROY signaling2006
- Author(s)
  T. Hisaoka, Y. Morikawa, T. Komori, T. Kitamura, E. Senba
- Organizer
  36th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Atlanta, GA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] Negative regulation of neuronal differentiation through TROY signaling2006
- Author(s)
  Hisaoka T, et. al.
- Organizer
  36th Annual Meeting of Society for Neuroscience
- Place of Presentation
  Atlanta,GA,U.S.A.
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] Expression of TROY/TNFRSF19 in the specific subsets of neural stem/precursor cells in the subventricular zone of adult mouse brain2006
- Author(s)
  T. Hisaoka, Y. Morikawa, T. Bando, E. Senba
- Organizer
  A Keystone Symposium
- Place of Presentation
  Whistler, Canada
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] The role of TROY in the development of the nervous system2006
- Author(s)
  久岡朋子, ら
- Organizer
  第49回日本神経化学大会
- Place of Presentation
  名古屋市、愛知県
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18300116
[Presentation] 発達過程の海馬歯状回におけるkirrel3発現細胞の同定
- Author(s)
  久岡朋子
- Organizer
  第１１８回解剖学会総会・全国学術集会
- Place of Presentation
  高松
- Data Source
  KAKENHI-PROJECT-22390036
[Presentation] 発達過程、及び成獣マウスの海馬におけるkirrel3の発現解析
- Author(s)
  久岡朋子
- Organizer
  第８０回和歌山医学会総会
- Place of Presentation
  和歌山
- Data Source
  KAKENHI-PROJECT-22390036

1. MORIKAWA Yoshihiro (60230108)

# of Collaborated Projects: 6 results

# of Collaborated Products: 27 results
2. KOMORI Tadasuke (90433359)

# of Collaborated Projects: 5 results

# of Collaborated Products: 17 results
3. KITAMURA Toshio (20282527)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
4. BANDO Takayoshi (00423963)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. FURUTA HIROTO (90238684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SENBA Emiko (00135691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. MIYAJIMA ATSUSHI (50135232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. GYOBU HIROAKI

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HISAOKA Tomoko 久岡 朋子

Research Projects

Research Products

Co-Researchers

ADHDを伴う自閉症の小脳シナプス病態の解明とそれに基づく治療法についての検討Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment and analysis of a mouse model of treatment-resistant autism comorbid with ADHDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Role of exercise-induced oncostatin M in the treatment of NASH

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Roles of AFF4, a member of the AF4 family of transcription factors, in FGF21 resistance

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Role of alpha-Klotho, an anti-aging gene, and its ligand , FGF23, in the regulation of food intake in the hypothalamus

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The role of TROY after the spinal cord injury and application ofTROY for the treatment of injuries of the central nervous system.Principal Investigator

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The kirrel family regulates neural circuits formation and higher brain functions.

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The role of orphan receptor, TROY, in the proliferation and differentiation of glioma stem cellsPrincipal Investigator

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The role of TROY in inner ear developmentPrincipal Investigator

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Roles of TROY in the development, differentiation and functions of astroglial lineage cells in the mouse brain

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フォークヘッド型転写因子Foxp1の神経系における役割の解析Principal Investigator

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[Journal Article] Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice2018

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[Journal Article] Characterization of TROY-expressing cells in the developing and postnatal CNS : the possible role in neuronal and glial cell development2006

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HISAOKA Tomoko 久岡朋子