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MARUYAMA MASATO  丸山 正人

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Maruyama Masato  丸山 正人

MARUYAMA Masato  丸山 正人

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Researcher Number 00399445
Other IDs
Affiliation (Current) 2025: 岡山大学, 医歯薬学域, 准教授
Affiliation (based on the past Project Information) *help 2021 – 2023: 岡山大学, 医歯薬学域, 准教授
2022: 岡山大学, 医歯薬学総合研究科, 准教授
2019 – 2020: 岡山大学, 医歯薬学総合研究科, 准教授
2017 – 2018: 関西医科大学, 医学部, 講師
2011 – 2015: 関西医科大学, 医学部, 講師
2008 – 2010: Kansai Medical University, 医学部, 助教
2005 – 2008: 独立行政法人理化学研究所, 辻本細胞生化学研究室, 協力研究員
Review Section/Research Field
Principal Investigator
Biological pharmacy / Basic Section 47060:Clinical pharmacy-related / Tumor biology / Physical pharmacy
Except Principal Investigator
Basic Section 47060:Clinical pharmacy-related / Chemical biology / Biological pharmacy
Keywords
Principal Investigator
がん幹細胞 / CD44 / 乳がん / グリオーマ / シグナル伝達 / 転移 / 薬物送達 / 血管正常化 / トリプルネガティブ乳がん / 薬物送達法 … More / ALDH1A1 / CD44変異体 / スフェア培養 / 腫瘍微小環境 / 分泌タンパク質 / グリオーマ癌幹細胞 / Crispr/Cas9 / microseminoprotein / MSMP / スフェロイド / 遺伝子発現解析 / 癌幹細胞 / トランスポゾン / 人工多能性幹細 / 分化 / 神経幹細胞 / iPS細胞 / 胎盤形成 / M1アミノペプチダーゼ / エキソペプチダーゼモチーフ / 絨毛外栄養膜細胞 / Laeverin / GFP / アンギオテンシンIV受容体 / 細胞膜移行 / アンギオテンシンIV / サブスタンスP / 胎盤性ロイシンアミノペプチダーゼ … More
Except Principal Investigator
消化管内移行性 / 腸神経系 / 消化管吸収 / セロトニン / 受動拡散 / アルカリフォスファターゼ / タンパク発現 / PEPT1 / 尿細管再吸収 / Western blot / 刷子縁膜 / PEPT2 / 滞留性 / gastrointestinal transit / Cephalexin / 共培養系 / 腸神経細胞 / 分布容積 / 血漿蛋白結合 / α1-acid glycoprotein / Quinidine / P-glycoprotein / セロトニン代謝異常 / FITC-dextran-4 / antipyrine / TEER / paracellular route / transcellular route / clorgyline / Caco-2細胞 / 慢性的セロトニン暴露 / activety-based probe / プロテオミクス解析 / アクティビティーベースドプローブ / プロテアーゼ / ユビキチン様ドメイン / プローブ / 酸化ストレス / 活性制御 / activity-based probe / 脱ユビキチン化酵素 / ユビキチン / アンギオテンシンIV / 立体構造解析 / 胎盤性ロイシンアミノペプチダーゼ / 白血球由来アルギニンアミノペップチダーゼ / アミノペプチダーゼA / リーベリン / 白血球由来アルギニンアミノペプチダーゼ / 脂肪細胞由来ロイシンアミノペプチダーゼ / オキシトシナーゼサブファミリー / 一塩基多型 / 基質特異性 / アミノペプチダーゼ Less
  • Research Projects

    (10 results)
  • Research Products

    (31 results)
  • Co-Researchers

    (18 People)
  •  乳がんの増殖・転移を抑制可能な新規がん幹細胞標的療法の確立Principal Investigator

    • Principal Investigator
      丸山 正人
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Establishment of a novel drug delivery system for targeting cancer stem cells based on the structual analysis of tumor blood vesseles.Principal Investigator

    • Principal Investigator
      Maruyama Masato
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Effect of ENS dysfunction on drug absorption from small intestine

    • Principal Investigator
      檜垣 和孝
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Okayama University
  •  Funcional analysis of a novel biomarker specifically expressed in glioma stem cell.Principal Investigator

    • Principal Investigator
      Maruyama Masato
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor biology
    • Research Institution
      Okayama University
      Kansai Medical University
  •  Novel therapeutic strategy for glioma by construction of glioma stem cell specific gene expression system.Principal Investigator

    • Principal Investigator
      MARUYAMA Masato
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Kansai Medical University
  •  Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics

    • Principal Investigator
      HATTORI Akira
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical biology
    • Research Institution
      Kyoto University
  •  iPS cell-based regeneration therapy for Alzheimer's disease.Principal Investigator

    • Principal Investigator
      MARUYAMA Masato
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kansai Medical University
  •  Elucidation of physiological role of Laeverin, a novel aminopeptidase.Principal Investigator

    • Principal Investigator
      MARUYAMA Masato
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Kansai Medical University
  •  Mechanisms of Enzymatic Action of the Oxytocinase Subfamily of Aminopeptidases

    • Principal Investigator
      TSUJIMOTO Masafumi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research
  •  アンギオテンシンIV受容体の細胞内ダイナミクスとその分子機構の解明Principal Investigator

    • Principal Investigator
      丸山 正人
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research

All 2023 2022 2020 2018 2017 2013 2012 2011 2009 2008 2007 2006

All Journal Article Presentation Book

  • [Book] Aminopeptidase Q/Laeverin in Handbook of Proteolytic Enzymes 3rd ed2013

    • Author(s)
      Hattori A, Maruyama M, Fujiwara H, & Tsujimoto M
    • Data Source
      KAKENHI-PROJECT-23310160
  • [Journal Article] Possible Regulation of P-Glycoprotein Function by Adrenergic Agonists II: Study with Isolated Rat Jejunal Sheets and Caco-2 Cell monolayers2023

    • Author(s)
      Mukai Hironori、Takanashi Masashi、Ogawara Ken-ichi、Maruyama Masato、Higaki Kazutaka
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: accepted Issue: 5 Pages: 1209-1219

    • DOI

      10.1016/j.xphs.2023.11.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Establishment of a novel co-culture system of enteric neurons and Caco-2 cells for evaluating the effect of enteric nervous system on transepithelial transport of drugs2023

    • Author(s)
      Masato Maruyama, Minami Yoshikata, Mana Sakaguchi, Shizuka Wakushima, Kazutaka Higaki
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 633 Pages: 122617-122617

    • DOI

      10.1016/j.ijpharm.2023.122617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Effect of excessive serotonin on pharmacokinetics of cephalexin after oral administration: Studies with serotonin-excessive model rats2022

    • Author(s)
      Shun Nakashima, Takeharu Iwamoto, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Pharmaceutical Research

      Volume: 39 Issue: 9 Pages: 2163-2178

    • DOI

      10.1007/s11095-022-03325-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] Possible regulation of P-glycoprotein function by adrenergic agonists in a vascular-luminal perfused preparation of small intestine.2022

    • Author(s)
      Hironori Mukai, Masashi Takanashi, Ken-ichi Ogawara, Masato Maruyama, Kazutaka Higaki
    • Journal Title

      Journal of Pharmaceutical Sciences

      Volume: 110 Issue: 12 Pages: 3889-3895

    • DOI

      10.1016/j.xphs.2021.09.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K07176
  • [Journal Article] ICOSLG-mediated regulatory T cell expansion and IL-10 production promote progression of glioblastoma2020

    • Author(s)
      Iwata Ryoichi、Lee Joo Hyoung、Hayashi Mikio、Dianzani Umberto、Ofune Kohei、Maruyama Masato、Oe Souichi、Ito Tomoki、Hashiba Tetsuo、Yoshimura Kunikazu、Nonaka Masahiro、Nakano Yosuke、Norian Lyse、Nakano Ichiro、Asai Akio
    • Journal Title

      Neuro-Oncology

      Volume: 22 Pages: 333-344

    • DOI

      10.1093/neuonc/noz204

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08983, KAKENHI-PROJECT-19K18408, KAKENHI-PROJECT-17K07183, KAKENHI-PROJECT-20K09400
  • [Journal Article] Laeverin/amino peptidase Q induces trophoblast invasion during human early placentation2012

    • Author(s)
      Horie A, Fujiwara H, Sato Y, Suginami K, Matsumoto H, Maruyama M, Konishi I, Hattori A.
    • Journal Title

      Hum Reprod

      Volume: 27 Issue: 5 Pages: 1267-76

    • DOI

      10.1093/humrep/des068

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390452, KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24592470, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-24659730, KAKENHI-PUBLICLY-23133504
  • [Journal Article] Histidine 379 of Human Laeverin/AminopeptidaseQ, a Nonconserved Residue within the Exopeptidase Motif, Defines Its Distinctive Enzymatic Properties2009

    • Author(s)
      Masato Maruyama
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 34692-34702

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790088
  • [Journal Article] Histidine 379 of Human Laeverin/AminopeptidaseQ, a Nonconserved Residue within the Exopeptidase Motif, Defines Its Distinctive Enzymatic Properties2009

    • Author(s)
      Masato Maruyama, Naomi Arisaka, Yoshikuni Goto, Yosuke Ohsawa, Hideshi Inoue, Hiroshi Fujiwara, Akira Hattori, Masafumi Tsujimoto
    • Journal Title

      The Journal of Biological Chemistry vol.284

      Pages: 34692-34702

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790088
  • [Journal Article] Biochemical and enzymatic properties of M1 family of aminopeptidases involved in the regulation of blood pressure2008

    • Author(s)
      Tsujimoto, M., Goto, Y., Maruyama, M. and Hattori, A.
    • Journal Title

      Heart Fail. Rev. 13

      Pages: 285-291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Journal Article] Laeverin/aminopeptidase Q,a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases2007

    • Author(s)
      Masato Maruyama
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 20088-20096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Journal Article] Laeverin/aminopeptidase Q, a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopsptidases2007

    • Author(s)
      Maruyama, M., Hattori, A., Goto, Y., Ueda, M., Maeda, M., Fujiwara, H. and Tsujimoto, M.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 20088-20096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] マウス乳がん4T1細胞より樹立したがん幹細胞様細胞の特性解析2023

    • Author(s)
      丸山 正人、瀬口 実穂、吉富 健人、檜垣 和孝
    • Organizer
      第39回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-23K06211
  • [Presentation] マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究2022

    • Author(s)
      瀬口 実穂、丸山 正人、檜垣 和孝
    • Organizer
      第38回 日本DDS学会
    • Data Source
      KAKENHI-PROJECT-20K07155
  • [Presentation] マウス乳がん由来4T1細胞におけるがん幹細胞様のモデル細胞株樹立に関する研究2022

    • Author(s)
      瀬口 実穂、丸山 正人、檜垣 和孝
    • Organizer
      第38回日本DDS学会
    • Data Source
      KAKENHI-PROJECT-20K07155
  • [Presentation] ヒトグリオブラストーマU87MG細胞から樹立した癌幹細胞様細胞に高発現する遺伝子の探索2018

    • Author(s)
      丸山正人, 中野洋輔, 岩田亮一, 西村拓也, 加瀬政彦, 杉本哲夫
    • Organizer
      日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-17K07183
  • [Presentation] ヒト神経膠芽腫由来U87MG細胞から樹立した高い腫瘍形成能を持つスフェロイドはPC3-Secreted Microprotein を高発現する2017

    • Author(s)
      丸山 正人, 中野 洋輔, 岩田 亮一, 西村 拓也, 加瀬 政彦, 杉本 哲夫
    • Organizer
      生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-17K07183
  • [Presentation] 薬剤耐性を利用したマウスiPS細胞由来神経幹細胞の純化2011

    • Author(s)
      丸山正人
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22790092
  • [Presentation] 薬剤耐性を利用したマウスiPS細胞由来神経幹細胞の純化2011

    • Author(s)
      丸山正人, 山下雄司, トリフォノフステファン, 加瀬政彦, 清水順一, 杉本哲夫
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-17
    • Data Source
      KAKENHI-PROJECT-22790092
  • [Presentation] 薬剤選択によるマウスiPS細胞由来神経幹細胞の純化2011

    • Author(s)
      丸山正人
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22790092
  • [Presentation] 薬剤選択によるマウスiPS細胞由来神経幹細胞の純化2011

    • Author(s)
      丸山正人, 山下雄司, トリフォノフステファン, 加瀬政彦, 杉本哲夫
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22790092
  • [Presentation] Histidine-379 of human laeverin/aminopeptidase Q, a non-conserved residue within the exopeptidase motif, defines its distinctive enzymatic properties2009

    • Author(s)
      Hattori A, Maruyama M, Arisaka N, Goto Y, Osawa Y, Inoue H, Fujiwara H, Tsujimoto M
    • Organizer
      6th General Meeting of the International Proteolysis Society
    • Place of Presentation
      Surfers Paradise, Australia
    • Data Source
      KAKENHI-PROJECT-20790088
  • [Presentation] ヒトLaeverin/Aminopeptidase QのHis379残基の機能解析2008

    • Author(s)
      丸山 正人
    • Organizer
      日本薬学会128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] 点変異導入によるヒトLaeverinのHis379残基の機能解析2008

    • Author(s)
      有坂尚美, 丸山正人, 服部明, 辻本雅文
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-20790088
  • [Presentation] 点変異導入によるヒトlaeverinのHis379残基の機能解明2008

    • Author(s)
      有坂尚美、丸山正人、服部 明、辻本雅文
    • Organizer
      第31回日本分子生物学会年会/第81回日本生化学会大会 (BMB2008)
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] Laeverin/aminopeptidase Q: a novel bestatin sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases2007

    • Author(s)
      Maruyama, M., Hattori, A, Goto, Y. Ueda, M. Maeda, M. Fujiwara, H. and Tsujimoto, M.
    • Organizer
      5th General Meeting of the International Proteolysis Society
    • Place of Presentation
      Patras, Greece
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] Laeverin/aminopeptidase Q:a novel bestatin sensitive leucine aminopept idase belonging to the M1 family of aminopeptidases2007

    • Author(s)
      Masato Maruyama
    • Organizer
      5th General meeting of the international proteolysis society
    • Place of Presentation
      ギリシャ
    • Year and Date
      2007-10-23
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] 新規アミノペプチダーゼLaeverinの酵素学的性状の解析2007

    • Author(s)
      丸山 正人
    • Organizer
      第30回日本分子生物学会年会・第80回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-14
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] 新規アミノペプチダーゼLaeverinの酵素学的性状の解析2007

    • Author(s)
      丸山正人、服部 明、後藤芳邦、藤原 浩、辻本雅文
    • Organizer
      第12回病態と治療におけるプロテアーゼとインヒビター研究会
    • Place of Presentation
      吹田
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] 新規アミノペプチダーゼLaeverinの酵素学的性状の解析2007

    • Author(s)
      丸山 正人
    • Organizer
      第12回病態と治療におけるプロテアーゼとインヒビター研究会
    • Place of Presentation
      大阪
    • Year and Date
      2007-08-03
    • Data Source
      KAKENHI-PROJECT-18390031
  • [Presentation] 神経細胞における胎盤性ロイシンアミノペプチダーゼの細胞膜移行誘導メカニズムの解明2006

    • Author(s)
      丸山正人、服部 明、辻本雅文
    • Organizer
      第11回病態と治療におけるプロテアーゼとインヒビター研究会
    • Place of Presentation
      仙台
    • Data Source
      KAKENHI-PROJECT-18390031
  • 1.  檜垣 和孝 (60284080)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  HATTORI Akira (50300893)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 3.  TSUJIMOTO Masafumi (00281668)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 4.  GOTO Yoshikuni (90455345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 5.  OISHI Shinya (80381739)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  FUJIWARA Hiroshi (30252456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  INOUE Hideshi (20184765)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NISHIMURA Shinichi (30415260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KASE Masahiko (10309221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  TRIFONOV Stefan (30598173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SAKURAI Fuminori (70370939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  中野 洋輔 (40776530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 13.  岩田 亮一 (60580446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 14.  大河原 賢一 (30291470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 15.  HIGAKI Kazutaka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results
  • 16.  ITO Tomoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  小西 郁生
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    # of Collaborated Products: 1 results
  • 18.  浅井 昭雄
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    # of Collaborated Products: 1 results

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