Takahashi Tsutomu 高橋勉

… Alternative Names

高橋勉タカハシツトム

TAKAHASHI Tsutomu 高橋勉

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Researcher Number	00400474
Other IDs
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 東京薬科大学, 薬学部, 講師 2023: 東京薬科大学, 薬学部, 講師 2015 – 2019: 東京薬科大学, 薬学部, 講師 2015: 東北大学, 大学院薬学研究科, 助教 2011 – 2014: 東北大学, 薬学研究科(研究院), 助教 2007 – 2012: Tohoku University, 大学院・薬学研究科, 助教 2006: 東北大学, 大学院・薬学研究科, リサーチレジデント
Review Section/Research Field	Principal Investigator Medical pharmacy / Environmental and hygienic pharmacy / Basic Section 63030:Chemical substance influence on environment-related Except Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Environmental and hygienic pharmacy / Risk sciences of radiation and chemicals / Environmental pharmacy / Risk sciences of radiation/Chemicals
Keywords	Principal Investigator 遺伝子 / 転写因子 / 癌 / エンドサイトーシス / 制がん剤 / 毒性 / 環境汚染物質 / 環境 / リボース－5－リン酸 / リボース-5-リン酸 … More / ヒ素 / リボース / ペントースリン酸経路 / がん / 亜ヒ酸 / セクレトグロビン / メチル水銀 / 細胞内小胞輸送経路 / siRNA / テーラーメイド医療 / 制癌剤 … More Except Principal Investigator メチル水銀 / ヒ素 / 血管内皮細胞 / ユビキチン・プロテアソームシステム / 血管毒性 / 血液凝固線溶系 / 動脈硬化症 / 血管周囲脂肪組織 / 環境毒性学 / 鉛 / 細胞防御因子 / 増殖因子 / カドミウム / 重金属 / 動脈硬化 / ヌクレオリン / 毒性 / オートファジー / ユビキチンプロテアソームシステム / 感受性決定因子 / プロテアソーム / ユビキチン / 培養細胞 / 毒性軽減機構 / 毒性増強機構 / 細胞毒性 / ピルビン酸 / 脱ユビキチン化酵素 / 毒性発現調節 / トキシコロジー Less

ヒ素によるAGEs受容体シグナルを介した血管障害メカニズムの解明Principal Investigator
- Principal Investigator
  
  高橋勉
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
血管周囲脂肪組織に着目したヒ素の血管毒性発現機構の解明
- Principal Investigator
  
  藤原泰之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
Role of pentose phosphate pathway in arsenite toxicityPrincipal Investigator
- Principal Investigator
  
  Tsutomu Takahashi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Mechanisms of vascular disease caused by cadmium and lead mediated by multifunctional protein nucleolin.
- Principal Investigator
  
  Fujiwara Yasuyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
Involvement of brain-specific induction of secretoglobin expression in methylmercury toxicityPrincipal Investigator
- Principal Investigator
  
  Takahashi Tsutomu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Tohoku University
Mechanism underlying the reduction of methylmercury toxicity by Ragulator complex which is an autophagy regulator
- Principal Investigator
  
  HWANG Gi-Wook
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tohoku University
Explanation of the mechanism that influence the cell sensitivity to the toxicity of methylmercury
- Principal Investigator
  
  NAGANUMA AKIRA
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Tohoku University
Involvement of intracellular vesicular trafficking in toxicity of anticancer drugsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Tsutomu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Studies on mechanism of adriamycin resistance induced by inhibition of endocytosisPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Tsutomu
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University
Cellular Systems Involved in Development and Regulation of Toxicity of Methylmercury
- Principal Investigator
  
  NAGANUMA Akira
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
siRNAライブラリーを用いた制癌剤感受性決定因子の網羅的検索とその作用機構解析Principal Investigator
- Principal Investigator
  
  高橋勉
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Tohoku University

[Journal Article] Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells2020
- Author(s)
  Takahashi T., Nakano T., Katoh G., Shinoda Y., Yamamoto C., Yoshida E., Kaji T., Fujiwara Y.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 4 Pages: 237-243
- DOI
  10.2131/jts.45.237
- NAID
  130007825358
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08391
[Journal Article] Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells2020
- Author(s)
  Wu D., Nakano T., Tsuneoka Y., Takahashi T., Shinoda Y., Kaji T., Fujiwara Y.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 7 Pages: 77-83
- NAID
  130007805132
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08391
[Journal Article] Identification of transcription factors activated by methylmercury in mouse brain2017
- Author(s)
  Kim M.S., Takahashi T., Lee J.Y., Miura N., Asanuma M., Hwang G.W., Naganuma A
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 4 Pages: 37-39
- NAID
  130005244551
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460170
[Journal Article] Whi2 enhances methylmercury toxicity in yeast via inhibition of Akr1 palmitoyltransferase activity2016
- Author(s)
  Hwang G.W., Fukumitsu T., Ogiwara Y., Takahashi T., Miura, N., Kuge S. and Naganuma A.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1860 Issue: 6 Pages: 1326-1333
- DOI
  10.1016/j.bbagen.2016.03.026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
[Journal Article] Transport of pyruvate into mitochondria is involved in methylmercury toxicity2016
- Author(s)
  Lee J.Y., Ishida Y., Takahashia T., Naganuma A. and Hwang G.W.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 21518-21528
- DOI
  10.1038/srep21518
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25281023, KAKENHI-PROJECT-15H05714
[Journal Article] Methylmercury induces expression of interleukin-1βand interleukin-19 in mice brains2015
- Author(s)
  Takahashi T., Iwai-Shimada M., Syakushi Y., Kim M. S., Hwang G. W., Miura N., Naganuma A.
- Journal Title
  
  Fundamental Toxicological Sciences
  
  Volume: 2 Pages: 239-243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460170
[Journal Article] The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity2014
- Author(s)
  Hwang G.W., Murai Y., Takahashi T., Naganuma A.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5888-5888
- DOI
  10.1038/srep05888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
[Journal Article] CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells2014
- Author(s)
  Du K., Takahashi T., Iwai-Shimada M., Miura N., Naganuma A., Hwang G.W.
- Journal Title
  
  Fundam. Toxicol. Sci.
  
  Volume: 1 Pages: 161-164
- NAID
  130005083345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Changes in the levels of low molecular weight metabolites in the mouse cerebellum following treatment with methylmercury2013
- Author(s)
  Hwang GW1, Lee JY, Kim MS, Sato M, Takahashi T, Naganuma A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 5 Pages: 703-706
- DOI
  10.2131/jts.38.703
- NAID
  10031191729
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008, KAKENHI-PROJECT-25281023
[Journal Article] Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells2013
- Author(s)
  Nakano R, Takahashi T, Naganuma A, Hwang GW
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 6 Pages: 821-822
- DOI
  10.2131/jts.38.821
- NAID
  130004447084
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] A Screen for Genes Involved in Adriamycin Resistance in <i>Saccharomyces cerevisiae</i>2013
- Author(s)
  Takahashi T
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 133 Issue: 3 Pages: 393-396
- DOI
  10.1248/yakushi.12-00279
- NAID
  130003361930
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2013-03-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790171
[Journal Article] Brain-specific induction of secretoglobin 3A1 expression in mice treated with methylmercury2013
- Author(s)
  Takahashi T, Kim MS, Saito T, Lee JY, Hwang GW, Naganuma A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 6 Pages: 963-965
- DOI
  10.2131/jts.38.963
- NAID
  130004447101
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL42013
- Author(s)
  Kim MS, Takahashi T, Lee JY, Hwang GW, Naganuma A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 6 Pages: 925-929
- DOI
  10.2131/jts.38.925
- NAID
  130004447096
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Deletion of the ubiquitin-conjugating enzyme Ubc2 confers resistance to methylmercury in budding yeast by promoting Whi2 degradation2013
- Author(s)
  Hwang GW, Mastuyama F, Takahashi T, Lee JY, Naganuma A
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 38 Issue: 2 Pages: 301-303
- DOI
  10.2131/jts.38.301
- NAID
  10031151434
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249008
[Journal Article] Studies on molecular mechanism of toxicity of anticancer drags2011
- Author(s)
  Takahashi T.
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131(3) Pages: 355-358
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790138
[Journal Article] siRNA-mediated silencing of the gene for heat shock transcription factor 1 causes hypersensitivity to methylmercury in HEK293 cells2011
- Author(s)
  Hwang, G. W., Ryoke, K., Lee, J. Y., Takahashi, T. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Pages: 851-853
- NAID
  10030037163
- URL
  http://dx.doi.org/10.2131/jts.36.851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Inhibition of F-box protein FBXO6 gene expression by RNA interference enhances cadmium toxicity in HEK293 cells2011
- Author(s)
  Hwang, G. W., Du, K., Takahashi, T. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 36 Pages: 847-849
- NAID
  10030037147
- URL
  http://dx.doi.org/10.2131/jts.36.847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Studies on molecular mechanism of toxicity of anticancer drugs2011
- Author(s)
  Takahashi T
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131 Pages: 355-358
- NAID
  130000678897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790138
[Journal Article] Overexpression of CLN1, CLN2, or ERG13 increases resistance to adriamycin in Saccharomyces cerevisiae2011
- Author(s)
  Takahashi T., Nakashima S., Masuda T., Yoneda S., Hwang G.W., Naganuma A.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 36 Issue: 6 Pages: 855-857
- DOI
  10.2131/jts.36.855
- NAID
  10030037179
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790171
[Journal Article] siRNA-mediated AMPKalpha1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010
- Author(s)
  Hwang, G. W., Tobita, M., Takahashi, T. Kuge, S., Kita, K. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 35 Pages: 601-604
- URL
  http://dx.doi.org/10.2131/jts.35.601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated AMPK1 subunit gene PRKAA1 silencing enhances methylmercury toxicity in HEK293 cells2010
- Author(s)
  Hwang, G. W., Tobita, M., Takahashi, T., Kuge, S., Kita, K., Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci. 34(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] Over expression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae2009
- Author(s)
  Hwang, G. W., Sasaki, K., Takahashi, T., Yamamoto, R. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 34 Pages: 441-443
- NAID
  110007359653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB)confers resistance to methyl mercury in HEK293 cells2007
- Author(s)
  Hwang, G. W., Hayashi, T., Kita, K., Takahashi, T., Kuge, S. and Naganuma, A.
- Journal Title
  
  J. Toxicol. Sci.
  
  Volume: 32 Pages: 581-583
- NAID
  110006531749
- URL
  http://dx.doi.org/10.2131/jts.32.581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19101003
[Journal Article] siRNA-mediated inhibition of phosphatidylinositol glycan class B (PIGB) confers resistance to methylmercury in HEK293 cells2007
- Author(s)
  Hwang G.W., Hayashi. T., Kita K., Takahashi T., Kuge S., Naganuma A.
- Journal Title
  
  J. Toxicol. Sci. 32
  
  Pages: 581-583
- NAID
  110006531749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18790110
[Presentation] 亜ヒ酸による血管内皮細胞のCSEの発現誘導に関わる転写制御機構．2024
- Author(s)
  山口尭大，丸山祐輝，宮川直也，高橋勉，篠田陽，藤江智也，山本千夏，鍜冶利幸，藤原泰之．
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K11438
[Presentation] 亜ヒ酸による血管内皮細胞の活性硫黄分子産生酵素CSEの発現誘導機構．2023
- Author(s)
  丸山祐輝，宮川直也，高橋勉，篠田陽，藤江智也，山本千夏，鍛冶利幸，藤原泰之．
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-23K11438
[Presentation] 亜ヒ酸曝露した血管内皮細胞におけるシスタチオニンγ-リアーゼの発現誘導機構．2023
- Author(s)
  高橋勉，丸山祐輝，宮川直也，篠田陽，藤江智也，山本千夏，鍜冶利幸，藤原泰之．
- Organizer
  メタルバイオサイエンス研究会2023
- Data Source
  KAKENHI-PROJECT-23K11438
[Presentation] Arsenite exerts cytotoxic effect through inhibition of synthesis of ribose-5-phosphate in human acute monocytic leukemia THP-1 cells.2019
- Author(s)
  Takahashi T., Nakano T., Fujiwara Y.
- Organizer
  IUTOX 15th International Congress of Toxicology (ICTXV)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸による細胞選択的な血液線溶系への影響とその分子メカニズム2019
- Author(s)
  中野毅，荒木祐美，高橋勉，山本千夏，鍜冶利幸，藤原泰之
- Organizer
  メタルバイオサイエンス研究会2019
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] ヒト血管内皮細胞株EA.hy926細胞の増殖と防御応答におけるヌクレオリンの役割2019
- Author(s)
  藤原泰之，佐野宏造，小坂真澄，篠田陽，恒岡弥生，高橋勉
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08350
[Presentation] 亜ヒ酸によるHeLa細胞のトランスケトラーゼ発現抑制を介した増殖阻害2019
- Author(s)
  高橋勉，細野雅人，中野毅，藤原泰之
- Organizer
  フォーラム2019：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸毒性発現機構におけるペントースリン酸経路の防御的役割2019
- Author(s)
  高橋勉，藤原泰之，黄基旭，永沼章
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸による転写因子の活性制御を介した毒性発現メカニズム2019
- Author(s)
  高橋勉，藤原泰之
- Organizer
  第63回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸による血管内皮細胞株EA.hy926細胞における線溶活性の抑制2018
- Author(s)
  中野毅，高橋勉，吉田映子，恒岡弥生，篠田陽，山本千夏，鍜冶利幸，藤原泰之
- Organizer
  第45回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸による血管内皮細胞における線溶活性の抑制機構2018
- Author(s)
  中野毅，高橋勉，加藤剛，恒岡弥生，篠田陽，山本千夏，鍜冶利幸，藤原泰之
- Organizer
  フォーラム2018：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸によるHeLa細胞のペントースリン酸経路の抑制を介した増殖阻害作用2018
- Author(s)
  高橋勉，細野雅人，佐久間竣介，中野毅，黄基旭，永沼章，藤原泰之
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] Arsenite suppresses expression of genes related to synthesis of ribose-5-phosphate in pentose phosphate pathway in human acute monocytic leukemia THP-1 cells.2018
- Author(s)
  Takahashi T., Nakano T., Fujiwara Y.
- Organizer
  The 8th International Congress of ASIAN Society of Toxicology (ASIATOX 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 亜ヒ酸による血管内皮細胞のNrf2経路を介したt-PA合成阻害2018
- Author(s)
  中野毅，高橋勉，恒岡弥生，篠田陽，山本千夏，鍜冶利幸，藤原泰之
- Organizer
  メタルバイオサイエンス研究会2018
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] ヒト血管内皮細胞株 EA.hy926細胞の線溶系に対する亜ヒ酸の抑制作用2018
- Author(s)
  中野　毅，高橋　勉，吉田映子，恒岡弥生，篠田　陽，山本千夏，鍜冶利幸，藤原泰之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] カドミウムの血管内皮細胞傷害作用におけるヌクレオリンの役割2017
- Author(s)
  湯本　藍，高橋　勉，篠田　陽，鍜冶利幸，藤原泰之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08350
[Presentation] カドミウムによる血管内皮細胞の細胞死様式の検討2017
- Author(s)
  中野毅 , 松原巧 , 高橋勉 , 藤原泰之
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K08350
[Presentation] TGF-βによる血管内皮細胞の増殖抑制におけるヌクレオリンの役割2017
- Author(s)
  高橋　勉，本間雄太，篠田　陽，鍜冶利幸，藤原泰之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08350
[Presentation] 亜ヒ酸毒性発現における転写因子WT1の関与2017
- Author(s)
  田中裕士，中野　毅，高橋　勉，篠田　陽，藤原泰之
- Organizer
  フォーラム2017：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] 酵母およびヒト子宮頸癌由来HeLa細胞における亜ヒ酸によるペントースリン酸経路関連遺伝子の転写抑制機構2017
- Author(s)
  高橋　勉，田中裕士，中野　毅，黄　基旭，永沼　章，藤原泰之
- Organizer
  第23回ヒ素シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] メチル水銀による脳選択的毒性に対する分泌性タンパク質群の役割2017
- Author(s)
  高橋　勉
- Organizer
  基盤研究S関連発表会：メチル水銀研究の現状と展望
- Place of Presentation
  仙台
- Year and Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-26460170
[Presentation] 酵母及びヒト細胞の亜ヒ酸毒性発現機構における転写因子Mig1及びWT1の役割2017
- Author(s)
  田中裕士, 中野　毅, 高橋　勉, 黄　基旭, 永沼　章, 藤原泰之
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08391
[Presentation] カドミウムによる血管内皮細胞毒性発現におけるヌクレオリンの関与2017
- Author(s)
  宮﨑有紀, 湯本藍, 高橋勉, 篠田陽, 鍜冶利幸, 藤原泰之
- Organizer
  第44回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-16K08350
[Presentation] メチル水銀によるSCGB3A1発現誘導におけるNF-κBの関与2015
- Author(s)
  高橋勉、趙倩、金ミンソク、岩井美幸、黄基旭、永沼章
- Organizer
  日本薬学会フォーラム2015 衛生薬学・環境トキシコロジー
- Place of Presentation
  神戸学院大学ポートアイランドキャンパス（神戸市）
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26460170
[Presentation] メチル水銀によってマウス脳特異的に発現誘導されるセクレトグロビン3A12015
- Author(s)
  高橋勉、金ミンソク、齋藤隆寛、趙倩，岩井美幸、黄基旭，永沼章
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県立音楽堂（石川県金沢市）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-26460170
[Presentation] 薬毒物の細胞毒性に影響を及ぼす蛋白質群に関する研究2014
- Author(s)
  ○高橋勉
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば市
- Year and Date
  2014-09-20
- Invited
- Data Source
  KAKENHI-PROJECT-26460170
[Presentation] Brain-specific induction of expression of Ccl4 and Scgb3a1 by methylmercury in mice2014
- Author(s)
  Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma
- Organizer
  53th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Phoenix (USA)
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] メチル水銀によってマウス脳組織中で発現誘導されるサイトカイン2014
- Author(s)
  ○岩井美幸、釋氏佑紀奈、金ミンソク、黄基旭、高橋勉、永沼章
- Organizer
  第41回日本毒性学会学術年会
- Place of Presentation
  神戸市
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-26460170
[Presentation] アドリアマイシン毒性軽減機構における小胞体-ゴルジ体間輸送経路の関与2013
- Author(s)
  高橋勉、晴山聖子、廣瀬健一郎、深澤ちさと、永沼章
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Year and Date
  2013-03-29
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] メチル水銀によってマウス脳特異的に発現誘導される遺伝子群2013
- Author(s)
  金ミンソク、斉藤隆寛、高橋勉、李辰竜、黄基旭、永沼章
- Organizer
  第40回日本毒性学会学術年会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Mevalonate pathway plays a major role in adriamycin resistance2013
- Author(s)
  高橋勉、中島伸吾、増田拓朗、米田茂広、永沼章
- Organizer
  52th Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio(USA)
- Year and Date
  2013-03-13
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] Involvement of NF-κB Signaling Pathway in Methylmercury-induced CCL4 Expression in Mouse Neural Progenitor Cells2013
- Author(s)
  Min-Seok Kim, Jin-Yong Lee, Gi-Wook Hwang, Tsutomu Takahashi, Akira Naganuma
- Organizer
  The 29th Annual Meeting of KSOT/KEMS
- Place of Presentation
  Buyeo（韓国）
- Data Source
  KAKENHI-PROJECT-25281023
[Presentation] Methylmercury Induces a Brain-Specific Increase in Chemokine CCL3 and CCL4 Expression in Mice2013
- Author(s)
  Min-Seok Kim, Jin-Yong Lee, Tsutomu Takahashi, Gi-Wook Hwang, Akira Naganuma
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul（Korea）
- Data Source
  KAKENHI-PROJECT-24249008
[Presentation] Overexpression of HMG-CoA synthase confers resistance to adriamycin in both yeast cells and mammalian cells2012
- Author(s)
  高橋勉、永沼章
- Organizer
  第71回日本癌学会学術大会
- Place of Presentation
  札幌市
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] リボース-5-リン酸による亜ヒ酸の毒性軽減作用2012
- Author(s)
  高橋勉、佐竹翔平、永沼章
- Organizer
  フォーラム2012:衛生薬学・環境トキシコロジー
- Place of Presentation
  名古屋市
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] 遺伝子ノックダウン酵母を用いた亜ヒ酸感受性に影響を与える遺伝子の検索2011
- Author(s)
  佐竹翔平、高橋勉、永沼章
- Organizer
  第50回日本薬学会東北支部大会
- Place of Presentation
  仙台市
- Year and Date
  2011-10-30
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] 酵母のペントースリン酸経路関連酵素が示す亜ヒ酸毒性軽減作用2011
- Author(s)
  佐竹翔平、高橋勉、永沼章
- Organizer
  フォーラム2011:衛生薬学・環境トキシコロジー
- Place of Presentation
  金沢市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] アドリアマイシン毒性軽減機構におけるCOPII小胞輸送経路の関与2011
- Author(s)
  深澤ちさと、晴山聖子、廣瀬健一郎、○高橋勉、永沼章
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] 亜ヒ酸毒性とペントースリン酸経路との関わり2011
- Author(s)
  佐竹翔平、高橋勉、永沼章
- Organizer
  第10回次世代を担うファーマバイオフォーラム
- Place of Presentation
  仙台市
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] アドリアマイシン毒性軽減機構におけるCOPII小胞輸送経路の関与2011
- Author(s)
  深澤ちさと、晴山聖子、廣瀬健一郎、高橋勉、永沼章
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  横浜市
- Year and Date
  2011-07-13
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] Relationship between Ptc1, a protein phosphatase, and ribosomal proteins in reduction of adriamycin toxicityin yeast2011
- Author(s)
  高橋勉、永沼章
- Organizer
  第70回日本癌学会学術大会
- Place of Presentation
  名古屋市
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] Involvement of ER-to-golgi transport pathway in protection against adriamycin toxicity2010
- Author(s)
  深澤ちさと、高橋勉、永沼章
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] HMG-CoA synthase高発現によるアドリアマイシン耐性獲得機構の解析2010
- Author(s)
  増田拓朗、中島伸吾、高橋勉、永沼章
- Organizer
  フォーラム2010; 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京(星薬科大学)
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] アドリアマイシン毒性軽減機構における脱ユビキチン化酵素Ubp3と小胞体-ゴルジ体間の小胞輸送経路との関係2010
- Author(s)
  晴山聖子、深澤ちさと、廣瀬健一郎、高橋勉、永沼章
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  那覇市
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] 酵母でのアドリアマイシン毒性軽減機構における細胞内小胞輸送の役割2010
- Author(s)
  深澤ちさと、晴山聖子、廣瀬健一郎、高橋勉、永沼章
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  郡山市
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] 制がん剤感受性を規定する遺伝子の同定およびその作用機構の解析2010
- Author(s)
  高橋勉
- Organizer
  日本薬学会第130年会(シンポジウム)
- Place of Presentation
  岡山市
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] Genome-wide screening for determinants of adriamycin sensitivity in Saccharomyces cerevisiae2010
- Author(s)
  Ken-ishiro Hirose, Tsutomu Takahashi, Akira Naganuama
- Organizer
  49th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Salt Lake City
- Year and Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] 酵母でのアドリアマイシン毒性軽減機構における細胞内小胞輸送の役割2010
- Author(s)
  深澤ちさと, 晴山聖子, 廣瀬健一郎, 高橋勉, 永沼, 章
- Organizer
  第49回日本薬学会東北支部大会
- Place of Presentation
  奥羽大学
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] アドリアマイシン毒性軽減機構における脱ユビキチン化酵素Ubp3と小胞体-ゴルジ体間の小胞輸送経路との関係2010
- Author(s)
  晴山聖子、深澤ちさと、廣瀬健一郎、高橋勉、永沼章
- Organizer
  第37回日本トキシコロジー学会学術年会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] 制がん剤感受性を規定する遺伝子の同定およびその作用機構の解析2010
- Author(s)
  高橋勉
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山大学
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] Role of protein phosphatase type 1 (PP1) in the protective mechanism against toxicity of Adriamycin2010
- Author(s)
  Tsutomu Takahashi, Ken-ishiro Hirose, Akira Naganuama
- Organizer
  49th Annual Meeting of the Society of Toxicology
- Place of Presentation
  Salt Lake City
- Year and Date
  2010-03-09
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] Vacuolar protein sorting plays a major role in adnamaycin resistance induced by inhibition of early step in endocytosis in Saccharomyces cerevisiae2009
- Author(s)
  廣瀬健一郎、高橋勉、永沼章
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790138
[Presentation] エンドサイトーシス制御に関わるArk/Prk kinase familyのアドリアマイシン耐性獲得機構における役割2007
- Author(s)
  高橋勉、永沼章
- Organizer
  第34回日本トキシコロジー学会学術年会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2007-06-27
- Data Source
  KAKENHI-PROJECT-18790110
[Presentation] Overexpression of HMG-CoA synthase confers resistance to adriamycin in both yeast cells and mammalian cells
- Author(s)
  ○高橋勉、永沼章
- Organizer
  第71回日本癌学会学術大会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] アドリアマイシン毒性軽減機構における小胞体―ゴルジ体間輸送経路の関与
- Author(s)
  ○高橋　勉、晴山聖子、廣瀬健一郎、深澤ちさと、永沼　章
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] Mevalonate pathway plays a major role in adriamycin resistance
- Author(s)
  ○高橋勉、中島伸吾、増田拓朗、米田茂広、永沼章
- Organizer
  52th Annual Meeting of the Society of Toxicology
- Place of Presentation
  San Antonio（ USA ）
- Data Source
  KAKENHI-PROJECT-23790171
[Presentation] メチル水銀によるオートファジー誘導におけるLAMTOR複合体の関与
- Author(s)
  松田健人、高橋勉、黄基旭、永沼章
- Organizer
  フォーラム2014：衛生薬学・環境トキシコロジー
- Place of Presentation
  つくば
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-25281023
[Presentation] マウス脳神経由来細胞におけるメチル水銀によるケモカインCCL4の発現誘導
- Author(s)
  金ミンソク、李辰竜、黄基旭、高橋勉、永沼章
- Organizer
  第52回日本薬学会東北支部大会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-24249008

1. HWANG Gi-wook (00344680)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. KUGE Shusuke (50186376)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. NAGANUMA Akira (80155952)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. Fujiwara Yasuyuki (40247482)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. TOYAMA TAKASHI (50720918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 恒岡弥生 (50734597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Takahashi Tsutomu 高橋 勉

高橋 勉 タカハシ ツトム

TAKAHASHI Tsutomu 高橋 勉

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ヒ素によるAGEs受容体シグナルを介した血管障害メカニズムの解明Principal Investigator

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血管周囲脂肪組織に着目したヒ素の血管毒性発現機構の解明

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Role of pentose phosphate pathway in arsenite toxicityPrincipal Investigator

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Mechanisms of vascular disease caused by cadmium and lead mediated by multifunctional protein nucleolin.

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Involvement of brain-specific induction of secretoglobin expression in methylmercury toxicityPrincipal Investigator

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Mechanism underlying the reduction of methylmercury toxicity by Ragulator complex which is an autophagy regulator

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Explanation of the mechanism that influence the cell sensitivity to the toxicity of methylmercury

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Involvement of intracellular vesicular trafficking in toxicity of anticancer drugsPrincipal Investigator

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Studies on mechanism of adriamycin resistance induced by inhibition of endocytosisPrincipal Investigator

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Cellular Systems Involved in Development and Regulation of Toxicity of Methylmercury

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siRNAライブラリーを用いた制癌剤感受性決定因子の網羅的検索とその作用機構解析Principal Investigator

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[Journal Article] Nuclear factor erythroid 2-related factor 2 (NRF2) is a negative regulator of tissue plasminogen activator synthesis in cultured human vascular endothelial EA.hy926 cells2020

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Takahashi Tsutomu 高橋勉

高橋勉タカハシツトム

TAKAHASHI Tsutomu 高橋勉