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SEKINE Osamu  関根 理

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関根 理  セキネ オサム

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Researcher Number 00402719
Other IDs
Affiliation (Current) 2025: 滋賀医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2017: 滋賀医科大学, 医学部, その他
2013 – 2017: 滋賀医科大学, 医学部, 助教
2012: 滋賀医科大学, 医学部, 特任助教
2008: 滋賀医大, 医学部
2007: Shiga University of Medical Science, 医学部, 医員
Review Section/Research Field
Principal Investigator
Metabolomics
Keywords
Principal Investigator
O-結合型糖修飾 / O-GlcNAc修飾 / 肝臓 / 果糖 / 膵臓 / 糖尿病 / インスリン分泌 / 膵β細胞 / マイクロアレイ / 肝蔵 / 糖・脂質代謝異常 / 脂質合成 / 転写因子
  • Research Projects

    (3 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (7 People)
  •  Abnormality of O-GlcNAcylation and pathogenesis of beta cell dysfunctionPrincipal Investigator

    • Principal Investigator
      SEKINE OSAMU
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Shiga University of Medical Science
  •  The impact of altered O-GlcNAcylation on fructose-derived metabolic derangements due to deletion of O-GlcNAc transferase in the hepatocytes.Principal Investigator

    • Principal Investigator
      SEKINE Osamu
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Shiga University of Medical Science
  •  脂肪合成系遺伝子発現調節における新たに発見した遺伝子の機能解析Principal Investigator

    • Principal Investigator
      関根 理
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Shiga University of Medical Science

All 2018 2017 2016 2015 2014 2013 2012 2007 Other

All Journal Article Presentation Book

  • [Book] 月刊糖尿病 今、明かされたSGLT2阻害薬の多面的作用と適正使用 SGLT2阻害薬に期待される臨床効果2017

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      12
    • Publisher
      医学出版
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 医薬ジャーナル 糖尿病の最新治療と総合戦略 SGLT2阻害薬2017

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      7
    • Publisher
      医薬ジャーナル社
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 糖尿病 最新の治療 2016-2018 糖尿病ケトアシドーシス2016

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      3
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 新時代の臨床糖尿病学(上) 糖尿病新薬2016

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      3
    • Publisher
      日本臨牀社
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 糖尿病ケア 2016年春期増刊 魔法の糖尿病患者説目シート+α 糖尿病だと何が悪いの?2016

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      3
    • Publisher
      メディカ出版
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 最新医学 別冊新ABC117「糖尿病」 糖尿病大血管症を伴う血糖管理2016

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      10
    • Publisher
      最新医学社
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] Modern Physician 35巻1号2015

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      5
    • Publisher
      新興医学出版社
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Book] ヴィジュアル 糖尿病臨床のすべて インクレチンの膵外作用(改訂板)2015

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      3
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Book] 糖尿病治療薬併用療法を究める インクレチン関連薬+α2013

    • Author(s)
      関根 理、前川 聡
    • Total Pages
      7
    • Publisher
      日本医事新報社
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle2018

    • Author(s)
      Murata Koichiro、Morino Katsutaro、Ida Shogo、Ohashi Natsuko、Lemecha Mengistu、Park Shi-Young、Ishikado Atsushi、Kume Shinji、Choi Cheol Soo、Sekine Osamu、Ugi Satoshi、Maegawa Hiroshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 495 Issue: 2 Pages: 2098-2104

    • DOI

      10.1016/j.bbrc.2017.12.081

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09383, KAKENHI-PROJECT-18H02862, KAKENHI-PROJECT-16K09744
  • [Journal Article] Diverse metabolic effects of O-GlcNAcylation in the pancreas but limited effects in insulin-sensitive organs in mice2017

    • Author(s)
      Ida Shogo、Morino Katsutaro、Sekine Osamu、Ohashi Natsuko、Kume Shinji、Chano Tokuhiro、Iwasaki Kanako、Harada Norio、Inagaki Nobuya、Ugi Satoshi、Maegawa Hiroshi
    • Journal Title

      Diabetologia

      Volume: 60 Issue: 9 Pages: 1761-1769

    • DOI

      10.1007/s00125-017-4327-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K09744, KAKENHI-PROJECT-15K09383
  • [Journal Article] Pivotal Role of O -GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis2017

    • Author(s)
      Ohashi Natsuko、Morino Katsutaro、Ida Shogo、Sekine Osamu、Lemecha Mengistu、Kume Shinji、Park Shi-Young、Choi Cheol Soo、Ugi Satoshi、Maegawa Hiroshi
    • Journal Title

      Diabetes

      Volume: 66 Issue: 9 Pages: 2351-2362

    • DOI

      10.2337/db16-1427

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09743, KAKENHI-PROJECT-15K09383
  • [Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017

    • Author(s)
      Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 未定 Issue: 9 Pages: 000-000

    • DOI

      10.1093/ndt/gfw463

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25713033, KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-15K09383, KAKENHI-PROJECT-15K19511, KAKENHI-PROJECT-16K09612, KAKENHI-PROJECT-17K09706
  • [Journal Article] O-GlcNAcylation plays a physiologically important role in glucose homeostasis in pancreatic β cells rather than in insulin target tissues2017

    • Author(s)
      Shogo Ida, Katsutaro Morino, Osamu Sekine, Natsuko Ohashi, Shinji Kume, Tokuhiro Chano, Kanako Iwasaki, Norio Harada, Nobuya Inagaki, Satoshi Ugi, Hiroshi Maegawa
    • Journal Title

      Diabetologia (in press)

      Volume: -

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Journal Article] Duality of n-3 Polyunsaturated Fatty Acids on Mcp-1 Expression in Vascular Smooth Muscle: A Potential Role of 4-Hydroxy Hexenal.2015

    • Author(s)
      Nagayama K, Morino K, Sekine O, Nakagawa F, Ishikado A, Iwasaki H, Okada T, Tawa M, Sato D, Imamura T, Nishio Y, Ugi S, Kashiwagi A, Okamura T, Maegawa H
    • Journal Title

      Nutrients

      Volume: 7(9) Issue: 9 Pages: 8112-8126

    • DOI

      10.3390/nu7095381

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Journal Article] Sonoda N, Morimoto A, Ugi S, Morino K, Sekine O, Nemoto K, Godai K, Maegawa H, Miyamatsu N. Predictors for Mild and Severe Hypoglycemia in Insulin-Treated Japanese Diabetic Patients.2015

    • Author(s)
      Sonoda N, Morimoto A, Ugi S, Morino K, Sekine O, Nemoto K, Godai K, Maegawa H, Miyamatsu N
    • Journal Title

      PLoS One

      Volume: 10(6) Issue: 6 Pages: e0130584-e0130584

    • DOI

      10.1371/journal.pone.0130584

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09383, KAKENHI-PROJECT-15K20762
  • [Journal Article] A fish-based diet intervention improves endothelial function in postmenopausal women with type 2 diabetes mellitus: a randomized crossover trial.2014

    • Author(s)
      Kondo K, Morino K, Nishio Y, Kondo M, Nakao K, Nakagawa F, Ishikado A, Sekine O, Yoshizaki T, Kashiwagi A, Ugi S, Maegawa H.
    • Journal Title

      Metabolism.

      Volume: 63(7) Issue: 7 Pages: 930-940

    • DOI

      10.1016/j.metabol.2014.04.005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs.2014

    • Author(s)
      Nakagawa F, Morino K, Ugi S, Ishikado A, Kondo K, Sato D, Konno S, Nemoto K, Kusunoki C, Sekine O, Sunagawa A, Kawamura M, Inoue N, Nishio Y, Maegawa H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 443 Issue: 3 Pages: 991-996

    • DOI

      10.1016/j.bbrc.2013.12.085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity.2014

    • Author(s)
      Satoshi Ugi, Shiro Maeda, Yoshihiro Kawamura, Masa-aki Kobayashi, Minako Imamura, Takeshi Yoshizaki, Katsutaro Morino, Osamu Sekine, Hiroshi Yamamoto, Toru Tani, Masatomo Rokushima, Atsunori Kashiwagi, Hiroshi Maegawa
    • Journal Title

      Obesity

      Volume: 22 Issue: 4 Pages: 1070-1077

    • DOI

      10.1002/oby.20645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591304, KAKENHI-PROJECT-24591350
  • [Journal Article] A high-fiber, low-fat diet improves periodontal disease markers in high-risk subjects: a pilot study.2014

    • Author(s)
      Kondo K, Ishikado A, Morino K, Nishio Y, Ugi S, Kajiwara S, Kurihara M, Iwakawa H, Nakao K, Uesaki S, Shigeta Y, Imanaka H, Yoshizaki T, Sekine O, Makino T, Maegawa H, King GL, Kashiwagi A.
    • Journal Title

      Nutr Res.

      Volume: 34(6) Issue: 6 Pages: 491-498

    • DOI

      10.1016/j.nutres.2014.06.001

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet.2013

    • Author(s)
      Ushio M, Nishio Y, Sekine O, Nagai Y, Maeno Y, Ugi S, Yoshizaki T, Morino K, Kume S, Kashiwagi A, Maegawa H.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 305 Issue: 2 Pages: E293-E304

    • DOI

      10.1152/ajpendo.00442.2012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation2013

    • Author(s)
      Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H
    • Journal Title

      PLoS One

      Volume: 8 Issue: 7 Pages: e69415-e69415

    • DOI

      10.1371/journal.pone.0069415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591350
  • [Journal Article] Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes.2012

    • Author(s)
      Kusunoki C, Yang L, Yoshizaki T, Nakagawa F, Ishikado A, Kondo M, Morino K, Sekine O, Ugi S, Nishio Y, Kashiwagi A, Maegawa H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 430 Issue: 1 Pages: 225-230

    • DOI

      10.1016/j.bbrc.2012.10.115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Journal Article] Autophagy regulates inflammation in adipocytes2012

    • Author(s)
      Yoshizaki T, Maegawa H., et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417 Issue: 1 Pages: 352-357

    • DOI

      10.1016/j.bbrc.2011.11.114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591129, KAKENHI-PROJECT-21591162, KAKENHI-PROJECT-24591322, KAKENHI-PROJECT-24591350
  • [Journal Article] RBMX is a novel hepatic transcriptional regulator of SREBP-lc generesponse tohigh-fructose diet.2007

    • Author(s)
      Takemoto T, Nishio Y, Sekine O, 他
    • Journal Title

      FEBS Lett 581

      Pages: 218-222

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790630
  • [Journal Article] Increased expression of CCAAT/enhancer binding protein-beta and-delta andmonocyte chemoattractant protein-1 genes in aortas from hyperinsulinaemic rats.2007

    • Author(s)
      Sato Y, Nishio Y, Sekine O, 他
    • Journal Title

      Diabetologia 50

      Pages: 481-489

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790630
  • [Presentation] 膵β細胞のO-GlcNAc修飾はインスリン分泌とβ細胞の恒常性維持に重要である2017

    • Author(s)
      井田 昌吾、森野勝太郎、大橋夏子、久米真司、関根 理、岩崎可南子、原田範雄、稲垣暢也、卯木 智、前川 聡
    • Organizer
      日本糖尿病学会年次学術集会 第60回
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] Comprehensive Analysis to Reveal Physiological Role of O-GlcNAcylation in Glucose Metabolism by Using Tissue-Specific Ogt Knockout Mice2017

    • Author(s)
      SHOGO IDA, KATSUTARO MORINO, OSAMU SEKINE, NATSUKO OHASHI, SHINJI KUME, KANAKO IWASAKI, NORIO HARADA, NOBUYA INAGAKI, SATOSHI UGI, HIROSHI MAEGAWA
    • Organizer
      American Diabetes Association 77th
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] Lack of O-GlcNAcylation Enhances Exercise-Dependent Glucose Utilization through Amp Kinase Activation in Skeletal Muscle2017

    • Author(s)
      KOICHIRO MURATA, KATSUTARO MORINO, SHOGO IDA, NATSUKO OHASHI, HIROTAKA IWASAKI, MENGISTU LEMECHA SHUKARE, OSAMU SEKINE, SHINJI KUME, SHI YOUNG PARK, CHEOL SOO CHOI, SATOSHI UGI, HIROSHI MAEGAWA
    • Organizer
      American Diabetes Association 77th
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] 褐色脂肪組織のO-GlcNAc修飾は寒冷環境における熱産生に重要である2017

    • Author(s)
      大橋夏子、森野勝太郎、井田昌吾、関根 理、Mengistu Lemecha, 久米真司、Shi-Young Park、Cheol Soo Choi、卯木 智、前川 聡
    • Organizer
      日本糖尿病学会年次学術集会 第60回
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] Metabolic Switch by O-GlcNAcylation Is Essential for Cold-Induced Thermogenesis in Brown Adipose Tissue2017

    • Author(s)
      NATSUKO OHASHI, KATSUTARO MORINO, SHOGO IDA, OSAMU SEKINE, MENGISTU LEMECHA, SHINJI KUME, SHE YOUNG PARK, CHEOL SOO CHOI, SATOSHI UGI, HIROSHI MAEGAWA
    • Organizer
      American Diabetes Association 77th
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] 骨格筋におけるO-GlcNAc修飾の低下はAMPK活性化を介して糖利用の亢進をもたらす2017

    • Author(s)
      村田 幸一郎、森野勝太郎、井田昌吾、大橋夏子、岩﨑広高、Mengistu Lemecha Shukare、関根 理、久米真司、卯木 智、前川 聡
    • Organizer
      日本糖尿病学会年次学術集会 第60回
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] 膵島特異的Ogt欠損マウスは二相性の血糖・インスリン分泌変化をきたす2016

    • Author(s)
      井田昌吾、関根理、他
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-21
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] 糖代謝関連臓器におけるO-GlcNAc修飾の網羅的機能解析2015

    • Author(s)
      井田昌吾、関根理、他
    • Organizer
      第58回日本糖尿病学会年次学術集会 若手研究奨励賞
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-15K09383
  • [Presentation] 2型糖尿病患者におけるDUALSCANを用いた内臓脂肪面積測定の有用性2014

    • Author(s)
      関根 理、近藤 慶子、根本 憲一、楠 知里、森野 勝太郎、卯木 智、前川 聡
    • Organizer
      第46回日本動脈硬化学会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-10
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Presentation] 当院外来患者におけるエゼチミブ投与の効果の検証-スタチン系薬剤との比較-

    • Author(s)
      関根 理、他
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Presentation] マウス系統間で、果糖摂取による肝臓内核蛋白のO-結合型糖修飾の機構に差異を認める

    • Author(s)
      関根 理、他
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Presentation] ω3多価不飽和脂肪酸の血管平滑筋細胞への作用

    • Author(s)
      関根 理、他
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      博多
    • Data Source
      KAKENHI-PROJECT-24591350
  • [Presentation] Docosahexaenoic acidの血管平滑筋細胞への作用

    • Author(s)
      関根 理、他
    • Organizer
      第45回日本動脈硬化学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591350
  • 1.  MORINO Katsutaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  YAMAHARA Mako
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  Ono Shinya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  卯木 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 5.  山本 雅之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  前川 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  久米 真司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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