TANAKA Takashi 田中貴志

… Alternative Names

田中貴志タナカタカシ

Less

Researcher Number	00415225
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人理化学研究所, 生命医科学研究センター, 上級研究員 2022: 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー 2015 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, チームリーダー 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター炎症制御研究チーム, チームリーダー 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー 2008 – 2012: The Institute of Physical and Chemical Research, 炎症制御研究ユニット, ユニットリーダー 2005 – 2007: 独立行政法人理化学研究所, 生体防御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49070:Immunology-related / Biological Sciences Except Principal Investigator Biological Sciences / Biological Sciences
Keywords	Principal Investigator ユビキチンリガーゼ / NF-κB / PDLIM2 / 免疫学 / STAT3 / 自己抗体産生 / Th17細胞分化 / 原発性免疫不全症 / LIMタンパクファミリー / PDLIM1 … More / 非アルコール性脂肪肝炎 / 非アルコール性脂肪肝 / 脂質代謝 / 腸内細菌 / 非アルコール性脂肪肝炎（NASH） / ubiouitin E3 Haase / innate immunity / LIM proteins / 樹状細胞 / 自然免疫 / LIMタンパク / 関節リウマチ / SNP / LIM蛋白 / Th17細胞 / アレルギー・ぜんそく / シグナル伝達 / 炎症性肉芽腫 / 3 / Smad2 / 創傷治癒 / HSP70 / 炎症反応 / がん細胞増殖抑制 … More Except Principal Investigator I型インターフェロン / Toll様受容体 / 樹状細胞 / 樹状細胞サブセット / 免疫アジュバント / 遺伝子欠損マウス / IκBキナーゼ / 炎症 / 病原体センサー / シグナル伝達 / サイトカイン / 自然免疫 / Toll様受受容体 / CpG DNA Less

Clarification of the molecular mechanisms how the defect of PDLIM1 causes human immunodeficiency and establishment of a novel classification of a human immunodeficiencyPrincipal Investigator
- Principal Investigator
  
  田中貴志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Institute of Physical and Chemical Research
Clarification of pathogenesis of NASH(non-alcoholic steatohepatitis) using PDLIM2-deficient micePrincipal Investigator
- Principal Investigator
  
  TANAKA TAKASHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
Clarification of the roles of LIM proteins in the negative regulation of Th17 cell differentiationPrincipal Investigator
- Principal Investigator
  
  TAKASHI TANAKA
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
Mechanisms for dendritic cell responses against host-derived molecules
- Principal Investigator
  
  KAISHO Tsuneyasu
- Project Period (FY)
  2009 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  The Institute of Physical and Chemical Research
核内ユビキチンリガーゼPDLIM2によるがん細胞増殖制御機構の解明Principal Investigator
- Principal Investigator
  
  田中貴志
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Clarification of molecular mechanisms how PDLIM2, a nuclear ubiquitin E3 ligase, regulates inflammatory responsesPrincipal Investigator
- Principal Investigator
  
  TANAKA Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
Clarification of LIM protein family-mediated system that regulates innate immune responses.Principal Investigator
- Principal Investigator
  
  TANAKA Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
核酸成分による樹状細胞活性化機構
- Principal Investigator
  
  KAISHO Tsuneyasu
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
形質細胞様樹状細胞活性化機構とその機能的意義の解明
- Principal Investigator
  
  改正恒康
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation Patent

[Journal Article] MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses2017
- Author(s)
  Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata-Sogawa K, Tanaka T
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 46097-46097
- DOI
  10.1038/srep46097
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118006, KAKENHI-PLANNED-25116007, KAKENHI-PROJECT-15K08536
[Journal Article] Clarification of the molecular mechanisms that negatively regulate inflammatory responses.2016
- Author(s)
  Tanaka, T.
- Journal Title
  
  Chronic Inflammation, Mechanisms and Regulation
  
  Volume: ー Pages: 109-118
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08536
[Journal Article] PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm.2015
- Author(s)
  Ono, R., Kaisho, T., Tanaka, T.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 18327-18327
- DOI
  10.1038/srep18327
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08536, KAKENHI-PROJECT-26293106
[Journal Article] HSP70 mediates degradation of the p65 subunit of nuclear factor κB to inhibit inflammatory signaling2014
- Author(s)
  T. Tanaka, A. Shibazaki, R. Ono, T. Kaisho
- Journal Title
  
  Sci. Signal
  
  Volume: 7(356) Issue: 356
- DOI
  10.1126/scisignal.2005533
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-26293106
[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013
- Author(s)
  C. Yamazaki, M. Sugiyama, T. Ohta, H. Hemmi, E. Hamada, I. Sasaki, Y. Fukuda, T. Yano, M. Nobuoka, T. Hirashima, A. Iizuka, K. Sato, T. Tanaka, K. Hoshino, T. Kaisho
- Journal Title
  
  J. Immunol
  
  Volume: 190 Issue: 12 Pages: 6071-6082
- DOI
  10.4049/jimmunol.1202798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-24590460, KAKENHI-PROJECT-25293117, KAKENHI-PROJECT-25870401
[Journal Article] Spi-B is critical for plasmacytoid dendritic cell function and development2012
- Author(s)
  Sasaki, K. Hoshino, T. Sugiyama, C. Yamazaki, T. Yano, A. Iizuka, H. Hemmi, T. Tanaka, M. Saito, M. Sugiyama, Y. Fukuda, T. Ohta, K. Sato, A. Ainai, T. Suzuki, H. Hasegawa, N. Toyama-Sorimachi, H. Kohara, T. Nagasawa, T. Kaisho
- Journal Title
  
  Blood
  
  Volume: 120 Issue: 24 Pages: 4733-4743
- DOI
  10.1182/blood-2012-06-436527
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-21117001, KAKENHI-PROJECT-22390096, KAKENHI-PROJECT-22590444, KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-23790454, KAKENHI-PROJECT-24590460, KAKENHI-PLANNED-21117003, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111003
[Journal Article] PDLIM2 inhibits T helper cell development and granulomatous inflammation through degradation of STAT32011
- Author(s)
  T.Tanaka
- Journal Title
  
  J.Immunol
  
  Volume: 188 Issue: 202 Pages: 141-151
- DOI
  10.1126/scisignal.2001637
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117003, KAKENHI-PROJECT-23390015, KAKENHI-PROJECT-23390124, KAKENHI-PROJECT-23590577, KAKENHI-PROJECT-23659245, KAKENHI-PROJECT-23790067
[Journal Article] Ablation of C/EBPβ alleviates ER stress and pancreatic b cell failure through the GRP78 chaperone in mice.2010
- Author(s)
  Matsuda T, Kido Y, Asahara S, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M
- Journal Title
  
  J.Clin.Invest. 120
  
  Pages: 115-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590499
[Journal Article] Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.2010
- Author(s)
  Yamazaki C., Miyamoto R., Hoshino K., Fukuda Y., Sasaki I., Saito M., Ishiguchi H. Yano T., Sugiyama T., Hemmi H., Tanaka T., Hamada E., Hirashima T., Amakawa R., Fukuhara S., Nomura S., Ito T., Kaisho T.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 397
  
  Pages: 756-761
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590499
[Journal Article] PDLIM2 suppresses HTLV-I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation.2009
- Author(s)
  Yan P., Fu J., Qu Z., Li S., Tanaka T., Grusby M.J., Xiao G.
- Journal Title
  
  Blood 113
  
  Pages: 4370-4380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590499
[Journal Article] Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effects in mouse sepsis model2009
- Author(s)
  K.Takashima
- Journal Title
  
  British J Pharmacology 157
  
  Pages: 1250-1262
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117003
[Journal Article] Turning NF-κB and IRFs on and off in DCs.2008
- Author(s)
  Kaisho T., Tanaka T.
- Journal Title
  
  Trends Immunol. 29
  
  Pages: 329-336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590499
[Journal Article] PDLIM2-mediated termination of transcription factor NF-kB activation by intranuclear sequestration and degradation fo the p65 subunit.2007
- Author(s)
  T. Tanaka
- Journal Title
  
  Nature Immunol. 8(6)
  
  Pages: 584-591
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Journal Article] PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit.2007
- Author(s)
  T. Tanaka
- Journal Title
  
  Nature Immunol. 8
  
  Pages: 584-591
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590480
[Journal Article] PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit.2007
- Author(s)
  Takashi Tanaka
- Journal Title
  
  Nature Immunology 8
  
  Pages: 584-591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590480
[Patent] 創傷修復促進剤2017
- Inventor(s)
  吉岡龍藏、田中陽子、矢口学、田中貴志
- Industrial Property Rights Holder
  吉岡龍藏、田中陽子、矢口学、田中貴志
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-081239
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-15K08536
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志、改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Overseas
- Data Source
  KAKENHI-PROJECT-20590499
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志, 改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Overseas
- Data Source
  KAKENHI-PROJECT-20013049
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Overseas
- Data Source
  KAKENHI-PROJECT-20590499
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-254379
- Filing Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590499
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志, 改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Industrial Property Number
  2009-254379
- Filing Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20013049
[Patent] 創傷治癒剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志、改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590499
[Patent] 創傷治療剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志, 改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Data Source
  KAKENHI-PLANNED-21117003
[Patent] 創傷治療剤及びそのスクリーニング方法2009
- Inventor(s)
  田中貴志, 改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2009-11-05
- Overseas
- Data Source
  KAKENHI-PLANNED-21117003
[Patent] p65媒介シグナル伝達の調節剤およびスクリーニング方法2007
- Inventor(s)
  田中貴志, 改正恒康, Michael J Grusby
- Industrial Property Rights Holder
  独立行政法人理化学研究所, President and Fellowsof HarvardCollege
- Filing Date
  2007-03-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Patent] p65媒介シグナル伝達の調節剤およびそのスクリーニング方法2007
- Inventor(s)
  田中貴志改正恒康Michael J Grusby
- Industrial Property Rights Holder
  理化学研究所
- Filing Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-18590480
[Patent] p65媒介シグナル伝達の調節剤及びそのスクリーニング方法2006
- Inventor(s)
  田中貴志, 改正恒康
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2006-03-21
- Data Source
  KAKENHI-PROJECT-17047046
[Patent] p65媒介シグナル伝達の調節剤およびそのスクリーニング方法2006
- Inventor(s)
  田中貴志
- Industrial Property Rights Holder
  独立行政法人理化学研究所
- Filing Date
  2006
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Loss-of-function mutation in human PDLIM1 causes immunodeficiency by T cell exhaustion.2022
- Author(s)
  田中貴志、Christoph B. Geier
- Organizer
  第51回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-23K24155
[Presentation] Loss-of-function mutations in PDLIM1 abrogates Th17 differentiation by T-cell exhaustion in humans and mice.2022
- Author(s)
  Geier, C. B., Leiss-Piller, A., Sauerwein, K.M.T., Rossmanith, R., Ujhazi, B., Csomos, K., Eibl, M.M., Walter, J.E., Wolf, H.M., Tanaka, T.
- Organizer
  第20回Biennial Meeting of the European Society for Immunodeficiencies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24155
[Presentation] Molecular mechanism how Nahlsgen controls biological function of the skin2017
- Author(s)
  Tanaka T.
- Organizer
  NAHLS Research Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] Microbiota-dependent development of non-alcoholic steatohepatitis (NASH) in PDLIM2-deficient mice2017
- Author(s)
  Tanaka T.
- Organizer
  Luxembourg FNR-RIKEN Joint Symposium, Understanding Inflammatory Diseases beyond Complexity
- Invited
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] Microbiota-dependent development of non-alcoholic steatohepatitis (NASH) in PDLIM2-deficient mice.2017
- Author(s)
  Tanaka T.
- Organizer
  The 46th Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] Negative regulation of inflammatory responses by LIM proteins2017
- Author(s)
  Tanaka T.
- Organizer
  The 1st RIKEN-McGill Symposium, Excellence in Immunology & Genetics
- Invited
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] MKRN2 is a novel ubiquitin E3 ligase for p65 subunit of NF-κB, negatively regulating NF-κB-mediated inflammatory responses.2016
- Author(s)
  Shin, C., Tanaka, T.
- Organizer
  第４５回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] The roles of LIM protein family in the regulation of inflammatory responses2016
- Author(s)
  Tanaka, T.
- Organizer
  第４５回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-07
- Invited
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] PDLIM7 promoted ubiquitin/proteasome-dependent degradation for p65 subunit of NF-κb through PDLIM2 protein stabilization.2015
- Author(s)
  Sibazaki A, Tanaka T.
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] Fbxo21, a component of ubiquitin E3 ligase complex, associates with PDLIM2 and specifically regulates NF-κB-mediated inflammatory signaling.2015
- Author(s)
  Tanaka T, Shibazaki A, Ono R
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] PDLIM1 negatively regulates NF-?B signaling by sequestrating p65 subunit of NF-κB in the cytoplasm in an IκBα-independent manner.2015
- Author(s)
  Ono R, Tanaka T
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-15K08536
[Presentation] Negative regulation for inflammatory responses and its association with autoimmune diseases.2014
- Author(s)
  Tanaka T.
- Organizer
  Monash Univ. & RIKEN IMS Workshop
- Place of Presentation
  RIKEN, IMS, Yokohama, Japan
- Year and Date
  2014-08-14
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] A non-synonymous SNP(single nucleotide polymorphism) of PDLIM4 is associated with susceptibility of rheumatoid arthritis and Graves diseases2012
- Author(s)
  T. Tanaka
- Organizer
  第 41回日本免疫学会総会学術集会
- Place of Presentation
  神戸ポートピアホテル（兵庫県）
- Year and Date
  2012-12-05
- Data Source
  KAKENHI-PLANNED-21117003
[Presentation] PDLIM4 negatively regulates the differentiation of multiple lineages of T-helper cells by dephosphorylation of STAT transcription factors2012
- Author(s)
  Takashi Tanaka, Takeshi Hirashima, Tsuneyasu Kaisho
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, "Th17 Cells in Health and Disease"
- Place of Presentation
  Keystone, Colorado, USA
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] HSP70 is essential for PDLIM2-mediated termination of NF-κB signaling2011
- Author(s)
  Takashi Tanaka, Tsuneyasu Kaisho
- Organizer
  2011 The annual meeting of the Japanese Society for Immunology
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT32011
- Author(s)
  Takashi Tanaka, Yu Yamamoto, Ryuta Muromoto, Osamu Ikeda, Yuichi Sekine, Michael J. Grusby, Tsuneyasu Kaisho, Tadashi Matsuda
- Organizer
  2011 The Annual Meeting of the Japanese Sciety of Immunology, Symposium 3. Effector T cells(招待講演)
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] Heat Shock Protein 70 (HSP70)によるNF-κBシグナルの不活性化機構2011
- Author(s)
  田中貴志
- Organizer
  第20回内毒素・LPS研究会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] PDLIM4 negatively regulates STAT signaling by recruiting protein tyrosine phosphatases.2011
- Author(s)
  Takeshi Hirashima, Tsuneyasu Kaisho, Takashi Tanaka
- Organizer
  2011 The annual meeting of the Japanese Society for Immunology
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] HSP70 terminates NF-κB activation by facilitating degradation of the p65 subunit2011
- Author(s)
  田中貴志
- Organizer
  新学術領域研究「自然炎症」第1回若手ワークショップ
- Place of Presentation
  蔵王、山形
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] HSP70はPDLIMによるNF-κBシグナルの負の制御に必須である/HSP70 is essential for PDLIM2-mediated termination of NF-κB signaling2011
- Author(s)
  田中貴志
- Organizer
  第40回日本免疫学会総会
- Place of Presentation
  幕張メッセ(千葉県)
- Data Source
  KAKENHI-PLANNED-21117003
[Presentation] HSP70 is essential for PDLIM2-mediated termination of NF-κB signaling2011
- Author(s)
  Takashi Tanaka
- Organizer
  University of Michigan-RCAI Joint Workshop(招待講演)
- Place of Presentation
  RIKEN RCAI, Yokohama
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] HSP70 terminates NF-κB activation by facilitating degradation of the p65 subunit.2011
- Author(s)
  田中貴志
- Organizer
  新学術領域研究「自然炎症」第1回若手ワークショップ
- Place of Presentation
  蔵王、山形
- Year and Date
  2011-01-26
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] 創傷治癒を促進するsiRNA製剤2011
- Author(s)
  田中貴志
- Organizer
  第10回国際バイオEXPO
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] Clarifying the molecular mechanisms that regulate inflammatory responses2011
- Author(s)
  Takashi Tanaka
- Organizer
  RIKEN RCAI-CGM Joint Meeting(招待講演)
- Place of Presentation
  RIKEN RCAI, Yokohama
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] PDLIM2, a nuclear ubiquitin E3 ligase, negatively regulates inflammatory responses.2010
- Author(s)
  田中貴志
- Organizer
  INSERM/Pasteur-RIKEN Joint Workshop "Frontier in Immunology-From basic to clinics".
- Place of Presentation
  横浜
- Year and Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2, a nuclear ubiquitin E3 ligase, negatively regulates inflammatory responses.2010
- Author(s)
  Takashi Tanaka
- Organizer
  INSERM/Pasteur-RIKEN Joint Workshop "Frontier in Immunology-From basic to clinics"
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-08-31
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2 regulates Th17-mediated responses through degradation of STAT3 transcription factor.2010
- Author(s)
  田中貴志
- Organizer
  The 14^<th> International Congress of Immunology.
- Place of Presentation
  神戸
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2 regulates Th17-mediated responses through degradation of STAT3 transcription factor2010
- Author(s)
  T.Tanaka
- Organizer
  The 14th International Congress of Immunology
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PLANNED-21117003
[Presentation] PDLIM2 regulates Th17-mediated responses through degradation of STAT3 transcription factor.2010
- Author(s)
  Takashi Tanaka
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-23
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2, a nuclear ubiquitin E3 ligase negatively regulates inflammatory responses.2009
- Author(s)
  田中貴志
- Organizer
  The 2009 fall conference of the Korean association of immunologists.
- Place of Presentation
  Seuol, Korea
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2はTh17細胞分化を負に制御する2009
- Author(s)
  田中貴志、改正恒康
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2, a nuclear ubiquitin E3 ligase negatively regulates inflammatory responses.2009
- Author(s)
  Takashi Tanaka
- Organizer
  The 2009 Fall Conference of The Korean Association of Immunologists
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2009-11-09
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDHM2はTh17細胞分化を負に制御する2009
- Author(s)
  田中貴志
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  (大阪国際会議場)大阪
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] Enhanced skin wound healing in PDLIM2-deficient mice.2009
- Author(s)
  Tanaka T., Kaisho T.
- Organizer
  The 9^<th> World Congress on Inflammation.
- Place of Presentation
  東京
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2はTh17細胞分化を負に制御する/PDLIM2 is a negative regulator for Th17 differentiation2009
- Author(s)
  T.Tanaka
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PLANNED-21117003
[Presentation] PDLIM2はTh17細胞分化を負に制御する2009
- Author(s)
  田中貴志
- Organizer
  第39回日本免疫学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20013049
[Presentation] PDLIM2, a nuclear ubiquitin E3 ligase negatively regulates inflammatory responses2009
- Author(s)
  田中貴志
- Organizer
  The 2009 Fall Conference of The Korean Association of Immunologists
- Place of Presentation
  Seoul, Republic of Korea
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-20013049
[Presentation] PDLIM2 and HSP70 cooperatively terminate Toll-like receptor-mediated NF-κB activation.2008
- Author(s)
  Takashi Tanaka
- Organizer
  The 10^<th> International Symposium on Dendritic cells
- Place of Presentation
  Kobe, JAPAN
- Data Source
  KAKENHI-PROJECT-20013049
[Presentation] PDLIM2 and HSP70 cooperatively terminate Toll-like receptor-mediated NF-κB activation2008
- Author(s)
  Takashi Tanaka
- Organizer
  The 10^<th> International Symposium on Dendritic cells
- Place of Presentation
  Kobe, JAPAN
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2 and HSP70 cooperatively terminate Toll-like receptor-mediated NF-κB activation.2008
- Author(s)
  Tanaka T., Kaisho T.
- Organizer
  The 10^<th> International Symposium on Dendritic Cells.
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] HSP70 terminates NF-kB activation by facilitating degradation of NF-kB p65 subunit.2008
- Author(s)
  T. Tanaka
- Organizer
  Keystone Symposia
- Place of Presentation
  Colorado, USA
- Year and Date
  2008-02-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] PDLIM2欠損マウスにおける皮膚創傷治癒反応の亢進2008
- Author(s)
  田中貴志
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] HSP70 terminates NF-κB activation by facilitating degradation of NF-κB p65 subunit.2008
- Author(s)
  T. Tanaka
- Organizer
  Keystone Symposia
- Place of Presentation
  Colorado, USA
- Year and Date
  2008-02-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] PDLIM2欠損マウスにおける皮膚創傷治癒反応の亢進2008
- Author(s)
  田中貴志、改正恒康
- Organizer
  日本免疫学会
- Place of Presentation
  大阪
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590499
[Presentation] PDLIM2 欠損マウスにおける皮膚創傷治癒反応の亢進2008
- Author(s)
  田中貴志
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20013049
[Presentation] Heat shock proteins regulate PDLIM2-mediated termination of NF-kB activation.2007
- Author(s)
  T. Tanaka
- Organizer
  The 37th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Heat shock proteins regulate PDLIM2-mediated NF-κB activation.2007
- Author(s)
  田中貴志
- Organizer
  20^<th>NAITO conference on Innate immunity in medicine and biology
- Place of Presentation
  湘南、神奈川
- Year and Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Heat shock proteins regulate PDLIM2-mediated NF-κB activation.2007
- Author(s)
  T. Tanaka
- Organizer
  20th Naito conference on Innate immunity in medicine and biology.
- Place of Presentation
  Kanagawa, Japan
- Year and Date
  2007-10-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Heat shock proteins regulate PDLIM2-mediated NF-kB2007
- Author(s)
  T. Tanaka
- Organizer
  20th Naito conference on Innate immunity in medicine and biology
- Place of Presentation
  Kanagawa, Japan
- Year and Date
  2007-10-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] PDLIM2依存性NF-κB不活性化機構は熱ショックタンパク質群によって制御される。2007
- Author(s)
  田中貴志
- Organizer
  日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Heat shock proteins regulate PDLIM2-mediated termination of NF-κB activation.2007
- Author(s)
  T. Tanaka
- Organizer
  The 37th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2007-11-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] SLIM, a nuclear ubiquitin E3 ligase, terminates NF-κB activation by itssequestration and degradation.2006
- Author(s)
  T. Tanaka
- Organizer
  The 36th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Osaka, Japan
- Year and Date
  2006-12-13
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] SLIM, a nuclear ubiquitin E3 ligase, terminates NF-kB activation by its sequestration and degiadation2006
- Author(s)
  T. Tanaka
- Organizer
  The 36th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Osaka, Japan
- Year and Date
  2006-12-13
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590480
[Presentation] Clarifying the molecular mechanisms that regulate inflammatory responses.
- Author(s)
  Tanaka T.
- Organizer
  RIKEN - Novo Nordisk A/S Scientific Forum
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] Negative regulation of inflammatory responses by LIM proteins.
- Author(s)
  Tanaka T.
- Organizer
  The 12th Biennial International Endotoxin & Innate Immunity Society Meeting
- Place of Presentation
  東京都千代田区
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] 分子から病気へ／炎症反応を負に制御する分子機構の解明とGWASを用いた自己免疫疾患との関連解析
- Author(s)
  田中貴志
- Organizer
  第三回　明石町リウマチ連携セミナー
- Place of Presentation
  聖路加国際病院、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] PDLIM4 negatively regulates Th17 cell differentiation by dephosphorylation of STAT3 transcription factor.
- Author(s)
  Tanaka T.
- Organizer
  JST-CREST International Symposium, Frontiers in Immunology and Inflammation: From Molecules to Disease
- Place of Presentation
  東京都千代田区
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] 分子から病気へ／炎症反応を負に制御する分子機構の解明とGWASを用いた自己免疫疾患との関連解析
- Author(s)
  田中貴志
- Organizer
  第6回リウマチ膠原病ウインターセミナー＠聖路加
- Place of Presentation
  聖路加国際病院、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] 炎症反応を負に制御する分子機構の解明
- Author(s)
  田中貴志
- Organizer
  大阪南医療センター／Talk with the expert セミナー
- Place of Presentation
  河内長野、大阪
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] Function of XCR1-expressing dendric cells in oral tolerance.
- Author(s)
  H. Hemmi, M. Sugiyama, T. Ohta, I. Sasaki, C. Yamazaki, T. Tanaka, K. Hoshino, T. Kaisho.
- Organizer
  第42回日本免疫学会総会;学術集会記録42:163, 2013
- Place of Presentation
  幕張メッセ（千葉県、千葉市）
- Year and Date
  2013-12-11 – 2013-12-13
- Data Source
  KAKENHI-PLANNED-21117003
[Presentation] PDLIM7 is a ubiquitin E3 ligase that heterodimerizes with PDLIM2 and negatively regulates NF-κB signaling
- Author(s)
  Sibazaki A, Tanaka T
- Organizer
  第４２回日本免疫学会
- Place of Presentation
  幕張、千葉
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] PDLIM1 negatively regulates NF-kB signaling by sequestrating p65 subunit of NF-kB in the cytoplasm.
- Author(s)
  小野瑠美子、田中貴志
- Organizer
  第４1回日本免疫学会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] Regulation of inflammatory responses by LIM proteins
- Author(s)
  Tanaka T
- Organizer
  The 5th LJI-RCAI Workshop “New Horizon in Immune Regulation towards Disease Intervention”
- Place of Presentation
  横浜、神奈川
- Invited
- Data Source
  KAKENHI-PROJECT-23590577
[Presentation] A non-synonymous SNP of PDLIM4 is associated with susceptibility of rheumatoid arthritis and Graves' diseases.
- Author(s)
  田中貴志、高地雄太、山本一彦、改正恒康
- Organizer
  第４1回日本免疫学会
- Place of Presentation
  兵庫県神戸市
- Data Source
  KAKENHI-PROJECT-23590577

1. KAISHO Tsuneyasu (60224325)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. HOSHINO Katsuaki (50324843)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. TANAKA Kiyoji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 十川久美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 伊藤敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TANAKA Takashi 田中 貴志

田中 貴志 タナカ タカシ

Research Projects

Research Products

Co-Researchers

Clarification of the molecular mechanisms how the defect of PDLIM1 causes human immunodeficiency and establishment of a novel classification of a human immunodeficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of pathogenesis of NASH(non-alcoholic steatohepatitis) using PDLIM2-deficient micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the roles of LIM proteins in the negative regulation of Th17 cell differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms for dendritic cell responses against host-derived molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

核内ユビキチンリガーゼPDLIM2によるがん細胞増殖制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of molecular mechanisms how PDLIM2, a nuclear ubiquitin E3 ligase, regulates inflammatory responsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of LIM protein family-mediated system that regulates innate immune responses.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

核酸成分による樹状細胞活性化機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

形質細胞様樹状細胞活性化機構とその機能的意義の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clarification of the molecular mechanisms that negatively regulate inflammatory responses.2016

Author(s)

Journal Title

Data Source

[Journal Article] PDLIM1 inhibits NF-κB-mediated inflammatory signaling by sequestering the p65 subunit of NF-κB in the cytoplasm.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HSP70 mediates degradation of the p65 subunit of nuclear factor κB to inhibit inflammatory signaling2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Critical roles of a dendritic cell subset expressing a chemokine receptor, XCR12013

Author(s)

TANAKA Takashi 田中貴志

田中貴志タナカタカシ