Sugyo Aya 須堯綾

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SUGYO Aya 須堯綾

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Researcher Number	00415415
Other IDs
Affiliation (Current)	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所分子イメージング診断治療研究部, 主任技術員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所分子イメージング診断治療研究部, 主任技術員 2021 – 2023: 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所分子イメージング診断治療研究部, 主任技術員 2018 – 2019: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 主任技術員(任常) 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 技術員 2017: 放射線医学総合研究所, 分子イメージング研究センター, 技術員 … More 2016 – 2017: 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所分子イメージング診断治療研究部, 技術員(任常) 2015: 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 技術員 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター・分子病態イメージング研究プログラム, 技術員 2013 – 2014: 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 技術員 Less
Review Section/Research Field	Principal Investigator Radiation science / Basic Section 52040:Radiological sciences-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Radiation science
Keywords	Principal Investigator 骨転移 / 膵臓がん / 脳転移 / トリプルネガティブ乳がん / 造骨 / Wntシグナルパスウェイ / Wnt / マイクロCT / 発光イメージング / 造骨性骨転移 … More / 抗がん剤 / 標的アイソトープ治療 / CD147 / RIT / 膵がんモデルマウス / 放射性標識抗体 / モデルマウス / 膵癌 / EMMPRIN / 内照射治療 … More Except Principal Investigator アミノ酸トランスポーター / PET / ルシフェラーゼアッセイ / Cre/loxPシステム / Cre/loxP発現制御システム / 放射線応答遺伝子 / メタボローム解析 / がん / アミノ酸 / 放射線 / 腫瘍画像診断 / 放射線治療 / PET薬剤 / 腫瘍イメージング / 核医学 Less

トリプルネガティブ乳がん治療薬候補の脳・骨転移治療への展開を目指した開発研究Principal Investigator
- Principal Investigator
  
  須堯綾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Institutes for Quantum Science and Technology
Elucidation of the role of the Wnt signaling pathway in the development of diagnostic treatments for "osteoblastic" bone metastasesPrincipal Investigator
- Principal Investigator
  
  Sugyo Aya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Institutes for Quantum Science and Technology
POC study of a new radioimmunotherapy targeting molecules response to therapyPrincipal Investigator
- Principal Investigator
  
  Sugyo Aya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Investigation of the molecular mechanism of transiently elevated tumor uptake of PET tracers at early time points after X-ray radiation
- Principal Investigator
  
  TSUJI Atsushi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of radiation exposed-cell tracking system for imaging within living cells
- Principal Investigator
  
  Sudo Hitomi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of diagnostic imaging and radioimmunotherapy targeting metastasis-associated factorPrincipal Investigator
- Principal Investigator
  
  Sugyo Aya
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  National Institutes for Quantum and Radiological Science and Technology
Development of new tumor PET probes: C-11-labeled aminoisobutyric acid and analogs
- Principal Investigator
  
  TSUJI Atsushi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  National Institute of Radiological Sciences

All 2023 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Wnt1 induces osteoblastic changes in a well‐established osteolytic skeletal metastatic model derived from breast cancer2023
- Author(s)
  Sugyo Aya、Tsuji Atsushi B.、Sudo Hitomi、Sugiura Yoshiya、Koizumi Mitsuru、Higashi Tatsuya
- Journal Title
  
  Cancer Reports
  
  Volume: 6 Issue: 12
- DOI
  10.1002/cnr2.1909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07230
[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019
- Author(s)
  Sugyo Aya、Aung Winn、Tsuji Atsushi、Sudo Hitomi、Takashima Hiroki、Yasunaga Masahiro、Matsumura Yasuhiro、Saga Tsuneo、Higashi Tatsuya
- Journal Title
  
  Oncology Reports
  
  Volume: 41 (4) Pages: 2371-2378
- DOI
  10.3892/or.2019.7017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10460, KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18H02774, KAKENHI-PROJECT-17K10497
[Journal Article] Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with 90Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer2018
- Author(s)
  Sugyo Aya、Tsuji Atsushi、Sudo Hitomi、Koizumi Mitsuru、Ukai Yoshinori、Kurosawa Gene、Kurosawa Yoshikazu、Saga Tsuneo、Higashi Tatsuya
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 10 Pages: 2979-2979
- DOI
  10.3390/ijms19102979
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10497, KAKENHI-PROJECT-18H02774
[Journal Article] ynthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression2017
- Author(s)
  6.Tateishi H, Tsuji AB, Kato K, Sudo H, Sugyo A, Hanakawa T, Zhang MR, Saga T, Arano Y, Higashi T
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 27 Pages: 4893-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09976
[Journal Article] Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor2017
- Author(s)
  3.Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T, Higashi T
- Journal Title
  
  World J Gastroenterol
  
  Volume: 23 Pages: 7551-62
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09976
[Journal Article] Uptake of 111In-labeled fully human monoclonal antibody TSP-A18 reflects transferrin receptor expression in normal organs and tissues of mice2017
- Author(s)
  Sugyo A, Tsuji AB, Sudo H, Nomura F, Satoh H, Koizumi M, Kurosawa G, Kurosawa Y, Saga T
- Journal Title
  
  Oncol Rep
  
  Volume: 37 Issue: 3 Pages: 1529-1536
- DOI
  10.3892/or.2017.5412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670642, KAKENHI-PROJECT-25861140, KAKENHI-PROJECT-15K06884
[Journal Article] αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4.2016
- Author(s)
  Jin ZH, Furukawa T, Degardin M, Sugyo A, Tsuji AB, Yamasaki T, Kawamura K, Fujibayashi Y, Zhang MR, Boturyn D, Dumy P, Saga T.
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 15 Issue: 9 Pages: 2076-85
- DOI
  10.1158/1535-7163.mct-16-0040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09976
[Journal Article] Immunotargeting of integrin α6β4 for single-photon emission computed tomography and near-infrared fluorescence imaging in a pancreatic cancer model2016
- Author(s)
  2.Winn Aung, Atsushi B.Tsuji, Hitomi Sudo, Aya Sugyo, Takako Furukawa, Yoshinori Ukai, Yoshikazu kurozawa, Tsuneo Saga
- Journal Title
  
  Molecular Imaging
  
  Volume: 15
- DOI
  10.1177/1536012115624917
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591804, KAKENHI-PROJECT-26670642, KAKENHI-PROJECT-15K09976
[Journal Article] Establishment and evaluation of a new highly metastatic tumor cell line 5a-D-Luc-ZsGreen expressing both luciferase and green fluorescent protein2016
- Author(s)
  Sudo H, Tsuji A B, Sugyo A, Takuwa H, Masamoto K, Tomita Y, Suzuki N, Imamura T, Koizumi M, Saga T
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 48 Issue: 2 Pages: 525-532
- DOI
  10.3892/ijo.2015.3300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06760, KAKENHI-PROJECT-26670642, KAKENHI-PROJECT-15K09976
[Journal Article] Radioimmunotherapy of pancreatic cancer xenografts in nude mice using 90Y-labeled anti-α6β4 integrin antibody2016
- Author(s)
  Aung W, Tsuji AB, Sudo H, Sugyo A, Ukai Y, Kouda K, Kurosawa Y, Furukawa T, Saga T
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 25 Pages: 38835-38844
- DOI
  10.18632/oncotarget.9631
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670642, KAKENHI-PROJECT-15K09976
[Journal Article] Preclinical assessment of early tumor response after irradiation by positron emission tomography with 2-amino-[3-11C]isobutyric acid2015
- Author(s)
  Tsuji AB, Sugyo A, Sudo H, Suzuki C, Wakizaka H, Zhang MR, Kato K, Saga T
- Journal Title
  
  Oncol Rep
  
  Volume: 33 Issue: 5 Pages: 2361-7
- DOI
  10.3892/or.2015.3868
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591803, KAKENHI-PROJECT-15K09976
[Journal Article] Evaluation of Efficacy of Radioimmunotherapy with 90Y-Labeled Fully Human Anti-Transferrin Receptor Monoclonal Antibody in Pancreatic Cancer Mouse Models.2015
- Author(s)
  Aya Sugyo
- Journal Title
  
  PloS one
  
  Volume: 10 Issue: 4 Pages: e0123761-e0123761
- DOI
  10.1371/journal.pone.0123761
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861140
[Journal Article] Preclinical evaluation of 89Zr-labeled human antitransferrin receptor monoclonal antibody as a PET probe using a pancreatic cancer mouse model.2015
- Author(s)
  Aya Sugyo
- Journal Title
  
  Nuclear medicine communications
  
  Volume: 36 Issue: 3 Pages: 286-294
- DOI
  10.1097/mnm.0000000000000245
- Data Source
  KAKENHI-PROJECT-25861140
[Journal Article] Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid2014
- Author(s)
  Suzuki C, Tsuji A, Kato K, Kikuchi T, Sudo H, Okada M, Sugyo A, Zhang MR, Arano Y, Saga T
- Journal Title
  
  J Nucl Med
  
  Volume: 55 Issue: 10 Pages: 1671-7
- DOI
  10.2967/jnumed.114.145086
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591803, KAKENHI-PROJECT-25861136, KAKENHI-PROJECT-26670642
[Journal Article] Comparison of 2-amino-[3-11C]isobutyric acid and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation2012
- Author(s)
  Tsuji AB, Kato K, Sugyo A, Okada M, Sudo H, Yoshida C, Wakizaka H, Zhang MR, Saga T
- Journal Title
  
  Nucl. Med. Commun.
  
  Volume: 33 Issue: 10 Pages: 1058-1064
- DOI
  10.1097/mnm.0b013e328356efb0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510289, KAKENHI-PROJECT-24591803
[Presentation] Effects of alpha-emitting meta-211At-astato-benzylguanidine (211At-MABG) on tumor growth suppression in a pheochromocytoma mouse model with histological analysis2017
- Author(s)
  H. Sudo, A. Sugyo, A. Tsuji, K. Nagatsu, Y. Ohshima, N. S. Ishioka, T. Higashi, K. Yoshinaga
- Organizer
  Society of Nuclear Medicine and Molecular Imaging Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10013
[Presentation] 放射線被ばく細胞のデュアル蛍光レポーターイメージングシステムの構築2017
- Author(s)
  須藤仁美、須堯綾、相良雅史、辻厚至、東達也
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K10013
[Presentation] 90Y標識抗トランスフェリン受容体抗体の膵癌モデルマウスにおける治療効果の評価2013
- Author(s)
  須堯　綾
- Organizer
  第５３回日本核医学会学術総会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-25861140

1. TSUJI Atsushi (60303559)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. SUDO Hitomi (10415416)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
3. KATO Koichi (50382198)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. SUZUKI Chie (20637285)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 田畑祥 (30708342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TOMITA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SUZUKI Norihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. MASAMOTO Kazuto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. U・WINN Aung

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Sugyo Aya 須堯 綾

SUGYO Aya 須堯 綾

Research Projects

Research Products

Co-Researchers

トリプルネガティブ乳がん治療薬候補の脳・骨転移治療への展開を目指した開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of the Wnt signaling pathway in the development of diagnostic treatments for "osteoblastic" bone metastasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

POC study of a new radioimmunotherapy targeting molecules response to therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the molecular mechanism of transiently elevated tumor uptake of PET tracers at early time points after X-ray radiation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of radiation exposed-cell tracking system for imaging within living cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of diagnostic imaging and radioimmunotherapy targeting metastasis-associated factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of new tumor PET probes: C-11-labeled aminoisobutyric acid and analogs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Wnt1 induces osteoblastic changes in a well‐established osteolytic skeletal metastatic model derived from breast cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy Evaluation of Combination Treatment Using Gemcitabine and Radioimmunotherapy with 90Y-Labeled Fully Human Anti-CD147 Monoclonal Antibody 059-053 in a BxPC-3 Xenograft Mouse Model of Refractory Pancreatic Cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ynthesis and evaluation of 11C-labeled coumarin analog as an imaging probe for detecting monocarboxylate transporters expression2017

Author(s)

Journal Title

Data Source

[Journal Article] Combined treatment of pancreatic cancer xenograft with 90Y-ITGA6B4-mediated radioimmunotherapy and PI3K/mTOR inhibitor2017

Author(s)

Journal Title

Data Source

[Journal Article] Uptake of 111In-labeled fully human monoclonal antibody TSP-A18 reflects transferrin receptor expression in normal organs and tissues of mice2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] αVβ3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4.2016

Author(s)

Journal Title

DOI

Data Source

Sugyo Aya 須堯綾

SUGYO Aya 須堯綾