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ZHANG Zhouen  張 周恩

ORCIDConnect your ORCID iD *help
Researcher Number 00416207
Other IDs
Affiliation (based on the past Project Information) *help 2018 – 2021: 国立研究開発法人理化学研究所, 生命機能科学研究センター, 研究員
2016 – 2017: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 研究員
2009 – 2010: 独立行政法人理化学研究所, 分子イメージング創薬化学研究チーム, 研究員
Review Section/Research Field
Principal Investigator
Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Except Principal Investigator
Synthetic chemistry
Keywords
Principal Investigator
PETイメージング / 芳香族スズ化合物 / Pd錯体 / [11C]シアン標識法 / 医薬品化学 / バイオイソスター / [cyano-11C]nitrile / C-11標識法 / PET トレーサー / マルチメタル協同作用 … More / マルチ金属協同作用 / [cyano-11C]芳香族ニトリル / Ni(0)錯体 / 芳香族フッ素 / PETトレーサー / Ni錯体 / 11C-カルボニル化標識法 / 芳香族フッ化物 / 芳香族塩化物 / マルチメタル協同型反応 / 11C-シアノ化標識法 / 環状内炭素の[11C]標識法 / PET分子イメージング / 創薬化学 / 環状内炭素の11C標識法 / 有機化学 / 芳香族ボロン酸誘導体 / [11C]Triazine / [11C]Tetrazole / [11C]triazine / [11C]tetrazole / 芳香族ホウ素化合物 / [11C]トリアジン / [11C]テトラゾール / 環状内炭素の11C標識法 / ドラッグデリバリー / PET / がん / ドラックデリバリー(DDS) / 超高感度イメージング / ホスト・ナノ粒子-ゲストPETプローブシステム … More
Except Principal Investigator
共触媒 / 銅 / ニッケル / 結合活性化 / 炭素–フッ素結合切断 / 銅触媒 / ロジウム触媒 / アリールスルフィド / 脱カルボニルホウ素化 / 脱フッ素ホウ素化 / 陽電子放射断層撮像(PET) / ミミック化合物 / フルオロアルケン / PET / 分子プローブ / 標識反応 / PETプローブ / 不活性結合切断反応 / 遷移金属触媒 / ホウ素化反応 Less
  • Research Projects

    (4 results)
  • Research Products

    (39 results)
  • Co-Researchers

    (1 People)
  •  Innovation of Multimetal-Mediated Rapid Carbon-11 Labeling Chemistry and its Versatile ApplicationPrincipal Investigator

    • Principal Investigator
      ZHANG ZHOUEN
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  Intracyclic 11C-Labeling via rapid cyclization of [cyano-11C]cyano(hetero)arenesPrincipal Investigator

    • Principal Investigator
      Zhang Zhouen
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Expeditious preparation of PET probes by molecular renovation strategy enabled by inert-bond cleavage

    • Principal Investigator
      Niwa Takashi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Synthetic chemistry
    • Research Institution
      Institute of Physical and Chemical Research
  •  Development of Host Nanoparticle - Guest PET Tracer System for Supersensitive Molecular Imaging and Drug DiscoveryPrincipal Investigator

    • Principal Investigator
      ZHANG Zhouen
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      The Institute of Physical and Chemical Research

All 2022 2021 2019 2018 2017 2016 2011 2010

All Journal Article Presentation

  • [Journal Article] Palladium(ii)-mediated rapid 11C-cyanation of (hetero)arylborons2018

    • Author(s)
      Zhang Zhouen、Niwa Takashi、Watanabe Yasuyoshi、Hosoya Takamitsu
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 16 Issue: 41 Pages: 7711-7716

    • DOI

      10.1039/c8ob02049c

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339, KAKENHI-PLANNED-17H06414
  • [Journal Article] Highly efficient syntheses of [methyl-11C] thymidine and its analogue 4'-[methyl-^<11>C] thiothymidine as nucleoside PET probes for cancer cell proliferation by Pd0- mediated rapid C-[^<11>C] methylation.2011

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al.
    • Journal Title

      Organic & Biomolecular Chemistry 9

      Pages: 4287-4294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790125
  • [Presentation] Metal-Mediated Rapid 11C-Cyantion of (Hetero)ArylBorons, -Stannanes, -Chlorides and -Fluorides2022

    • Author(s)
      Zhang Zhouen
    • Organizer
      PET Chemistry Workshop 2022, Winter School
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Innovation of Multimetallic-Mediated Carbon-11 Labeling Chemistry2022

    • Author(s)
      Zhang Zhouen
    • Organizer
      A3 Foresight Project Symposium 2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Innovation of carbon-11 labeling chemistry for PET-imaging based drug development2022

    • Author(s)
      Zhang Zhouen
    • Organizer
      IAEA/RCA RAS6097 Enhancing Capacity and Capability for the Production of Cyclotron-Based Radiopharmaceuticals (RCA)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Nickel-mediated 11C-cyanation of (hetero)aryl halides and its versatile application2021

    • Author(s)
      Zhang Zhouen, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya;
    • Organizer
      The 61st Annual Scientific Meeting of the Japanese Society of Nuclear Medicine, Japan-China Nuclear Medicine
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Nickel-mediated rapid 11C-cyanation of (hetero)aryl fluorides and chlorides2021

    • Author(s)
      Zhang Zhouen
    • Organizer
      Asia-3(Japan-China-Korean) Foresight Program Symposium 2020
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons and (hetero)arylstannanes2019

    • Author(s)
      Zhang Zhouen, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      第59回日本核医学会学術交流会, The 12th Japan-China Nuclear Medicine Exchange Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Innovation on Metal-mediated 11C-cyanation and Intracyclic 11C-Labeling2019

    • Author(s)
      Zhang Zhouen
    • Organizer
      The All-RIKEN Workshop 2019
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Development of Boron-Rich PET Tracers for Imaging-Guided Boron Neutron Capture Therapy2019

    • Author(s)
      Zhang Zhouen
    • Organizer
      A3 Foresight Program Symposium 2019 (Cancer Research Institute, Seoul National University College of Medicine)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Innovation on Metal-mediated 11C-cyanation and Intracyclic 11C-Labeling2019

    • Author(s)
      Zhang Zhouen
    • Organizer
      The All-RIKEN Workshop 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Rapid 11C-Cyanation of (Hetero)arylstannanes Mediated by Combined Use of Pd and Cu Complexes2019

    • Author(s)
      4.Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      The 99th CSJ Annual Meeting
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Radiopharmaceutical Chemistry for Imaging-Based Drug Discovery2019

    • Author(s)
      Zhang Zhouen*
    • Organizer
      Workshop for Clinical Phase 0 and PET-based Micro-dose Clinical Study ((School of Pharmacy, Fudan University)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Radiopharmaceutical Chemistry for Imaging-Based Drug Discovery2019

    • Author(s)
      Zhang Zhouen
    • Organizer
      Workshop for Clinical Phase 0 and PET-based Micro-dose Clinical Study, (School of Pharmacy, Fudan University)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Facile Radiosyntheses of [11C]Tetrazoles and [11C]Triazines from (Hetero)Arylborons2019

    • Author(s)
      Zhouen Zhang*, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      23rd International Symposium on Radiopharmaceutical Sciences (ISRS 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium/Copper-mediated Rapid 11C-Cyanation of (Hetero)arylstannanes2019

    • Author(s)
      Zhouen Zhang*, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      23rd International Symposium on Radiopharmaceutical Sciences (ISRS 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons and (hetero)arylstannanes2019

    • Author(s)
      Zhang Zhouen, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      第59回日本核医学会学術交流会, The 12th Japan-China Nuclear Medicine Exchange Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06987
  • [Presentation] Development of Boron-Rich PET Tracers for Imaging-Guided Boron Neutron Capture Therapy2019

    • Author(s)
      Zhang Zhouen*
    • Organizer
      A3 Foresight Program Symposium 2019, (Cancer Research Institute, Seoul National University College of Medicine)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium/Copper-mediated Rapid 11C-Cyanation of (Hetero)arylstannanes2019

    • Author(s)
      Zhouen Zhang*, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya,
    • Organizer
      23rd International Symposium on Radiopharmaceutical Sciences (ISRS 2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Facile Synthesis of PET Radiotracers [11C]Tetrazoles and [11C]Triazines by Utilizing Palladium-Mediated 11C-Cyanation of (Hetero)Arylborons2018

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      日本化学会第98春季年会
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] Palladium(II)-mediated rapid 11C-cyanation of (hetero)arylborons and (hetero)arylstannanes2018

    • Author(s)
      3.Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      A3 Foresight Program Meeting 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] General and efficient methods for the radiosyntheses of [11C]tetrazoles and [11C]triazine from (hetero)arylborons2018

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      The 10th China-Japan-Korea Symposium on Radiopharmaceutical Sciences (CJKSRS 2018)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium(II)-mediated 11C-Cyanation of (Hetero)Arylborons and its Application2018

    • Author(s)
      Zhouen Zhang
    • Organizer
      A3 Foresight Program Seminar
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Facile Syntheses of PET Radiotracers [11C]Tetrazoles and [11C]Triazines by Utilizing Palladium-Mediated 11C-Cyanation of (Hetero)Arylborons2017

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe
    • Organizer
      2018年日本化学年会
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Molecular imaging2017

    • Author(s)
      Zhouen Zhang
    • Organizer
      International Symposium on Smart Brain Medical Informatics and Engineering 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium(II)-Mediated Rapid 11C-Cyanation of Aryl Borons: a General Method for the Synthesis of PET Tracers with a [cyano-11C]Cyanoarene Structure2017

    • Author(s)
      Zhouen, Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      22nd International Symposium on Radiopharmaceutical Sciences (ISRS2017)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] Facile Synthesis of 5-Aryl[11C]tetrazoles via Palladium(II)-Mediated Rapid 11C-Cyanation of (Hetero)Arylborons2017

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Takamitsu Hosoya
    • Organizer
      12th Annual Meeting of the Japanese Society for Molecular Imaging
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] パラジウム錯体を用いるアリールボロン酸誘導体の11C-シアノ化反応2017

    • Author(s)
      張周恩、○丹羽節、渡辺恭良、細谷孝充
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学 日吉キャンパス(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] Facile Synthesis of 5-Aryl[11C]tetrazoles via Palladium(II)-Mediated Rapid 11C-Cyanation of (Hetero)Arylborons2017

    • Author(s)
      Zhouen, Zhang, Takashi Niwa, Takamitsu Hosoya
    • Organizer
      日本分子イメージング学会 第12回学会総会・学術総会(JSMI 2017)
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] Palladium-Mediated Rapid 11C-Cyanation of (Hetero)Arylborons and its Application for Syntheses of 11C-Labeled PET Tracers2017

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      The 4th RIKEN-Karolinska Institutet-SciLifeLab Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium-Mediated Rapid 11C-Cyanation of (Hetero)Arylborons and Its Application for Syntheses of 11C-Labeled PET Tracers2017

    • Author(s)
      Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      The 4th RIKEN / Karolinska Institute / SciLifeLab Joint Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] パラジウム錯体を用いるアリールボロン酸誘導体の11C-シアノ化反応2017

    • Author(s)
      張周恩、丹羽節、渡辺恭良、細谷孝充
    • Organizer
      日本化学会第97春季年会(2017)
    • Place of Presentation
      慶應義塾大学日吉キャンパス(神奈川県・横浜市)
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium(II)-Mediated Rapid C-[11C]Cyanation of Arylboron Compounds with Various Functional Groups Applicable to the Synthesis of PET Imaging Tracers2016

    • Author(s)
      張周恩、丹羽節、渡辺恭良、細谷孝充
    • Organizer
      11th Annual Meeting of the Japanese Society for Molecular Imaging
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2016-05-28
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Palladium(II)-Mediated Rapid C-[11C]Cyanation of Arylboron Compounds with Various Functional Groups Applicable to the Synthesis of PET Imaging Tracers2016

    • Author(s)
      ○Zhouen Zhang, Takashi Niwa, Yasuyoshi Watanabe, Takamitsu Hosoya
    • Organizer
      第11回日本分子イメージング学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Data Source
      KAKENHI-PROJECT-15K05509
  • [Presentation] Palladium(II)-Mediated Rapid C-[11C]Cyanation of Arylborons2016

    • Author(s)
      張周恩、丹羽節、渡辺恭良、細谷孝充
    • Organizer
      第13回中国放射線薬物と標識化合物学術交流会
    • Place of Presentation
      Beijing (China)
    • Year and Date
      2016-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08339
  • [Presentation] Efficient syntheses of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine based on the Pd^0-mediated rapid C-[^<11>C]methylations.2010

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al
    • Organizer
      Pacifichem 2010 Congress
    • Place of Presentation
      Honolulu, Hawaii.
    • Year and Date
      2010-12-16
    • Data Source
      KAKENHI-PROJECT-21790125
  • [Presentation] High-yield practical synthesis of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine by Pd^0-mediated rapid C-[11C] methylation2010

    • Author(s)
      H.Koyama, Z.Zhang, M.Suzuki, et al
    • Organizer
      2010 World Molecular Imaging Congress
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-21790125
  • [Presentation] High-yield practical synthesis of [methyl-^<11>^C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine by Pd^0-mediated rapid C-[^<11>C] methylation.2010

    • Author(s)
      Koyama H., Zhang Z., Suzuki M., et al
    • Organizer
      2010 world Molecular Imaging Congress.
    • Place of Presentation
      Kyoto.
    • Year and Date
      2010-09-09
    • Data Source
      KAKENHI-PROJECT-21790125
  • [Presentation] Efficient syntheses of [methyl-^<11>C] thymidine and its stable analogue 4'-[methyl-^<11>C] thiothymidine based on the Pd^0-mediated rapid C-[11C] methylations2010

    • Author(s)
      H.Koyama, Z.Zhang, M.Suzuki, et al
    • Organizer
      Pacifichem 2010 Congress
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Data Source
      KAKENHI-PROJECT-21790125
  • 1.  Niwa Takashi (30584396)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results

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