OHSUGI MITSURU 大杉満

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OHSUGI Mitsuru 大杉満

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Researcher Number	00420216
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, センター長
Affiliation (based on the past Project Information) *help	2008 – 2010: The University of Tokyo, 医学部附属病院, 助教 2007: The University of Tokyo, Graduate School of Medicine, Assistant Professor 2006: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Metabolomics
Keywords	Principal Investigator 糖尿病 / Pancreatic β cells / Signal Transduction / Diabetes Melitus / 膵ベータ細胞 / シグナル伝達 / カルモジュリン依存性キナーゼ / lRS-2 / 代償性肥大 / CaMK / CREB / IRS / 膵β細胞

Molecular biology of pancreatic islet β cell proliferation and failurePrincipal Investigator
- Principal Investigator
  
  OHSUGI Mitsuru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo
Molecular Mechanisms on Pancreatic β cell ProliferationPrincipal Investigator
- Principal Investigator
  
  MITSURU Ohsugi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokyo

All 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] インスリン抵抗性と膵B細胞の増殖カラー版糖尿病学基礎と臨床2007
- Author(s)
  大杉満
- Total Pages
  1373
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-18590978
[Book] インスリン抵抗性と膵β細胞の増殖カラー版糖尿病学基礎と臨床2007
- Author(s)
  大杉満
- Total Pages
  1373
- Publisher
  西村書店
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms.2010
- Author(s)
  Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T
- Journal Title
  
  Cell Metab. 12(6)
  
  Pages: 619-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] Y, Ueki K, Kadowaki T2010
- Author(s)
  Okazaki Y, Eto K, Yamashita T, Okamoto M, Ohsugi M, Noda M, Terauchi
- Journal Title
  
  Decreased Insulin Secretion and Accumulation of Triglyceride in beta Cells Overexpressing a Dominant-Negative Form of AMP-Activated Protein Kinase Endocr J. 57(2)
  
  Pages: 141-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice.2009
- Author(s)
  Hashimoto H, Arai T, Hikishima K, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Okano H, Yamauchi T, Kubota N, Ueki K, Tobe K, Tamaoki N, Kadowaki T, Kosaka K
- Journal Title
  
  Exp Clin Endocrinol Diabetes. 117(10)
  
  Pages: 577-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009
- Author(s)
  Nishimura S, Manabe I, Naga, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
- Journal Title
  
  Nat. Med. 15(8)
  
  Pages: 914-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice.2008
- Author(s)
  Arai T, Hashimoto H, Kawai K, Mori A, Ohnishi Y, Hioki K, Ito M, Saito M, Ueyama Y, Ohsugi M, Suzuki R, Kubota N, Yamauchi T, Tobe K, Kadowaki T, Kosaka K
- Journal Title
  
  Clin Exp Med. 8
  
  Pages: 93-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, Hosoya Y, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.
- Journal Title
  
  J Clin Invest 118(2)
  
  Pages: 710-21
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.2008
- Author(s)
  Takamoto I, Terauchi Y, Kubota N, Ohsugi M, Ueki K, Kadowaki T
- Journal Title
  
  Diabetes Obes Metab. 10(Suppl 4)
  
  Pages: 147-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] An Efficient Reproductive Method for Irs2(-/-) Mice with C57BL/6JJcl Genetic Background.2008
- Author(s)
  Hashimoto H, Eto T, Kamisako T, Hoya N, Hatakeyama T, Arai T, Yokosuka M, Ohnishi Y, Ito M, Hioki K, Suzuki R, Ohsugi M, Saito M, Ueyama Y, Yamauchi T, Kubota N, Tobe K, Kadowaki T, Tamaoki N, Nomura T, Kosaka K
- Journal Title
  
  Exp Anim. 57
  
  Pages: 407-11
- NAID
  10024166620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.2008
- Author(s)
  Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
- Journal Title
  
  Cell Metab. 8(1)
  
  Pages: 49-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.2008
- Author(s)
  Oishi Y, Manabe I, Tobe K, Ohsugi M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R
- Journal Title
  
  Nat Med. 14(6)
  
  Pages: 656-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591051
[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels2007
- Author(s)
  Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, Ohsugi M, Tobe K, Kadowaki T, Nagai R, Sugiura S.
- Journal Title
  
  Diabetes 56(6)
  
  Pages: 1517-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Insulin Resistance and β cell proliferation2007
- Author(s)
  Ohsugi M
- Journal Title
  
  In Kadowaki T, Ishibashi S, Sakura H, Tobe K, and Noda M(editors) Textbook of Diabetes Mellitus-Basic and Clinical Sciences, Nishimura shoten
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] A global approach to identify differentially expressed genes in cDNA(two-color) microarray experiments2007
- Author(s)
  Zhou Y, Cras-Meneur C, Ohsugi M, Stormo GD, Permutt MA.
- Journal Title
  
  Bioinformatics 23(16)
  
  Pages: 2073-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable2007
- Author(s)
  Hashimoto H, Arai T, Ohnishi Y, Eto T, Ito M, Hioki K, Suzuki R, Yamauchi T, Ohsugi M. Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.
- Journal Title
  
  Exp Anim 56(2)
  
  Pages: 149-54
- NAID
  130000068045
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Overexpression of MCP-1 in adipose tissues causes macrophage recruitment and insulin resistance2006
- Author(s)
  Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 26602-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Journal Article] Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BLJ6J : Jcl mice deficient in insulin receptor substrate 22006
- Author(s)
  Hashimoto H, Arai T, Takeguchi A, Hioki K, Ohnishi Y, Kawai K, Ito M, Suzuki R, Yamauchi T, Ohsugi M, Saito M, Ueyama Y, Tobe K, Kadowaki T, Tamaoki N, Kosaka K.
- Journal Title
  
  Comp Med 56(3)
  
  Pages: 176-87
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] 膵島IRS-2量調節の分子機構:分子メカニズム2010
- Author(s)
  大杉満、勝山修行、窪田直人、植木浩二郎、門脇孝
- Organizer
  第3回日本肥満症治療学会学術集会
- Place of Presentation
  東京(口頭発表)
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島IRS-2量調節の分子機構:肥満・糖尿病モデルにおけるIRS-2量2010
- Author(s)
  勝山修行、大杉満、窪田直人、植木浩二郎、門脇孝
- Organizer
  第3回日本肥満症治療学会学術集会
- Place of Presentation
  東京
- Year and Date
  2010-09-11
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島IRS-2量調節の分子機構2:分子メカニズム2010
- Author(s)
  大杉満
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島IRS-2量調節の分子機構1:肥満・糖尿病モデルにおけるIRS-2量2010
- Author(s)
  勝山修行、大杉満、窪田直人、植木浩二郎、門脇孝
- Organizer
  第53回日本糖尿病学会学術総会
- Place of Presentation
  岡山(口頭発表)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島IRS-2量調節の分子機構2:分子メカニズム2010
- Author(s)
  大杉満、勝山修行、窪田直人、植木浩二郎、門脇孝
- Organizer
  第53回日本糖尿病学会学術総会
- Place of Presentation
  岡山(口頭発表)
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島代償性増殖とその破綻における膵島IRS-2量調節の分子機構2009
- Author(s)
  大杉満、窪田直人、小林正稔、笹子敬洋、金子和真、勝山修行、植木浩二郎、門脇孝
- Organizer
  第59回日本体質医学会総会
- Place of Presentation
  東京(口頭発表)
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島代償性増殖とその破綻における膵島IRS-2量調節の分子機構:糖代謝の重要性2009
- Author(s)
  勝山修行、大杉満、窪田直人、戸邉一之、小林正稔、笹子敬洋、金子和真、植木浩二郎、門脇孝
- Organizer
  第52回日本糖尿病学会学術総会
- Place of Presentation
  大阪(口頭発表)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島代償性増殖とその破綻における膵島IRS-2量調節の分子機構:CaMキナーゼ4-転写因子CREBの役割2009
- Author(s)
  大杉満
- Organizer
  第52回糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-05-23
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵島代償性増殖とその破綻における膵島IRS-2量調節の分子機構:CaMキナーゼ4転写因子CREBの役割2009
- Author(s)
  大杉満、窪田直人、戸邉一之、小林正稔、笹子敬洋、金子和真、勝山修行、植木浩二郎、門脇孝
- Organizer
  第52回日本糖尿病学会学術総会
- Place of Presentation
  大阪(口頭発表)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] GlucoseEB-IR Pathway isponsible for the Failure of Compensatory β Hyperplasia in the Pogression to Diabetes.2008
- Author(s)
  Mitsuru Ohsugi, Naoto Kubota, Kohjiro Ueki, Takashi Kadowaki
- Organizer
  American Diabetes Association Annual Scientific Sessions
- Place of Presentation
  San Francisco, CA, USA(Oral Presentation)
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] Dysfunction of Glucose-CREB-IRS-2 Pathway is Responsible for the Failure of Compensatory 5 Hyperplasia in the Progression to Diabetes2008
- Author(s)
  大杉満
- Organizer
  American Diabetes Association Annual Scientific Sessions
- Place of Presentation
  San Francisco, USA
- Year and Date
  2008-06-06
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵β細胞の代償性増殖とその破綻におけるIRS-2の役割2008
- Author(s)
  大杉満
- Organizer
  第51回日本糖尿病学会学術総会
- Place of Presentation
  東京(シンポジスト)
- Year and Date
  2008-05-22
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] 膵β細胞の代償性増殖とその破綻におけるIRS-2の役割2008
- Author(s)
  大杉満
- Organizer
  第51回日本糖尿病学会学術総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591051
[Presentation] Islet IRS-2 Increases in Response to Systemic Insulin Resistance2007
- Author(s)
  Ohsugi M, Tobe K, Kobayashi M, Suzuki R, Sasako T, and Kadowaki T
- Organizer
  50th Annual Scientific Meeting of the Japan Diabetes Society
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] Critical Roles of IRS-1 and IRS-2 in the Development of Fetal Pancreatic Islets2007
- Author(s)
  Ohsugi M, Tobe K, Suzuki R, Kowatari-Otsuka N, Kubota N, Terauchi Y, and 10th Annual Kadowaki T
- Organizer
  Scientific Meeting of Japan Society of Metabolism and Clinical Nutrition
- Place of Presentation
  Yokohama, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] Exocytosis Complex Molecules Rab3 and SNAP25 in Islet β cells in Response to Systemic Insulin Resistance and Glucotoxicity2007
- Author(s)
  Kobayashi M, Tobe K, Suzuki R, Ohsugi M, Kowatari-Otsuka N, Sakamoto K Kubota N, Terauchi Y, Nagamatsu S, and Kadowaki T
- Organizer
  49th Annual Scientific Meeting of the Japan Diabetes Society
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] 膵島IRS-2はインスリン抵抗性存在で上昇する2007
- Author(s)
  大杉満
- Organizer
  第50回日本糖尿病学会学術総会
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] Mice Overexpressing Monocyte Chemoattract Protein 1(MCP-1) in Adipose Tissues Exhibit Insulin Resistance in the Skeltal Muscle2007
- Author(s)
  Kamei N, Tobe K, Suzuki R, Ohsugi M, Sakamoto K, Kobayashi M, Kowatari-Otsuka N, Kubota N, and Kadowaki T.
- Organizer
  49th Annual Scientific Meeting of the Japan Diabetes Society
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] IRS-1およびIRS-2は胎生期の膵島形成に関与する2007
- Author(s)
  大杉満
- Organizer
  第10回日本病態栄養学会年次学術集会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590978
[Presentation] Mice Overexpressing Monocyte Chemoattract Protein 1(MCP-1) in Adipose Tissues Exhibit Whole Body Insulin Resistance2006
- Author(s)
  Kamei N, Tobe K, Suzuki R, Ohsugi M, Kubota N, and Kadowaki T.
- Organizer
  American Diabetes Association Annual Scientific Sessions, Washington DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590978

1. KADOWAKI Takashi (30185889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 26 results
2. KUBOTA Naoto (50396719)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. UEKI Kohjiro (00396714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. TOBE Kazuyuki (30251242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

OHSUGI MITSURU 大杉 満

OHSUGI Mitsuru 大杉 満

Research Projects

Research Products

Co-Researchers

Molecular biology of pancreatic islet β cell proliferation and failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Mechanisms on Pancreatic β cell ProliferationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] インスリン抵抗性と膵B細胞の増殖 カラー版糖尿病学基礎と臨床2007

Author(s)

Total Pages

Publisher

Data Source

[Book] インスリン抵抗性と膵β細胞の増殖 カラー版糖尿病学基礎と臨床2007

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms.2010

Author(s)

Journal Title

Data Source

[Journal Article] Y, Ueki K, Kadowaki T2010

Author(s)

Journal Title

Data Source

[Journal Article] Reconsideration of Insulin Signals Induced by Improved Laboratory Animal Diets, Japanese and American Diets, in IRS-2 Deficient Mice.2009

Author(s)

Journal Title

Data Source

[Journal Article] CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.2009

Author(s)

Journal Title

Data Source

[Journal Article] Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice.2008

Author(s)

Journal Title

Data Source

[Journal Article] In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Crucial role of insulin receptor substrate-2 in compensatory beta-cell hyperplasia in response to high fat diet-induced insulin resistance.2008

Author(s)

Journal Title

Data Source

[Journal Article] An Efficient Reproductive Method for Irs2(-/-) Mice with C57BL/6JJcl Genetic Background.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.2008

Author(s)

Journal Title

Data Source

[Journal Article] SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.2008

Author(s)

Journal Title

Data Source

[Journal Article] Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Insulin Resistance and β cell proliferation2007

Author(s)

Journal Title

Description

Data Source

OHSUGI MITSURU 大杉満

OHSUGI Mitsuru 大杉満

[Book] インスリン抵抗性と膵B細胞の増殖カラー版糖尿病学基礎と臨床2007

[Book] インスリン抵抗性と膵β細胞の増殖カラー版糖尿病学基礎と臨床2007