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OBATA Miki  小幡 美貴

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小幡 美貫  オバタ ミキ

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Researcher Number 00420307
Affiliation (based on the past Project Information) *help 2009 – 2015: 新潟大学, 医学部, 教務職員
2013: 新潟大学, 医歯学系, 教務職員
2008 – 2009: 新潟大学, 医歯学系, 教務職員
2005 – 2007: 新潟大学, 医学部, 教務職員
Review Section/Research Field
Principal Investigator
Risk sciences of radiation and chemicals
Except Principal Investigator
Risk sciences of radiation/Chemicals / Functional basic dentistry / Biological Sciences
Keywords
Principal Investigator
DNAチップ解析 / グリセロール密度勾配遠心法 / SWI/SNIF複合体 / がん抑制因子 / p53-MDM2フィードバックループ / 放射線応答 / SWI/SNF複合体 / がん抑制遺伝子 / BCL11B
Except Principal Investigator
Bcl11b … More / リンパ腫 / アポトーシス / がん抑制遺伝子 / Bcl11b遺伝子 / ROS / シグナル伝達 / 電離放射線 / 腸管腫瘍 / 発がん感受性 / Chk1 / 胸腺リンパ腫 / Bclllb遺伝子 / 大腸がん / 細胞増殖 / Atrophic thymus / susceptibility / radiation / lymphomas / 2 / MTF-1 / アポーシス / 発がん感受性遺伝子 / リンパ腫抑制遺伝子 / 萎縮胸腺 / 放射線 / 細胞の増殖と消失 / 発がん母細胞 / 放射線標的細胞 / Bcl11b / 幹細胞 / 発がん / 腸管組織肥厚 / 転写制御 / βカテニン / p57遺伝子 / p27遺伝子 / Bck11b / Lucレポーターアッセイ / Mdm2 / がん抑制因子 / 発現制御 / Mdm2/HDM2 / p53 / Mdm2/HDM2 / p^53 / 転写因子Bcl11b/BCL11B / 腸管組織の肥厚 / 過剰歯形成 / 遺伝学 / がん / β-カテニン / 癌細胞幹細胞 / 放射線発がん初期過程 / 放射線ターゲット細胞 / 前リンパ腫細胞・腸管腫瘍 / 電離放射線影響 / 亜鉛フィンガードメイン / TOP/FOPflash / Wnt/β-cateninシグナル / 機能解析 / 研究分担者 Less
  • Research Projects

    (6 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (11 People)
  •  Effect of BCL11B and its mutations on the radiation response: analysis of a p53-MDM2 feed-back loopPrincipal Investigator

    • Principal Investigator
      OBATA Miki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Niigata University
  •  Radiation target and mutagenesis in intestinal tumors

    • Principal Investigator
      KOMINAMI Ryo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Niigata University
  •  Analysis of mouse teeth hyperplasia and gut tissue enlargement by mutation of transcription factor Bcl11b

    • Principal Investigator
      MISHIMA Yukio
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Niigata University
  •  Host factors and genetic mutations in radiation carcinogenesis

    • Principal Investigator
      KOMINAMI Ryo
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Niigata University
  •  Isolation and characterization of cancer-related genes in mouse models

    • Principal Investigator
      KOMINAMI Ryo
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Niigata University
  •  Isolation and characterization of genes involved in radiogenic mouse thymic lymphomas

    • Principal Investigator
      KOMINAMI Ryo
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Risk sciences of radiation/Chemicals
    • Research Institution
      Niigata University

All 2015 2014 2013 2012 2011 2010 2009 2007 Other

All Journal Article Presentation

  • [Journal Article] Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway.2015

    • Author(s)
      Sakamaki A, Katsuragi Y, Otsuka K, Tomita M, Obata M, Iwasaki T, Abe M, Sato T, Ochiai M, Sakuraba Y, Aoyagi Y, Gondo Y, Sakimura K, Nakagama H, Mishima Y, Kominami R
    • Journal Title

      Carcinogenesis

      Volume: 36 Issue: 6 Pages: 622-631

    • DOI

      10.1093/carcin/bgv044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25340027
  • [Journal Article] Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells2015

    • Author(s)
      Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.
    • Journal Title

      Cance Science

      Volume: 106(4) Issue: 4 Pages: 461-465

    • DOI

      10.1111/cas.12618

    • NAID

      120006844098

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26670222, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26461417, KAKENHI-PROJECT-15H04704, KAKENHI-PROJECT-25340027, KAKENHI-PROJECT-26242088
  • [Journal Article] Successful management of severe intrahepatic cholestasis of pregnancy: report of a first Japanese case.2014

    • Author(s)
      Kamimura K, Abe H, Kamimura N, Yamaguchi M, Mamizu M, Ogi K, Takahashi Y, Mizuno K, Kamimura H, Kobayashi Y, Takeuchi M, Yoshida K, Yamada K, Enomoto T, Takakuwa K, Nomoto M, Obata M, Katsuragi Y, Mishima Y, Kominami R, Kamimura T, Aoyagi Y.
    • Journal Title

      BMC Gastroenterol.

      Volume: 14 Issue: 1 Pages: 160-4

    • DOI

      10.1186/1471-230x-14-160

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25340027
  • [Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors2013

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R
    • Journal Title

      Mech Dev

      Volume: 130 Pages: 482-492

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310036
  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele2013

    • Author(s)
      Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 1009-1016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310036
  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele.2013

    • Author(s)
      Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R.
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 8 Pages: 1009-1016

    • DOI

      10.1111/cas.12193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310036, KAKENHI-PROJECT-23710067, KAKENHI-PROJECT-23792100, KAKENHI-PROJECT-24700321, KAKENHI-PROJECT-24790465, KAKENHI-PROJECT-25340027
  • [Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors.2013

    • Author(s)
      Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
    • Journal Title

      Mechanism and Development

      Volume: 130 Issue: 9-10 Pages: 482-492

    • DOI

      10.1016/j.mod.2013.05.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310036, KAKENHI-PROJECT-23593026, KAKENHI-PROJECT-23792100, KAKENHI-PROJECT-24659810, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25340027
  • [Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p^53-dependent manner2012

    • Author(s)
      M. Obata, R. Kominami and Y. Mishima
    • Journal Title

      Cellular Signalling

      Volume: 24 Issue: 5 Pages: 1047-1052

    • DOI

      10.1016/j.cellsig.2011.12.026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Journal Article] BCL11B tumor suppressor inhibits HDM2 expression in a p53-dependent manner2012

    • Author(s)
      Obata M, Kominami R, Mishima Y
    • Journal Title

      Cell Signal

      Volume: 24 Pages: 1047-52

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23310036
  • [Journal Article] Clonally expanding thymocytes having lineage capability inγ-ray induced mouse atrophic thymus.2010

    • Author(s)
      Yamamoto T, Morita S, Go E, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R
    • Journal Title

      Int. J. Radiation Oncology Biol. 77

      Pages: 235-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18201009
  • [Journal Article] Clonally expanding thymocytes having lineage capability in y-ray induced mouse atrophic thymus.2010

    • Author(s)
      Yamamoto T, Morita S, Go E, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
    • Journal Title

      Int.J.Radiation Oncology Biol. 77

      Pages: 235-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013033
  • [Journal Article] Clonally expanding thymocytes having lineage capability in γ-ray induced mouse atrophic thymus.2010

    • Author(s)
      Yamamoto T, Morita S, Go E, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
    • Journal Title

      Int.J.Radiation Oncology Biol Phys 77(1)

      Pages: 235-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18201009
  • [Journal Article] Clonally expanding thymocytes having lineage capability in γ-ray induced mouse atrophic thymus2010

    • Author(s)
      T. Yamamoto, S. Morita, E. Go, M. Obata, Y. Katsuragi, Y. Fujita, Y. Maeda, M. Yokoyama, Y. Aoyagi, H. Ichikawa, Y. Mishima and R. Kominami
    • Journal Title

      International Journal of Radiation Oncology. Biology. Physics

      Volume: 77 Issue: 1 Pages: 235-243

    • DOI

      10.1016/j.ijrobp.2009.11.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Journal Article] Clonally expanding thymocytes having lineage capability in γ-ray induced mouse atrophic thymus.2010

    • Author(s)
      Yamamoto T, Morita S, Go E, Obata M, Katsuragi T, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
    • Journal Title

      Int.J.Radiation Oncology Biol Phys

      Volume: 77 Pages: 235-243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013033
  • [Journal Article] Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress andd amages.2007

    • Author(s)
      Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R
    • Journal Title

      Oncogene 26

      Pages: 5840-5850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18201009
  • [Journal Article] Lack of Bclllb tumor suppressor results in vulnerability to DNA replication stress andd amages.2007

    • Author(s)
      Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R.
    • Journal Title

      Oncogene 26

      Pages: 5840-5850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013033
  • [Journal Article] Cell of origin in radiation-induced premalignant thymocytes with differentiation capability in mice conditionally losing one Bcl11b allele

    • Author(s)
      R. Go, S. Hirose, Y. Katsuragi, M. Obata, M. Abe, Y. Mishima, K. Sakimura and R.Kominami
    • Journal Title

      Cancer Science

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] 転写因子BCL11Bはp53を介して細胞周期を調節する?2013

    • Author(s)
      小幡 美貴 ・ 木南 凌 ・ 三嶋 行雄
    • Organizer
      第56回日本放射線影響学会大会
    • Place of Presentation
      ホテルクラウンパレス青森 (青森市)
    • Data Source
      KAKENHI-PROJECT-25340027
  • [Presentation] 放射線発がんにおける発がん母細胞と標的細胞2013

    • Author(s)
      木南 凌, 郷 梨江香, 葛城 美徳, 小幡美貴, 三嶋行雄
    • Organizer
      第55回大会 日本放射線影響学会
    • Place of Presentation
      青森市
    • Year and Date
      2013-10-18
    • Data Source
      KAKENHI-PROJECT-23310036
  • [Presentation] BCL11B mutations identified in T-ALL leukemias negatively or positively affect the activity of SWI/SNF chromatin remodeling complexes2013

    • Author(s)
      小幡 美貴 ・ 木南 凌 ・ 三嶋 行雄
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド (神戸市)
    • Data Source
      KAKENHI-PROJECT-25340027
  • [Presentation] 放射線発がんにおける発がん母細胞と標的細胞2013

    • Author(s)
      木南凌、 郷梨江香、葛城美徳、小幡美貴、三嶋行雄
    • Organizer
      日本放射線影響学会
    • Place of Presentation
      青森
    • Invited
    • Data Source
      KAKENHI-PROJECT-23310036
  • [Presentation] ヒトT細胞急性リンパ芽球性白血病で見いだされたBCL11B突然変異はp53依存性にHDM2プロモーター活性の抑制効果を阻害する2012

    • Author(s)
      小幡美貴、木南凌、三嶋行雄
    • Organizer
      第35回日本分子生物学会年
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] 放射線照射後の腸上皮におけるBcl11bの働き2012

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄、大塚健介、木南凌
    • Organizer
      第55回日本放射線影響学会
    • Place of Presentation
      仙台
    • Year and Date
      2012-09-07
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] Bcl11bの片アリル欠損はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する2011

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、三嶋行雄、木南凌
    • Organizer
      第54回日本放射線影響学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] 転写因子Bcl11bはp^53経路を介して細胞増殖を抑制する2011

    • Author(s)
      小幡美貴、坂牧僚、木南凌、三嶋行雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] BCL11B inhibits HDM2 expression in a p^53-denpendent manner2011

    • Author(s)
      小幡美貴、木南凌、三嶋行雄
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation2011

    • Author(s)
      葛城美徳、小幡美貴、三嶋行雄、木南凌
    • Organizer
      第14回国際放射線研究会議
    • Place of Presentation
      ワルシャワ、ポーランド
    • Year and Date
      2011-08-28
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] BCL11B inhibits HDM2 expression in a p53-dependent manner2011

    • Author(s)
      小幡、木南、三嶋
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] 転写因子Bcl11bはp53経路を介して細胞増殖を抑制する2011

    • Author(s)
      小幡、坂牧、木南、三嶋
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-09-23
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] p27/p57遺伝子内のBcl11b依存性転写活性化及び抑制化制御配列2010

    • Author(s)
      小幡美貴、西川敦、木南凌、三嶋行雄
    • Organizer
      第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] Bcl11bは腸上皮細胞の恒常性を制御する大腸がん抑制遺伝子である2010

    • Author(s)
      葛城美徳、坂牧僚、小幡美貴、郷梨江香、三嶋行雄、権藤洋一、落合雅子、中釜斉、木南凌
    • Organizer
      第83回日本生化学会大会/第33回日本分子生物学会年会合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] P27/p57遺伝子内のBcl11b依存性転写活性化及び抑制化制御配列2010

    • Author(s)
      小幡美貴
    • Organizer
      第33回日本分子生物学会年会,第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸)
    • Year and Date
      2010-12-09
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] Bcl11b is an intestinal tumor suppressor that controls intestinal cell homeostasis2010

    • Author(s)
      坂牧僚、葛城美徳、小幡美貴、落合雅子、中釜斉、権藤洋一、三嶋行雄、木南凌
    • Organizer
      第69回 日本癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Data Source
      KAKENHI-PROJECT-22592062
  • [Presentation] γ線照射によるマウス萎縮胸腺内の前リンパ腫細胞形成には細胞増殖と分化停止が必要である2009

    • Author(s)
      葛城美徳、郷梨江香、森田慎一、小幡美貴、木南凌
    • Organizer
      第52回日本放射線影響学会
    • Place of Presentation
      広島
    • Year and Date
      2009-11-11
    • Data Source
      KAKENHI-PROJECT-18201009
  • [Presentation] Role of BCL11B in the SWI/SNF chromatin remodeling complexes

    • Author(s)
      小幡 美貴 ・ 木南 凌・ 三嶋 行雄
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-25340027
  • [Presentation] Effect of mutations in BCL11B on the SWI/SNF chromatin remodeling complexes

    • Author(s)
      小幡 美貴 ・ 木南 凌 ・葛城 美徳 ・ 三嶋 行雄
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-25340027
  • [Presentation] ヒトT細胞急性リンパ芽球性白血病で見いだされたBCL11B突然変異はp53依存性にHDM2プロモーター活性の抑制効果を阻害する

    • Author(s)
      小幡 美貴
    • Organizer
      第三十五回日本分子生物学会年会
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-22592062
  • 1.  KATSURAGI Yoshinari (60401759)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 13 results
  • 2.  KOMINAMI Ryo (40133615)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 19 results
  • 3.  HIROSE Satoshi (10415276)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 4.  MISHIMA Yukio (30166003)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 26 results
  • 5.  MISHIMA Yukio (30142029)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  INOUE Jun (70323962)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  HIGUCHI Masaya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  TAKAHASHI Masahiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  三島 行雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 10.  権藤 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  藤井 雅寛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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