Mimura Naoya 三村尚也

… Alternative Names

MIMURA Naoya 三村尚也

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Researcher Number	00422220
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 千葉大学, 医学部附属病院, 講師 2014 – 2020: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 多発性骨髄腫 / モデルマウス / EZH2/EZH1共阻害剤 / ヒストンメチル化異常 / プロテアソーム阻害剤 / 免疫逃避 / 成熟B細胞腫瘍 / 制御性T細胞 / 疲弊T細胞 / エピジェネティック … More / BMI1ダウンレギュレーター / 選択的Akt阻害剤 / エピジェネティクス / 血液内科学 / EZH2/1共阻害剤 / BRAF / UTX / EZH2/EZH1阻害剤 / 骨髄腫モデルマウス / EZH2阻害剤 / EZH2 / EZH2阻害薬 / ヒストンメチル化 / エピジェネティック異常 … More Except Principal Investigator POEMS症候群 / 微小残存病変 / クローン / 形質細胞 / 次世代シークエンサー / 巨核球 / 血小板 / 形質細胞腫瘍類縁疾患 / クロウ・深瀬症候群 / 骨髄腫類縁疾患 / クロナリティ / アミロイドーシス / 腫瘍クローン / 形質細胞類縁疾患 / ALアミロイドーシス / 次世代シーケンサー / POEMS syndrome / 形質細胞腫瘍 / Osteopontin / MHC class II / VEGF / RNAシーケンス / シングルセル解析 Less

成熟B細胞腫瘍モデルマウスが明らかにするCD38陽性免疫抑制細胞の病的意義Principal Investigator
- Principal Investigator
  
  三村尚也
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
The role of megakaryocytes and platelets in pathogenesis of POEMS syndrome
- Principal Investigator
  
  塚本祥吉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
POEMS症候群における微小クローン同定による診断治療戦略の確立
- Principal Investigator
  
  堺田惠美子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Elucidation of the mechanisms of immune escape in a mouse model of mature B cell neoplasms for the development of novel therapiesPrincipal Investigator
- Principal Investigator
  
  三村尚也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Integrative epigenetic therapies using novel myeloma mouse modelsPrincipal Investigator
- Principal Investigator
  
  Mimura Naoya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Elucidation of the molecular pathology of AL amyloidosis by gene expression analysis of bone marrow plasma cells
- Principal Investigator
  
  Sakaida Emiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Elucidation of the molecular mechanism of POEMS syndrome by single cell analysis of bone marrow plasma cells
- Principal Investigator
  
  Nakaseko Chiaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  International University of Health and Welfare
Epigenetic pathogenesis of multiple myeloma related to drug resistancePrincipal Investigator
- Principal Investigator
  
  Naoya Mimura
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Abberant histone methylation as a therapeutic target in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  MIMURA Naoya
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation Book

[Book] 血液内科2019年1月特集「多発性骨髄腫の分子病態解明の進歩と新たな治療展開」2019
- Author(s)
  三村尚也（分担）
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16K09839
[Book] 日本臨牀2018年7月特集「多発性骨髄腫-基礎・臨床研究の最新動向」2018
- Author(s)
  三村尚也（分担）
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-16K09839
[Book] 多発性骨髄腫学ー最新の診療と基礎研究ー2016
- Author(s)
  三村尚也　岩間厚志（分担著者）
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-16K09839
[Book] 多発性骨髄腫Updating第10巻2016
- Author(s)
  三村尚也（分担著者）
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-16K09839
[Book] 日本臨牀　多発性骨髄腫学　2016年7月増刊号2016
- Author(s)
  三村尚也、岩間厚志
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-26860719
[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023
- Author(s)
  Rizq Ola、Mimura Naoya、Oshima Motohiko、Momose Shuji、Takayama Naoya、Itokawa Naoki、Koide Shuhei、Shibamiya Asuka、Miyamoto-Nagai Yurie、Rizk Mohamed、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Wang Changshan、Saraya Atsunori、Ito Ryoji、Seimiya Masanori、et al
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 9 Pages: 1895-1907
- DOI
  10.1038/s41375-023-01928-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K05608, KAKENHI-PROJECT-23K06449, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16318, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023
- Author(s)
  1.Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: － Issue: 8 Pages: 2635-2648
- DOI
  10.1007/s00262-023-03447-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19497, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] Unraveling unique features of plasma cell clones in POEMS syndrome with single-cell analysis.2022
- Author(s)
  Isshiki Y, Oshima M, Mimura N, Kayamori K, Miyamoto-Nagai Y, Seki M, Nakajima-Takagi Y, Kanamori T, Iwamoto E, Muto T, Tsukamoto S, Takeda Y, Ohwada C, Misawa S, Ikeda JI, Sanada M, Kuwabara S, Suzuki Y, Sakaida E, Nakaseko C, Iwama A.
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 20 Pages: 1-13
- DOI
  10.1172/jci.insight.151482
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07955, KAKENHI-PROJECT-21K06881, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K08447, KAKENHI-PROJECT-22K08471, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20K08723, KAKENHI-PLANNED-19H05746
[Journal Article] POEMS症候群に特徴的な免疫グロブリン軽鎖変異パターン2021
- Author(s)
  一色佑介，三村尚也，塚本祥吉，堺田惠美子，中世古知昭
- Journal Title
  
  血液内科
  
  Volume: in press
- NAID
  40022600467
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08338
[Journal Article] The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells.2021
- Author(s)
  Nagai Y, Mimura N, Nakaseko C et al
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 2074-2074
- DOI
  10.1038/s41598-021-81577-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-19K08807, KAKENHI-PROJECT-20K08276, KAKENHI-PROJECT-21K19497
[Journal Article] Identification of clonal immunoglobulin λ light-chain gene rearrangements in AL amyloidosis using next-generation sequencing2021
- Author(s)
  Kimura K、Tsukamoto S、Miyazaki K、Kawajiri-Manako C、Ishii A、Rahmutulla B、Fukuyo M、Oshima-Hasegawa N、Mitsukawa S、Takeda Y、Mimura N、Takeuchi M、Ohwada C、Iseki T、Matsusaka K、Sanada M、Yokote K、Kaneda A、Ishida T、Suzuki K、Nakaseko C、Sakaida E
- Journal Title
  
  Experimental Hematology
  
  Volume: 101-102 Pages: 34-41
- DOI
  10.1016/j.exphem.2021.08.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-19K07457, KAKENHI-PROJECT-19K08831, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-20K08723
[Journal Article] Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B‐cell lymphoma in a Japanese cohort2021
- Author(s)
  Mishina T、Oshima‐Hasegawa N、Tsukamoto S、Fukuyo M、Kageyama H、Muto T、Mimura N、Rahmutulla B、Nagai Y、Kayamori K、Hino Y、Mitsukawa S、Takeda Y、Ohwada C、Takeuchi M、Tsujimura H、Iseki T、Nakaseko C、Ikeda J、Itami M、Yokote K、Ohara O、Kaneda A、Sakaida E
- Journal Title
  
  British Journal of Haematology
  
  Volume: 195 Issue: 5 Pages: 731-742
- DOI
  10.1111/bjh.17765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-19K16707, KAKENHI-PROJECT-21K06881
[Journal Article] Pharmacokinetically guided, once-daily intravenous busulfan in combination with fludarabine for elderly AML/MDS patients as a conditioning regimen for allogeneic stem cell transplantation2021
- Author(s)
  Ohwada C、Yamazaki S、Shono K、Kayamori K、Hino Y、Oshima-Hasegawa N、Muto T、Tsukamoto S、Mitsukawa S、Takeda Y、Mimura N、Takeuchi M、Iseki T、Onoda M、Yokota A、Suzuki T、Ishii I、Nakaseko C、Sakaida E
- Journal Title
  
  International Journal of Hematology
  
  Volume: 114 Issue: 6 Pages: 664-673
- DOI
  10.1007/s12185-021-03188-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08338
[Journal Article] Successful allogeneic bone marrow transplantation after massive gastrointestinal bleeding in a patient with myelodysplastic syndrome associated with intestinal Beh?et-like disease2021
- Author(s)
  Ishii A、Tsukamoto S、Mishina T、Izumi S、Nagai Y、Yamazaki M、Hino Y、Kayamori K、Oshima-Hasegawa N、Muto T、Mitsukawa S、Takeda Y、Mimura N、Ohwada C、Nakaseko C、Ikeda J、Sakaida E
- Journal Title
  
  Leukemia Research Reports
  
  Volume: 16 Pages: 100278-100278
- DOI
  10.1016/j.lrr.2021.100278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08338, KAKENHI-PROJECT-21K06881
[Journal Article] Genetic and transcriptional landscape of plasma cells in POEMS syndrome2019
- Author(s)
  Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, Aoyama K, Nishijima D, Isshiki Y, Kayamori K, Kawajiri-Manako C, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Miyano S, Ohara O, Yokote K, Sakaida E, Kuwabara S, Sanada M, Iwama A, Ogawa S, Nakaseko C.
- Journal Title
  
  Leukemia
  
  Volume: － Issue: 7 Pages: 1723-1735
- DOI
  10.1038/s41375-018-0348-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10136, KAKENHI-PROJECT-18K08338, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-19H05656
[Journal Article] POEMS症候群の形質細胞における遺伝子異常2019
- Author(s)
  三村尚也、堺田惠美子、中世古知昭
- Journal Title
  
  腫瘍内科
  
  Volume: 24 Pages: 691-696
- NAID
  40022108670
- Data Source
  KAKENHI-PROJECT-18K08338
[Journal Article] Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.2019
- Author(s)
  Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
- Journal Title
  
  Cancer Sci
  
  Volume: 110 Issue: 12 Pages: 3695-3707
- DOI
  10.1111/cas.14207
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-19K08807, KAKENHI-PUBLICLY-18H05095, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-17H05086, KAKENHI-PROJECT-18K19555
[Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23(16) Issue: 16 Pages: 4817-4830
- DOI
  10.1158/1078-0432.ccr-16-2735
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Presentation] Utx欠損によるクロマチンおよびトランスクリプトームリモデリングはマウスの骨髄腫様疾患を誘発する2023
- Author(s)
  Ola Rizq,　三村尚也, 小出周平, 柴宮明日香, 宮本（長井）友莉恵, Mohamed Rizk, 大島基彦, 百瀬修二, 中島やえ子, 青山和正, 更屋敦則, 堺田惠美子, 中世古知昭, 田丸淳一, 本田浩章, 岩間厚志.
- Organizer
  第48回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08495
[Presentation] Utx loss and Braf V600E triggers myeloma-like disease in mice with increased exhausted T cells.2023
- Author(s)
  Naoya Mimura, Ola Rizq, Asuka Shibamiya, Emiko Sakaida, and Atsushi Iwama.
- Organizer
  The 13th JSH International Symposium 2023 in Tsukuba
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08495
[Presentation] 成熟B細胞腫瘍モデルマウスにおける疲弊T細胞の意義2022
- Author(s)
  柴宮明日香、三村尚也、長井友莉恵、小出周平、リズクオラ、大島基彦、青山和正、中島やえ子、栢森健介、一色佑介、大島渚、武藤朋也、塚本祥吉、竹田勇輔、岩間厚志、堺田惠美子.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08495
[Presentation] Functional and transcriptional analyses of exhausted T cells in a mouse model of plasma cell neoplasms with human MM mutations2022
- Author(s)
  柴宮明日香 ,三村尚也 ,長井友莉恵 ,小出周平 ,リズクオラ ,大島基彦 ,栢森健介 ,一色佑介 ,日野裕太郎 ,大島渚 ,武藤朋也 ,塚本祥吉 ,竹田勇輔 ,岩間厚志 ,堺田惠美子
- Organizer
  第47回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08495
[Presentation] 次世代シークエンサーでの免疫グロブリン軽鎖遺伝子再構成の同定によるPOEMS症候群のクローン検出.2022
- Author(s)
  15.石井改、塚本祥吉、三村尚也、木村賢司、真子-川尻千華、バハテヤリラヒムトラ、福世真樹、中尾三四郎、日野裕太郎、栢森健介、大島-長谷川渚、武藤朋也、三川紫緒、竹田勇輔、水地智基、三澤園子、大和田千桂子、桑原聡史、中世古知昭、金田厚志、堺田惠美子.
- Organizer
  第84回日本血液学会学術集会.
- Data Source
  KAKENHI-PROJECT-22K08471
[Presentation] Exhausted T Cells Characterized By Upregulation of Specific Transcription Factors Are Increased in a Mouse Model of De Novo Mature B Cell Neoplasms.2022
- Author(s)
  Asuka Shibamiya, Naoya Mimura, Yurie Miyamoto-Nagai, et al.
- Organizer
  64th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08495
[Presentation] マルチパラメータフローサトメトリーによるＰＯＥＭＳ症候群のクローン性形質細胞の検出2022
- Author(s)
  石井改，塚本祥吉, 三村尚也, 長井友莉恵，一色祐介，松井愼一郎，中尾三四郎，柴宮明日香，日野祐太郎, 栢森健介, 大島渚, 武藤朋也, 三川紫緒, 竹田勇輔, 水地智基，三澤園子，大和田千桂子，横手幸太郎，桑原聡，中世古知昭, 高松博幸，堺田惠美子
- Organizer
  第47回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] マルチパラメーターフローサイトメトリーによるPOEMS症候群のクローン性形質細胞の検出2022
- Author(s)
  石井改、塚本祥吉、三村尚也、長井友莉恵、一色佑介、松井慎一郎、中尾三四郎、柴宮明日香、日野裕太郎、栢森健介、大島渚、武藤朋也、三川紫緒、竹田勇輔、水地智基、三澤園子、大和田千桂子、横手幸太郎、桑原聡、中世古知昭、高松博幸、堺田惠美子.
- Organizer
  第47回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K08471
[Presentation] POEMS症候群のクローナル形質細胞に特有な遺伝子発現と表面マーカーの同定2021
- Author(s)
  一色佑介, 大島基彦, 三村尚也, 栢森健介, 長井友莉恵, 関真秀, 中島やえ子, 武藤朋也, 塚本祥吉, 竹田勇輔, 大和田千桂子, 三澤園子, 池田純一郎, 真田昌, 桑原聡, 鈴木穣, 堺田惠美子, 中世古知昭, 岩間厚志
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] 移植適応多発性骨髄腫における初回採取レジメンによる自家末梢血幹細胞採取不良例の解析2021
- Author(s)
  三村尚也, 長井友莉恵, 塚田信弘,青墳信之, 李政樹, 勝岡優奈, 若山聡雄, 鈴木利貴央, 尾崎修治, 村上博和, 中世古知昭, 堺田惠美子.
- Organizer
  日本輸血・細胞治療学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Detection of Clonal Plasma Cells in POEMS Syndrome Using Multiparameter Flow Cytometry2021
- Author(s)
  Ishii A, Tsukamoto S, Mimura N, Nagai Y, Matsui S, Nakao S, Shibamiya A, Hino Y, Kayamori K, Oshima-Hasegawa N, Muto T, Mitsukawa S, Takeda Y, Suichi , Misawa S, Ohwada C, Yokote K, Kuwabara S, Nakaseko C, Takamatsu H, Sakaida E
- Organizer
  63rd ASH Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Utx loss acts in concert with BrafV600E mutation to induce multiple myeloma-like disease in mice.2021
- Author(s)
  Ola Rizq, Naoya Mimura, Shuhei Koide, et al.
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08807
[Presentation] 骨髄形質細胞シングルセル解析によるPOEMS症候群の分子病態の解明2021
- Author(s)
  中世古知昭, 織谷健司, 森直樹, 大和田千桂子, 渡部玲子, 東ヶ崎絵美, 桐戸敬介, 塚本祥吉, 三村尚也, 堺田恵美子
- Organizer
  国際医療福祉大学学会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Utxの喪失はBrafV600E変異と協調して多発性骨髄腫様疾患を誘発する2021
- Author(s)
  Ola Rizq, 三村尚也, 小出周平, モハメドリズク, 大島基彦, 百瀬修二, 中島やえ子, 青山和正, 更屋敦則, 井関徹, 堺田惠美子, 中世古知昭, 奥野豊, 田丸淳一, 本田浩章, 岩間厚志
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Single-cell analyses unravel unique features of plasma cell clones in POEMS syndrome.2020
- Author(s)
  Isshiki Y, Mimura N, Nakaseko C et al.
- Organizer
  The 62nd Annual Meeting of the American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Single plasma cell transcriptome analysis in POEMS syndrome.2020
- Author(s)
  Yusuke Isshiki, Naoya Mimura, Motohiko Oshima, Kensuke Kayamori, Masahide Seki, Kiyomi Imamura, Terumi Horiuchi, Yurie Nagai, Shokichi Tsukamoto, Yusuke Takeda, Chikako Ohwada, Sonoko Misawa, Satoshi Kuwabara, Yutaka Suzuki, Emiko Sakaida, Chiaki Nakaseko, Atsushi Iwama.
- Organizer
  25th Congress of European Hematology Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Novel epigenetic therapies for multiple myeloma2020
- Author(s)
  Naoya Mimura
- Organizer
  第82回日本血液学会学術集会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-19K08807
[Presentation] 自家移植後再燃 POEMS 症候群に対し複数回移植は有用である2020
- Author(s)
  松井慎一郎、大和田千桂子、相関祥穂、塩入勇翔、礒貝俊太郎、中尾三四郎、柴宮明日香、石井改、山﨑美貴、三科達三、長井友莉恵、日野裕太郎、木村賢司、栢森健介、大島渚、塚本祥吉、三川紫緒、竹田勇輔、三村尚也、武内正博、井関徹、中世古知昭、堺田惠美子
- Organizer
  第42回日本造血細胞移植学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Single plasma cell transcriptome analysis in POEMS syndrome.2020
- Author(s)
  Isshiki Y, Mimura N, Nakaseko C et al.
- Organizer
  The European Hematology Association Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Preclinical activities of a novel BMI1 inhibitor PTC596 in multiple myeloma2019
- Author(s)
  Yurie Nagai, Naoya Mimura, Ola Rizq, et al.
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08807
[Presentation] Cooperative impact of Utx loss and Braf V600E mutation induces myeloma in mice2019
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, et al.
- Organizer
  The 17th International Myeloma Workshop (IMW)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08807
[Presentation] 再発POEMS症候群に対する再移植の有用性2019
- Author(s)
  柴宮明日香、大和田千桂子、松井愼一郎、中尾三四郎、石井改、長井友莉恵、三科達三、山崎美貴、一色佑介、高石浩司、木村賢司、大島渚、塚本祥吉、竹田勇輔、三川紫緒、三村尚也、武内正博、井関徹、三澤園子、桑原聡、中世古知昭、堺田惠美子
- Organizer
  第81回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma2019
- Author(s)
  Yurie Nagai, Naoya Mimura, Ola Rizq, et al.
- Organizer
  The 61st ASH annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08807
[Presentation] POEMS症候群における形質細胞の網羅的遺伝子解析2018
- Author(s)
  三村尚也
- Organizer
  第43回日本骨髄腫学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K08338
[Presentation] Utx Insufficiency Cooperates with Braf V600E in the Induction of Myeloma in Mice2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  The 60th ASH annual meeting (SanDiego, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 新規骨髄腫マウスモデルの作成2018
- Author(s)
  リズクオラ, 三村尚也, 井関徹, 堺田惠美子, 中世古知昭, 岩間厚志
- Organizer
  第43回日本骨髄腫学会学術集会 (千葉市)
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Loss of Utx with Braf V600E induces mature B-cell tumorigenesis in a conditional mouse model2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  第80回日本血液学会総会（大阪市）
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Loss of Utx Cooperates with Braf V600E Mutation to Induce Post-Germinal Center B-cell Disorders in Mice2018
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Syuji Momose, Yaeko Nakajima-Takagi, Kazumasa Aoyama, Atsunori Saraya, Tohru Iseki, Emiko Sakaida, Chiaki Nakaseko, Yutaka Okuno, Hiroaki Honda, Jun-ichi Tamaru, and Atsushi Iwama
- Organizer
  The 9th JSH international symposium (Kyoto, Japan)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 骨髄腫治療におけるプロテアソーム阻害剤とEZH2/1共阻害剤の相乗効果の分子メカニズム2017
- Author(s)
  三村尚也
- Organizer
  第42回日本骨髄腫学会学術集会
- Place of Presentation
  日本赤十字看護大学（東京都渋谷区）
- Year and Date
  2017-05-27
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 骨髄腫における治療標的としてのエピゲノム異常2017
- Author(s)
  三村尚也
- Organizer
  第58回日本リンパ網内系学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 骨髄腫治療におけるプロテアソーム阻害剤とEZH2/1阻害剤の相乗効果の分子メカニズム2017
- Author(s)
  三村尚也
- Organizer
  第42回日本骨髄腫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Combined inhibition of PRC2 and proteasome as a potential therapy for multiple myeloma2016
- Author(s)
  Ola Rizq, 三村尚也, 大島基彦, 更屋敦則, 小出周平, 加藤裕子, 青山和正, 井関徹, 中世古知昭, 岩間厚志
- Organizer
  第78回日本血液学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 多発性骨髄腫に対する新規エピジェネティック治療2016
- Author(s)
  三村尚也
- Organizer
  第41回日本骨髄腫学会学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] PRC2 Inhibition Sensitizes Myeloma Cells to Proteasome Inhibitor.2016
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Changshan Wang, Tetsuhiro Chiba, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
- Organizer
  The 5th Japanese Cancer Association (JCA) - American Association for Cancer Research (AACR) Special Joint Conference
- Place of Presentation
  Tokyo Bay Maihama Hotel Club Resort（千葉県浦安市）
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Molecular mechanism behind the synergistic activity of proteasome inhibition and PRC2 inhibition in the treatment of multiple myeloma.2016
- Author(s)
  14.Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama.
- Organizer
  The 58th Annual Meeting of the American Society of Hematology
- Place of Presentation
  San Diego Convention Center, California, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] 多発性骨髄腫に対する新規エピジェネティック治療2016
- Author(s)
  三村尚也
- Organizer
  第41回日本骨髄腫学会学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2016-05-29
- Data Source
  KAKENHI-PROJECT-26860719
[Presentation] Dual inhibition of EZH2 and EZH1 sensitizes myeloma cells to bortezomib2016
- Author(s)
  Ola Rizq、三村尚也、井関徹、中世古知昭、岩間厚志
- Organizer
  第41回日本骨髄腫学会学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2016-05-29
- Data Source
  KAKENHI-PROJECT-26860719
[Presentation] EZH2・EZH1阻害剤は骨髄腫細胞のボルテゾミブ感受性を増強する2016
- Author(s)
  Ola Rizq, 三村尚也, 井関徹, 中世古知昭, 岩間厚志
- Organizer
  第41回日本骨髄腫学会学術集会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-16K09839
[Presentation] Synergistic activity of a novel EZH2 inhibitor UNC1999 and bortezomib in multiple myeloma2015
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Shuhei Koide, Tohru Iseki, Chiaki Nakaseko and Atsushi Iwama
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ホテル日航金沢（石川県金沢市）
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26860719
[Presentation] EZH2阻害による多発性骨髄腫の新規治療戦略2015
- Author(s)
  三村尚也、Ola Rizq、井関徹、中世古知昭、岩間厚志
- Organizer
  第40回日本骨髄腫学会学術集会
- Place of Presentation
  くまもと森都心プラザ（熊本県熊本市）
- Year and Date
  2015-05-17
- Data Source
  KAKENHI-PROJECT-26860719
[Presentation] EZH2 Inhibition and the Combination with Proteasome Inhibition Are Novel Potential Strategies for the Treatment of Multiple Myeloma2014
- Author(s)
  Ola Rizq, Naoya Mimura, Shuhei Koide, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, Atsushi Iwama
- Organizer
  第56回アメリカ血液学会年次総会
- Place of Presentation
  Moscone Center （米国サンフランシスコ）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-26860719

1. Sakaida Emiko (60422218)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. 塚本祥吉 (00814617)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
3. Nakaseko Chiaki (30323398)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
4. IWAMA Atsushi (70244126)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. OHSHIMA Motohiko (70506287)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 武内正博 (50466702)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. 大和田千桂子 (80436352)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
8. NAKAJIMA Yaeko (50749497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Iseki Tohru (10232365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
10. 竹田勇輔 (60772746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
11. SANADA Masashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. SEIMIYA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 三澤園子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mimura Naoya 三村 尚也

MIMURA Naoya 三村 尚也

Research Projects

Research Products

Co-Researchers

成熟B細胞腫瘍モデルマウスが明らかにするCD38陽性免疫抑制細胞の病的意義Principal Investigator

Principal Investigator

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Review Section

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The role of megakaryocytes and platelets in pathogenesis of POEMS syndrome

Principal Investigator

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POEMS症候群における微小クローン同定による診断治療戦略の確立

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Elucidation of the mechanisms of immune escape in a mouse model of mature B cell neoplasms for the development of novel therapiesPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Integrative epigenetic therapies using novel myeloma mouse modelsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Elucidation of the molecular pathology of AL amyloidosis by gene expression analysis of bone marrow plasma cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism of POEMS syndrome by single cell analysis of bone marrow plasma cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic pathogenesis of multiple myeloma related to drug resistancePrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Abberant histone methylation as a therapeutic target in multiple myelomaPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 血液内科2019年1月特集「多発性骨髄腫の分子病態解明の進歩と新たな治療展開」2019

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[Book] 日本臨牀2018年7月特集「多発性骨髄腫-基礎・臨床研究の最新動向」2018

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[Book] 多発性骨髄腫学ー最新の診療と基礎研究ー2016

Author(s)

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Data Source

[Book] 多発性骨髄腫Updating第10巻2016

Author(s)

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Data Source

[Book] 日本臨牀 多発性骨髄腫学 2016年7月増刊号2016

Author(s)

Publisher

Data Source

[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023

Mimura Naoya 三村尚也

MIMURA Naoya 三村尚也

[Book] 日本臨牀　多発性骨髄腫学　2016年7月増刊号2016