SONOBE Makoto 園部誠

Researcher Number	00432378
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2019: 京都大学, 医学研究科, 准教授 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2014: 京都大学, 大学院医学研究科胸部外科学, 助教 2011 – 2014: 京都大学, 医学(系)研究科(研究院), 講師 2013: 京都大学, 医学(系)研究科 … More 2010 – 2012: 京都大学, 医学研究科, 講師 2008: Kyoto University, 大学院医学研究科, 助教 2007 – 2008: Kyoto University, 医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Thoracic surgery / Respiratory surgery Except Principal Investigator Respiratory surgery / Experimental pathology / Thoracic surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator ビノレルビン / 薬剤耐性 / 呼吸器外科学 / 肺癌 / 肺腺がん / 上皮成長因子受容体 / AID / 原発性肺癌 / 腺癌 / ALK … More / 融合遺伝子 / 分子マーカー / 補助化学療法 / Saracatinib / VRB耐性株 / 非小細胞肺癌 / ABCB1 / FA PatHway / 薬剤耐性化株 / 遺伝子発現 / 耐性化メカニズム / Focal Adhesion Pathway … More Except Principal Investigator 肺癌 / 浸潤転移 / EGFR / EMT / Arf6 / GEP100 / Grb2 / 上皮間葉転換 / 遺伝子 / 癌 / ゲノム / 突然変異 / FGFR / ｓｈRNA / アデノウィルス / ベクター / 遺伝子治療 / shRNA / ＦＧＦＲ / ｓｈＲＮＡ / sh RNA / アダプター分子 / リンパ節転移モデル / 線維芽細胞 / 悪性化進展 / 胸腺癌 / トランスクリプトーム / DNAコピー数変化 / 胸腺上皮性腫瘍 / 遺伝子発現 / コピー数 / 胸腺腫瘍 / コピー数異常 / クラスター解析 / 上皮間葉転換、ＥＭＴ / ＥＧＦＲ / ＧＥＰ１００ / Ａｒｆ６ / Ｇｒｂ２ / 肺腺癌 / ＥＭＴ / 浸潤転移能 / EGFR陽性肺腺癌 / AMAP1 / EPB41L5 / 予後不良 / Arf6活性化 / p53 / 上皮間葉転換（EMT） / スタチン / 変異型p53遺伝子 / 上皮間葉転換（EMT / 変異型p５３ / シグナル経路 / 治療 Less

The elucidation of key signaling pathways and the establishment of treatment strategies for mutant p53-induced epithelio-mesenchymal transition in lung cancer
- Principal Investigator
  
  Date Hiroshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Kyoto University
The elucidation of the novel therapy specific for lung cancer targeting Arf6-induced EMT
- Principal Investigator
  
  Menju Toshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
The elucidation of the clinical significance and the mechanisms of acquired drug resistance with activated FA pathway in cancer cellsPrincipal Investigator
- Principal Investigator
  
  園部誠
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
Comprehensive analyses of transcriptome and DNA copy number variations in thymic cancer
- Principal Investigator
  
  Date Hiroshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
The identification of targeting molecules for EMT-activating signals from ErbB family receptor in lung cancer
- Principal Investigator
  
  MENJU Toshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
臨床と基礎をつなぐ視点からの肺癌悪性化進展における繊維芽細胞、繊維化の役割解明
- Principal Investigator
  
  大政貢
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
The analysis of predictive markers for the efficacy of cisplatin and vinorelbine regimens as postoperative adjuvant chemotherapy of lung cancerPrincipal Investigator
- Principal Investigator
  
  SONOBE Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Kyoto University
Carcinogenesis by a mutagenic enzyme AID
- Principal Investigator
  
  KAZUO Kinoshita
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Research Institute, Shiga Medical Center
Gene therapy using FGFR-inhibiting vector against lung squamous cell carcinoma
- Principal Investigator
  
  DATE Horoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyoto University
Detection of new fusion partner genes with ALK genePrincipal Investigator
- Principal Investigator
  
  SONOBE Makoto
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyoto University
Is activation-induced cytidine deaminase related to oncogenesis of lung cancer with induction of gene mutations observed in lung cancer?Principal Investigator
- Principal Investigator
  
  SONOBE Makoto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Kyoto University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial-mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma2019
- Author(s)
  Neri, S., T. Menju, T. Sowa, Y. Yutaka, D. Nakajima, M. Hamaji, A. Ohsumi, T. F. Chen-Yoshikawa, T. Sato, M. Sonobe, A. Yoshizawa, H. Haga and H. Date
- Journal Title
  
  Lung Cancer
  
  Volume: 128 Pages: 13-19
- DOI
  10.1016/j.lungcan.2018.12.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10781, KAKENHI-PROJECT-18K19578
[Journal Article] P40 expression in small cell lung cancer: The presence of p40-positive cells does not always indicate squamous differentiation.2019
- Author(s)
  Nakajima, N., A. Yoshizawa, K. Moriyoshi, M. Sonobe, T. Menju, S. Sumiyoshi, H. Date and H. Haga
- Journal Title
  
  Thoracic Cancer
  
  Volume: 11 Pages: 3410-3432
- DOI
  10.1111/1759-7714.13062
- NAID
  120006624101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10781
[Journal Article] Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection.2019
- Author(s)
  Nishikawa, S., T. Menju, K. Takahashi, R. Miyata, M. Sonobe, A. Yoshizawa and H. Date
- Journal Title
  
  Annals of Thoracic Cardiovascular Surgery
  
  Volume: 5 Pages: 246-252
- NAID
  130007731493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19578
[Journal Article] Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection2019
- Author(s)
  Nishikawa Shigeto、Menju Toshi、Takahashi Koji、Miyata Ryo、Chen Yoshikawa Toyofumi Fengshi、Sonobe Makoto、Yoshizawa Akihiko、Sabe Hisataka、Sato Tosiya、Date Hiroshi
- Journal Title
  
  Cancer Manag Res
  
  Volume: Volume 11 Pages: 3419-3432
- DOI
  10.2147/cmar.s200819
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02608, KAKENHI-PROJECT-17K10781, KAKENHI-PROJECT-18K19578
[Journal Article] Prognostic Significance of Phosphorylated Fyn in Patients with Lung Adenocarcinoma after Lung Resection2019
- Author(s)
  Nishikawa S, Menju T, Takahashi K, Miyata R, Sonobe M, Yoshizawa A, Date H
- Journal Title
  
  Ann Thorac Cardiovasc Surg
  
  Volume: 5 Issue: 5 Pages: 246-252
- DOI
  10.5761/atcs.oa.19-00078
- NAID
  130007731493
- ISSN
  1341-1098, 2186-1005
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10781
[Journal Article] Adjuvant vinorelbine and cisplantin after complete resection of stage II and III non-small cell lung cancer: long-term follow-up of our study of Japanease patients.2018
- Author(s)
  371.Sonobe M, Hamaji M, Motoyama H, Menju T, Aoyama A, Chen-Yoshikawa TF, Sato T, Date H.
- Journal Title
  
  Surgery Today
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10782
[Journal Article] horacoscopic rebiopsy to detect T790M mutation after postoperative recurrence.2018
- Author(s)
  376.Hamaji M, Motoyama H, Menju T, Chen-Yoshikawa TF, Sonobe M, Kim YH, Date H.
- Journal Title
  
  Interact Cardiovasc Thorac Surg
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10782
[Journal Article] Second malignancy versus recurrence after complete resection of thymoma.2018
- Author(s)
  373.Hamaji M, Sozu T, Machida R, Omasa M, Menju T, Aoyama A, Sato T, Chen-Yoshikawa TF, Sonobe M, Date H.
- Journal Title
  
  Asian Cardiovasc Thorac Ann
  
  Volume: -
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10782
[Journal Article] The synergistic role of ATP-dependent drug efflex pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer.2018
- Author(s)
  368.Nakanishi T, Menju T, Nishikawa S, Takahashi K, Miyata R, Shikuma K, Sowa T, Imamura N, Hamaji M, Motoyama H, Hijiya K, Aoyama A, Sato T, Chen-Yoshikawa TF, Sonobe M, Date H.
- Journal Title
  
  Cancer Medicne
  
  Volume: 7(2) Pages: 408-19
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10782
[Journal Article] Clinicopathologic significance of epithelio-mesenchymal transition in human lung adenocarcinomas: an integrative analysis, inclusive of genetic alterations, on 256 surgically resected cases2017
- Author(s)
  Toshi Menju, Terumasa Sowa, Makoto Sonobe, Ryo Miyata, Koji Takahashi, Shigeto Nishikawa, Takao Nakanishi, Shinya Neri1, Hiroyuki Cho1, Masatsugu Hamaji, Kyoko Hijiya, Hideki Motoyama, Akihiro Aoyama, Toyofumi F. Chen-Yoshikawa, Toshihiko Sato, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date
- Journal Title
  
  Cancer Treatment and Research Communications
  
  Volume: 12 Pages: 62-68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10781
[Journal Article] The synergistic role of ATP-Dependent Drug efflux pnmp and focal adhesion signaling pathways in vinorelbine resistance in lung cancer2017
- Author(s)
  Takao Nakanishi,Toshi Menjyu, Makoto Sonobe, 　他14名
- Journal Title
  
  Cancer Medicine
  
  Volume: - Pages: 408-419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10782
[Journal Article] Ad-shWint2b vector therapy demonstrates antitumor activity in orthotopic models as monitored with the invitro imaging system (IVIS).2016
- Author(s)
  Kobayashi M, Huang CL, Sonobe M, Kikuchi R, Date H.
- Journal Title
  
  Anticancer Res
  
  Volume: 36(11) Pages: 5887-5893
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15636
[Journal Article] Is volumetric 3-dimensional computed tomography useful to predict histological tumour invasiveness? Analysis of 211 lesions of cT1N0M0 lung adenocarcinoma.2016
- Author(s)
  Shikuma K, Menju T, Chen F, Kubo T, Muro S, Sumiyoshi S, Ohata K, Sowa T, Nanaknishi T, Cho H, Neri S, Aoyama A, Sato T, Sonobe M, Date H.
- Journal Title
  
  Interact Cardiovasc Thorac Surg
  
  Volume: 22(6) Pages: 831-8
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15636
[Journal Article] Surgical and non-surgical management of repeat pulmonary metastasis from sarcoma following first pulmonary metastatectomy.2016
- Author(s)
  Hamaji M, Chen F, Miyamoto E, Kondo T, Ohata K, Motoyama H, Hijiya K, Menju T, Aoyama A, Sato T, Sonobe M, Date H.
- Journal Title
  
  Surg Today
  
  Volume: 46(11) Pages: 1296-1300
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15636
[Journal Article] Trametinib plus 4-methylumbelliferone exhibits antitumor effects by ERK blockade and CD44 downregulation and affects PD1 and PD-L1 in malignant pleural mesothelioma.2016
- Author(s)
  Cho H, Matsumoto S, Fujita Y, Kuroda A, Menju T, Sonobe M, Kondo N, Torii I, Nakano T, Lara PN, Gandara DR, Date H, Hasegawa S.
- Journal Title
  
  J Thorac Oncol
  
  Volume: -
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15636
[Journal Article] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.2015
- Author(s)
  Goto Y, Zeng L, YeomCJ, Zhu Y, Morinibu A, Shinoyam K, Kobayashi M, Hirota K, Itasaka S, Yoshimura M, Tanimoto K, Sowa T, Menju T, Sonobe M, Kakeya H, Toi M, Date H, Hammond EM, Hiraoka M, Harada H.
- Journal Title
  
  Nature communication
  
  Volume: 6 Pages: 1-10
- DOI
  10.1038/ncomms7153
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592322, KAKENHI-PROJECT-24592336, KAKENHI-PROJECT-24659563, KAKENHI-PROJECT-25861088, KAKENHI-PROJECT-26461886, KAKENHI-PROJECT-26462125, KAKENHI-PROJECT-26670555, KAKENHI-PROJECT-26670558, KAKENHI-PROJECT-26670693, KAKENHI-PROJECT-15K10551, KAKENHI-PROJECT-15K15577, KAKENHI-PROJECT-25462457, KAKENHI-PROJECT-26293276
[Journal Article] Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer2015
- Author(s)
  Kitamura, J., Uemura, M., Kurozumi, M., Sonobe, M., Manabe, T., Hiai, H., Date, H., and Kinoshita, K.
- Journal Title
  
  PLoS One
  
  Volume: 10
- DOI
  10.1371/journal.pone.0117986
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390097
[Journal Article] Association between epithelial-mesenchymal transition and cancer stemness and their effect on the prognosis of lung adenocarcinoma.2015
- Author(s)
  405.Sowa T, Menju T, Sonobe M, Nakanishi T, Shikuma K, Imamura N, Motoyama H, Hijiya K, Aoyama A, Chen F, Sato T, Kobayashi M, Yoshizawa A, Haga H, Sozu T, Date H.
- Journal Title
  
  Cancer Med
  
  Volume: 4(12) Pages: 1853-62
- NAID
  120005971039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462174
[Journal Article] Video-assisted thoracoscopic lobectomy versus stereotactic radiotherapy for stage I lung cancer.2015
- Author(s)
  Hamaji M, Chen F, Matsuo Y, Kawaguchi A, Morita S, Ueki N, Sonobe M, Nagata Y, Hiraoka M, Date H.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: 99(4) Pages: 1122-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462174
[Journal Article] Use of virtual assisted lung mapping (VAL-MAP), a bronchoscopic multispot dye-marking technique using virtual images, for precise navigation of thoracoscopic sublobar lung resection2014
- Author(s)
  Sato M, Omasa M, Chen F, Sato T, Sonobe M, Bando T, Date H
- Journal Title
  
  J Thorac Cardiovasc Surg
  
  Volume: 147 Pages: 1813-1819
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Indentification of subsets of patients with favorable prognosis after recurrence in completely resected non-small cell lung cancer.2014
- Author(s)
  335.Sonobe M, Yamada T, Sato M, Menju T, Aoyama A, Sato T, Chen F, Omasa M, Bando T, Date H.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 21(8) Pages: 2546-54
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26462125
[Journal Article] The Japan-Multinational Traial Organization. Prognostic factors after complete resection of pN2 non-small cell lung cancer.2013
- Author(s)
  319. Sonobe M, Date H, Wada H, Okubo K, Hamakawa H, Teramukai S, Matsumura A, Nakagawa T, Sumitomo S, Miyamoto Y, Okumura N, Takeo S, Kawakami K, Aoki M, Kosaka S
- Journal Title
  
  J Thorac Cardiovasc Surg
  
  Volume: 146 Pages: 788-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Snail expression is associated with a poor prognosis in malignant pleural mesotheliomas.2013
- Author(s)
  309. Kobayashi M, Huang CL, Sonobe M, Kikuchi R, Ishikawa M, Imamura N, Kitamura J, Iwakiri S, Itoi K, Yasumizu R, Date H.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: 95 Pages: 1181-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Snail expression is associated with a poor prognosis in malignantpleural mesotheliomas2013
- Author(s)
  Kobayashi M, Huang CL, Sonobe M, Kikuchi R, Ishikawa M, Imamura N, Kitamura J, Iwakiri S, Itoi K, Yasumizu R, Date H
- Journal Title
  
  Ann Thorac Surg
  
  Volume: 95 Pages: 1181-1188
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] The Japan-Multinational Trial Organization. Prognostic factors after complete resection of pN2 non-small cell lung cancer2013
- Author(s)
  Sonobe M, Date H, Wada H, Okubo K, Hamakawa H, Teramukai S, Matsumura A, Nakagawa T, Sumitomo S, Miyamoto Y, Okumura N, Takeo S, Kawakami K, Aoki M, Kosaka S
- Journal Title
  
  J Thorac Cardiovasc Surg
  
  Volume: 146 Pages: 788-795
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Higher expression of receptor tyrosine kinase Axl, and differential expression of its ligand, Gas6, predict poor survival in lung adenocarcinoma patients2013
- Author(s)
  Ishikawa M, Sonobe M, Nakayama E, Kobayashi M, Kikuchi R, Kitamura J, Imamura N, Date H
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 20 Suppl 3
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Short-term outcome in living donors forlung transplantation : the role of preoperative computer tomographic evaluations of fissures and vascular anatomy2012
- Author(s)
  Chen F, Fujinaga T, Shoji T, Kubo T, Sonobe M, Sato M, Aoyama A, Sato T, Sakai H, Bando T, Date H
- Journal Title
  
  Transpl Int
  
  Volume: 25 Pages: 732-738
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Impact of KRAS and EGFR gene mutations on recurrence and survival in patients with surgically resected lung adenocarcinomas2012
- Author(s)
  Sonobe M, Kobayashi M, Ishikawa M, Kikuchi R, Nakayama E, Takahashi T, Menju T, Takenaka K, Miyahara R, Huang CL, Okubo K, Bando T, Date H
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 19 Suppl 3
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Detection of ALK fusion in lung cancer using fluorescence in situ hybridization.2012
- Author(s)
  Kobayashi M, Sonobe M, Takahashi T, Yoshizawa A, Kikuchi R, Date H.
- Journal Title
  
  Asian Cardiovasc Thorac Ann.
  
  Volume: 20 Pages: 426-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591563
[Journal Article] Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients2012
- Author(s)
  Kobayashi M, Huang CL, Sonobe M, Kikuchi R, Ishikawa M, Kitamura J, Miyahara R, Menju T, Iwakiri S, Itoi K, Yasumizu R, Date H
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 3 Pages: 952-958
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Clinicopathological characteristics of surgically resected pulmonary pleomorphic carcinoma2012
- Author(s)
  Chen F, Sonobe M, Sato T, Sakai H, Huang CL, Bando T, Date H
- Journal Title
  
  Eur J Cardiothorac Surg
  
  Volume: 41 Pages: 1037-1042
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Detection of ALK fusion in lung cancer using fluorescence in situ hybridization2012
- Author(s)
  Kobayashi M, Sonobe M, Takahashi T, Yoshizawa A, Kikuchi R, Date H
- Journal Title
  
  Asian Cardiovasc Thorac Ann
  
  Volume: 20 Pages: 426-31
- Data Source
  KAKENHI-PROJECT-22591563
[Journal Article] Detection of ALK fusion in lung cancer using fluorescence in situ hybridization2012
- Author(s)
  Kobayashi M, Sonobe M, Takahashi T, Yoshizawa A, Kikuchi R, Date H
- Journal Title
  
  Asian Cardiovasc Thorac Ann
  
  Volume: 20 Pages: 426-431
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Outcomes and pulmonary function in living lobar lung transplant donors2012
- Author(s)
  Chen F, Fujinaga T, Shoji T, Sonobe M, Sato T, Sakai H, Bando T, Date H
- Journal Title
  
  Transpl Int
  
  Volume: 25 Pages: 153-157
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Pharmacokinetic study of weekly (days 1-5) low-dose S-1 in patients with non-small-cell lung cancer2012
- Author(s)
  Shoji T, Sonobe M, Sakai H, Fujinaga T, Sato T, Chen F, Miyahara R, Bando T, Wada H, Date H
- Journal Title
  
  Rev Recent Clin Trials
  
  Volume: 7 Pages: 167-172
- NAID
  120005285491
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Expression of IGF1R is associated with tumor differentiation and survival in patients with lung adenocarcinoma2012
- Author(s)
  Kikuchi R, Sonobe M, Kobayashi M, Ishikawa M, Kitamura J, Nakayama E, Menju T, Miyahara R, Huang CL, Date H
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 3 Pages: 412-420
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma2012
- Author(s)
  Ishikawa M, Miyahara R, Sonobe M, Horiuchi M, Mennju T, Nakayama E, Kobayashi M, Kikuchi R, Kitamura J, Imamura N, Huang CL, Date H
- Journal Title
  
  Lung Cancer
  
  Volume: 76 Pages: 431-438
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer2011
- Author(s)
  Kobayashi M, Sonobe M, Takahashi T, Yoshizawa A, Ishikawa M, Kikuchi R, Okubo K, Huang CL, Date H
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 4619-4623
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Impact of KRAS and EGFR gene mutations on recurrence and survival in patients with surgically resected lung adenocarcinomas2011
- Author(s)
  Sonobe M, Date H, et al.
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: -
- DOI
  10.1245/s10434-011-1799-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659666
[Journal Article] Clinicopathologic features of non-small cell lung cancer with EML4-ALK fusion gene2010
- Author(s)
  Takahashi T, Sonobe M, Kobayashi M, Yoshizawa A, Menju T, Nakayama E, Mino N, Iwakiri S, Sato K, Miyahara R, Okubo K, Manabe T, Date H
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 17 Pages: 889-897
- NAID
  120002036596
- Data Source
  KAKENHI-PROJECT-22591563
[Journal Article] Clinicopathologic features of non-small cell lung cancer with EML4-ALK gene.2010
- Author(s)
  Takahashi T, Sonobe M, et al.
- Journal Title
  
  Ann Surg Oncol
  
  Volume: 17 Pages: 889-897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591563
[Journal Article] Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I non-small cell lung cancer. Cancer2009
- Author(s)
  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R
- Journal Title
  
  E-pub
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390363
[Presentation] Suppression of mutant-p53-induced EMT by statins have double-edged effects on the patients with lung adenocarcinoma according to p53 mutation status2019
- Author(s)
  S.Nishikawa, T.Menju, T.Sowa, K.Takahashi, R.Miyata, H.Ishikawa, D.Nakajima, M.Hamaji, H.Motoyama, A.Aoyama, T.sato, F.Chen-Yoshikawa, M.Sonobe, H.Date
- Organizer
  American Association for Cancer Research, Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19578
[Presentation] Grb2 promotes cancer invasiveness via EGF-induced GEP100-Arf6 pathway Grb2はEGF刺激によるGEP100-Arf6経路活性化を介した腫瘍浸潤転移能を促進する2015
- Author(s)
  Toshi Menju, Naoto Imamura, Shinya Neri, Hiroyuki Cho, Takao Nakanishi, Kei Shikuma, Terumasa Sowa, Makoto Sonobe, Hisataka Sabe, Hiroshi Date
- Organizer
  第１８回欧州癌治療学会
- Place of Presentation
  ウィーン、オーストリア
- Year and Date
  2015-09-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462125
[Presentation] Clinicopathological analysis on EMT activation in lung adenocarcinoma 肺腺癌切除検体におけるEMT活性化に伴う臨床病理学的解析2015
- Author(s)
  Toshi Menju, Terumasa Sowa, Shinya Neri, Takao Nakanishi, Hiroyuki Cho, Kei Shikuma, Kyoko Hijiya, Hideki Motoyama, Akihiro Aoyama, Fengshi Chen, Makoto Sonobe, Toshihiko Sato, Mitsugu Oomasa, *Akihiko Yoshizawa, *Hironori Haga, Hiroshi Date
- Organizer
  第１６回世界肺癌学会総会
- Place of Presentation
  デンバー、コロラド州、USA
- Year and Date
  2015-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462125
[Presentation] Ad-shWnt2B 胸腔内投与モデルに対するIVIS を用いた治療評価2013
- Author(s)
  小林正嗣、黄政龍、菊地柳太郎、今村直人、志熊啓、曽和輝正、園部誠、伊達洋至
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-10-04
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] Snail expression is associated with epithelial to mesenchymal transition and a poor prognosis in malignant pleural mesotheliomas2012
- Author(s)
  Masashi K, Huang CL, Sonobe M, Kikuchi R, Ishikawa M, Imamura N, Kitamura J, Iwakiri S, Itoi K, Yasumizu R, Date H
- Organizer
  AACR 103rd Annual Meeting
- Place of Presentation
  Chicago, U.S.A.
- Year and Date
  2012-04-04
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] 非小細胞肺癌におけるFGFR2 発現の検討2011
- Author(s)
  菊地柳太郎、喜多村次郎、石川将史、小林正嗣、中山英、毛受暁史、園部誠、宮原亮、黄政龍、伊達洋至
- Organizer
  第28回日本呼吸器外科学会総会
- Place of Presentation
  大分
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] 肺癌における腫瘍内Wnt 発現とWnt 抑制遺伝子治療2011
- Author(s)
  黄政龍、劉大革、中島成泰、横見瀬裕保、小林正嗣、菊地柳太郎、石川将史、堀内真理佳、園部誠、伊達洋至
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] 非小細胞肺癌におけるWnt familyの腫瘍内発現の臨床的検討2011
- Author(s)
  黄政龍、中島成泰、横見瀬裕保、小林正嗣、菊地柳太郎、石川将史、今村直人、園部誠、伊達洋至
- Organizer
  第52回日本肺癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] Overexpression of FGFR2 gene is associated with advanced stage squamous cell carcinoma of the lung2011
- Author(s)
  Kikuchi R, Huang CL, Miyahara R, Sonobe M, Menju T, Kobayashi M, Ishikawa M, Kitamura J, Date H
- Organizer
  AACR 102nd Annual Meeting
- Place of Presentation
  Orlang, U.S.A.
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] 悪性胸膜中皮腫においてWnt2B は腫瘍増殖に影響する2011
- Author(s)
  小林正嗣、黄政龍、喜多村次郎、菊地柳太郎、石川将史、毛受暁史、園部誠、宮原亮、伊達洋至
- Organizer
  第28回日本呼吸器外科学会総会
- Place of Presentation
  大分
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] The intratumoral Wnt2B expression affects tumor progression in malignant pleural mesotheliomas2011
- Author(s)
  Kobayashi M, Huang CL, Miayahara R, Sonobe M, Menju T, Kikuchi R, Ishikawa M, Kitamura J, Itoi K, Date H
- Organizer
  AACR 102nd Annual Meeting
- Place of Presentation
  Orlang, U.S.A.
- Year and Date
  2011-04-02
- Data Source
  KAKENHI-PROJECT-23659666
[Presentation] 非小細胞肺癌における EML4-ALK 融合遺伝子の臨床病理学的検討2010
- Author(s)
  小林正嗣、園部誠、石川将史、菊地柳太郎、喜多村次郎、中山英、毛受暁史、高橋剛士、大久保憲一、伊達洋至
- Organizer
  第27回日本呼吸器外科学会総会
- Place of Presentation
  仙台
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22591563
[Presentation] 術後73ヶ月後に再発したEML4-ALK融合遺伝子を有する原発性肺癌の一例2010
- Author(s)
  高橋剛士、園部誠, 他
- Organizer
  第27回日本呼吸器外科学会総会
- Place of Presentation
  仙台市、宮城県
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22591563
[Presentation] 非小細胞肺癌におけるEML4-ALK融合遺伝子の臨床病理学的検討2010
- Author(s)
  小林正嗣、園部誠, 他
- Organizer
  第27回日本呼吸器外科学会総会
- Place of Presentation
  仙台市、宮城県
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-22591563
[Presentation] ケモカインレセプターCXCR7 高発現はI 期非小細胞肺癌における早期の遠隔再発に関与する2008
- Author(s)
  岩切章太郎、中山英、高橋剛士、毛受暁史、三野暢也、長井信二郎、佐藤澄、園部誠、平田敏樹、宮原亮、大久保憲一、和田洋巳、伊達洋至
- Organizer
  第61回日本胸部外科学会定期学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19390363
[Presentation] ケモカインレセプターCXCR7高発現はI期非小細胞肺癌における早期の遠隔再発に関与する2008
- Author(s)
  岩切章太郎, 中山英, 高橋剛士, 毛受暁史, 三野暢也, 長井信二郎, 佐藤澄, 園部誠, 平田敏樹, 宮原亮, 大久保憲一, 和田洋巳, 伊達洋至
- Organizer
  第61回日本胸部外科学会定期学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-10-15
- Data Source
  KAKENHI-PROJECT-19390363

1. MENJYU Toshi (30527081)

# of Collaborated Projects: 8 results

# of Collaborated Products: 28 results
2. DATE Herushi (60252962)

# of Collaborated Projects: 5 results

# of Collaborated Products: 39 results
3. KINOSHITA Kazuo (50293874)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. MIYAHARA Ryo (20335285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. NAGAI Shinjiro (50447984)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TAKAHASHI Tiyoshi (90527079)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. UEMURA Munehiro (30568390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 黄政龍 (10271511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
9. 大政貢 (80379049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SABE Hisataka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. ITASAKA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 廣田喜一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 小林稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 原田浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 吉村通央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 森鳰章代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 平岡真寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 佐邉寿孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SONOBE Makoto 園部 誠

Research Projects

Research Products

Co-Researchers

The elucidation of key signaling pathways and the establishment of treatment strategies for mutant p53-induced epithelio-mesenchymal transition in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of the novel therapy specific for lung cancer targeting Arf6-induced EMT

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the clinical significance and the mechanisms of acquired drug resistance with activated FA pathway in cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analyses of transcriptome and DNA copy number variations in thymic cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The identification of targeting molecules for EMT-activating signals from ErbB family receptor in lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

臨床と基礎をつなぐ視点からの肺癌悪性化進展における繊維芽細胞、繊維化の役割解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of predictive markers for the efficacy of cisplatin and vinorelbine regimens as postoperative adjuvant chemotherapy of lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Carcinogenesis by a mutagenic enzyme AID

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene therapy using FGFR-inhibiting vector against lung squamous cell carcinoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of new fusion partner genes with ALK genePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Is activation-induced cytidine deaminase related to oncogenesis of lung cancer with induction of gene mutations observed in lung cancer?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial-mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] P40 expression in small cell lung cancer: The presence of p40-positive cells does not always indicate squamous differentiation.2019

Author(s)

Journal Title

DOI

NAID

SONOBE Makoto 園部誠