ISHIKAWA Tomomoto 石川智基

Researcher Number	00432576
Other IDs
Affiliation (based on the past Project Information) *help	2008: 医学部附属病院, 医員 2008: Kobe University, 医学部・附属病院, 助教 2008: 神戸大学, 医学部附属病院, 助教 2007: Kobe University, 医学部・附属病院, 医員 2006 – 2007: 神戸大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Urology Except Principal Investigator Urology
Keywords	Principal Investigator Nitric Oxide / IL1β / 細胞間機能調節機構 / IL / サイトカイン / NO / セルトリ細胞 / 精子形成 Except Principal Investigator apoptosis / eNOS / NO / 精細胞 / 精子形成

Specific components of NO pathways may provide novel therapeutic targets for interventional use to prevent testicular dysfunctionPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Tomomoto
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Kobe University
The challenge for a useful therapeutic strategy for infertile male using eNOS-Tg mice
- Principal Investigator
  
  FUJISAWA Masato
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  Kobe University

All 2008 2007 2006 Other

All Journal Article Presentation Book

[Book] Regulation of Testicular Function : Signaling Molecules and Cell-Cell Communicatin2008
- Author(s)
  石川智基, 藤澤正人
- Total Pages
  1648
- Publisher
  「産婦人科治療」精巣内の局所調節機構
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Cisplatin regulates Sertoli cell expression of transferrin and interleukins.2008
- Author(s)
  Yamaguchi K, Ishikawa T, Kondo Y, Fujisawa M
- Journal Title
  
  Mol Cell Endocrinol 283
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Cisplatin Regulates Sertoli Cell Expression of Transferrin and Interleukins2008
- Author(s)
  Yamaguchi K, Ishikawa T, Kondo Y, Fujisawa M
- Journal Title
  
  Mol Cell Endocrinol 283
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008
- Author(s)
  Kondo Y Ishikawa T, YamaguchiK, Yada T, Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 153-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Expression and distribution of laminin chains in the testis for patients withazoospermia.2008
- Author(s)
  Ooba T, Ishikawa T, Yamaguchi K, Kondo Y, Sakamoto Y Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 147-152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008
- Author(s)
  Kondo Y, Ishikawa T, Yamaguchi K, Yada T, Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 153-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Cisplatin Regulates Sertoli Cell Expression of Transferrin and Interleukins2008
- Author(s)
  Yamaguchi K, Ishikawa T, Kondo Y, Fujisawa M
- Journal Title
  
  Mol Cell Endocrinol 283
  
  Pages: 68-75
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model.2008
- Author(s)
  Kondo Y, Ishikawa T, Yamaguchi K, Yada T, Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 153-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008
- Author(s)
  Kondo Y, Ishikawa T, Yamaguchi K, Yada T, Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 153-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Oral administration of tetrahydrobiopterin attenuates testicular damage byreducing nitric oxide synthase activity in a cryptorchid mouse model.2008
- Author(s)
  Kondo Y, Ishikawa T, YamaguchiK, Yada T, Fujisawa M
- Journal Title
  
  J Androl 29
  
  Pages: 153-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] The assessment of oxidative stress in infertile patients with varicocele.2008
- Author(s)
  Sakamoto Y, Ishikawa T, Kondo Y, Yamaguchi K, Fujisawa M
- Journal Title
  
  BJU Int 101
  
  Pages: 1547-1552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Assessment of gonadotropin therapy in male hypogonadotropic hypogonadism.2007
- Author(s)
  Ishikawa T, Ooba T, Kondo Y, Yamaguchi K, Fujisawa M.
- Journal Title
  
  Fertil Steril. 88(6)
  
  Pages: 1697-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] 研究フロンティアセルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007
- Author(s)
  石川智基、PATRICIA L. MORRIS、藤澤正人
- Journal Title
  
  日本生殖内分泌学会雑 12
  
  Pages: 21-25
- NAID
  40015686181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] 研究フロンティアセルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007
- Author(s)
  石川智基, PATRICIA L. MORRIS, 藤澤正人
- Journal Title
  
  日本生殖内分泌学会雑誌 12
  
  Pages: 21-25
- NAID
  40015686181
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia.2007
- Author(s)
  Ishikawa T, Kondo Y, Ymaguchi K, Sakamoto Y, Fujisawa M.
- Journal Title
  
  BJU Int. 101(2)
  
  Pages: 216-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] Increased testicular 8-hydroxy-2'-deoxyguanosine in patients with varicocele.2007
- Author(s)
  Ishikawa T, Fujioka H, Ishimura T, Tkenaka A, Fujisawa M.
- Journal Title
  
  BJU Int. 100(4)
  
  Pages: 863-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] セルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007
- Author(s)
  石川智基, PATR1CIA L MORRIS, 藤澤正人
- Journal Title
  
  日本生殖内分泌学会雑誌 12
  
  Pages: 21-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19791111
[Journal Article] Interleukin-1β Signals Through a cJun-N-terminal kinase (JNK)-dependent Inducible Nitric Oxide Synthase and Nitric Oxide Production Pathway in Sertoli Epithelial Cells2006
- Author(s)
  Ishikawa T, Morris PL
- Journal Title
  
  Endocrinology 147
  
  Pages: 5424-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Journal Article] A Multi-Step Kinase-Based Sertoli Cell Autocrine-Amplifying Loop Regulates Prostaglandins(PG), their Receptors, and Cytokines2006
- Author(s)
  Ishikawa T, Morris PL
- Journal Title
  
  Endocrinology 147
  
  Pages: 1706-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Interleukin-1β Signals Through a cJun-N-terminal kinase (JNK)-dependent Inducible Nitric Oxide Synthase and Nitric Oxide Production Pathway in Sertoli Epithelial Cells2008
- Author(s)
  Ishikawa T., Morris PL.
- Organizer
  AUA annual meeting
- Place of Presentation
  Anaheim USA
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] 精子形成に関わる精巣内細胞間情報伝達機構2008
- Author(s)
  石川智基
- Organizer
  第53回日本生殖医学会
- Place of Presentation
  神戸
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] 精子形成に関わる精巣内細胞間情報伝達機構2008
- Author(s)
  石川智基
- Organizer
  第53回日本生殖医学会
- Place of Presentation
  神戸
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] セルトリ細胞においてFSH はPKA, PKB, PKC 経路を介しSteroidogenicacute regulatory protein(StAR)を調節する2007
- Author(s)
  石川智基
- Organizer
  第12回日本生殖内分泌学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] nterleukin-1β Signals Through a cJun-N-terminal kinase (JNK)-dependent Inducible Nitric Oxide Synthase and Nitric Oxide Production Pathway in Sertoli Epithelial Cells2007
- Author(s)
  Ishikawa T
- Place of Presentation
  AUA annual meeting、Anaheim
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Cisplatin induces interleukin (IL)-1beta and IL-6 expression through a cyclooxygenase 2 regulation of prostaglandin (PG) E2, PGF2alpha, PGD2, and PGI2 production pathway in rat Sertoli cells2007
- Author(s)
  Yamaguchi K, Ishikawa T, Kondo Y, Sakamoto Y, Takenaka A, Fujisawa M
- Organizer
  ASRM annual meeting
- Place of Presentation
  USA
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] セルトリ細胞におけるプロスタグランディンのparacrine/autocrine作用2007
- Author(s)
  石川智基
- Organizer
  第26回日本アンドロロジー学会
- Place of Presentation
  浦安
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Interleukin-Iβ Signals Through a cJun-N-terminal kinase (JNK)-dependent Inducible Nitric Oxide Synthase and Nitric Oxide Production Pathway in Sertoli Epithelial Cells2007
- Author(s)
  Ishikawa T, Morris PL.
- Organizer
  American Urological Association annual meeting
- Place of Presentation
  Anabeim, Ca
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] セルトリ細胞においてFSHはPKA,PKB,PKC経路を介しSteroidogenic acute regulatory protein(StAR)を調節する2007
- Author(s)
  石川智基, Patricia L. Morris, 藤澤正人
- Organizer
  第16回泌尿器科分子・細胞研究会
- Place of Presentation
  福岡市
- Year and Date
  2007-02-24
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] セントリ細胞におけるプロスタグランディンのparacrine/autocrine作用2007
- Author(s)
  石川智基, 山口耕平, 近藤有, 阪本祐一, 原口貴裕, 武中篤, 藤澤正人
- Organizer
  第26回日本アンドロロジー学会総会
- Place of Presentation
  浦安
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] セルトリ細胞においてシスプラチンはCOX-2経路を活性化し、プロスタグランディンおよびインターロイキンの産生を誘導する2007
- Author(s)
  山口耕平, 石川智基, 近藤有, 阪本祐一, 原口貴裕, 武中篤, 藤澤正人
- Organizer
  第12回日本生殖内分泌学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19791111
[Presentation] セルトリ細胞においてインターロイキン1βはJNK, COX-2経路を介しサイトカインを誘導する2006
- Author(s)
  石川智基
- Organizer
  第15回泌尿器科分子・細胞研究会
- Place of Presentation
  京都
- Year and Date
  2006-02-25
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] セルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2006
- Author(s)
  石川智基
- Organizer
  第11回日本生殖内分泌学会
- Place of Presentation
  東京
- Year and Date
  2006-11-25
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Multiple protein kinases mediate follicle stimulating hormone (FSH) regulation of steroidogenic acute regulatory(STAR)-related lipid transfer proteins in Sertoli cell2006
- Author(s)
  Ishikawa T
- Organizer
  2^<nd> Asia Pacific Forum on
- Place of Presentation
  Andrology meeting、Shanghai
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] セルトリ細胞におけるproinflammatory cytokine のautocrine loop2006
- Author(s)
  石川智基
- Organizer
  第21回日本生殖免疫学会
- Place of Presentation
  東京
- Year and Date
  2006-12-02
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] セルトリ細胞におけるproinflammatory cytokine のparacrine/autocrine 機構2006
- Author(s)
  石川智基
- Organizer
  第26回日本アンドロロジー学会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] 精子形成障害 : 間質細胞からのアプローチ2006
- Author(s)
  石川智基
- Organizer
  第94回日本泌尿器科学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] セルトリ細胞におけるIL-1βのparacrine/autocrine機構2006
- Author(s)
  石川智基
- Organizer
  第32回関西アンドロロジーカンファレンス
- Place of Presentation
  大阪
- Year and Date
  2006-03-04
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Multiple protein kinases mediate follicle stimulationg hormone (FSH) regulation of Sertoli cell steroidogenic acute regulatory (StAR)-related lipid transfer (START-domain-containing) proteins2006
- Author(s)
  Ishikawa T
- Place of Presentation
  ASA annual meeting、Chicago
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] Follicle stimulationg hormone(FSH)regulates Sertoli cell expression of steroidogenic acute regulatory-related lipid transfer(START-domain)proteins by activation of protein kinase A(PKA) and C(PKC)
- Author(s)
  Ishikawa T
- Organizer
  AUA annual meeting
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-18390436
[Presentation] A multi-step kinase-based Sertoli cell autocrine-amplyfying loop regulates prostaglandins
- Author(s)
  Ishikawa T
- Organizer
  their receptors, and cytokines,AUA annual meeting
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-18390436

1. FUJISAWA Masato (30243314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. TANAKA Kazushi (20335433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YAMAGUCHI Kouhei (50457107)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. GOUDA Kazumasa (80403278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ISHIKAWA Tomomoto 石川 智基

Research Projects

Research Products

Co-Researchers

Specific components of NO pathways may provide novel therapeutic targets for interventional use to prevent testicular dysfunctionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The challenge for a useful therapeutic strategy for infertile male using eNOS-Tg mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Regulation of Testicular Function : Signaling Molecules and Cell-Cell Communicatin2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Cisplatin regulates Sertoli cell expression of transferrin and interleukins.2008

Author(s)

Journal Title

Data Source

[Journal Article] Cisplatin Regulates Sertoli Cell Expression of Transferrin and Interleukins2008

Author(s)

Journal Title

Data Source

[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008

Author(s)

Journal Title

Data Source

[Journal Article] Expression and distribution of laminin chains in the testis for patients withazoospermia.2008

Author(s)

Journal Title

Data Source

[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008

Author(s)

Journal Title

Data Source

[Journal Article] Cisplatin Regulates Sertoli Cell Expression of Transferrin and Interleukins2008

Author(s)

Journal Title

Data Source

[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model.2008

Author(s)

Journal Title

Data Source

[Journal Article] Oral Administration of Tetrahydrobiopterin Attenuates Testicular damage by Reducing Nitric Oxide Synthase Activity in a Cryptorchid Mouse Model2008

Author(s)

Journal Title

Data Source

[Journal Article] Oral administration of tetrahydrobiopterin attenuates testicular damage byreducing nitric oxide synthase activity in a cryptorchid mouse model.2008

Author(s)

Journal Title

Data Source

[Journal Article] The assessment of oxidative stress in infertile patients with varicocele.2008

Author(s)

Journal Title

Data Source

[Journal Article] Assessment of gonadotropin therapy in male hypogonadotropic hypogonadism.2007

Author(s)

Journal Title

Data Source

[Journal Article] 研究フロンティアセルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 研究フロンティア セルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia.2007

Author(s)

Journal Title

Data Source

[Journal Article] Increased testicular 8-hydroxy-2'-deoxyguanosine in patients with varicocele.2007

ISHIKAWA Tomomoto 石川智基

[Journal Article] 研究フロンティアセルトリ細胞においてIL-1βはJNK経路を活性化し、一酸化窒素(NO)発現を亢進させる2007