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Tokuda Shinsaku  徳田 深作

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… Alternative Names

徳田 深作  トクダ シンサク

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Researcher Number 00433277
Other IDs
Affiliation (Current) 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help 2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師
2021 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 助教
2016 – 2017: 京都大学, 医学研究科, 医員
2007: Kyoto Prefectural University of Medicine, 医学研究科, 助教
2006: 京都府立医科大学, 医学研究科, 助手
Review Section/Research Field
Principal Investigator
Basic Section 50010:Tumor biology-related / General physiology
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related / General physiology
Keywords
Principal Investigator
細胞極性 / クローディン / タイトジャンクション / PKA / EGFR / 細胞運動 / 腫瘍微小環境 / 間質圧 / 肺癌 / プロテインキナーゼA … More / 細胞増殖 / 癌 / 静水圧 / アクチン / 浸透圧 / タイト結合 / 低浸透圧 / カルモデュリン / ENaC … More
Except Principal Investigator
がん分子標的薬 / 治療抵抗性 / 低酸素血症 / 肺がん / 細胞死 / チロシンリン酸化 / VSOR / NKCC / JNK / Akt / クロライドイオン Less
  • Research Projects

    (6 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (8 People)
  •  間質圧によるがん促進メカニズムの解明と新たな治療分野の開拓Principal Investigator

    • Principal Investigator
      徳田 深作
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidation of drug resistance by the hypoxic environment adaptation mechanism in lung cancer and development of novel therapeutic strategy

    • Principal Investigator
      山田 忠明
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Elucidation of the role of the increase of interstitial pressure on the pathophysiology of lung cancer and the development of novel treatmentPrincipal Investigator

    • Principal Investigator
      Tokuda Shinsaku
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  Mechanism of the regulation of epithelial function by hydrostatic pressure and the application for canter treatmentPrincipal Investigator

    • Principal Investigator
      Tokuda Shinsaku
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      General physiology
    • Research Institution
      Kyoto University
  •  Cell survival and apoptosis through Cl_-dependent regulation of Akt and JNK in renal epithelium

    • Principal Investigator
      NIISATO Naoml
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General physiology
    • Research Institution
      Kyoto Prefectural University of Medicine
  •  低浸透圧によるカルモデュリン依存性ENaC局在の分子メカニズムの解明Principal Investigator

    • Principal Investigator
      徳田 深作
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      General physiology
    • Research Institution
      Kyoto Prefectural University of Medicine

All 2024 2023 2022 2017 2016 2008 2007

All Journal Article Presentation

  • [Journal Article] AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.2024

    • Author(s)
      Morimoto K, Yamada T, Hirai S, Katayama Y, Fukui S, Sawada R, Tachibana Y, Matsui Y, Nakamura R, Ishida M, Kawachi H, Kunimasa K, Sasaki T, Nishida M, Furuya N, Watanabe S, Shiotsu S, Nishioka N, Horinaka M, Sakai T, Uehara H, Yano S, Son BK, Tokuda S, Takayama K.
    • Journal Title

      Cancer Lett

      Volume: 587 Pages: 216692-216692

    • DOI

      10.1016/j.canlet.2024.216692

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-22K20833, KAKENHI-PROJECT-23K27609
  • [Journal Article] Effects of combined therapeutic targeting of AXL and ATR on pleural mesothelioma cells2024

    • Author(s)
      Hirai S, Yamada T, Katayama Y, Ishida M, Kawachi H, Matsui Y, Nakamura R, Morimoto K, Horinaka M, Sakai T, Sekido Y, Tokuda S, Takayama K
    • Journal Title

      Mol Cancer Ther

      Volume: 23 Issue: 2 Pages: 212-222

    • DOI

      10.1158/1535-7163.mct-23-0138

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-19H01079
  • [Journal Article] Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors.2023

    • Author(s)
      Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim YH, Konishi E, Itoh K, Takayama K.
    • Journal Title

      JTO Clin Res Rep

      Volume: 4 Issue: 6 Pages: 100525-100525

    • DOI

      10.1016/j.jtocrr.2023.100525

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K07607
  • [Journal Article] Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells2022

    • Author(s)
      Katayama Y, Yamada T, Tokuda S, Okura N, Nishioka N, Morimoto K, Tanimura K, Morimoto Y, Iwasaku M, Horinaka M, Sakai T, Kita K, Yano S, Takayama K
    • Journal Title

      Cancer Medicine

      Volume: 11 Issue: 4 Pages: 944-955

    • DOI

      10.1002/cam4.4504

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-21K15513
  • [Journal Article] Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells2017

    • Author(s)
      Tokuda Shinsaku、Hirai Toyohiro、Furuse Mikio
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 8 Pages: e0182521-e0182521

    • DOI

      10.1371/journal.pone.0182521

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21101
  • [Journal Article] Effects of osmolality on paracellular transport in MDCK II cells2016

    • Author(s)
      Tokuda S, Hirai T, Furuse M
    • Journal Title

      PLoS One

      Volume: 11

    • NAID

      120005980913

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21101
  • [Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

    • Author(s)
      Tokuda, S.
    • Journal Title

      Biochemican and Biophysical Research Communications 366

      Pages: 464-470

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18890157
  • [Journal Article] Regulation of the paracellular Na+ and Cl- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

    • Author(s)
      Tokuda S, Niisato N, Nakajima K, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun. 366(2)

      Pages: 464-70

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

    • Author(s)
      Tokuda S, NIISATO N, Nakajima K, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun 366

      Pages: 464-470

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats.2007

    • Author(s)
      Aoi W, Niisato N, Sawabe Y, Miyazaki H, Tokuda S, Nishio K, Yoshikawa T, Marunaka Y.
    • Journal Title

      Cell Biol Int. 31(10)

      Pages: 1288-1291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Action of neltenexine on anion secretion in human airway epithelia.2007

    • Author(s)
      Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun 356(4)

      Pages: 1050-1055

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.2007

    • Author(s)
      Tokuda S, Niisato N, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun. 363(3)

      Pages: 566-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.2007

    • Author(s)
      Tokuda, S.
    • Journal Title

      Biochemican and Biophysical Research Communications 363

      Pages: 566-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18890157
  • [Journal Article] HCO_3^--dependent pH_i recovery and overacidification induced by NH_4^+ pulse in rat lung alveolar type II cells: HCO_3^--dependent NH_3 excretion from lungs?2007

    • Author(s)
      Tokuda S, Shimamoto C, Yoshida H, Murao H, Kishima G, Ito S, Kubota T, Hanafusa T, Sugimoto T, Niisato N, Marunaka Y, Nakahari T.
    • Journal Title

      Pflugers Arch. 455(2)

      Pages: 223-239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Journal Article] Regulation of paracellular ion conductances by NaCI gradients in renal epithelial cells2007

    • Author(s)
      Tokuda S, MISATO N, Marunaka Y.
    • Journal Title

      Biochem Biophys Res Commun 363

      Pages: 566-571

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590212
  • [Presentation] Effects of interstitial pressure on lung cancer cells2023

    • Author(s)
      Shinsaku Tokuda, Keisuke Onoi, Tadaaki Yamada, Koichi Takayama
    • Organizer
      AACR Annual Meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15513
  • [Presentation] Effects of interstitial pressure on lung cancer cells2023

    • Author(s)
      Tokuda Shinsaku, Onoi Keisuke, Yamada Tadaaki, Takayama Koichi
    • Organizer
      AACR Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15513
  • [Presentation] Effects of claudin-2 and claudin-4 knockouts in MDCK II cells2016

    • Author(s)
      Tokuda S, Hirai T, Furuse M
    • Organizer
      International conference "Tight junctions and their proteins"
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2016-08-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K21101
  • [Presentation] 浸透圧・静水圧による細胞間隙コンダクタンスの調節2007

    • Author(s)
      徳田 深作
    • Organizer
      第54回中部日本生理学会・第100回近畿生理学談話会 合同大会
    • Place of Presentation
      三重大学(津)
    • Year and Date
      2007-10-20
    • Data Source
      KAKENHI-PROJECT-18890157
  • [Presentation] フラボノイドによる血圧制御の分子機構2007

    • Author(s)
      丸中良典、新里直美、青井渉、宮崎裕明、中島謙一、徳田深作
    • Organizer
      日本農芸化学会2007年度大会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-24
    • Data Source
      KAKENHI-PROJECT-19590212
  • 1.  NIISATO Naoml (00237645)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 2.  MARUNAKA Yoshinori (00127036)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 3.  MIYAZAKI Hiroaki (30360027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 4.  NAKAJIMA Ken-ichi (40398392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 5.  山田 忠明 (00507048)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  高山 浩一 (50274444)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  HORINAKA Mano
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  酒井 敏行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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