Tokuda Shinsaku 徳田深作

… Alternative Names

徳田深作トクダシンサク

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Researcher Number	00433277
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師
Affiliation (based on the past Project Information) *help	2025: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2023: 京都府立医科大学, 医学(系)研究科(研究院), 講師 2021 – 2022: 京都府立医科大学, 医学(系)研究科(研究院), 助教 2016 – 2017: 京都大学, 医学研究科, 医員 2007: Kyoto Prefectural University of Medicine, 医学研究科, 助教 2006: 京都府立医科大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / General physiology Except Principal Investigator Basic Section 53030:Respiratory medicine-related / General physiology
Keywords	Principal Investigator 腫瘍微小環境 / 間質圧 / 細胞極性 / クローディン / タイトジャンクション / メカノトランスダクション / 足場非依存性 / EMT / PKA / EGFR … More / 細胞運動 / 肺癌 / プロテインキナーゼA / 細胞増殖 / 癌 / 静水圧 / アクチン / 浸透圧 / タイト結合 / 低浸透圧 / カルモデュリン / ENaC … More Except Principal Investigator がん分子標的薬 / 治療抵抗性 / 低酸素血症 / 肺がん / 細胞死 / チロシンリン酸化 / VSOR / NKCC / JNK / Akt / クロライドイオン Less

Mechanism of cancer progression by interstitial pressure and therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  徳田深作
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of drug resistance by the hypoxic environment adaptation mechanism in lung cancer and development of novel therapeutic strategy
- Principal Investigator
  
  山田忠明
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kyoto Prefectural University of Medicine
Elucidation of the role of the increase of interstitial pressure on the pathophysiology of lung cancer and the development of novel treatmentPrincipal Investigator
- Principal Investigator
  
  Tokuda Shinsaku
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kyoto Prefectural University of Medicine
Mechanism of the regulation of epithelial function by hydrostatic pressure and the application for canter treatmentPrincipal Investigator
- Principal Investigator
  
  Tokuda Shinsaku
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Kyoto University
Cell survival and apoptosis through Cl_-dependent regulation of Akt and JNK in renal epithelium
- Principal Investigator
  
  NIISATO Naoml
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University of Medicine
低浸透圧によるカルモデュリン依存性ENaC局在の分子メカニズムの解明Principal Investigator
- Principal Investigator
  
  徳田深作
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  General physiology
- Research Institution
  Kyoto Prefectural University of Medicine

All 2024 2023 2022 2017 2016 2008 2007

All Journal Article Presentation

[Journal Article] AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.2024
- Author(s)
  Morimoto K, Yamada T, Hirai S, Katayama Y, Fukui S, Sawada R, Tachibana Y, Matsui Y, Nakamura R, Ishida M, Kawachi H, Kunimasa K, Sasaki T, Nishida M, Furuya N, Watanabe S, Shiotsu S, Nishioka N, Horinaka M, Sakai T, Uehara H, Yano S, Son BK, Tokuda S, Takayama K.
- Journal Title
  
  Cancer Lett
  
  Volume: 587 Pages: 216692-216692
- DOI
  10.1016/j.canlet.2024.216692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-22K20833, KAKENHI-PROJECT-23K27609
[Journal Article] Effects of combined therapeutic targeting of AXL and ATR on pleural mesothelioma cells2024
- Author(s)
  Hirai S, Yamada T, Katayama Y, Ishida M, Kawachi H, Matsui Y, Nakamura R, Morimoto K, Horinaka M, Sakai T, Sekido Y, Tokuda S, Takayama K
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 23 Issue: 2 Pages: 212-222
- DOI
  10.1158/1535-7163.mct-23-0138
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-23K07607, KAKENHI-PROJECT-21K15513, KAKENHI-PROJECT-19H01079
[Journal Article] Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors.2023
- Author(s)
  Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim YH, Konishi E, Itoh K, Takayama K.
- Journal Title
  
  JTO Clin Res Rep
  
  Volume: 4 Issue: 6 Pages: 100525-100525
- DOI
  10.1016/j.jtocrr.2023.100525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07607
[Journal Article] Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells2022
- Author(s)
  Katayama Y, Yamada T, Tokuda S, Okura N, Nishioka N, Morimoto K, Tanimura K, Morimoto Y, Iwasaku M, Horinaka M, Sakai T, Kita K, Yano S, Takayama K
- Journal Title
  
  Cancer Medicine
  
  Volume: 11 Issue: 4 Pages: 944-955
- DOI
  10.1002/cam4.4504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06398, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-21K15513
[Journal Article] Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells2017
- Author(s)
  Tokuda Shinsaku、Hirai Toyohiro、Furuse Mikio
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 8 Pages: e0182521-e0182521
- DOI
  10.1371/journal.pone.0182521
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21101
[Journal Article] Effects of osmolality on paracellular transport in MDCK II cells2016
- Author(s)
  Tokuda S, Hirai T, Furuse M
- Journal Title
  
  PLoS One
  
  Volume: 11
- NAID
  120005980913
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K21101
[Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008
- Author(s)
  Tokuda, S.
- Journal Title
  
  Biochemican and Biophysical Research Communications 366
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890157
[Journal Article] Regulation of the paracellular Na+ and Cl- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008
- Author(s)
  Tokuda S, Niisato N, Nakajima K, Marunaka Y.
- Journal Title
  
  Biochem Biophys Res Commun. 366(2)
  
  Pages: 464-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008
- Author(s)
  Tokuda S, NIISATO N, Nakajima K, Marunaka Y.
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 464-470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats.2007
- Author(s)
  Aoi W, Niisato N, Sawabe Y, Miyazaki H, Tokuda S, Nishio K, Yoshikawa T, Marunaka Y.
- Journal Title
  
  Cell Biol Int. 31(10)
  
  Pages: 1288-1291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Action of neltenexine on anion secretion in human airway epithelia.2007
- Author(s)
  Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y.
- Journal Title
  
  Biochem Biophys Res Commun 356(4)
  
  Pages: 1050-1055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.2007
- Author(s)
  Tokuda S, Niisato N, Marunaka Y.
- Journal Title
  
  Biochem Biophys Res Commun. 363(3)
  
  Pages: 566-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Regulation of paracellular ion conductances by NaCl gradients in renal epithelial cells.2007
- Author(s)
  Tokuda, S.
- Journal Title
  
  Biochemican and Biophysical Research Communications 363
  
  Pages: 566-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18890157
[Journal Article] HCO_3^--dependent pH_i recovery and overacidification induced by NH_4^+ pulse in rat lung alveolar type II cells: HCO_3^--dependent NH_3 excretion from lungs?2007
- Author(s)
  Tokuda S, Shimamoto C, Yoshida H, Murao H, Kishima G, Ito S, Kubota T, Hanafusa T, Sugimoto T, Niisato N, Marunaka Y, Nakahari T.
- Journal Title
  
  Pflugers Arch. 455(2)
  
  Pages: 223-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Journal Article] Regulation of paracellular ion conductances by NaCI gradients in renal epithelial cells2007
- Author(s)
  Tokuda S, MISATO N, Marunaka Y.
- Journal Title
  
  Biochem Biophys Res Commun 363
  
  Pages: 566-571
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590212
[Presentation] Effects of interstitial pressure on lung cancer cells2023
- Author(s)
  Shinsaku Tokuda, Keisuke Onoi, Tadaaki Yamada, Koichi Takayama
- Organizer
  AACR Annual Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15513
[Presentation] Effects of interstitial pressure on lung cancer cells2023
- Author(s)
  Tokuda Shinsaku, Onoi Keisuke, Yamada Tadaaki, Takayama Koichi
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15513
[Presentation] Effects of claudin-2 and claudin-4 knockouts in MDCK II cells2016
- Author(s)
  Tokuda S, Hirai T, Furuse M
- Organizer
  International conference "Tight junctions and their proteins"
- Place of Presentation
  Berlin, Germany
- Year and Date
  2016-08-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21101
[Presentation] 浸透圧・静水圧による細胞間隙コンダクタンスの調節2007
- Author(s)
  徳田深作
- Organizer
  第54回中部日本生理学会・第100回近畿生理学談話会合同大会
- Place of Presentation
  三重大学(津)
- Year and Date
  2007-10-20
- Data Source
  KAKENHI-PROJECT-18890157
[Presentation] フラボノイドによる血圧制御の分子機構2007
- Author(s)
  丸中良典、新里直美、青井渉、宮崎裕明、中島謙一、徳田深作
- Organizer
  日本農芸化学会2007年度大会
- Place of Presentation
  東京
- Year and Date
  2007-03-24
- Data Source
  KAKENHI-PROJECT-19590212

1. NIISATO Naoml (00237645)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. MARUNAKA Yoshinori (00127036)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. MIYAZAKI Hiroaki (30360027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. NAKAJIMA Ken-ichi (40398392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 山田忠明 (00507048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 高山浩一 (50274444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 酒井敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Tokuda Shinsaku 徳田 深作

徳田 深作 トクダ シンサク

Research Projects

Research Products

Co-Researchers

Mechanism of cancer progression by interstitial pressure and therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of drug resistance by the hypoxic environment adaptation mechanism in lung cancer and development of novel therapeutic strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of the increase of interstitial pressure on the pathophysiology of lung cancer and the development of novel treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of the regulation of epithelial function by hydrostatic pressure and the application for canter treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cell survival and apoptosis through Cl_-dependent regulation of Akt and JNK in renal epithelium

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

低浸透圧によるカルモデュリン依存性ENaC局在の分子メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] AXL signal mediates adaptive resistance to KRAS G12C inhibitors in KRAS G12C-mutant tumor cells.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of combined therapeutic targeting of AXL and ATR on pleural mesothelioma cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of osmolality on paracellular transport in MDCK II cells2016

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of the paracellular Na+ and Cl- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of the paracellular Na^+ and Cl^- conductances by the NaCl-generated osmotic gradient in a manner dependent on the direction of osmotic gradients.2008

Tokuda Shinsaku 徳田深作

徳田深作トクダシンサク