Kaitsuka Taku 貝塚拓

… Alternative Names

KAITSUKA Taku 貝塚拓

Less

Researcher Number	00435926
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 福岡薬学部, 講師
Affiliation (based on the past Project Information) *help	2025: 国際医療福祉大学, 福岡薬学部, 講師 2020: 国際医療福祉大学, 福岡薬学部, 講師 2016 – 2019: 熊本大学, 大学院生命科学研究部(医), 助教 2016: 熊本大学, その他の研究科, 助教 2015: 熊本大学, 生命科学研究部, 助教 2012 – 2013: 熊本大学, 大学院生命科学研究部, 助教
Review Section/Research Field	Principal Investigator General physiology / Basic Section 47060:Clinical pharmacy-related / Basic Section 48020:Physiology-related
Keywords	Principal Investigator てんかん / タンパク質翻訳因子 / 遺伝子転写 / 選択的スプライシング / タンパク質導入 / エピゲノム / 難治性がん / 時計遺伝子 / 概日リズム / 神経発達障害 … More / タンパク質翻訳 / 下垂体前葉ホルモン / 脱リン酸化 / タンパク質合成 / ストレス応答 / 分子シャペロン / 転写因子 / 翻訳伸長因子 / 発現制御 / 脳神経疾患 / 神経科学 / カルシウムチャネル / クロマチン免疫沈降 / 翻訳因子 / スプライシング / ストレス / 熱ショックタンパク質 / 恐怖条件付け / 熱ストレス応答 / 学習・記憶 / 行動解析 / ポリグルタミン病 Less

A novel strategy for the therapy of refractory cancers based on the restoration of disrupted circadian rhythmPrincipal Investigator
- Principal Investigator
  
  貝塚拓
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  International University of Health and Welfare
Study on the control of stress response in the brain via the regulation of protein translation and gene transcription by eEF1BdeltaLPrincipal Investigator
- Principal Investigator
  
  Kaitsuka Taku
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  International University of Health and Welfare
  Kumamoto University
A study on the molecular mechanisms of epileptic phenotype in eEF1BdeltaL knockout mice(Fostering Joint International Research)Principal Investigator
- Principal Investigator
  
  Kaitsuka Taku
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University
A study on the molecular mechanisms of epileptic phenotype in eEF1BdeltaL knockout micePrincipal Investigator
- Principal Investigator
  
  KAITSUKA Taku
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University
Control of polyglutamine protein aggregation by eEF1BdeltaLPrincipal Investigator
- Principal Investigator
  
  KAITSUKA Taku
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Kumamoto University

All 2021 2020 2019 2018 2017 2016 2015 2014 2012

All Journal Article Presentation

[Journal Article] Heat Shock-Induced Dephosphorylation of Eukaryotic Elongation Factor 1BδL by Protein Phosphatase 12021
- Author(s)
  Kaitsuka Taku、Tomizawa Kazuhito、Matsushita Masayuki
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 7 Pages: 598578-598578
- DOI
  10.3389/fmolb.2020.598578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] Response of Pluripotent Stem Cells to Environmental Stress and Its Application for Directed Differentiation2021
- Author(s)
  Kaitsuka Taku、Hakim Farzana
- Journal Title
  
  Biology
  
  Volume: 10 Issue: 2 Pages: 84-84
- DOI
  10.3390/biology10020084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase‐dead mice2021
- Author(s)
  Beesetty Pavani、Rockwood Jananie、Kaitsuka Taku、Zhelay Tetyana、Hourani Siham、Matsushita Masayuki、Kozak J. Ashot
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 11 Pages: 3585-3601
- DOI
  10.1111/febs.15683
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] Response to Stimulations Inducing Circadian Rhythm in Human Induced Pluripotent Stem Cells2020
- Author(s)
  Kaneko Hitomi、Kaitsuka Taku、Tomizawa Kazuhito
- Journal Title
  
  Cells
  
  Volume: 9 Issue: 3 Pages: 620-620
- DOI
  10.3390/cells9030620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06876, KAKENHI-PROJECT-16KK0205
[Journal Article] eEF1BδL欠損で生じる聴原性発作2020
- Author(s)
  貝塚拓
- Journal Title
  
  Medical Science Digest
  
  Volume: 46 Pages: 111-114
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] SIRT2 inhibition activates hypoxia-inducible factor 1α signaling and mediates neuronal survival2020
- Author(s)
  Kaitsuka Taku、Matsushita Masayuki、Matsushita Nobuko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 4 Pages: 957-962
- DOI
  10.1016/j.bbrc.2020.06.159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06876, KAKENHI-PROJECT-19K07053
[Journal Article] TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity2020
- Author(s)
  Mellott Alayna、Rockwood Jananie、Zhelay Tetyana、Luu Charles Tuan、Kaitsuka Taku、Kozak J. Ashot
- Journal Title
  
  Pflugers Archiv - European Journal of Physiology
  
  Volume: 472 Issue: 11 Pages: 1589-1606
- DOI
  10.1007/s00424-020-02457-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] eEF1BδL欠損で生じる聴原性発作2020
- Author(s)
  貝塚拓
- Journal Title
  
  Medical Science Digest
  
  Volume: 46 Pages: 111-114
- Data Source
  KAKENHI-PROJECT-16KK0205
[Journal Article] 翻訳伸長因子Eef1dの変異が引き起こすてんかん様発作とその発症メカニズムに関する研究2020
- Author(s)
  貝塚拓
- Journal Title
  
  BIO Clinica
  
  Volume: 35 Pages: 92-95
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells2019
- Author(s)
  Kaitsuka Taku、Kojima Rie、Kawabe Masaaki、Noguchi Hirofumi、Shiraki Nobuaki、Kume Shoen、Tomizawa Kazuhito
- Journal Title
  
  Biomedical Materials
  
  Volume: 14 Issue: 4 Pages: 045019-045019
- DOI
  10.1088/1748-605x/ab261c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06876, KAKENHI-PROJECT-18H02861, KAKENHI-PROJECT-18H02865, KAKENHI-PROJECT-16KK0205, KAKENHI-PROJECT-18H02154
[Journal Article] Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.2018
- Author(s)
  Kaitsuka, T., Kiyonari, H., Shiraishi, A., Tomizawa, K., Matsushita, M
- Journal Title
  
  Front. Mol. Neurosci.
  
  Volume: 11 Pages: 358-358
- DOI
  10.3389/fnmol.2018.00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06876
[Journal Article] Erythropoietin facilitates definitive endodermal differentiation of mouse embryonic stem cells via activation of ERK signaling2017
- Author(s)
  Kaitsuka T, Kobayashi K, Otsuka W, Kubo T, Hakim F, Wei FY, Shiraki N, Kume S and Tomizawa K
- Journal Title
  
  Am. J. of Physiology - Cell Physiology
  
  Volume: 312 Issue: 5 Pages: C573-C582
- DOI
  10.1152/ajpcell.00071.2016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-16K01362, KAKENHI-PROJECT-15F15110
[Journal Article] HDAC9 regulates the alternative lengthening of telomere (ALT) pathway via the formation of ALT-associated PML bodies.2016
- Author(s)
  Mohd. Raeed Jamiruddin, Taku Kaitsuka, Farzana Hakim, Atsushi Fujimura, Fan-Yan Wei, Hisato Saitoh, Kazuhito Tomizawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 481 Issue: 1-2 Pages: 25-30
- DOI
  10.1016/j.bbrc.2016.11.026
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-15K08178, KAKENHI-PROJECT-16K18989, KAKENHI-PROJECT-15F15110
[Journal Article] Mutation of the key residue for extraribosomal function of ribosomal protein S19 cause increased grooming behaviors in mice.2016
- Author(s)
  Jun Chen, Taku Kaitsuka, Rika Fujino, Kimi Araki, Kazuhito Tomizawa, Tetsuro Yamamoto
- Journal Title
  
  Neuroscience letters
  
  Volume: 629 Pages: 221-226
- DOI
  10.1016/j.neulet.2016.07.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18971, KAKENHI-PROJECT-16K07093
[Journal Article] Cell-Penetrating Peptide as a Means of Directing the Differentiation of Induced-Pluripotent Stem Cells.2015
- Author(s)
  Taku Kaitsuka, Kazuhito Tomizawa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 16 Issue: 11 Pages: 26667-26676
- DOI
  10.3390/ijms161125986
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18971
[Journal Article] Generation of Functional Insulin-Producing Cells From Mouse Embryonic Stem Cells Through 804G Cell-Derived Extracellular Matrix and Protein Transduction of Transcription Factors.2014
- Author(s)
  Kaitsuka T, Noguchi H, Shiraki N, Kubo T, Wei FY, Hakim F, Kume S, Tomizawa K.
- Journal Title
  
  Stem Cells Transl Med.
  
  Volume: 3 Issue: 1 Pages: 114-127
- DOI
  10.5966/sctm.2013-0075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390316, KAKENHI-PROJECT-24790217, KAKENHI-PROJECT-25860753
[Journal Article] High Oxygen Condition Facilitates the Differentiation of Mouse and Human Pluripotent Stem Cells into Pancreatic Progenitors and Insulin-producing Cells.2014
- Author(s)
  Farzana Hakim, Taku Kaitsuka, Jamiruddin Mohd. Raeed, Fan-Yan Wei, Nobuaki Shiraki, Tadayuki Akagi, Takashi Yokota, Shoen Kume, and Kazuhito Tomizawa
- Journal Title
  
  The journal of biological chemistry
  
  Volume: 289 Issue: 14 Pages: 9623-9638
- DOI
  10.1074/jbc.m113.524363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790217, KAKENHI-PROJECT-24790274, KAKENHI-PROJECT-25860753, KAKENHI-PROJECT-26461638, KAKENHI-PROJECT-26253059
[Journal Article] Induction of autophagic cell death of glioma-initiating cells by cell-penetrating d-isomer peptides consisting of Pas and the p53 C-terminus.2012
- Author(s)
  Ueda Y
- Journal Title
  
  Biomaterials.
  
  Volume: 33 Issue: 35 Pages: 9061-9069
- DOI
  10.1016/j.biomaterials.2012.09.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591615, KAKENHI-PROJECT-22591616, KAKENHI-PROJECT-23390351, KAKENHI-PROJECT-24790217
[Presentation] 熱ストレス応答タンパク質eEF1BδLのリン酸化/脱リン酸化による機能制御2021
- Author(s)
  貝塚拓、高松岳矢、片桐千秋、松下正之
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] ヒトiPS細胞の概日リズム特性に関する研究2020
- Author(s)
  金子瞳、貝塚拓、富澤一仁
- Organizer
  第27回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] 網目構造の合成繊維シートから成る培養担体は多能性幹細胞の膵臓系譜への分化を促進する2019
- Author(s)
  貝塚拓, 小島理恵, 川部雅章, 野口洋文, 白木伸明, 粂昭苑, 富澤一仁
- Organizer
  日本組織培養学会第92回大会
- Data Source
  KAKENHI-PROJECT-16KK0205
[Presentation] 網目構造の合成繊維シートから成る培養担体は多能性幹細胞の膵臓系譜への分化を促進する2019
- Author(s)
  貝塚拓, 小島理恵, 川部雅章, 野口洋文, 白木伸明, 粂昭苑, 富澤一仁
- Organizer
  日本組織培養学会第92回大会
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] ヒトiPS細胞の概日リズムの同調刺激に対する反応とそのメカニズムに関する研究2019
- Author(s)
  金子瞳, 貝塚拓, 富澤一仁
- Organizer
  第26回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-16KK0205
[Presentation] ヒトiPS細胞の概日リズムの同調刺激に対する反応とそのメカニズムに関する研究2019
- Author(s)
  金子瞳, 貝塚拓, 富澤一仁
- Organizer
  第26回日本時間生物学会学術大会
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] Regulation of brain-specific splicing of Eef1d and activity control of its nuclear variant, eEF1BδL by stress-induced dephosphorylation2018
- Author(s)
  Taku Kaitsuka, Masayuki Matsushita
- Organizer
  NEUROSCIENCE 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] 翻訳因子の長鎖アイソフォームeEF1BδLの欠損マウスは聴原生てんかんを呈する2018
- Author(s)
  貝塚　拓、富澤　一仁、松下　正之
- Organizer
  第４１回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06876
[Presentation] ヒトiPS細胞の内胚葉へのヘテロ分化の要因に関する研究2017
- Author(s)
  金子　瞳、貝塚　拓、富澤　一仁
- Organizer
  第９４回　日本生理学会大会
- Place of Presentation
  浜松アクトシティコングレスセンター（静岡県浜松市）
- Data Source
  KAKENHI-PROJECT-15K18971
[Presentation] HDAC9によるテロメア維持の組換え依存的経路の制御2016
- Author(s)
  Jamiruddin Mohd. Raeed、貝塚　拓、富澤　一仁
- Organizer
  第９３回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K18971
[Presentation] The role of histone deacetylase 11 in the pluripotency of the mouse pluripotent stem cells2016
- Author(s)
  Taku Kaitsuka, Taketo Nakashima, Kazuhito Tomizawa
- Organizer
  Cold Spring Harbor Laboratory Meeting-Mechanisms of Aging
- Place of Presentation
  コールドスプリングハーバー（米国）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18971
[Presentation] マウス胚性幹細胞の内胚葉への分化にはエリスロポエチンによるMAPK経路の活性化が有効である2016
- Author(s)
  小林　幸平、貝塚　拓、Hakim Farzana、魏　范研、富澤　一仁
- Organizer
  第９３回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2016-03-22
- Data Source
  KAKENHI-PROJECT-15K18971
[Presentation] エリスロポエチンはマウスES細胞からインスリン産生細胞への分化を促進する2014
- Author(s)
  大塚和華子、貝塚拓、久保拓也、魏范研、富澤一仁
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス(鹿児島鹿児島市)
- Data Source
  KAKENHI-PROJECT-24790217
[Presentation] チャネルロドプシンを利用した光応答性のインスリン分泌誘導技術の開発2014
- Author(s)
  水民敬浩、貝塚拓、羅歓、魏范研、宋文杰、富澤一仁
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24790217
[Presentation] エリスロポエチンはマウスES細胞からインスリン産生細胞への分化を促進する2014
- Author(s)
  大塚和華子、貝塚拓、久保拓也、魏范研、富澤一仁
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24790217
[Presentation] 高酸素条件下での培養はヒトiPS細胞から膵臓前駆細胞およびインスリン産生細胞への分化に促進的に働く2014
- Author(s)
  Hakim Farzana、貝塚拓、Mohd. Raeed Jamiruddin、魏范研、富澤一仁
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス(鹿児島鹿児島市)
- Data Source
  KAKENHI-PROJECT-24790217
[Presentation] チャネルロドプシンを利用した光応答性のインスリン分泌誘導技術の開発2014
- Author(s)
  水民敬浩、貝塚拓、羅歓、魏范研、宋文杰、富澤一仁
- Organizer
  第91回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス(鹿児島鹿児島市)
- Data Source
  KAKENHI-PROJECT-24790217
[Presentation] High oxygen condition facilitates the differentiation of mouse and human pluripotent stem cells into pancreatic progenitors and insulin-producing cells2014
- Author(s)
  Farzana Hakim, Taku Kaitsuka, Jamiruddin Mohd. Raeed, Fan-Yan Wei, and Kazuhito Tomizawa
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島大学郡元キャンパス（鹿児島県鹿児島市）
- Data Source
  KAKENHI-PROJECT-24790217

1. 金子瞳 (70966324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. SHIRAKI Nobuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 野口洋文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kaitsuka Taku 貝塚 拓

KAITSUKA Taku 貝塚 拓

Research Projects

Research Products

Co-Researchers

A novel strategy for the therapy of refractory cancers based on the restoration of disrupted circadian rhythmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the control of stress response in the brain via the regulation of protein translation and gene transcription by eEF1BdeltaLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on the molecular mechanisms of epileptic phenotype in eEF1BdeltaL knockout mice(Fostering Joint International Research)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the molecular mechanisms of epileptic phenotype in eEF1BdeltaL knockout micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Control of polyglutamine protein aggregation by eEF1BdeltaLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Heat Shock-Induced Dephosphorylation of Eukaryotic Elongation Factor 1BδL by Protein Phosphatase 12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Response of Pluripotent Stem Cells to Environmental Stress and Its Application for Directed Differentiation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase‐dead mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Response to Stimulations Inducing Circadian Rhythm in Human Induced Pluripotent Stem Cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] eEF1BδL欠損で生じる聴原性発作2020

Author(s)

Journal Title

Data Source

[Journal Article] SIRT2 inhibition activates hypoxia-inducible factor 1α signaling and mediates neuronal survival2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] eEF1BδL欠損で生じる聴原性発作2020

Author(s)

Journal Title

Data Source

[Journal Article] 翻訳伸長因子Eef1dの変異が引き起こすてんかん様発作とその発症メカニズムに関する研究2020

Author(s)

Journal Title

Data Source

[Journal Article] A culture substratum with net-like polyamide fibers promotes the differentiation of mouse and human pluripotent stem cells to insulin-producing cells2019

Author(s)

Journal Title

Kaitsuka Taku 貝塚拓

KAITSUKA Taku 貝塚拓

[Presentation] 熱ストレス応答タンパク質eEF1BδLのリン酸化/脱リン酸化による機能制御2021