Ninomiya Kensuke 二宮賢介

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NINOMIYA Kensuke 二宮賢介

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Researcher Number	00437279
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 特任講師(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, 大学院生命機能研究科, 特任講師(常勤) 2020 – 2021: 大阪大学, 生命機能研究科, 特任講師(常勤) 2019: 北海道大学, 遺伝子病制御研究所, 助教 2015: 北海道大学, 遺伝子病制御研究所, 助教 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 助教 2014: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 43010:Molecular biology-related / Molecular biology Except Principal Investigator General pharmacology / Chemical biology
Keywords	Principal Investigator スプライシング / ストレス応答 / 核内構造体 / 長鎖非コードRNA / 遺伝子発現制御 / RNA結合タンパク質 / ncRNA / 非膜性構造体 / 熱ストレス応答 / DNA損傷修復 / RNAプロセシング / RNA … More Except Principal Investigator … More スプライシング / iPS / CRISPR / 創薬 / ハイスループット / 低分子化合物 / DYRK1A / 細胞 / ストレス / FTDP-17 / アルツハイマー / 神経変性疾患 / 急性ストレス / リン酸化酵素 / タウ / スクリーニング / 化合物 / アルツハイマー病 / タウオパチー Less

多機能を有するリピート型RNAの機能解析Principal Investigator
- Principal Investigator
  
  二宮賢介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Osaka University
Compositional dynamics of nuclear stress bodies and its roles in stress responsePrincipal Investigator
- Principal Investigator
  
  Ninomiya Kensuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Osaka University
  Hokkaido University
トランスクリプトームの人為的操作による遺伝病の治療
- Principal Investigator
  
  萩原正敏
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Analysis of intron-retaining form of DNA repair-related mRNAsPrincipal Investigator
- Principal Investigator
  
  Ninomiya Kensuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Hokkaido University
  Kyoto University
Identification of a small molecule that induces autophagy-mediated degradation of TAU
- Principal Investigator
  
  HAGIWARA Masatoshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
analyses of splicing-dependent stress response mechanismPrincipal Investigator
- Principal Investigator
  
  NINOMIYA Kensuke
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  Kyoto University

All 2023 2022 2021 2020 2019 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] 月刊「細胞」2022年7月号 Architectural RNAと液－液相分離2022
- Author(s)
  二宮賢介, 廣瀬哲郎
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-22K06083
[Book] 「化学工業」2020年4月号「注目される最先端相分離研究」2020
- Author(s)
  二宮賢介　廣瀬哲郎
- Publisher
  化学工業社
- Data Source
  KAKENHI-PROJECT-19K06478
[Book] 「化学工業」2020年4月号「注目される最先端相分離研究」2020
- Author(s)
  二宮賢介　廣瀬哲郎　(分担執筆)
- Total Pages
  86
- Publisher
  化学工業社
- Data Source
  KAKENHI-PROJECT-19K06478
[Book] ヒートショック誘導性lncRNAと核内構造体　実験医学増刊「ノンコーディングRNAテキストブック」2015
- Author(s)
  二宮賢介　廣瀬哲郎
- Total Pages
  2
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26840008
[Journal Article] Nascent ribosomal RNA act as surfactant that suppresses growth of fibrillar centers in nucleolus2023
- Author(s)
  Yamamoto Tetsuya、Yamazaki Tomohiro、Ninomiya Kensuke、Hirose Tetsuro
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1129-1129
- DOI
  10.1038/s42003-023-05519-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18112, KAKENHI-PROJECT-22K06083, KAKENHI-PROJECT-21K03479, KAKENHI-PLANNED-21H05276, KAKENHI-PUBLICLY-23H04258, KAKENHI-PROJECT-23K23809
[Journal Article] Satellite RNAs: emerging players in subnuclear architecture and gene regulation2023
- Author(s)
  Ninomiya Kensuke、Yamazaki Tomohiro、Hirose Tetsuro
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 18
- DOI
  10.15252/embj.2023114331
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06083, KAKENHI-PROJECT-22K19293, KAKENHI-PLANNED-21H05276, KAKENHI-PUBLICLY-23H04258
[Journal Article] A guide to membraneless organelles and their various roles in gene regulation2022
- Author(s)
  Hirose Tetsuro、Ninomiya Kensuke、Nakagawa Shinichi、Yamazaki Tomohiro
- Journal Title
  
  Nature Reviews Molecular Cell Biology
  
  Volume: 24 Issue: 4 Pages: 288-304
- DOI
  10.1038/s41580-022-00558-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06083, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-20H00448, KAKENHI-PUBLICLY-21H00253, KAKENHI-PROJECT-23K23809, KAKENHI-PROJECT-22K19293
[Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021
- Author(s)
  Shibata Tomonori、Nagano Konami、Ueyama Morio、Ninomiya Kensuke、Hirose Tetsuro、Nagai Yoshitaka、Ishikawa Kinya、Kawai Gota、Nakatani Kazuhiko
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-020-20487-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22254, KAKENHI-PROJECT-19H00924, KAKENHI-PROJECT-17K01962, KAKENHI-PLANNED-20H05927, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20H02880
[Journal Article] m6A modification of HSATIII lncRNAs regulates temperature‐dependent splicing2021
- Author(s)
  Ninomiya Kensuke、Iwakiri Junichi、Aly Mahmoud Khamis、Sakaguchi Yuriko、Adachi Shungo、Natsume Tohru、Terai Goro、Asai Kiyoshi、Suzuki Tsutomu、Hirose Tetsuro
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 15
- DOI
  10.15252/embj.2021107976
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PUBLICLY-20H05377, KAKENHI-PLANNED-21H05276, KAKENHI-PROJECT-20H00448, KAKENHI-PROJECT-20K12041, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-18H05272
[Journal Article] Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases2020
- Author(s)
  Ninomiya Kensuke、Hirose Tetsuro
- Journal Title
  
  Non-Coding RNA
  
  Volume: 6 Issue: 1 Pages: 6-6
- DOI
  10.3390/ncrna6010006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22374, KAKENHI-WRAPUP-19H05439, KAKENHI-PROJECT-17H03630, KAKENHI-PROJECT-16H06279
[Journal Article] LncRNA ‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation2019
- Author(s)
  Ninomiya Kensuke、Adachi Shungo、Natsume Tohru、Iwakiri Junichi、Terai Goro、Asai Kiyoshi、Hirose Tetsuro
- Journal Title
  
  The EMBO Journal
  
  Volume: 39 Issue: 3
- DOI
  10.15252/embj.2019102729
- NAID
  120006876293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22374, KAKENHI-PROJECT-17H03630, KAKENHI-PROJECT-16K16143, KAKENHI-PROJECT-16H06279
[Journal Article] Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure2019
- Author(s)
  Aly Mahmoud Khamis、Ninomiya Kensuke、Adachi Shungo、Natsume Tohru、Hirose Tetsuro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 516 Issue: 2 Pages: 419-423
- DOI
  10.1016/j.bbrc.2019.06.061
- NAID
  120006878349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06478, KAKENHI-PROJECT-19K22374, KAKENHI-PROJECT-17H03630
[Journal Article] Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.2015
- Author(s)
  Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, et al.
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 88 Issue: 2 Pages: 316-325
- DOI
  10.1124/mol.114.097345
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20257, KAKENHI-PROJECT-15H05721, KAKENHI-PROJECT-15H02505, KAKENHI-PROJECT-24390392, KAKENHI-PROJECT-21249013
[Presentation] HSATIII lncRNAのm6A修飾と多機能性2023
- Author(s)
  二宮賢介
- Organizer
  遺伝研研究会「エピトランスクリプトーム制御の分子機構と生理機能」
- Invited
- Data Source
  KAKENHI-PROJECT-22K06083
[Presentation] Short-tandem repeat型RNAであるHSATIIIの多彩な分子機能2023
- Author(s)
  二宮賢介
- Organizer
  RNAフロンティアミーティング2023
- Data Source
  KAKENHI-PROJECT-22K06083
[Presentation] Characterization and functional analysis of HSATIII-derived repetitive proteins2023
- Author(s)
  Kensuke Ninomiya, Shungo Adachi, Tetsuro Hirose
- Organizer
  第24回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-22K06083
[Presentation] HSATIII lncRNAの多機能性とその制御機構2022
- Author(s)
  二宮賢介, 足達俊吾, 廣瀬哲郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K06083
[Presentation] The dynamics and functions of cytoplasmic HSATIII lncRNAs2022
- Author(s)
  二宮賢介, 廣瀬哲郎
- Organizer
  第23回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-22K06083
[Presentation] HSATIII lncRNAの細胞質における動態と分子機能2022
- Author(s)
  二宮賢介, 廣瀬哲郎
- Organizer
  RNAフロンティアミーティング2021
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] 霊長類特異的なHSATIII lncRNAの細胞質における新規分子機能2021
- Author(s)
  二宮賢介, 廣瀬哲郎
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] The novel molecular function of HSATIII lncRNAs in cytoplasm2021
- Author(s)
  二宮賢介, 廣瀬哲郎
- Organizer
  第22回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] HSATIII lncRNAs dictate primate-specific response to thermal stress through the dual mechanisms of splicing control2020
- Author(s)
  二宮賢介
- Organizer
  第43回日本分子生物学会年会フォーラム
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] HSATIII lncRNAによる２つのスプライシング制御機構2019
- Author(s)
  二宮賢介
- Organizer
  2019年度北海道大学共同利用・共同研究拠点アライアンス部局横断シンポジウム「計算科学が拓く汎分野研究」
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] 核内ストレス体による２つのスプライシング制御機構2019
- Author(s)
  二宮賢介
- Organizer
  第21回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] HSATIII lncRNAによる２つのスプライシング制御機構2019
- Author(s)
  二宮賢介
- Organizer
  第４２回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] HSATIII lncRNAによる２つのスプライシング制御機構2019
- Author(s)
  二宮賢介
- Organizer
  第５回北大部局間横断シンポジウム
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] HSATIII lncRNAによる２つのスプライシング制御機構2019
- Author(s)
  二宮賢介
- Organizer
  RNAフロンティアミーティング2019
- Data Source
  KAKENHI-PROJECT-19K06478
[Presentation] 新規核内 intron-retaining RNA の探索2016
- Author(s)
  二宮賢介、飯田慶、萩原正敏
- Organizer
  北大・部局横断シンポジウム
- Place of Presentation
  北海道大学フラテホール（北海道札幌市）
- Year and Date
  2016-03-07
- Data Source
  KAKENHI-PROJECT-26840008
[Presentation] 変異ジストロフィン遺伝子に対するエクソンスキップ誘導活性を有する化合物の探索2015
- Author(s)
  佐古有季哉、二宮賢介、喜井勲、細谷孝充、萩原正敏
- Organizer
  第17回日本RNA学会年会　ポスター発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 新規核内 intron-retaining RNA の探索と解析2015
- Author(s)
  二宮賢介、飯田慶、佐久間真紀、佐古有季哉、萩原正敏
- Organizer
  第１７回RNA学会年会
- Place of Presentation
  ホテルライフォート札幌（北海道札幌市）
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26840008
[Presentation] 新規核内intron-retaining RNA の探索と解析2015
- Author(s)
  二宮賢介、飯田慶、佐久間真紀、佐古有季哉、萩原正敏
- Organizer
  第17回日本RNA学会年会　ポスター発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 哺乳類の超長鎖遺伝子発現に必要である、RNA結合タンパク質によるmRNAプロセッシングと転写伸長活性化機構2015
- Author(s)
  武内章英、飯田慶、二宮賢介、出縄政嗣、坪田智明、伊藤美佳子、大野欽司、萩原正敏
- Organizer
  第17回日本RNA学会年会　口頭発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] RBM24 IS RESPONSIBLE FOR TISSUE-SPECIFIC ABERRANT SPLICING IN FAMILIAL DYSAUTONOMIA2015
- Author(s)
  Kenji Ohe, Mayumi Yoshida, Kensuke Ninomiya, Maki Sakuma, Tomomi Usui, Takayuki Nojima, Naoyuki Kataoka, Masatoshi Hagiwara
- Organizer
  CSHL Eukaryotic mRNA Processing, 2015 Oral presentation
- Place of Presentation
  Cold Spring Harbor Laboratory, NY
- Year and Date
  2015-08-18
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 家族性自律神経失調症におけるIKBKAP遺伝子の組織特異的異常スプライシングの責任分子の同定2015
- Author(s)
  大江賢治、吉田真弓、二宮賢介、佐久間真紀、薄井知美、野島孝之、萩原正敏、片岡直行
- Organizer
  第17回日本RNA学会年会　口頭発表
- Place of Presentation
  ホテルライフォート札幌
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-15H02505
[Presentation] 変異ジストロフィン遺伝子のエキソンスキップによる筋ジストロフィー治療法開発の試み2014
- Author(s)
  二宮賢介, 佐古有季哉, 萩原正敏
- Organizer
  第119回日本解剖学会総会全国学術集会
- Place of Presentation
  栃木県下野市
- Year and Date
  2014-03-28
- Data Source
  KAKENHI-PROJECT-24770166
[Presentation] 変異ジストロフィン遺伝子のエキソンスキップによる筋ジストロフィー治療法開発の試み
- Author(s)
  二宮賢介　佐古有季哉　萩原正敏
- Organizer
  第119回日本解剖学会総会全国学術集会
- Place of Presentation
  栃木県下野市
- Data Source
  KAKENHI-PROJECT-24770166

1. HAGIWARA Masatoshi (10208423)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. TAKEUCHI Akihide (90436618)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. HOSOYA Takamitsu (60273124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KATAOKA Naoyuki (60346062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大江賢治 (30419527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 飯田慶 (00387961)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 奥野友紀子 (00372524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山崎智弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 諸岡諭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ninomiya Kensuke 二宮 賢介

NINOMIYA Kensuke 二宮 賢介

Research Projects

Research Products

Co-Researchers

多機能を有するリピート型RNAの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Compositional dynamics of nuclear stress bodies and its roles in stress responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

トランスクリプトームの人為的操作による遺伝病の治療

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of intron-retaining form of DNA repair-related mRNAsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a small molecule that induces autophagy-mediated degradation of TAU

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

analyses of splicing-dependent stress response mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 月刊「細胞」2022年7月号 Architectural RNAと液－液相分離2022

Author(s)

Total Pages

Publisher

Data Source

[Book] 「化学工業」2020年4月号 「注目される最先端相分離研究」2020

Author(s)

Publisher

Data Source

[Book] 「化学工業」2020年4月号 「注目される最先端相分離研究」2020

Author(s)

Total Pages

Publisher

Data Source

[Book] ヒートショック誘導性lncRNAと核内構造体 実験医学増刊「ノンコーディングRNAテキストブック」2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Nascent ribosomal RNA act as surfactant that suppresses growth of fibrillar centers in nucleolus2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Satellite RNAs: emerging players in subnuclear architecture and gene regulation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A guide to membraneless organelles and their various roles in gene regulation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model2021

Author(s)

Journal Title

DOI

Data Source

Ninomiya Kensuke 二宮賢介

NINOMIYA Kensuke 二宮賢介

[Book] 「化学工業」2020年4月号「注目される最先端相分離研究」2020

[Book] 「化学工業」2020年4月号「注目される最先端相分離研究」2020

[Book] ヒートショック誘導性lncRNAと核内構造体　実験医学増刊「ノンコーディングRNAテキストブック」2015