Ohata Shinya 大畑慎也

Researcher Number	00442939
Other IDs	https://orcid.org/0000-0003-4333-4433
Affiliation (Current)	2025: 武蔵野大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2022: 武蔵野大学, 薬学部, 准教授 2017 – 2021: 武蔵野大学, 薬学部, 講師 2016: 武蔵野大学, 薬学研究所, 講師
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Functional biochemistry
Keywords	Principal Investigator NF-kB / 希少疾患 / ZFTA / RelA / C11orf95 / 遺伝子発現制御 / ドラッグスクリーニング / ノックアウトマウス / 脳 / 腫瘍 … More / 創薬 / 細胞内局在制御 / 上衣腫 / 薬学 / 脳・神経 / 神経科学 / 発生・分化 / 低分子領Gタンパク質 / 平面細胞極性 / Ras / PCP / 神経管 / 低分子量Gタンパク質 / R-Ras / 神経管形成不全 Less

Elucidation of ependymoma pathogenesis mechanism and search for therapeutic targetsPrincipal Investigator
- Principal Investigator
  
  Ohata Shinya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Musashino University
Molecular mechanism of neural tube formation by the small GTPase R-RasPrincipal Investigator
- Principal Investigator
  
  Ohata Shinya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Musashino University

All 2023 2022 2021 2020 2019 2018 2016

All Journal Article Presentation

[Journal Article] 上衣細胞分化の異常による上衣腫発症機構の解明2023
- Author(s)
  大畑慎也
- Journal Title
  
  薬学研究の進歩
  
  Volume: 39 Pages: 17-28
- Data Source
  KAKENHI-PROJECT-20K07038
[Journal Article] Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice2022
- Author(s)
  Herranz-P?rez Vicente、Nakatani Jin、Ishii Masaki、Katada Toshiaki、Garc?a-Verdugo Jose Manuel、Ohata Shinya
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1493-1493
- DOI
  10.1038/s41598-022-05526-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06550, KAKENHI-PROJECT-20K07038, KAKENHI-PROJECT-19K16656, KAKENHI-PROJECT-21K15438
[Journal Article] epi-Aszonalenin B from Aspergillus novofumigatus inhibits NF-κB activity induced by ZFTA-RELA fusion protein that drives ependymoma2022
- Author(s)
  Ishikawa Kazuki、Ishii Masaki、Yaguchi Takashi、Katada Toshiaki、Ichinose Koji、Ohata Shinya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 596 Pages: 104-110
- DOI
  10.1016/j.bbrc.2022.01.076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06550, KAKENHI-PROJECT-20K07038, KAKENHI-PROJECT-19K16656, KAKENHI-PROJECT-21K15438
[Journal Article] Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice2021
- Author(s)
  Herranz-Perez Vicente、Nakatani Jin、Ishii Masaki、Katada Toshiaki、Garcia-Verdugo Jose Manuel、Ohata Shinya
- Journal Title
  
  Research Square (preprint server)
  
  Volume: NA
- DOI
  10.21203/rs.3.rs-948030/v1
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07038
[Journal Article] 上衣腫発症に関わる機能未知遺伝子C11orf95の機能解析と上衣腫治療薬の開発2020
- Author(s)
  大畑慎也
- Journal Title
  
  加藤記念バイオサイエンス振興財団2019年度年報
  
  Volume: 21 Pages: 36-37
- Data Source
  KAKENHI-PROJECT-20K07038
[Journal Article] Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos2019
- Author(s)
  Hashimoto Keisuke、Yamaguchi Yoshifumi、Kishi Yusuke、Kikko Yorifumi、Takasaki Kanako、Maeda Yurie、Matsumoto Yudai、Oka Miho、Miura Masayuki、Ohata Shinya、Katada Toshiaki、Kontani Kenji
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 6 Pages: 436-448
- DOI
  10.1111/gtc.12687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-16H06163, KAKENHI-PROJECT-17H03981
[Journal Article] 上衣腫発症につながる恒常的NF-κB経路活性化の分子機構解明と阻害剤の開発2019
- Author(s)
  大畑慎也
- Journal Title
  
  SGHがん研究報告
  
  Volume: 29 Pages: 35-38
- Data Source
  KAKENHI-PROJECT-16H06163
[Journal Article] Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord2018
- Author(s)
  Ohata Shinya、Uga Hideko、Okamoto Hitoshi、Katada Toshiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 501 Issue: 3 Pages: 786-790
- DOI
  10.1016/j.bbrc.2018.05.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06163
[Journal Article] Roles of Wnt signaling in the neurogenic niche of the adult mouse ventricular-subventricular zone2016
- Author(s)
  Hirota Y, Sawada M, Huang SH, Ogino T, Ohata S, Kubo A, Sawamoto K
- Journal Title
  
  Neurochemical Research
  
  Volume: 41 Issue: 1-2 Pages: 222-230
- DOI
  10.1007/s11064-015-1766-z
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440114, KAKENHI-PUBLICLY-15H01217, KAKENHI-PUBLICLY-15H01219, KAKENHI-PUBLICLY-15H01384, KAKENHI-PROJECT-26250019, KAKENHI-PROJECT-26640046, KAKENHI-PROJECT-23229001, KAKENHI-PROJECT-16H06163
[Journal Article] Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium.2016
- Author(s)
  2)Ohata S, Alvarez-Buylla A.
- Journal Title
  
  Trends Neurosci.
  
  Volume: 39 Issue: 8 Pages: 543-551
- DOI
  10.1016/j.tins.2016.05.004
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23229001, KAKENHI-PROJECT-16H06163
[Presentation] 上衣腫原因タンパク質ZFTA-RELAの核移行機構の解明2023
- Author(s)
  小島瑠莉,石井雅樹,大畑慎也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 脳上衣腫原因融合タンパク質ZFTA-RelAの核内輸送機構の構造生物研究2023
- Author(s)
  藤間祥子,松浦滉明,坂井直樹,平田邦生,松谷優輝,清水光,端山浩輝,今村尚真,小島瑠璃,清水敏之,上久保裕生,川内大輔,大畑慎也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 上衣細胞の運動性繊毛に局在するGαi共役型受容体の探索2023
- Author(s)
  細谷拓郎,石井雅樹,大畑慎也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] ｍTOR及びトポイソメラーゼⅠ阻害はテント上上衣腫原因タンパク質によるNF-κB経路活性化を抑制する2023
- Author(s)
  中尾英嘉,石井雅樹,大畑慎也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 階層的クラスタリングによって明らかになった脳上衣腫原因遺伝子ZFTA-RELAの核内輸送機構2022
- Author(s)
  藤間祥子, 大畑慎也, 松浦滉明, 坂井直樹, 平田邦生, 松谷優輝, 清水光, 端山浩輝, 鈴木雄登, 米澤健人, 林有吾, 山崎洋一, 堅田利明, 清水敏之, 上久保裕生
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] Aspergillus属真菌由来の抗Rhizopus oryzae活性物質の探索（第1報）2022
- Author(s)
  澤田悠佳, 石川和樹, 石井雅樹, 大畑慎也, 矢口貴志, 堅田利明, 市瀬浩志
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 上衣腫原因融合タンパク質ZFTA-RELAの核移行機構2022
- Author(s)
  大畑慎也
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] PPARg核内輸送機構の構造生物学的研究2022
- Author(s)
  藤間祥子, 中村雄太郎, 寺谷俊昭, 川本晃大, 清水光, 廣瀬未果, 端山浩輝, 大畑慎也, 林有吾, 山崎洋一, 岩崎憲治, 加藤貴之, 上久保裕生, 伊藤俊将, 冨田謙吾, 清水敏之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 発がん性NF-κBシグナルを阻害する真菌代謝物の探索2022
- Author(s)
  大畑慎也,石川和樹,石井雅樹,矢口貴志,市瀬浩志
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] ｍTOR及びトポイソメラーゼⅠ阻害はテント上上衣腫原因タンパク質によるNF-κB経路活性化を抑制する2022
- Author(s)
  中尾英嘉,石井雅樹,堅田利明,大畑慎也
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] Exploratory research of bioactive compounds from Fungi Aspergillus species to address unmet medical needs2021
- Author(s)
  Kazuki Ishikawa, Shinya Ohata, Masaki Ishii, Takashi Yaguchi, Toshiaki Katada, Koji Ichinose
- Organizer
  The 11th JSP, CSP, KSP Joint Symposium on Pharmacognosy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 上衣腫原因融合タンパク質ZFTA-RELAFUS2の核輸送機構2021
- Author(s)
  小島瑠莉, 石井雅樹, 堅田利明, 大畑慎也
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 上衣腫原因融合遺伝子 C11orf95-RelA の発現制御機構2020
- Author(s)
  西村知晃、中村匠、宇賀英子、堅田利明、大畑慎也
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 上衣腫原因融合タンパク質 C11orf95-RelA の核移行機構2020
- Author(s)
  内田有紀、栄祐美、松谷優輝、石井雅樹、藤間祥子、清水敏之、堅田利明、大畑慎也
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] 皮膚糸状菌 Rac 及び CDC42 の菌糸成長における機能解析2020
- Author(s)
  松原理佳、石井雅樹、高橋沙由美、堀越えみり、宇賀英子、大畑慎也、堅田利明
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-20K07038
[Presentation] Trichophyton rubrumの低分子量Gタンパク質Ras-related C3 botulinum toxin substrate (Rac)のcell division cycle 24 (CDC24)を介した活性化と胞子発芽調節2019
- Author(s)
  石井雅樹、大畑慎也、山田剛、宇賀英子、堅田利明
- Organizer
  第40回関東医真菌懇話会
- Data Source
  KAKENHI-PROJECT-16H06163
[Presentation] 低分子量Gタンパク質Rac GEF抑制による皮膚糸状菌菌糸成長の阻害2019
- Author(s)
  石井雅樹、大畑慎也、山田剛、宇賀英子、堅田利明
- Organizer
  第93回細菌学会総
- Data Source
  KAKENHI-PROJECT-16H06163
[Presentation] 上衣腫原因融合タンパク質C11orf95-RelAの核移行機構2019
- Author(s)
  大畑慎也
- Organizer
  第18回生命科学研究会
- Data Source
  KAKENHI-PROJECT-16H06163
[Presentation] 上衣腫関連遺伝子2700081O15Rik/C11orf95の発現プロファイルと機能解析2019
- Author(s)
  大畑慎也、堅田利明
- Organizer
  第42回日本分子生物学会年
- Data Source
  KAKENHI-PROJECT-16H06163

1. 廣田ゆき

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 堅田利明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 岸雄介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohata Shinya 大畑 慎也

Research Projects

Research Products

Co-Researchers

Elucidation of ependymoma pathogenesis mechanism and search for therapeutic targetsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of neural tube formation by the small GTPase R-RasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 上衣細胞分化の異常による上衣腫発症機構の解明2023

Author(s)

Journal Title

Data Source

[Journal Article] Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] epi-Aszonalenin B from Aspergillus novofumigatus inhibits NF-κB activity induced by ZFTA-RELA fusion protein that drives ependymoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 上衣腫発症に関わる機能未知遺伝子C11orf95の機能解析と上衣腫治療薬の開発2020

Author(s)

Journal Title

Data Source

[Journal Article] Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 上衣腫発症につながる恒常的NF-κB経路活性化の分子機構解明と阻害剤の開発2019

Author(s)

Journal Title

Data Source

[Journal Article] Small GTPase R-Ras participates in neural tube formation in zebrafish embryonic spinal cord2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of Wnt signaling in the neurogenic niche of the adult mouse ventricular-subventricular zone2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium.2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] 上衣腫原因タンパク質ZFTA-RELAの核移行機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] 脳上衣腫原因融合タンパク質ZFTA-RelAの核内輸送機構の構造生物研究2023

Author(s)

Organizer

Data Source

[Presentation] 上衣細胞の運動性繊毛に局在するGαi共役型受容体の探索2023

Author(s)

Organizer

Data Source

[Presentation] ｍTOR及びトポイソメラーゼⅠ阻害はテント上上衣腫原因タンパク質によるNF-κB経路活性化を抑制する2023

Author(s)

Organizer

Data Source

[Presentation] 階層的クラスタリングによって明らかになった脳上衣腫原因遺伝子ZFTA-RELAの核内輸送機構2022

Ohata Shinya 大畑慎也

[Presentation] Aspergillus属真菌由来の抗Rhizopus oryzae活性物質の探索（第1報）2022