TOKUDOME TAKESHI 徳留健

… Alternative Names

TOKUDOME Takeshi 徳留健

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Researcher Number	00443474
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 横浜市立大学, 医学研究科, 教授 2015 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 室長 2014: 国立循環器病研究センター, 研究所, 室長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2010 – 2011: 独立行政法人国立循環器病研究センター, 生化学部, 室長 … More 2007 – 2009: National Cardiovascular Center Research Institute, Department of Etiology and Pathogenesis, Laboratory chief 2008: National Cardiovascular Center Research Institute, 病因部, 室長 2008: National Cardiovascular Center Research Institute, 高血圧研究室, 室長 2007: National Cardiovascular Center Research Institute, 研究所・病因部, 室長 Less
Review Section/Research Field	Principal Investigator Endocrinology / Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Cardiovascular medicine / Basic Section 48030:Pharmacology-related / Basic Section 53020:Cardiology-related / Kidney internal medicine
Keywords	Principal Investigator グレリン / 心筋梗塞 / ナトリウム利尿ペプチド / 内分泌学 / 心肥大 / GC-A / BNP / ANP / トラスツズマブ / マウス … More / ドキソルビシン / ペプチドホルモン / 心不全 / 抗癌剤誘発性心筋症 / 内科 / 心臓ホルモン / 骨格筋血流 / インスリン抵抗性 / 血管内皮 / メタボリックシンドローム / 遺伝子改変マウス / 炎症性サイトカイン / 心臓リモデリング / 自律神経 / 副交感神経 / 交感神経 / 末梢動脈閉塞性疾患 / 致死性不整脈 / 心臓交感神経 / カルシニューリン / RGS4 / 心臓病態学 … More Except Principal Investigator ナトリウム利尿ペプチド / 周産期心筋症 / グレリン / 心肥大 / 授乳 / 生理活性ペプチド / 糖尿病 / 心不全 / 心筋梗塞 / 自律神経 / 副交感神経 / 脳内報酬系 / 慢性心不全 / バイオマーカー / 妊娠高血圧症候群 / 妊娠・出産 / Neovascularization / Natriuretic peptides / Atherosclerosis / 平滑筋細胞 / 血管新生 / 動脈硬化 / 生理活性 / トランスレーショナルリサーチ / 循環器・高血圧 / 腎疾患 / 迷走神経 / 肥満 / 交感神経 / 心臓保護 / グアニル酸シクラーゼ / 心臓リモデリング / RGS Less

脳内報酬系・副交感神経系に着目した難治性心疾患およびその合併症の画期的治療法開発
- Principal Investigator
  
  増川太輝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Yokohama City University
周産期心筋症の病態－遺伝要因・心筋炎症・血管障害－解明研究
- Principal Investigator
  
  神谷千津子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Development of an novel treatment for "Anticancer drug-induced cardiomyopathy" by utilizing the physiological effects of ghrelinPrincipal Investigator
- Principal Investigator
  
  TOKUDOME Takeshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yokohama City University
  National Cardiovascular Center Research Institute
Development of novel therapy for postpartum cardiomyopathy based on the comprehensive analysis of animal model and clinical gene sample
- Principal Investigator
  
  OTANI KENTARO
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of innovative therapy of metabolic syndrome applying physiological effects of cardiac hormonesPrincipal Investigator
- Principal Investigator
  
  Tokudome Takeshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  National Cardiovascular Center Research Institute
Development of a novel therapy for peripartum cardiomyopathy using natriuretic peptides
- Principal Investigator
  
  OTANI KENTARO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of new therapy of cardiac disease utilizing physiological effect of ghrelinPrincipal Investigator
- Principal Investigator
  
  TOKUDOME TAKESHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
Translational Research of Ghrelin in Cardiometabolic Diseases and Its Potent Regulatory Role of Autonomic Nerve Function
- Principal Investigator
  
  KISHIMOTO Ichiro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Basic Research toward Discovery for New Renal Treatment using Bioactive Peptides
- Principal Investigator
  
  YOSHIHARA Fumiki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of new therapy of cardiovascular disease utilizing specificity of biologically active peptide hormonesPrincipal Investigator
- Principal Investigator
  
  TOKUDOME Takeshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Endocrinology
- Research Institution
  National Cardiovascular Center Research Institute
The therapeutic potentials of ghrelin in cardiovascular diseases-roles of the autonomic nervous system
- Principal Investigator
  
  KISHIMOTO Ichiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Molecular Elucidation for Endogenous Cardioprotective Mechanism -Towards Discovery for New Cardiac Treatment
- Principal Investigator
  
  KISHIMOTO Ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.Principal Investigator
- Principal Investigator
  
  TOKUDOME Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute
Antiatherosclerotic therapy using cell differentiation-promoting effect of biologically active peptides
- Principal Investigator
  
  HORIO Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

[Book] Current Hypertension Reports2016
- Author(s)
  Mao , Tokudome T, Kishimoto I.
- Total Pages
  6
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-25461082
[Book] Frontiers of Hormone Research2014
- Author(s)
  Tokudome T, Kishimoto I, Miyazato M, Kangawa K
- Total Pages
  9
- Publisher
  Karger Publishers
- Data Source
  KAKENHI-PROJECT-25461082
[Book] 最新内分泌代謝学「ナトリウム利尿ペプチド系」2013
- Author(s)
  岸本一郎, 徳留健
- Publisher
  (株)診断と治療社
- Data Source
  KAKENHI-PROJECT-24390204
[Book] ペプチドと創薬寒川賢治、南野直人(編) (循環器疾患におけるCNP の意義) (pp143-147) (ISSN 1349-2527)
- Author(s)
  岸本一郎、添木武、徳留健、堀尾武史、寒川賢治
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Dual deletion of guanylyl cyclase-A and p38 mitogen-activated protein kinase in podocytes with aldosterone administration causes glomerular intra-capillary thrombi2023
- Author(s)
  Sugioka Sayaka、Yamada Hiroyuki、Ishii Akira、Kato Yukiko、Yamada Ryo、Mori Keita P.、Ohno Shoko、Handa Takaya、Ikushima Akie、Ishimura Takuya、Osaki Keisuke、Tokudome Takeshi、Matsusaka Taiji、Nebreda Angel R.、Yanagita Motoko、Yokoi Hideki
- Journal Title
  
  Kidney International
  
  Volume: 104 Issue: 3 Pages: 508-525
- DOI
  10.1016/j.kint.2023.06.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15226, KAKENHI-PROJECT-23K15227, KAKENHI-PROJECT-22K08310, KAKENHI-PROJECT-23K07717, KAKENHI-PROJECT-20K08505, KAKENHI-PROJECT-23K21437
[Journal Article] Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide2022
- Author(s)
  Tokudome T, Otani K, Mao Y, Jensen LJ, Arai Y, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H.
- Journal Title
  
  Hypertension
  
  Volume: 79 Issue: 7 Pages: 1409-1422
- DOI
  10.1161/hypertensionaha.121.18114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08505, KAKENHI-PROJECT-21K05986, KAKENHI-PROJECT-20K08414, KAKENHI-PROJECT-20K08506
[Journal Article] 妊娠中および産褥期における心臓ナトリウム利尿ペプチドの生理的意義の解明2021
- Author(s)
  大谷健太郎、神谷千津子、徳留健
- Journal Title
  
  循環器内科
  
  Volume: 89 Pages: 386-394
- Data Source
  KAKENHI-PROJECT-17K09543
[Journal Article] Deficiency of natriuretic peptide signaling promotes peripartum cardiomyopathy-like remodeling in the mouse heart.2020
- Author(s)
  Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K.
- Journal Title
  
  Circulation
  
  Volume: 141 Issue: 7 Pages: 571-588
- DOI
  10.1161/circulationaha.119.039761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09543, KAKENHI-PROJECT-18K08127, KAKENHI-PROJECT-19K17727, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-17K07131, KAKENHI-PROJECT-17K11041, KAKENHI-PROJECT-17K18414, KAKENHI-PROJECT-17K09897
[Journal Article] Ghrelin and the heart2019
- Author(s)
  Tokudome T, Otani K, Miyazato M, Kangawa K
- Journal Title
  
  Peptides
  
  Volume: 111 Pages: 42-46
- DOI
  10.1016/j.peptides.2018.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05306, KAKENHI-PROJECT-17K09897
[Journal Article] Physiological significance of ghrelin in the cardiovascular system2019
- Author(s)
  Tokudome T, Kangawa K
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 8 Pages: 459-467
- DOI
  10.2183/pjab.95.032
- NAID
  130007728133
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-10-11
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09897
[Journal Article] A New Secretory Peptide of Natriuretic Peptide Family,Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.2018
- Author(s)
  Miyazaki T, Otani K, Chiba A, Nishimura H, Tokudome T, Takano-Watanabe H, Matsuo A, Ishikawa H, Shimamoto K, Fukui H, Kanai Y, Yasoda A, Ogata S, Nishimura K, Minamino N, Mochizuki N.
- Journal Title
  
  Circ Res.
  
  Volume: 122(5) Issue: 5 Pages: 742-751
- DOI
  10.1161/circresaha.117.312624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05646, KAKENHI-PROJECT-17K15587, KAKENHI-PROJECT-17K09897
[Journal Article] Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells2018
- Author(s)
  Ishikane S, Hosoda H, Nojiri T, Tokudome T, Mizutani T, Miura K, Akitake Y, Kimura T, Imamichi Y, Kawabe S, Toyohira Y, Yanagihara N, Takahashi-Yanaga F, Miyazato M, Miyamoto K, Kangawa K
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 154 Pages: 136-147
- DOI
  10.1016/j.bcp.2018.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K00904, KAKENHI-PROJECT-17K09897, KAKENHI-PROJECT-18K06907, KAKENHI-PROJECT-16K09798
[Journal Article] Guanylyl cyclase A in both renal proximal tubular and vascular endothelial cells protects the kidney against acute injury in rodent experimental endotoxemia models.2018
- Author(s)
  Kidney against Acute Injury in Rodent Experimental Endotoxemia Models. Kitamura H, Nakano D, Sawanobori Y, Asaga T, Yokoi H, Yanagita M, Mukoyama M, Tokudome T, Kangawa K, Shirakami G, Nishiyama A.
- Journal Title
  
  Anesthesiology
  
  Volume: 印刷中 Issue: 2 Pages: 296-310
- DOI
  10.1097/aln.0000000000002214
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15KK0346, KAKENHI-PROJECT-17K09697, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-17K09897, KAKENHI-PUBLICLY-18H04673, KAKENHI-PROJECT-18H03191, KAKENHI-PROJECT-17K19677
[Journal Article] Adipocyte-specific expression of C-type natriuretic peptide suppresses lipid metabolism and adipocyte hypertrophy in adipose tissues in mice fed high-fat diet.2018
- Author(s)
  Bae CR, Hino J, Hosoda H, Son C, Makino H, Tokudome T, Tomita T, Hosoda K, Miyazato M, Kangawa K.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 2093-2093
- DOI
  10.1038/s41598-018-20469-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09897, KAKENHI-PROJECT-17K11041, KAKENHI-PROJECT-16H05306, KAKENHI-PROJECT-17K16159
[Journal Article] Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.2017
- Author(s)
  Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 9807-9807
- DOI
  10.1038/s41598-017-10240-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09897, KAKENHI-PROJECT-17K11041, KAKENHI-PROJECT-17K16159, KAKENHI-PROJECT-16H05306
[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A pathway counteracts glomerular injury evoked by aldosterone through p38 mitogen-activated protein kinase inhibition.2017
- Author(s)
  Y. Kato, K. Mori, M. Kasahara, K. Osaki, A. Ishii, K.P. Mori, N. Toda, S. Ohno, T. Kuwabara, T. Tokudome, I. Kishimoto, M.A. Saleem, T. Matsusaka, K. Nakao, M. Mukoyama, M. Yanagita, H. Yokoi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 46624-46624
- DOI
  10.1038/srep46624
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461226, KAKENHI-PROJECT-15K09268, KAKENHI-PROJECT-17K09697, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-17K09897, KAKENHI-PROJECT-17K16079, KAKENHI-PROJECT-17K16080, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-16K15469
[Journal Article] Importance of endogenous atrial and brain natriuretic peptides in murine embryonic vascular and organ development.2016
- Author(s)
  Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.
- Journal Title
  
  Endocrinology
  
  Volume: 157 Issue: 1 Pages: 358-367
- DOI
  10.1210/en.2015-1344
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461100, KAKENHI-PROJECT-25461082, KAKENHI-PROJECT-25293188, KAKENHI-PROJECT-26293183
[Journal Article] Endogenous Ghrelin Attenuates Pressure Overload-Induced Cardiac Hypertrophy via a Cholinergic Anti-Inflammatory Pathway2015
- Author(s)
  Mao Y, Tokudome T, Kishimoto I, Otani K, Nishimura H, Yamaguchi O, Otsu K, Miyazato M, Kangawa K
- Journal Title
  
  Hypertension
  
  Volume: 65 Issue: 6 Pages: 1238-1244
- DOI
  10.1161/hypertensionaha.114.04864
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461082, KAKENHI-PROJECT-25293188
[Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015
- Author(s)
  Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 112 Issue: 13 Pages: 4086-4091
- DOI
  10.1073/pnas.1417273112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22112005, KAKENHI-PROJECT-24300330, KAKENHI-PUBLICLY-25122710, KAKENHI-PROJECT-26461393, KAKENHI-PROJECT-26861136, KAKENHI-PROJECT-26861319, KAKENHI-PROJECT-26461100, KAKENHI-PROJECT-15H04943, KAKENHI-PROJECT-25462176
[Journal Article] Ghrelin and the cardiovascular system2014
- Author(s)
  Tokudome T, Kishimoto I, Miyazato M, Kangawa K
- Journal Title
  
  Front Horm Res
  
  Volume: 43 Pages: 125-133
- DOI
  10.1159/000360593
- ISBN
  9783318026733, 9783318026740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390204, KAKENHI-PROJECT-25293188
[Journal Article] The cardiovascular action of hexarelin2014
- Author(s)
  Mao Y, Tokudome T, Kishimoto I
- Journal Title
  
  Journal of Geriatric Cardiology
  
  Volume: 11 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390204
[Journal Article] One dose of oral hexarelin protects chronic cardiac function after myocardial infarction2014
- Author(s)
  Mao Y, Tokudome T, Kishimoto I, Otani K, Miyazato M, Kangawa K
- Journal Title
  
  Peptides
  
  Volume: 56 Pages: 156-162
- DOI
  10.1016/j.peptides.2014.04.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22126002, KAKENHI-PROJECT-24390204, KAKENHI-PROJECT-25293188, KAKENHI-PROJECT-25461082
[Journal Article] Ghrelin as a treatment for cardiovascular diseases2014
- Author(s)
  Mao Y, Tokudome T, Kishimoto I
- Journal Title
  
  Hypertension
  
  Volume: 64 Issue: 3 Pages: 450-454
- DOI
  10.1161/hypertensionaha.114.03726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390204
[Journal Article] 生理活性ペプチドグレリンの循環器疾患治療への応用の可能性2014
- Author(s)
  宮里　幹也、徳留健、岸本　一郎、寒川　賢治
- Journal Title
  
  生命科学から創薬へのイノベーション
  
  Volume: 1 Pages: 23-29
- Data Source
  KAKENHI-PROJECT-24390204
[Journal Article] 授乳期における内因性心臓ナトリウム利尿ペプチド系による心保護作用のメカニズム解析2014
- Author(s)
  大谷健太郎、徳留　健、岸本一郎、池田智明、中尾一和、寒川賢治
- Journal Title
  
  血管
  
  Volume: 37 Pages: 93-93
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461100
[Journal Article] グレリンによる循環器疾患治療の可能性、Recent Advances in Cardiovascular Disease2013
- Author(s)
  徳留健、岸本一郎、宮里幹也、寒川賢治
- Journal Title
  
  循環器病研究の進歩
  
  Volume: XXXIV No.1 Pages: 58-68
- Data Source
  KAKENHI-PROJECT-24390204
[Journal Article] Hexarelin treatment in male ghrelin knockout mice after myocardial infarction2013
- Author(s)
  Mao Y, Tokudome T, Kishimoto I, Otani K, Hosoda H, Nagai C, Minamino N, Miyazato M, Kangawa K
- Journal Title
  
  Endocrinology
  
  Volume: 154 Issue: 10 Pages: 3847-3845
- DOI
  10.1210/en.2013-1291
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126002, KAKENHI-PROJECT-23310155, KAKENHI-PROJECT-24390204, KAKENHI-PROJECT-24890306, KAKENHI-PROJECT-25293188
[Journal Article] Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice2013
- Author(s)
  Mao Y, Tokudome T, Otani K, Kishimoto I, Miyazato M, Kangawa K
- Journal Title
  
  Endocrinology
  
  Volume: 154 Issue: 5 Pages: 1854-1863
- DOI
  10.1210/en.2012-2132
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22126002, KAKENHI-PROJECT-24390204, KAKENHI-PROJECT-25293188
[Journal Article] Ghrelin Prevents Incidence of Malignant Arrhythmia after Acute Myocardial Infarction through Vagal Afferent Nerves2012
- Author(s)
  Mao Y, Tokudome T, Otani K, Kishimoto I, Nakanishi M, Hosoda H, Miyazato M, Kangawa K
- Journal Title
  
  Endocrinology
  
  Volume: (in press) Issue: 7 Pages: 3426-3434
- DOI
  10.1210/en.2012-1065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591189, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-24390204, KAKENHI-PUBLICLY-23122525
[Journal Article] Natriuretic peptide receptor guanylyl cyclase-A protects podocytes from aldosterone-induced glomerular injury2012
- Author(s)
  Ogawa Y, Mukoyama M, Yokoi H, Kasahara M, Mori K, Kato Y, Kuwabara T, Imamaki H, Kawanishi T, Koga K, Ishii A, Tokudome T, Kishimoto I, Sugawara A, Nakao K
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 23:1198-1209 Issue: 7 Pages: 1198-1209
- DOI
  10.1681/asn.2011100985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590910, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23390225, KAKENHI-PROJECT-23591190, KAKENHI-PROJECT-23591191, KAKENHI-PROJECT-23790939, KAKENHI-PROJECT-24390204, KAKENHI-PUBLICLY-23122525
[Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice2012
- Author(s)
  Fukuhara S, et al
- Journal Title
  
  J Clin Invest
  
  Volume: (In press)(未定) Issue: 4 Pages: 1416-1426
- DOI
  10.1172/jci60746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390015, KAKENHI-PLANNED-22113007, KAKENHI-PLANNED-22113009, KAKENHI-ORGANIZER-22116001, KAKENHI-PLANNED-22116004, KAKENHI-PROJECT-22390040, KAKENHI-PROJECT-22659013, KAKENHI-PROJECT-22689030, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23300152, KAKENHI-PROJECT-24390204, KAKENHI-PROJECT-24659025
[Journal Article] Ghrelin and cardiovascular diseases2012
- Author(s)
  Kishimoto I, Tokudome T, Hosoda H, Miyazato M, Kangawa K
- Journal Title
  
  J Cardiology
  
  Volume: 59 Issue: 1 Pages: 8-13
- DOI
  10.1016/j.jjcc.2011.11.002
- NAID
  10019807283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252, KAKENHI-PROJECT-21591189, KAKENHI-PROJECT-22790891, KAKENHI-PUBLICLY-23122525
[Journal Article] One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction2012
- Author(s)
  Schwenke DO, Tokudome T, Kishimoto I, Horio T, Cragg PA, Shirai M, Kangawa K
- Journal Title
  
  Endocrinology
  
  Volume: 153(5) Issue: 5 Pages: 2436-2443
- DOI
  10.1210/en.2011-2057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23650213, KAKENHI-PROJECT-24390204, KAKENHI-PUBLICLY-23122525
[Journal Article] Natriuretic peptide system : an overview of studies using genetically engineered animal models2011
- Author(s)
  Kishimoto I, Tokudome T, Nakao K and Kangawa K
- Journal Title
  
  FEBS Journal
  
  Volume: 278 Issue: 11 Pages: 1830-1841
- DOI
  10.1111/j.1742-4658.2011.08116.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252, KAKENHI-PLANNED-22126002, KAKENHI-PROJECT-22790891, KAKENHI-PUBLICLY-23122525
[Journal Article] Centrally administered ghrelin activates cardiac vasal nerve in anesthetized rabbits2011
- Author(s)
  Shimizu S, Akiyama T, Kawada T, Sonobe T, Kamiya A, Shishido T, Tokudome T, Hosoda H, Shirai M, Kangawa K, Sugimachi M
- Journal Title
  
  Auton Neurosci
  
  Volume: 162 Issue: 1-2 Pages: 60-65
- DOI
  10.1016/j.autneu.2011.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10987, KAKENHI-PROJECT-21591190, KAKENHI-PROJECT-22790891, KAKENHI-PROJECT-23592691, KAKENHI-PROJECT-23650213
[Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生促進作用2011
- Author(s)
  徳留健,岸本一郎,寒川賢治
- Journal Title
  
  治療
  
  Volume: 93 Pages: 686-688
- NAID
  40018739233
- URL
  http://jglobal.jst.go.jp/detail.php?JGLOBAL_ID=201102206638182146
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] ナトリウム利尿ペプチドと肥満・インスリン抵抗性2011
- Author(s)
  岸本一郎、徳留健、槇野久士、寒川賢治
- Journal Title
  
  実験医学増刊
  
  Volume: 29(5) Pages: 194-201
- Data Source
  KAKENHI-PROJECT-22790891
[Journal Article] ナトリウム利尿ペプチドと肥満・インスリン抵抗性2011
- Author(s)
  岸本一郎, 槇野久士, 徳留健, 寒川賢治
- Journal Title
  
  実験医学増刊代謝・内分泌ネットワークと医薬応用
  
  Volume: 29 Pages: 194-201
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生促進作用2011
- Author(s)
  徳留健、岸本一郎、寒川賢治
- Journal Title
  
  治療
  
  Volume: 93(4) Pages: 686-688
- NAID
  40018739233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790891
[Journal Article] Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients : comparison with Oreactive protein.2011
- Author(s)
  Nishida H, Horio T, Suzuki Y, Iwashima Y, Tokudome T, Yoshihara F, Nakamura S, Kawano Y.
- Journal Title
  
  Cytokine.
  
  Volume: 53(3) Pages: 342-346
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590906
[Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生における役割2010
- Author(s)
  徳留健,岸本一郎,寒川賢治
- Journal Title
  
  The Journal of Japanese College of Angiology
  
  Volume: 50 Pages: 169-174
- NAID
  10026911904
- URL
  http://www.jc-angiology.org/journal/pdf/2010/169.pdf
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] グレリンの心血管作用とその機序2010
- Author(s)
  岸本一郎,徳留健,寒川賢治
- Journal Title
  
  循環器内科
  
  Volume: 67 Pages: 171-177
- URL
  http://www.kahyo.com/item/J201002-672
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] 内因性ナトリウム利尿ペプチドの虚血組織血管新生における役割2010
- Author(s)
  徳留健、岸本一郎、寒川賢治
- Journal Title
  
  脈管学
  
  Volume: 50(2) Pages: 169-174
- NAID
  10026911904
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790891
[Journal Article] SPring-8高輝度放射光を用いた小動物の心臓・血管機能の画像解析2010
- Author(s)
  白井幹康, James Pearson, Daryl Schwenke,曽野部崇,藤井豊,吉本光佐,徳留健,清水壽一郎,寒川賢治,梅谷啓二,八木直人
- Journal Title
  
  循環器研究の進歩
  
  Volume: 30(1) Pages: 70-82
- URL
  http://jglobal.jst.go.jp/public/20090422/201002296524328312
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] 内因性ANP・BNPによる血管新生,血管恒常性維持機構2010
- Author(s)
  徳留健,岸本一郎,山原研一,新藤隆行,川上速人,白井幹康,寒川賢治
- Journal Title
  
  血管
  
  Volume: 33 Pages: 75-80
- NAID
  10027705041
- URL
  http://pgx.medic.mie-u.ac.jp/upload/p4_zf20110201144112.pdf
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] Association of insulin-like growth factor-1 receptor gene polymorphisms with left ventricular mass and geometry in essential hypertension2010
- Author(s)
  Hori T, Kamide K, Takiuchi S. Yoshii M, Miwa Y, Matayoshi T, Yoshihara F, Nakamura S, Tokudome T, Miyata T, Kawano Y
- Journal Title
  
  J Hum Hypertens
  
  Volume: 24(5) Issue: 5 Pages: 320-326
- DOI
  10.1038/jhh.2009.73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790891
[Journal Article] Spring-8高輝度放射光を用いた小動物の心臓・血管機能の画像解析2010
- Author(s)
  白井幹康、James Pearson, Daryl Schwenke,曽野部崇、藤井豊、吉本光佐、徳留健、清水壽一郎、寒川賢治、梅谷啓二、八木直人
- Journal Title
  
  循環器研究の進歩
  
  Volume: 30(1) Pages: 70-82
- Data Source
  KAKENHI-PROJECT-22790891
[Journal Article] Chronic kidney disease as an independent risk factor for new-onset atrial fibrillation in hypertensive patients.2010
- Author(s)
  Horio T, Iwashima Y, Kamide K, Tokudome T, Yoshihara F, Nakamura S, Kawano Y.
- Journal Title
  
  J Hypertens.
  
  Volume: 28(8) Pages: 1738-1744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590906
[Journal Article] Therapeutic potentials of ghrelin in cardiac diseases.2009
- Author(s)
  Kishimoto I, Tokudome T, Schwenke DO, Soeki T, Hosoda Y, Nagaya N, Kangawa K
- Journal Title
  
  Expert Review of Endocrinology and Metabolism 4(3)
  
  Pages: 283-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] Natriuretic Peptide Signaling via Guanylyl Cyclase(GC)-A : An Endogenous Protective Mechanism of the Heart2009
- Author(s)
  Kishimoto I, Tokudome T, Horio T, Garbers DL, Nakao K and Kangawa K
- Journal Title
  
  Current Cardiology Reviews
  
  Volume: 5 Issue: 1 Pages: 45-51
- DOI
  10.2174/157340309787048068
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] Therapeutic potentials of ghrelin in cardiac diseases2009
- Author(s)
  Kishimoto I, Tokudome T, Schwenke DO, Soeki T, Hosoda Y, Nagaya N and Kangawa K
- Journal Title
  
  Expert Review of Endocrinology and Metabolism
  
  Volume: 4 Issue: 3 Pages: 283-289
- DOI
  10.1586/eem.09.7
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides.2009
- Author(s)
  Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K
- Journal Title
  
  Arterioscler Thromb Vasc Biol. 29
  
  Pages: 1516-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] Impaired Recovery of Blood Flow After Hind-Limb Ischemia in Mice Lacking Guanylyl Cyclase-A, a Receptor for Atrial and Brain Natriuretic Peptides2009
- Author(s)
  Tokudome T, Kishimoto I, Yamahara K, Osaki T, Minamino N, Horio T, Sawai K, Kawano Y, Miyazato M, Sata M, Kohno M, Nakao K, Kangawa K
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 29(10) Issue: 10 Pages: 1516-1521
- DOI
  10.1161/atvbaha.109.187526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252, KAKENHI-PROJECT-21591189
[Journal Article] Natriuretic Peptide Signaling via Guanylyl Cyclase(GC)-A : An Endogenous Protective Mechanism of the Heart.2009
- Author(s)
  Kishimoto I, Tokudome T, Horio T, Garbers DL, Nakao K, Kangawa K
- Journal Title
  
  Current Cardiology Reviews 5
  
  Pages: 45-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390252
[Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008
- Author(s)
  Takeshi Tokudome, et al.
- Journal Title
  
  Circulation 117
  
  Pages: 2329-2339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurones2008
- Author(s)
  Kishimoto I,Tokudome T,Horio T,Soeki T, Chusho H, Nakao K, Kangawa K
- Journal Title
  
  J Neuroendocrinol 20(11)
  
  Pages: 1213-1223
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart2008
- Author(s)
  Tokudome T
- Journal Title
  
  Circulation 117(18)
  
  Pages: 2329-2339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats2008
- Author(s)
  Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K
- Journal Title
  
  Endocrinology 149(1)
  
  Pages: 237-244
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] ナトリウム利尿ペプチド系の基礎と新たな展開の可能性2008
- Author(s)
  岸本一郎、徳留健、寒川賢治
- Journal Title
  
  循環器科 64(5)
  
  Pages: 411-423
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] RGS4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2008
- Author(s)
  Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K,Kangawa K
- Journal Title
  
  Circulation 117
  
  Pages: 2329-2339
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction2008
- Author(s)
  Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K
- Journal Title
  
  Am J Physiol Heart Circ Physiol 294(1)
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Ghrelin Suppresses Cardiac Sympathetic Activity and Prevents Early Left Ventricular Remodeling in Rats With Myocardial Infarction.2008
- Author(s)
  Soeki T, Kishimoto I, Schwenke DO, Tokudome T, Horio T, Yoshida M, Hosoda H, Kangawa K
- Journal Title
  
  Am J Physiol Heart Circ Physiol 294(1)
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality.2008
- Author(s)
  Schwenke DO, Tokudome T, Shirai M, Horio T, Kishimoto I, Klagg P, Kangawa K
- Journal Title
  
  Endocrinology 149
  
  Pages: 5127-5176
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Exogenous ghrelin attenuates the progression of chronic hypoxia-induced pulmonary hypertension in conscious rats.2008
- Author(s)
  Schwenke DO, Tokudome T, Shirai M, Hosoda H, Horio T, Kishimoto I, Kangawa K
- Journal Title
  
  Endocrinology 149(1)
  
  Pages: 237-44
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart2008
- Author(s)
  Tokudome T, Kishimoto I, Horio T, Arai Y, Schwenke DO, Hino J, Okano I, Kawano Y, Kohno M, Miyazato M, Nakao K, Kangawa K
- Journal Title
  
  Circulation 117(18)
  
  Pages: 2329-2339
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Early ghrelin treatment after myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality2008
- Author(s)
  Schwenke DO, Tokudome T, Kishimoto I, Horio T, Shirai M, Cragg PA, Kangawa K
- Journal Title
  
  Endocrinology 149(10)
  
  Pages: 5172-5176
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] 内因性ナトリウム利尿ペプチドの心保護作用-遺伝子改変マウスからのレッスン2007
- Author(s)
  徳留健, 他
- Journal Title
  
  循環器病研究の進歩 28
  
  Pages: 40-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] 内因性ナトリウム利尿ペプチドの心保護作用-遺伝子改変マウスからのレッスン2007
- Author(s)
  徳留健、岸本一郎、堀尾武史、荒井勇二、河野雄平、寒川賢治
- Journal Title
  
  循環器病研究の進歩 18(1)
  
  Pages: 40-52
- Data Source
  KAKENHI-PROJECT-19590845
[Journal Article] Cardioprotective effects of natriuretic peptides2007
- Author(s)
  Takeshi Tokudome, et. al.
- Journal Title
  
  Nippon Rinsho 65 Suppl 4
  
  Pages: 165-169
- NAID
  40015438296
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] Cardioprotective effect of endogenous natriuretic peptides. Lesson from gene-targeting mice.2007
- Author(s)
  Takeshi Tokudome, et. al.
- Journal Title
  
  Advance in Cardiovasc Dis 28
  
  Pages: 40-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] 心不全(上)成因・病態に関する基礎的研究ナトリウム利尿ペプチド2007
- Author(s)
  徳留健, 他
- Journal Title
  
  日本臨床 65(増刊号4)
  
  Pages: 165-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Cardioprotective effects of natriuretic peptides.2007
- Author(s)
  Tokudome T, Kishimoto I, Horio T, kangawa K.
- Journal Title
  
  Nippon Rinsho 65(Suppl 4)
  
  Pages: 165-169
- NAID
  40015438296
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] RGS4 mediates anti-hypertrophic effects of locally secreted natriuretic peptides in the heart
- Author(s)
  Takeshi Tokudome, et. al.
- Journal Title
  
  Circulation (in press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] C-type natriuretic peptide is a Schwann cell-derived factor for development and function of sensory neurons.
- Author(s)
  Kishimoto I, Tokudome T, Horio T, Soeki T, Chusho H, Nakao K, Kangawa K
- Journal Title
  
  J Neuroendocrinol 20(11)
  
  Pages: 1213-1223
- Data Source
  KAKENHI-PROJECT-19790548
[Journal Article] RGS4 mediates anti-hypertrophic effects of locally secreted natriuretic peptides in the heart.
- Author(s)
  Takeshi Tokudome, et. al.
- Journal Title
  
  Circulation (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Journal Article] Basic research for pathophysiology of heart failure. 2007 Natriuretic peptides.
- Author(s)
  Takeshi Tokudome, et. al.
- Journal Title
  
  Nihon Rinsho 65(Suppl 4)
  
  Pages: 165-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Patent] 周産期心筋症治療剤2020
- Inventor(s)
  大谷健太郎、神谷千津子、徳留健
- Industrial Property Rights Holder
  国立循環器病研究センター、中外製薬株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-17K09543
[Patent] 周産期心筋症治療剤2020
- Inventor(s)
  大谷健太郎, 徳留健, 神谷千津子
- Industrial Property Rights Holder
  大谷健太郎, 徳留健, 神谷千津子
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] ナトリウム利尿ペプチドのトランスレーショナルリサーチ2024
- Author(s)
  徳留　健
- Organizer
  第53回日本心脈管作動物質学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08505
[Presentation] Cardiac natriuretic peptides protect the heart from lactation-dependent remodeling2021
- Author(s)
  大谷健太郎、神谷千津子、徳留健
- Organizer
  第85回　日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09543
[Presentation] Physiological roles of endogenous natriuretic peptides during gestation and peripartum period2021
- Author(s)
  大谷健太郎、徳留健
- Organizer
  第24回　日本心血管内分泌代謝学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09543
[Presentation] ナトリウム利尿ペプチド研究の最前線2020
- Author(s)
  徳留　健
- Organizer
  第84回日本循環器学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] 内因性心臓ナトリウム利尿ペプチドが摂食およびエネルギー代謝に及ぼす影響についての検討2019
- Author(s)
  徳留　健
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] Atrial natriuretic peptide exerts hypotensive effect via regulator f G-protein signaling 2-mediated endothelial hyperpolarization2019
- Author(s)
  徳留　健
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] モデル動物を用いた周産期心筋症発症機序の解明2019
- Author(s)
  大谷健太郎、徳留健、神谷千津子、池田智明
- Organizer
  第67回日本心臓病学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09543
[Presentation] 周産期心筋症におけるナトリウム利尿ペプチド系の病態生理学的意義2018
- Author(s)
  徳留　健
- Organizer
  第7回臨床高血圧フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] Atrial natriuretic peptideによる血圧調節のメカニズム解析2018
- Author(s)
  徳留　健
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] 組織特異的AT1a受容体ノックアウトマウスを用いた血圧制御の解析2018
- Author(s)
  徳留　健
- Organizer
  第54回高血圧関連疾患モデル学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] 周産期心筋症発症における内因性ナトリウム利尿ペプチド系の意義2017
- Author(s)
  大谷健太郎、徳留　健、神谷千津子、西村博仁、寒川賢治
- Organizer
  第3回　日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-17K09543
[Presentation] 心房性ナトリウム利尿ペプチドによる血圧調節のメカニズム解析2017
- Author(s)
  徳留　健
- Organizer
  第53回高血圧関連疾患モデル学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09897
[Presentation] ANPの腫瘍血管制御による新しい癌治療戦略2017
- Author(s)
  野尻崇、徳留健、西村博仁、大谷健太郎、三浦浩一、細田洋司、日野純、宮里幹也、寒川賢治
- Organizer
  第46回日本心脈管作動物質学会
- Place of Presentation
  琉球大学医学部　臨床講義棟
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 血管内皮ANP/GC-A系を介した血圧調節作用のメカニズム解析2016
- Author(s)
  西村博仁、徳留健、大谷健太郎、寒川賢治
- Organizer
  第21回日本心血管内分泌代謝学会
- Place of Presentation
  東京コンベンションホール
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 遠位尿細管・集合管特異的AT1aダブルノックアウトマウスの表現型解析2016
- Author(s)
  徳留健、大谷健太郎、西村博仁、宮里幹也
- Organizer
  第39回日本高血圧学会総会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-30
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 周産期心筋症患者ゲノムにおけるナトリウム利尿ペプチド関連遺伝子の多型性解析2016
- Author(s)
  大谷健太郎、徳留健、神谷千津子、西村博仁、岸本一郎、寒川賢治
- Organizer
  第21回日本心血管内分泌代謝学会
- Place of Presentation
  東京コンベンションホール
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] ANP・グレリン研究の新展開2016
- Author(s)
  徳留　健
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル
- Year and Date
  2016-02-05
- Invited
- Data Source
  KAKENHI-PROJECT-25461082
[Presentation] 授乳はアルドステロン/ミネラロコルチコイド系を活性化し心臓リモデリングを来す2015
- Author(s)
  大谷健太郎、徳留健、岸本一郎、池田智明、中尾一和、寒川賢治
- Organizer
  第88回　日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 心臓ナトリウム利尿ペプチドシグナルの欠損は授乳期に産褥心筋症を惹起する2015
- Author(s)
  大谷健太郎、徳留健、岸本一郎、西村博仁、寒川賢治
- Organizer
  第51回　高血圧関連疾患モデル学会学術総会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2015-10-30
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] グレリンによる循環器疾患治療の可能性2014
- Author(s)
  徳留　健
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-25461082
[Presentation] 生理活性ペプチドを応用した心血管疾患の新規治療法開発に関する研究2014
- Author(s)
  徳留　健
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-25461082
[Presentation] 心脈管作動物質に関連した、次世代研究者による今後の研究展開2012
- Author(s)
  徳留健
- Organizer
  第41回日本心脈管作動物質学会物質学会
- Place of Presentation
  秋田
- Year and Date
  2012-02-11
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] 内因性ナトリウム利尿ペプチドの尿細管障害や間質線維化への関与-グアニリルシクラーゼーA(GC-A)欠損および内皮特異的GC-A強発現マウスでの検討-2011
- Author(s)
  吉原史樹、徳留健、岸本一郎、堀尾武史、河野雄平、寒川賢治
- Organizer
  第40回日本心脈管作動物質学会
- Place of Presentation
  香川
- Data Source
  KAKENHI-PROJECT-22590906
[Presentation] 血管恒常性維持におけるANP・BNPの多彩な作用2011
- Author(s)
  徳留健
- Organizer
  第15回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] 内因性ナトリウム利尿ペプチドの心血管保護作用2011
- Author(s)
  徳留健
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] 心血管病を内分泌・代謝面から考察する2011
- Author(s)
  徳留健
- Organizer
  察する第84回日本内分泌学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2011-04-22
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] Na利尿ペプチド受容体:グアニリルシクラーゼA(GC-A)欠損マウスでは尿細管障害や間質線維化が亢進する2010
- Author(s)
  吉原史樹, 徳留健, ら
- Organizer
  日本腎臓学会学術集会
- Place of Presentation
  神戸市
- Year and Date
  2010-06-16
- Data Source
  KAKENHI-PROJECT-22590906
[Presentation] Regulator of G-protein signaling subtype 4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart.2010
- Author(s)
  徳留健
- Organizer
  The XX World Congress of the International Society for Heart Research
- Place of Presentation
  国立京都国際会館
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] Na利尿ペプチド受容体 : グアニリルシクラーゼA(G(ンA)欠損マウスでは尿細管障害や間質線維化か先進する2010
- Author(s)
  吉原史樹徳留健岸本一郎桑原篤憲堀尾武史河野雄平寒川賢治
- Organizer
  第53回日本腎臓学会学術総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590906
[Presentation] Aggravated renal tubular damage and interstitial fibrosis in mice lacking guanylyl cyclase-A (GC-A), a receptor for atrial and B-type natriuretic peptides2010
- Author(s)
  Fumiki Yoshihara, Takeshi Tokudome, Ichiro Kishimoto, Takeshi Horio, Yuhei Kawano, Kenji Kangawa
- Organizer
  American Society of Nephrology 2010
- Place of Presentation
  Denver, USA
- Data Source
  KAKENHI-PROJECT-22590906
[Presentation] 日本人高血圧患者におけるRA阻害薬の心房細動新規発症抑制効果を検証する2010
- Author(s)
  堀尾武史岩嶋義雄神出計徳留健高田英明藤井健吉原史樹堀尾武史中村敏子河野雄平
- Organizer
  第33回日本高血圧学会総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590906
[Presentation] Regulator of G-protein signaling subtype 4 mediates anti-hypertrophic effect of locally secreted natriuretic peptides in the heart2010
- Author(s)
  徳留健
- Organizer
  XX^<th> World Congress International Society for Heart Research
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790891
[Presentation] 内因性ナトリウム利尿ペプチド系の血管形成における新たな意義とその機序2009
- Author(s)
  岸本一郎、徳留健、寒川賢治
- Organizer
  第82回日本内分泌学会学術総会
- Place of Presentation
  群馬県民会館
- Year and Date
  2009-04-23
- Data Source
  KAKENHI-PROJECT-21390252
[Presentation] 内因性ANP,BNP の血管新生、血管形成における役割2008
- Author(s)
  徳留健
- Organizer
  第31回高血圧学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590845
[Presentation] 内因性ANP, BNPの血管新生、血管形成における役割2008
- Author(s)
  徳留健
- Organizer
  第31回高血圧学会総会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19590845
[Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertrophic Effect of Endogenous Natriuretic Peptides in the Heart.2008
- Author(s)
  徳留健
- Organizer
  第31回日本高血圧学会
- Place of Presentation
  ロイトン札幌
- Year and Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19790548
[Presentation] Regulator of G-protein signaling-4 mediates antihypertrophic effect of atrial natriuretic peptide in cardiac myocytes.2007
- Author(s)
  Takeshi Tokudome, et. al.
- Organizer
  71st Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Kobe
- Year and Date
  2007-03-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertrophic Effect of Endogenous Natriuretic Peptides in the Heart2007
- Author(s)
  徳留健
- Organizer
  第11回日本心不全学会(YIA口演)
- Place of Presentation
  浦安(ヒルトン東京ベイ)
- Year and Date
  2007-09-09
- Data Source
  KAKENHI-PROJECT-19790548
[Presentation] Regulator of G-protein signaling 4 mediates antihypertrophic effect of endogenous natriuretic peptides in the heart2007
- Author(s)
  徳留健, 他
- Organizer
  第11回日本心不全学会学術集会
- Place of Presentation
  ヒルトン東京ベイ
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Regulator of G-protein signaling 4 mediates antihypertrophic effect of endogenous natriuretic peptides in the heart.2007
- Author(s)
  Takeshi Tokudome, et. al.
- Organizer
  11th Annual Scientific Meeting of the Japanese Heart Failure Society
- Place of Presentation
  Chiba
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Regulator of G-protein signaling-4 mediates antihypertrophic effect of atrial natriuretic peptide in cardiac myocytes2007
- Author(s)
  徳留健, 他
- Organizer
  第71回日本循環器学会総会・学術集会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2007-03-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] 内因性ANP、BNPの心臓リモデリング抑制効果のメカニズム2006
- Author(s)
  徳留健, 他
- Organizer
  第10回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  福井フェニックスプラザ
- Year and Date
  2006-11-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] Mechanism of inhibition by endogenous ANP and BNP of cardiac remodeling.2006
- Author(s)
  Takeshi Tokudome, et. al.
- Organizer
  10th Scientific Session of the Society of Cardiovascular Endocrinology and Merabolism
- Place of Presentation
  Fukui
- Year and Date
  2006-11-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590829
[Presentation] グレリンによる循環器疾患治療の可能性
- Author(s)
  徳留　健
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24390204
[Presentation] Protective role of endogenous natriuretic peptide/GC-A signaling on the maternal heart during the postpartum period
- Author(s)
  Kentaro Otani, Takeshi Tokudome, Ichiro Kishimoto, Kazuwa Nakao, Kenji Kangawa
- Organizer
  The Conference on Bioactive Peptides for Cell-Cell Communication 2014
- Place of Presentation
  Hotel Granvia Kyoto
- Year and Date
  2014-09-10 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 授乳期心肥大におけるアルドステロン系の関与
- Author(s)
  大谷健太郎、徳留　健、岸本一郎、中尾一和、寒川賢治
- Organizer
  第44回　日本心脈管作動物質学会
- Place of Presentation
  高松センタービル
- Year and Date
  2015-02-06 – 2015-02-07
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 内因性ナトリウム利尿ペプチド系による授乳期心保護作用のメカニズム解析
- Author(s)
  大谷健太郎、徳留　健、岸本一郎、山原研一、池田智明、中尾一和、寒川賢治
- Organizer
  第87回　日本内分泌学会学術総会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 授乳期肥大におけるアルドステロン系の関与
- Author(s)
  大谷健太郎、徳留健、岸本一郎、池田智明、中尾一和、寒川賢治
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24390204
[Presentation] 授乳期心肥大におけるアルドステロン系の関与
- Author(s)
  大谷健太郎、徳留　健、岸本一郎、中尾一和、寒川賢治
- Organizer
  第18回　日本心血管内分泌代謝学会　学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-26461100
[Presentation] 生理活性ペプチドを応用した心血管疾患の新規治療法開発に関する研究
- Author(s)
  徳留　健
- Organizer
  第18回日本心血管内分泌代謝学会学術総会
- Place of Presentation
  横浜市開港記念会館
- Year and Date
  2014-11-21 – 2014-11-22
- Data Source
  KAKENHI-PROJECT-24390204
[Presentation] Regulator of G-protein Signaling 4 Mediates Antihypertropnic Effect of Endogenous Natriuretic Peptides in the heart.
- Author(s)
  徳留健
- Organizer
  第11回日本心不全学会(YIA口演)
- Data Source
  KAKENHI-PROJECT-19790548
[]
[]

1. KISHIMOTO Ichiro (80312221)

# of Collaborated Projects: 5 results

# of Collaborated Products: 38 results
2. KANGAWA Kenji (00112417)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
3. OTANI KENTARO (50470191)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
4. KAMIYA CHIZUKO (10551301)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. HORIO Takeshi (50393228)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. YOSHIHARA Fumiki (70393220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. AKAMIZU Takashi (20231813)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SOEKI Takeshi (60393211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NISHIMURA HIROHITO (30739735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
10. 吉松淳 (20221674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 高橋篤 (50392014)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 増川太輝 (10711898)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SCHWENKE Daryl O.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. MAO Yuanjie

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KASAHARA Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TOYOHIRA Yumiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 高野晴子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 宮里幹也

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
19. 横井秀基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 森潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 中野大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 加藤有希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 高倉伸幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 桑原孝成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 向山政志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOKUDOME TAKESHI 徳留 健

TOKUDOME Takeshi 徳留 健

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Development of an novel treatment for "Anticancer drug-induced cardiomyopathy" by utilizing the physiological effects of ghrelinPrincipal Investigator

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Development of innovative therapy of metabolic syndrome applying physiological effects of cardiac hormonesPrincipal Investigator

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Development of new therapy of cardiac disease utilizing physiological effect of ghrelinPrincipal Investigator

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Development of new therapy of cardiovascular disease utilizing specificity of biologically active peptide hormonesPrincipal Investigator

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Development of the new cardiovascular disease therapy making the most of unique characterization of physiologically active peptides.Principal Investigator

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TOKUDOME TAKESHI 徳留健

TOKUDOME Takeshi 徳留健

[Book] 最新内分泌代謝学「ナトリウム利尿ペプチド系」2013

[Book] ペプチドと創薬寒川賢治、南野直人(編) (循環器疾患におけるCNP の意義) (pp143-147) (ISSN 1349-2527)