KUZUYA Takafumi 葛谷孝文

Researcher Number	00444406
Affiliation (based on the past Project Information) *help	2013: 名古屋大学, 医学部附属病院, 薬剤部副長 2008 – 2012: Nagoya University, 医学部附属病院, 副部長
Review Section/Research Field	Principal Investigator Medical pharmacy / General surgery Except Principal Investigator General surgery / Medical pharmacy
Keywords	Principal Investigator 薬剤暴露時間 / フローサイトメトリー / リンパ球増殖抑制効果 / in vitro / 免疫抑制剤 / 臓器移植 / IC50値 / real-time RT-PCR / インターロイキン2 / PCNA … More / Bリンパ球 / CFSE / 免疫卸制薬 / 細胞増殖抑制効果 / IL-2 / 薬力学 / 免疫抑制薬 … More Except Principal Investigator 抗体 / HLA抗体 / 培養 / 形質細胞 / Ｂリンパ球 / 移植・再生医療 / 免疫抑制学 / B細胞 / 免疫機能モニタリング / 感受性試験 / 免疫抑制薬 / 薬力学解析 / B 細胞 Less

Development of in vitro culture for peripheral B cell differentiation into plasma cell
- Principal Investigator
  
  KOBAYASHI Takaaki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Nagoya University
薬力学および免疫機能モニタリングによる臓器移植患者の包括的支援体制の構築Principal Investigator
- Principal Investigator
  
  葛谷孝文
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagoya University
Introduction of novel pharmacodynamics in transplant medicine: Elucidation of the effect of immunosuppressive drugs on B cell
- Principal Investigator
  
  KURATA Yoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kinjo Gakuin University
Individualization of Immunosuppressive Therapy Using Pharmacodynamics, Immunology and Molecular BiologyPrincipal Investigator
- Principal Investigator
  
  KUZUYA Takafumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Nagoya University

All 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Comparative analysis of drug action on B-cell proliferation and differentiation for mycophenolic acid, everolimus, and prednisolone.2014
- Author(s)
  Haneda M, Owaki M, Kuzuya T, Iwasaki K, Miwa Y, Kobayashi T.
- Journal Title
  
  Transplantation.
  
  Volume: 97 Issue: 11 Pages: 405-412
- DOI
  10.1097/01.tp.0000441826.70687.f6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591874, KAKENHI-PROJECT-24659587, KAKENHI-PROJECT-25293335, KAKENHI-PROJECT-25461942
[Journal Article] AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: implications for induction of accommodation.2013
- Author(s)
  Iwasaki K, Miwa Y, Haneda M, Kuzuya T, Ogawa H, Onishi A, Kobayashi T.
- Journal Title
  
  Transpl Int.
  
  Volume: 26 Issue: 11 Pages: 1138-1148
- DOI
  10.1111/tri.12186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591874, KAKENHI-PROJECT-24659587, KAKENHI-PROJECT-25293335, KAKENHI-PROJECT-25461942
[Journal Article] Comparative study on signal transduction in endothelial cells after anti-A/B and HLA antibody reaction : implication of accommodation2012
- Author(s)
  Iwasaki K, Miwa Y, Ogawa H, Iwamoto M, Furusawa T, Onishi A, Kuzuya T, Haneda M, Watarai Y, Uchida K, Kobayashi T.
- Journal Title
  
  Transplantation
  
  Volume: 93 Issue: 4 Pages: 390-397
- DOI
  10.1097/tp.0b013e3182424df3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380168, KAKENHI-PROJECT-22590152, KAKENHI-PROJECT-22591403, KAKENHI-PROJECT-24591874, KAKENHI-PROJECT-24659587
[Journal Article] Production of cloned pigs expressing human thrombomodulin in endothelial cells2012
- Author(s)
  Yazaki S, Iwamoto M, Onishi A, Miwa Y,Hashimoto M, Oishi T, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Liu D, Nagasaka T, Kuzuya T,Ogawa H, Yamamoto K, Iwasaki K, Maruyama S, Kobayashi T.
- Journal Title
  
  Xenotransplantation
  
  Volume: 19 Pages: 82-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590152
[Journal Article] Clinical Significance of Regulatory T Cell-Related Gene Expression in Peripheral Blood After Renal Transplantation.2011
- Author(s)
  H. Iwase, T. Kobayashi, Y. Kodera, Y.Miwa, T. Kuzuya, K. Iwasaki, M. Haneda, A.Katayama, A. Takeda, K. Morozumi, Y.Watarai, K. Uchida and A. Nakao.
- Journal Title
  
  Transplantation
  
  Volume: 91 Pages: 191-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590152
[Journal Article] Evaluation of Interleukin-2 mRNA in Whole Blood as a parameter for Monitoring Cyclosporine Pharmacodynamics.2009
- Author(s)
  Takafumi Kuzuya, et al.
- Journal Title
  
  Bio. Pharm. Bull. 32
  
  Pages: 604-608
- NAID
  110007160695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] Evaluation of IL-2 mRNA in Whole Blood as a Parameter for Monitoring Cyclosporine Pharmacodynamics2009
- Author(s)
  Takafumi Kuzuya, Takaaki Kobayashi, Akio Katayama, Takaharu Nagasaka, Yuko Miwa, Kazuharu Uchida, Akimasa Nalao
- Journal Title
  
  Biological Pharmaceutical Bulletin 32
  
  Pages: 604-608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] 腎移植後の免疫抑制療法の個別化2009
- Author(s)
  葛谷孝文、加藤真梨奈、倉田洋子、片山昭男、打田和治、丹羽操、三輪祐子、岩崎研太、羽根田正隆、小林孝彰
- Journal Title
  
  Organ Biology 16
  
  Pages: 5-11
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] Evaluation of Interleukin-2 mRNA in Whole Blood as a parameter for Monitoring Cyclosporine Pharamacodynamics.2009
- Author(s)
  Takafumi Kuzuya, et al.
- Journal Title
  
  Bio. Pharm. Bull. 32(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] Pretransplant Pharmacodynamic Analysis of Immunosuppressive Agents using CFSE-based T Cell Proliferation Assay2009
- Author(s)
  Yoko Kurata, Marina Kato, Takafumi Kuzuya, Yuko Miwa, Kenta Iwasaki, Masataka Haneda, Katsuo Amioka, Yoshihiko Watarai, Kazuharu Uchida, Akimasa Nakao, Takaaki Kobayashi
- Journal Title
  
  Clinical Pharmacology & Therapeutics 86
  
  Pages: 285-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] Stimulation Index for PCNA mRNA in Peripheral Blood as Immune Function Monitoring after Renal Transplantation2009
- Author(s)
  Misao Niwa, Yuko Miwa, Takafumi Kuzuya, Kenta Iwasaki, Masataka Haneda, Tsuneo Ueki, Akio Katayama, Takahisa Hiramitsu, Norihiko Goto, Takaharu Nagasaka, Yoshihiko Watarai, Kazuharu Uchida, Akimasa Nakao, Takaaki Kobayashi
- Journal Title
  
  Transplantation 87
  
  Pages: 1411-1414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] Pharmacodynamicsを用いた代謝拮抗薬およびmTOR阻害薬の薬効評価2009
- Author(s)
  水谷加代子、葛谷孝文、加藤真梨奈、倉田洋子、岩崎研太、野田幸裕、網岡克雄、山田清文、小林孝彰
- Journal Title
  
  愛知県病院薬剤師会雑誌 36
  
  Pages: 2-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591517
[Journal Article] 免疫抑制薬の分子論的解析と臨床応用可能なPDモニタリングの開発2008
- Author(s)
  倉田洋子, 網岡克雄, 加藤真梨奈, 野田幸裕, 葛谷孝文, 羽根田正隆, 長坂隆治, 打田和治, 中尾昭公, 岩崎研太, 小林孝彰
- Journal Title
  
  今日の移植 21
  
  Pages: 602-604
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] In vitro B cell differentiation assayを用いたDSA検出法の検討2012
- Author(s)
  羽根田正隆、黒木聖久、成田由紀子、大脇麻未、葛谷孝文、岩崎研太、渡井至彦、打田和治、小林孝彰
- Organizer
  48回日本移植学会
- Place of Presentation
  愛知県産業労働センター、名古屋
- Data Source
  KAKENHI-PROJECT-24659587
[Presentation] 免疫抑制薬の抗体産生抑制効果に対する薬力学解析の試み2012
- Author(s)
  大脇麻未、成田由紀子、羽根田正隆、倉田洋子、葛谷孝文、網岡克雄、三輪祐子、岩崎研太、小林孝彰
- Organizer
  48回日本移植学会
- Place of Presentation
  愛知県産業労働センター、名古屋
- Data Source
  KAKENHI-PROJECT-24659587
[Presentation]2010
- Author(s)
  平林彩、岩崎研太、加藤真梨奈、葛谷孝文、野田幸裕、三輪祐子、羽根田正隆、小林孝彰
- Organizer
  日本移植学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] The Implication of AMP-Activated Protein Kinase As A Target To Suppress Lymphocyte Proliferation.2010
- Author(s)
  Iwasaki K, Hirabayashi A, Kato M,Kuzuya T, Miwa Y, Haneda M, Uchida K, Nakao A, Kobayashi T.
- Organizer
  International Congress of The Transplantation Society
- Place of Presentation
  Vancouver
- Data Source
  KAKENHI-PROJECT-22590152
[Presentation] Pharmacodynamic Evaluation of Cyclosporine in B-Cell.2010
- Author(s)
  Takafumi Kuzuya, et al.
- Organizer
  International Congress of The Transplantation Society
- Place of Presentation
  Vancouver (Canada)
- Year and Date
  2010-08-18
- Data Source
  KAKENHI-PROJECT-22590152
[Presentation] Pharmacodynamic Evaluation of Cyclosporine in B-Cell2010
- Author(s)
  Kuzuya T., Kato M., Iwasaki K., Haneda M., Miwa Y., Kobayashi T., Uchida K., Yamada K
- Organizer
  International Congress of The Transplantation Society
- Place of Presentation
  Vancouver (Canada)
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] B細胞を用いた免疫抑制剤の薬力学的解析:シクロスポリンはB細胞を抑制するか?2009
- Author(s)
  加藤真梨奈、倉田洋子、葛谷孝文、羽根田正隆、岩崎研太、野田幸裕、小林孝彰
- Organizer
  日本移植学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] 腎移植患者を対象とした免疫抑制薬の薬力学的解析2009
- Author(s)
  葛谷孝文、加藤真梨奈、倉田洋子、片山昭男、打田和治、丹羽操、三輪祐子、岩崎研太、羽根田正隆、小林孝彰
- Organizer
  日本臨床腎移植学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] 移植後の免疫機能モニタリング2009
- Author(s)
  小林孝彰、丹羽操、馬亮、三輪祐子、岩崎研太、中尾昭公、羽根田正隆、葛谷孝文、植木常雄、片山昭男、平光高久、佐藤哲彦、後藤憲彦、長坂隆治、渡井至彦、打田和治
- Organizer
  日本臨床腎移植学会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] 免疫抑制療法におけるT cell proliferationを指標としたPD assayの有用性2009
- Author(s)
  倉田洋子、加藤真梨奈、葛谷孝文、岩崎研太、羽根田正隆、打田和治、中尾昭公、小林孝彰、網岡克雄
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] リンパ球を用いた免疫抑制薬のPD解析方法の確立2009
- Author(s)
  加藤真梨奈、倉田洋子、葛谷孝文、羽根田正隆、岩崎研太、小林孝彰、野田幸裕
- Organizer
  日本薬学東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] 腎移植後の免疫抑制療法個別化プロジェクト2008
- Author(s)
  葛谷孝文、加藤真梨奈、倉田洋子、片山昭男、打田和治、丹羽操、三輪祐子、岩崎研太、羽根田正隆、小林孝彰
- Organizer
  日本臓器保存生物医学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] Pharmacodynamics(PD)を用いた代謝拮抗薬の薬効評価と個人差の解析2008
- Author(s)
  水谷加代子、倉田洋子、加藤真梨奈、葛谷孝文、野田幸裕、小林孝彰
- Organizer
  日本移植学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] Pharmacodynamic Characteristics of Renal Transplant Resipients.2008
- Author(s)
  Takafumi Kuzuya, et al.
- Organizer
  XXII International Congress of the Transplantation Society
- Place of Presentation
  シドニー
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] Cell proliferationを指標としたPD assayの開発2008
- Author(s)
  倉田洋子、加藤真梨奈、葛谷孝文、中尾昭公、打田和治、小林孝彰、網岡克雄
- Organizer
  日本移植学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] Stimulation Index for PCNA mRNA Expression in Peripheral Blood as a Predictive Indicator of Over Immunosuppression2008
- Author(s)
  Kobayashi T., Niwa M., Miwa Y., Katayama A., Haneda M., Kuzuya T., Nagasaka T., Ueki T., Uchida K., Nakao A.
- Organizer
  International Congress Transplantation of The Society
- Place of Presentation
  Sydney (Australia)
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] Pharmacodynamic Characta-ristics of Renal Transplant Resipients2008
- Author(s)
  Kuzuya T., Kobayashi A., Katayama Y., Miwa T., Nagasaka K., Uchida K., Yamada K.
- Organizer
  International Congress Transplantation of The Society
- Place of Presentation
  Sydney (Australia)
- Data Source
  KAKENHI-PROJECT-20591517
[Presentation] 免疫抑制薬の薬力学的モニタリングの開発とその有用性の検討2008
- Author(s)
  加藤真梨奈、倉田洋子、葛谷孝文、打田和治、野田幸裕、小林孝彰
- Organizer
  日本移植学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20591517

1. KOBAYASHI Takaaki (70314010)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. HANEDA Masataka (50436995)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. IWASAKI Kenta (10508881)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
4. KODERA Yasuhiro (10345879)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KURATA Yoko (80513928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. AMIOKA Katsuo (50387594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIWA Yuko (90572941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 田中友加 (90432666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OGAWA Haruko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. OHNISHI Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUZUYA Takafumi 葛谷 孝文

Research Projects

Research Products

Co-Researchers

Development of in vitro culture for peripheral B cell differentiation into plasma cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

薬力学および免疫機能モニタリングによる臓器移植患者の包括的支援体制の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Introduction of novel pharmacodynamics in transplant medicine: Elucidation of the effect of immunosuppressive drugs on B cell

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Individualization of Immunosuppressive Therapy Using Pharmacodynamics, Immunology and Molecular BiologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparative analysis of drug action on B-cell proliferation and differentiation for mycophenolic acid, everolimus, and prednisolone.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AMP-activated protein kinase as a promoting factor, but complement and thrombin as limiting factors for acquisition of cytoprotection: implications for induction of accommodation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative study on signal transduction in endothelial cells after anti-A/B and HLA antibody reaction : implication of accommodation2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of cloned pigs expressing human thrombomodulin in endothelial cells2012

Author(s)

Journal Title

Data Source

[Journal Article] Clinical Significance of Regulatory T Cell-Related Gene Expression in Peripheral Blood After Renal Transplantation.2011

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of Interleukin-2 mRNA in Whole Blood as a parameter for Monitoring Cyclosporine Pharmacodynamics.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Evaluation of IL-2 mRNA in Whole Blood as a Parameter for Monitoring Cyclosporine Pharmacodynamics2009

Author(s)

Journal Title

Data Source

[Journal Article] 腎移植後の免疫抑制療法の個別化2009

Author(s)

Journal Title

Data Source

[Journal Article] Evaluation of Interleukin-2 mRNA in Whole Blood as a parameter for Monitoring Cyclosporine Pharamacodynamics.2009

Author(s)

Journal Title

Data Source

[Journal Article] Pretransplant Pharmacodynamic Analysis of Immunosuppressive Agents using CFSE-based T Cell Proliferation Assay2009

Author(s)

Journal Title

Data Source

[Journal Article] Stimulation Index for PCNA mRNA in Peripheral Blood as Immune Function Monitoring after Renal Transplantation2009

Author(s)

Journal Title

Data Source

[Journal Article] Pharmacodynamicsを用いた代謝拮抗薬およびmTOR阻害薬の薬効評価2009

Author(s)

Journal Title

Data Source

KUZUYA Takafumi 葛谷孝文