OKABE YASUNORI 岡部恭典

… Alternative Names

岡部恭典オカベヤスノリ

OKABE Yasunori 岡部恭典

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Researcher Number	00446098
Affiliation (Current)	2025: 久留米大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2015: 久留米大学, 医学部, 助教 2008 – 2012: Kurume University, 医学部, 助教
Review Section/Research Field	Principal Investigator Pediatrics Except Principal Investigator Pediatrics
Keywords	Principal Investigator 小児神経学 / 遺伝子疾患 / グリア細胞 / グルタミン酸 / シナプス情報伝達 / レット症候群 / 移植・再生医療 / iPS細胞 / 胚性幹細胞 / 脳神経疾患 / 再生医学 … More Except Principal Investigator … More MeCP2 / Rett症候群 / rett症候群 / Mecp2 / レット症候群 / 再生医学 / 疾患モデル / iPS細胞 / レット症候群(RTT) / Rett 症候群 Less

Glial cells differentiation of MeCP2 deficient ES/iPS cells and pathophysiology of Rett syndrome
- Principal Investigator
  
  TAKAHASHI TOMOYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Ｒｅｔｔ症候群モデルマウスを用いた病態機構解明と移植再生治療開発の試みPrincipal Investigator
- Principal Investigator
  
  岡部恭典
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Generation of iPS cells derived form an Rett syndrome model mouse and drug screening for Rett syndrome using MeCP2 deficient iPS cells
- Principal Investigator
  
  TAKAHASHI Tomoyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Pathologic analysis of Rett syndrome with the model induced pluripotent stem cells for development of treatment methodPrincipal Investigator
- Principal Investigator
  
  OKABE Yasunori
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Neural Development of Methyl-CpG-Binding Protein 2-Null Embryonic Stem Cells : A System for Studing Rett SyndromePrincipal Investigator
- Principal Investigator
  
  OKABE Yasunori
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University

All 2015 2012 2011 2010 2009 Other

All Journal Article Presentation

[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015
- Author(s)
  Hara M, Takahashi T, Mistumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 11204-11204
- DOI
  10.1038/srep11204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461137, KAKENHI-PROJECT-25461568, KAKENHI-PROJECT-25670194, KAKENHI-PROJECT-26670292, KAKENHI-PROJECT-26860832, KAKENHI-PROJECT-24300145, KAKENHI-PROJECT-25293234
[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012
- Author(s)
  Okabe Y., Takahashi T., et al
- Journal Title
  
  PLoS One
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012
- Author(s)
  Okabe Y, Takahashi T, Mitsumasu C, Kosai K, MD, Tanaka E, Matsuishi T
- Journal Title
  
  PLoS ONE
  
  Volume: 7(4) Issue: 4 Pages: e35354-e35354
- DOI
  10.1371/journal.pone.0035354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390210, KAKENHI-PROJECT-22591144, KAKENHI-PROJECT-23590269, KAKENHI-PROJECT-23659159, KAKENHI-PROJECT-24591531, KAKENHI-PROJECT-24591532
[Journal Article] These authors were equally contributed to this work.)Neural Development ofMethyl-CpG-Binding Protein 2 Null Embryonic Stem Cells: A System for Studying Rett Syndrome.2010
- Author(s)
  *Okabe Y., *Kusaga A., * Takahashi T., Mitsumasu C., Murai Y., Tanaka E., Higashi H., Matsuishi T., Kosai K.
- Journal Title
  
  Brain Res
  
  Volume: 1360 Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Neural Development of Methyl-CpG-Binding Protein 2 Null Embryonic Stem Cells : A System for Studying Rett Syndrome.2010
- Author(s)
  Okabe Y, Takahashi T., et al.
- Journal Title
  
  Brain Res
  
  Volume: 1360 Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Neural development of methyl. CpG-binding protein 2 null embryonic stem cells : a system for studying Rett syndrome2010
- Author(s)
  Okabe Y, Takahashi T, Murai Y, Tanaka E, Matsuishi T
- Journal Title
  
  Brain Res
  
  Volume: Nov 11 Pages: 17-27
- Data Source
  KAKENHI-PROJECT-22791009
[Journal Article] Neural development of methyl-CpG-binding protein 2 nullembryonic stem cells : a system for studying Rett syndrome.2010
- Author(s)
  Okabe Yasunori
- Journal Title
  
  Brain research
  
  Volume: 1360 Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791009
[Journal Article] Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans2009
- Author(s)
  Eiichiro Tanaka, Toshiyuki Tobita, Yoshinaka Murai, Yasunori Okabe, Aya Yamada, Tatsuhiko Kano, Hideho Higashi, Koki Shimoji
- Journal Title
  
  Neuroscience Research 64
  
  Pages: 391-396
- Data Source
  KAKENHI-PROJECT-20790756
[Journal Article] Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans2009
- Author(s)
  Tanaka E.Okabe Y.et al.
- Journal Title
  
  Neuroscience Research 64
  
  Pages: 391-396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790756
[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome
- Author(s)
  Okabe Y., Takahashi T., Mitsumasu T., Eiichiro Tanaka., Matsuishi T.
- Journal Title
  
  PLoS ONE
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791009
[Journal Article] Activati on of protein kinase A and C prevents the recovery from persistent depolarization produced by oxygen and glucose deprivation in rathippocampal neurons
- Author(s)
  Murai Y, Okabe Y, Tanaka E
- Journal Title
  
  J Neurophysiol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791009
[Presentation] Electrophysiological analysis of RTT model ES cell-derived neurons2011
- Author(s)
  Okabe Y, Takahashi T, Murai Y, Tanaka E, Matsuishi T
- Organizer
  第88回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-22791009
[Presentation] RTTモデルES細胞由来神経細胞の電気生理学的解析2011
- Author(s)
  岡部恭典
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22791009
[Presentation] MeCP2遺伝子欠損ES細胞のin vitro分化誘導法によるRett症候群/神経発生の研究システム2011
- Author(s)
  小賎健一郎、岡部恭典, 他
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-22791009
[Presentation] RTTモデルES細胞由来神経細胞の電気生理学的解析2011
- Author(s)
  岡部恭典、久佐賀晃、高橋知之、光益千秋、村井恵良、東英穂、松石豊次郎、小戝健一郎、田中永一郎
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] MeCP2遺伝子欠損ES細胞のin vitro分化誘導法によるRett症候群/神経発生の研究システム2011
- Author(s)
  小戝健一郎、岡部恭典、久佐賀晃、高橋知之、光益千秋、村井恵良、松石豊次郎、田中永一郎
- Organizer
  第10回日本再生医療学会総会(横浜)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] Neural development of MeCP2 null embryonic stem cells
- Author(s)
  岡部　恭典
- Organizer
  第115回日本小児科学会学術集会
- Place of Presentation
  ホテルオークラ福岡
- Data Source
  KAKENHI-PROJECT-24591532
[Presentation] Analysis of cardiac arrthymias and gene expression in MeCP2-null mice
- Author(s)
  Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Okabe Y, Tanaka E, Matsuishi T.
- Organizer
  13th Rett syndrome Symposium
- Place of Presentation
  Chantilly, VA, USA.
- Year and Date
  2014-06-24 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25461568

1. NISHI Yoshihiro (20352122)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. TAKAHASHI Tomoyuki (20332687)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MATSUISHI Toyojiro (60157237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. TANAKA Eiichiro (80188284)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. MURAI Yoshinaka (40322820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUNISADA TAKAHIRO (30205108)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 高橋和之

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
8. 安川秀雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小戝健一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OKABE YASUNORI 岡部 恭典

岡部 恭典 オカベ ヤスノリ

OKABE Yasunori 岡部 恭典

Research Projects

Research Products

Co-Researchers

Glial cells differentiation of MeCP2 deficient ES/iPS cells and pathophysiology of Rett syndrome

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ｒｅｔｔ症候群モデルマウスを用いた病態機構解明と移植再生治療開発の試みPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of iPS cells derived form an Rett syndrome model mouse and drug screening for Rett syndrome using MeCP2 deficient iPS cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathologic analysis of Rett syndrome with the model induced pluripotent stem cells for development of treatment methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neural Development of Methyl-CpG-Binding Protein 2-Null Embryonic Stem Cells : A System for Studing Rett SyndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012

Author(s)

Journal Title

Data Source

[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] These authors were equally contributed to this work.)Neural Development ofMethyl-CpG-Binding Protein 2 Null Embryonic Stem Cells: A System for Studying Rett Syndrome.2010

Author(s)

Journal Title

Data Source

[Journal Article] Neural Development of Methyl-CpG-Binding Protein 2 Null Embryonic Stem Cells : A System for Studying Rett Syndrome.2010

Author(s)

Journal Title

Data Source

[Journal Article] Neural development of methyl. CpG-binding protein 2 null embryonic stem cells : a system for studying Rett syndrome2010

Author(s)

Journal Title

Data Source

[Journal Article] Neural development of methyl-CpG-binding protein 2 nullembryonic stem cells : a system for studying Rett syndrome.2010

Author(s)

Journal Title

Data Source

[Journal Article] Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans2009

Author(s)

Journal Title

Data Source

[Journal Article] Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans2009

Author(s)

Journal Title

Data Source

[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome

Author(s)

Journal Title

Data Source

[Journal Article] Activati on of protein kinase A and C prevents the recovery from persistent depolarization produced by oxygen and glucose deprivation in rathippocampal neurons

Author(s)

OKABE YASUNORI 岡部恭典

岡部恭典オカベヤスノリ

OKABE Yasunori 岡部恭典