Shinnakasu Ryo 新中須亮

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SHINNAKASU Ryo 新中須亮

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Researcher Number	00451758
Other IDs	https://orcid.org/0000-0002-5369-3424
Affiliation (Current)	2025: 愛媛大学, 学術支援センター, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 愛媛大学, 学術支援センター, 准教授 2021: 大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) 2017 – 2019: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) 2015: 大阪大学, 免疫学フロンティア研究センター, 特任助教 2015: 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) … More 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2008: Chiba University, 大学院・医学研究院, 産学官連携研究員 2007: Chiba University, 大学院・医学研究院, 産学官連携研究院 Less
Review Section/Research Field	Principal Investigator Immunology / Basic Section 49060:Virology-related / Virology
Keywords	Principal Investigator B細胞 / 抗体 / 免疫学 / 免疫記憶 / 感染防御 / 液性免疫 / インフルエンザ / 胚中心 / 変異インフルエンザウイルス / 免疫記憶B細胞 … More / ウイルス / メモリーB細胞 / 免疫 / 感染防御・制御 / B-1細胞 / B－１細胞 / アレルギー・喘息 / アレルギー・ぜんそく / ぜんそく / アレルギー Less

Activation mechanism of memory B cell for protection against variant influenza virus infectionPrincipal Investigator
- Principal Investigator
  
  Shinnakasu Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Ehime University
  Osaka University
Elucidation of induction and maintenance mechanism of universal cross reactive B cells against influenza virusPrincipal Investigator
- Principal Investigator
  
  Shinnakasu Ryo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Osaka University
Critical role for differentiation and maintenance of B-1 cells by transcriptional regulator MeninPrincipal Investigator
- Principal Investigator
  
  Shinnakasu Ryo
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
  The Institute of Physical and Chemical Research
Functional analysis of transcription factor Gfi1 for the regulation of allergic inflammationPrincipal Investigator
- Principal Investigator
  
  SHINNAKASU Ryo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Immunology
- Research Institution
  Chiba University

All 2023 2022 2021 2019 2018 2017 2015 2014 2008

All Journal Article Presentation Book

[Book] 細胞工学2008
- Author(s)
  新中須亮
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-19890041
[Book] 細胞工学2008
- Author(s)
  新中須亮、山下政克、中山俊憲
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-19890041
[Journal Article] CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes2023
- Author(s)
  Onodera T, Sax N, Sato T, Adachi Y, Kotaki R, Inoue T, Shinnakasu R, Nakagawa T, Fukushi S, Terooatea T, Yoshikawa M, Tonouchi K, Nagakura T, Moriyama S, Matsumura T, Isogawa M, Terahara K, Takano T, Sun L, Nishiyama A, Omoto S, Shinkai M, Kurosaki T, Yamashita K, Takahashi Y.
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 24
- DOI
  10.1126/sciadv.adf0661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-21H02740, KAKENHI-PROJECT-21H02749
[Journal Article] Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees2023
- Author(s)
  Inoue T, Shinnakasu R, Kawai C, Yamamoto H, Sakakibara S, Ono C, Itoh Y, Terooatea T, Yamashita K, Okamoto T, Hashii N, Ishii-Watabe A, Butler NS, Matsuura Y, Matsumoto H, Otsuka S, Hiraoka K, Teshima T, Murakami M, Kurosaki T.
- Journal Title
  
  J Exp Med.
  
  Volume: 220(2) Issue: 2
- DOI
  10.1084/jem.20221786
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00502, KAKENHI-PROJECT-22H00450, KAKENHI-PROJECT-21H02740, KAKENHI-PROJECT-21H02749, KAKENHI-PROJECT-21K19364
[Journal Article] Generation of High Quality Memory B Cells2022
- Author(s)
  Inoue Takeshi、Shinnakasu Ryo、Kurosaki Tomohiro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 825813-825813
- DOI
  10.3389/fimmu.2021.825813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02740, KAKENHI-PROJECT-21H02749
[Journal Article] Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients2021
- Author(s)
  Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.
- Journal Title
  
  J Exp Med.
  
  Volume: 218 Issue: 12
- DOI
  10.1084/jem.20211327
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-21H02740, KAKENHI-PROJECT-20K06575, KAKENHI-PROJECT-18H05279
[Journal Article] Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses2021
- Author(s)
  Shinnakasu Ryo、Sakakibara Shuhei、Yamamoto Hiromi、Wang Po-hung、Moriyama Saya、Sax Nicolas、Ono Chikako、Yamanaka Atsushi、Adachi Yu、Onodera Taishi、Sato Takashi、Shinkai Masaharu、Suzuki Ryosuke、Matsuura Yoshiharu、Hashii Noritaka、Takahashi Yoshimasa、Inoue Takeshi、Yamashita Kazuo、Kurosaki Tomohiro
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 218 Issue: 12
- DOI
  10.1084/jem.20211003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-21H02740
[Journal Article] Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies2019
- Author(s)
  Adachi Yu、Tonouchi Keisuke、Nithichanon Arnone、Kuraoka Masayuki、Watanabe Akiko、Shinnakasu Ryo、Asanuma Hideki、Ainai Akira、Ohmi Yusuke、Yamamoto Takuya、Ishii Ken J.、Hasegawa Hideki、Takeyama Haruko、Lertmemongkolchai Ganjana、Kurosaki Tomohiro、Ato Manabu、Kelsoe Garnett、Takahashi Yoshimasa
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41467-019-11821-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] Requirement for memory B-cell activation in protection from heterologous influenza virus reinfection2019
- Author(s)
  Leach Sarah、Shinnakasu Ryo、Adachi Yu、Momota Masatoshi、Makino-Okamura Chieko、Yamamoto Takuya、Ishii Ken J、Fukuyama Hidehiro、Takahashi Yoshimasa、Kurosaki Tomohiro
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 12 Pages: 771-779
- DOI
  10.1093/intimm/dxz049
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21601, KAKENHI-PROJECT-19K17656, KAKENHI-PROJECT-19H01028, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-18K19447
[Journal Article] Functional clustering of B cell receptors using sequence and structural features2019
- Author(s)
  Xu Zichang、Li Songling、Rozewicki John、Yamashita Kazuo、Teraguchi Shunsuke、Inoue Takeshi、Shinnakasu Ryo、Leach Sarah、Kurosaki Tomohiro、Standley Daron M.
- Journal Title
  
  Molecular Systems Design & Engineering
  
  Volume: 4 Issue: 4 Pages: 769-778
- DOI
  10.1039/c9me00021f
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-17K08856
[Journal Article] KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity2018
- Author(s)
  Dietmar Herndler-Brandstetter, Harumichi Ishigame, Ryo Shinnakasu, Valerie Plajer, Carmen Stecher, Jun Zhao, Melanie Lietzenmayer, Lina Kroehling, Akiko Takumi, Kohei Kometani, Takeshi Inoue, Yuval Kluger, Susan M. Kaech, Tomohiro Kurosaki, Takaharu Okada & Richard A. Flavell
- Journal Title
  
  Immunity
  
  Volume: 48(4) Issue: 4 Pages: 716-729
- DOI
  10.1016/j.immuni.2018.03.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19166, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-17K08882, KAKENHI-PROJECT-18K19447, KAKENHI-PROJECT-26221306
[Journal Article] Generation of memory B cells and their reactivation.2018
- Author(s)
  Inoue T, Moran I, Shinnakasu R, Phan TG, Kurosaki T.
- Journal Title
  
  Immunological Reviews
  
  Volume: 283(1) Issue: 1 Pages: 138-149
- DOI
  10.1111/imr.12640
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-17K08882, KAKENHI-PROJECT-18K19447, KAKENHI-PROJECT-26221306
[Journal Article] The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help.2017
- Author(s)
  Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 214 Issue: 4 Pages: 1181-1198
- DOI
  10.1084/jem.20161263
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-17K08882, KAKENHI-PROJECT-17K08883, KAKENHI-PROJECT-26221306
[Journal Article] Regulation of memory B and plasma cell differentiation.2017
- Author(s)
  Shinnakasu R, Kurosaki T.
- Journal Title
  
  Curr. Opin. Immunol.
  
  Volume: 45 Pages: 126-131
- DOI
  10.1016/j.coi.2017.03.003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-17K08856, KAKENHI-PROJECT-26221306
[Journal Article] αβT cell receptors expressed by CD4(-)CD8αβ(-) intraepithelial T cells drive their fate into a unique lineage with unusual MHC reactivities.2014
- Author(s)
  Mayans S, Stepniak D, Palida SF, Larange A, Dreux J, Arlian BM, Shinnakasu R, Kronenberg M, Cheroutre H, Lambolez F.
- Journal Title
  
  Immunity
  
  Volume: 41(2) Issue: 2 Pages: 207-218
- DOI
  10.1016/j.immuni.2014.07.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860343
[Journal Article] Bmil regulates memory CD42008
- Author(s)
  Yamashita, M. Kuwahara, M., Suzuki, A., Hirahara, K., Shinnakasu, R., Hosokawa, H., Hasegawa, A., Motohashi, S., Iwama, A., and Nakayama, T.
- Journal Title
  
  T cell survival via repression of the Noxa gene 205
  
  Pages: 1109-1120
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890041
[Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.2008
- Author(s)
  Shinnakasu, R.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 28216-28225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890041
[Journal Article] Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation. Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation2008
- Author(s)
  Shinnakasu, R., Yamashita, M., Kuwahara, M., Hosokawa, H., Hasegawa, A., Motohashi, S., and Nakayama, T.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 28216-28225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19890041
[Presentation] CD62L expression marks SARS-CoV-2 memory B-cell subset with preference for neutralizing epitopes2023
- Author(s)
  Taishi Onodera, Yu Adachi, Ryutaro Kotaki, Takeshi Inoue, Ryo Shinnakasu, Saya Moriyama, Takayuki Matsumura, Masanori Isogawa, Masaharu Shinkai, Tomohiro Kurosaki, Kazuo Yamashita, Yoshimasa Takahashi
- Organizer
  2023年度　第52回免疫学会
- Data Source
  KAKENHI-PROJECT-21H02740
[Presentation] Single-cell transcriptome and repertoire analysis of antigen specific B cells in phase 1/2 priming and booster study of COVID-19 vaccine S-268019-b2023
- Author(s)
  Masaya Fujitani, Ryo Shinnakasu, Yujiro Kidani, Naomi Seki, Satoru Ishida, Takuhiro Sonoyama, Mari Ariyasu, Shinya Omoto, Tomohiro Kurosaki
- Organizer
  2023年度　第52回免疫学会
- Data Source
  KAKENHI-PROJECT-21H02740
[Presentation] Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses2021
- Author(s)
  Ryo Shinnakasu, Shuhei Sakakibara, Tomohiro Kurosaki
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21H02740
[Presentation] メモリーＢ細胞への選択・生成メカニズム2015
- Author(s)
  新中須亮、黒崎知博
- Organizer
  第７回シグナルネットワーク研究会
- Place of Presentation
  沖縄科学技術大学院大学 (沖縄県国頭群恩納村)
- Year and Date
  2015-06-19
- Data Source
  KAKENHI-PROJECT-26860343
[Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する, 第31回日本分子生物学会年会2008
- Author(s)
  山下政克、新中須亮、桑原誠、中山俊憲
- Organizer
  第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-19890041
[Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する/Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation2008
- Author(s)
  Shinnakasu, R., Yamashita, M., Kuwahara, M., Kitajima, M., and Nakayama, T.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19890041
[Presentation] Gfi1はGATA3蛋白質の安定化を介してTh2細胞分化を制御する/Gfi1-mediated stabilization of GATA3 protein is required for Th2 cell differentiation.2008
- Author(s)
  Shinnakasu, R.
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19890041

1. 井上毅 (80466838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 山本拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 黒崎知博

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 石亀晴道

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 山崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村上正晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. STANDLEY Daron

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinnakasu Ryo 新中須 亮

SHINNAKASU Ryo 新中須 亮

Research Projects

Research Products

Co-Researchers

Activation mechanism of memory B cell for protection against variant influenza virus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of induction and maintenance mechanism of universal cross reactive B cells against influenza virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Critical role for differentiation and maintenance of B-1 cells by transcriptional regulator MeninPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of transcription factor Gfi1 for the regulation of allergic inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 細胞工学2008

Author(s)

Publisher

Data Source

[Book] 細胞工学2008

Author(s)

Publisher

Data Source

[Journal Article] CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of High Quality Memory B Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Requirement for memory B-cell activation in protection from heterologous influenza virus reinfection2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional clustering of B cell receptors using sequence and structural features2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory T cell lineages, and convey enhanced protective immunity2018

Author(s)

Journal Title

Shinnakasu Ryo 新中須亮

SHINNAKASU Ryo 新中須亮