KUNII Naoki 國井直樹

… Alternative Names

國井直樹クニイナオキ

Less

Researcher Number	00456047
Other IDs
Affiliation (based on the past Project Information) *help	2013 – 2018: 千葉大学, 医学部附属病院, 助教 2017: 千葉大学, 大学院医学研究院, 助教 2009: 千葉大, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Otorhinolaryngology Except Principal Investigator Otorhinolaryngology
Keywords	Principal Investigator トランスレーショナル・リサーチ / mesothelin / 免疫療法 / 唾液腺癌 / キメラ抗原受容体 / 唾液腺がん / がん免疫 / メソテリン / 標的分子 / 移植・再生医療 … More / 癌 / 免疫学 / トランスレーショナルリサーチ / NKT細胞 / 免疫細胞療法 / がん免疫療法 / 癌免疫 … More Except Principal Investigator 光線力学治療 / アレルギー性鼻炎 / アミノレブリン酸 / 光線力学的治療 Less

唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究Principal Investigator
- Principal Investigator
  
  國井直樹
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Adoptive Immunotherapy using the Lymphocytes transduced with Chmeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator
- Principal Investigator
  
  KUNII Naoki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Development of photodynamic therapy for the allergic rhinitis
- Principal Investigator
  
  SUZUKI TAKESHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
Adoptive Immunotherapy using the Lymphocytes transduced with Chimeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator
- Principal Investigator
  
  KUNII Naoki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University
NKT細胞免疫系と血管成熟化因子Apelinの併用による相乗的抗腫瘍効果の検討Principal Investigator
- Principal Investigator
  
  國井直樹
- Project Period (FY)
  2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Chiba University

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer2018
- Author(s)
  Makita Yuji、Kunii Naoki、Sakurai Daiju、Ihara Fumie、Motohashi Shinichiro、Suzuki Akane、Nakayama Toshinori、Okamoto Yoshitaka
- Journal Title
  
  BMC Cancer
  
  Volume: 18 Issue: 1 Pages: 1254-1254
- DOI
  10.1186/s12885-018-5179-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
[Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018
- Author(s)
  Sakurai D, Uchida R, Ihara F, Kunii N, Nakagawa T, Chazono H, Hanazawa T, Motohashi S, Okamoto Y
- Journal Title
  
  BMC Research Notes
  
  Volume: 11 Issue: 1 Pages: 479-479
- DOI
  10.1186/s13104-018-3587-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
[Journal Article] Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.2017
- Author(s)
  Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A.
- Journal Title
  
  Cancer Letters
  
  Volume: 407 Pages: 21-31
- DOI
  10.1016/j.canlet.2017.08.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08729, KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16530
[Journal Article] CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma2017
- Author(s)
  Ihara Fumie、Sakurai Daiju、Horinaka Atsushi、Makita Yuji、Fujikawa Akira、Sakurai Toshioki、Yamasaki Kazuki、Kunii Naoki、Motohashi Shinichiro、Nakayama Toshinori、Okamoto Yoshitaka
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 66 Issue: 10 Pages: 1275-1285
- DOI
  10.1007/s00262-017-2021-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26221305
[Journal Article] A Case of Oropharyngeal Squamous Cell Carcinoma who Developed Sigmoid Colon Perforation after Cetuximab Treatment2016
- Author(s)
  浜崎佐和子, 國井直樹, 蒔田勇治, 有本昇平, 木谷令, 鈴木猛司, 山崎一樹, 米倉修二, 茶薗英明, 櫻井大樹, 花澤豊行, 岡本美孝
- Journal Title
  
  Practica Oto-Rhino-Laryngologica
  
  Volume: 109 Issue: 11 Pages: 803-808
- DOI
  10.5631/jibirin.109.803
- NAID
  130005268091
- ISSN
  0032-6313, 1884-4545
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20181
[Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016
- Author(s)
  Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 107 Issue: 3 Pages: 207-16
- DOI
  10.1111/cas.12866
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181
[Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016
- Author(s)
  Kamata T, Suzuki A, Mise N, Ihara F, Takami T, Makita Y, Horinaka A, Harada K, Kunii K, Yoshida S, Yoshino I, Nakayama T, and Motohashi S.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: 65 Issue: 12 Pages: 1477-1489
- DOI
  10.1007/s00262-016-1901-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181, KAKENHI-PROJECT-26861119, KAKENHI-PROJECT-16K19974
[Journal Article] Three Cases of Neck Swelling after FNAC (fine-needle aspiration cytology)2016
- Author(s)
  大塚雄一郎, 根本俊光, 國井直樹, 花澤豊行, 岡本美孝
- Journal Title
  
  Nippon Jibiinkoka Gakkai Kaiho
  
  Volume: 119 Issue: 9 Pages: 1225-1230
- DOI
  10.3950/jibiinkoka.119.1225
- NAID
  130005420700
- ISSN
  0030-6622, 1883-0854
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019
- Author(s)
  國井直樹、伊原史英、松島可奈、飯沼智久、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] The efficacy of measuring the anti-moesin antibody titer in the patients with granulomatosis with polyangiitis limited to the upper respiratory tract.2019
- Author(s)
  Naoki Kunii, Kazuo Suzuki, Wako Yumura, Kaori Tateyama, Kan Kishibe, Yasuaki Harabuchi, Yoshitaka Okamoto
- Organizer
  International vasculitis and ANCA workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 診断に苦慮した上気道限局型多発血管炎性肉芽腫症における抗moesin抗体価の変動2018
- Author(s)
  國井直樹、飯沼智久、櫻井利興、大木雄示、山﨑一樹、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第57回日本鼻科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] メソテリン発現唾液腺がんに対するCART細胞と活性化NKT細胞を併用した免疫細胞療法に関する前臨床研究2018
- Author(s)
  國井直樹、茶薗英明、岡本美孝
- Organizer
  第63回日本唾液腺学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 上気道限局型多発血管炎性肉芽腫症における抗moesin抗体価測定の意義2018
- Author(s)
  國井直樹、鈴木和男、湯村和子、立山香織、岸部幹、原渕保明、岡本美孝
- Organizer
  第24回MPO研究会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 上気道限局型多発血管炎性肉芽腫症の診断に抗moesin抗体価測定が有用であった1例2018
- Author(s)
  國井直樹、飯沼智久、鈴木和男、湯村和子、立山香織、岸部幹、原渕保明、岡本美孝
- Organizer
  第67回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] NKT細胞免疫系を利用した頭頸部扁平上皮癌患者に対する免疫細胞療法2017
- Author(s)
  國井直樹、櫻井大樹、伊原史英、岡本美孝
- Organizer
  第41回日本頭頸部癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 被裂喉頭蓋ヒダ切除により経口的に切除し得た咽喉頭表在がんT2症例３例2017
- Author(s)
  國井直樹、茶薗英明、鈴木猛司、新井智之、吉川直子、米倉修二、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  日本耳鼻咽喉科臨床学会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 唾液腺がんに対するメソテリン特異的キメラ抗原受容体導入T細胞と活性化NKT細胞を併用したがん免疫療法2017
- Author(s)
  國井直樹、蒔田勇治、伊原史英、中川拓也、山﨑一樹、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
- Organizer
  第118回日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-17K11376
[Presentation] 中下咽頭癌CR例に対するiNKT細胞アジュバント療法の有効性に関するランダム化試験2016
- Author(s)
  國井直樹, 山崎一樹, 茶薗英明, 花澤豊行, 岡本美孝
- Organizer
  日本口腔咽頭科学会
- Place of Presentation
  松江テルサ（島根県・松江市）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 頭頸部扁平上皮癌患者における制御性T細胞の機能的分画と臨床的意義2016
- Author(s)
  伊原史英, 堀中敦史, 蒔田勇治, 國井直樹, 櫻井大樹, 岡本美孝
- Organizer
  日本頭頸部癌学会
- Place of Presentation
  ソニックシティ（埼玉県・さいたま市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 唾液腺がん症例に対する α-galactosylceramideパルス樹状細胞の鼻粘膜下投与を用いた第Ⅰ/Ⅱ相臨床研究2016
- Author(s)
  國井直樹
- Organizer
  第34回日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  鳥羽国際ホテル（三重県・鳥羽市）
- Year and Date
  2016-02-06
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] Ⅳ期中下咽頭癌治療後CR例に対する NKT細胞免疫療法に関する第Ⅱ相ランダム化二重盲検試験2016
- Author(s)
  國井直樹
- Organizer
  第26回日本頭頸部外科学会学術講演会
- Place of Presentation
  名古屋国際会議場（愛知県・名古屋市）
- Year and Date
  2016-01-28
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 制御性T細胞の機能的分類と臨床経過との関連2016
- Author(s)
  伊原史英, 櫻井大樹, 本橋新一郎, 國井直樹, 岡本美孝
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 中咽頭癌におけるエピゲノム変化とHPV感染の検討2016
- Author(s)
  中川拓也, 松坂恵介, 高根希世子, 福世真樹, 太田聡, 中谷行雄, 國井直樹, 櫻井大樹, 花澤豊行, 岡本美孝, 金田篤志
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] The phase I / II study about iNKT cell-mediated immunotherapy against salivary gland cancer2015
- Author(s)
  國井直樹
- Organizer
  第60回日本唾液腺学会学術集会
- Place of Presentation
  文教学院大学本郷キャンパス（東京都・文京区）
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム化二重盲検試験2015
- Author(s)
  國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Place of Presentation
  東武レバントホテル（東京都墨田区）
- Year and Date
  2015-02-27
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] The Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T cells Targeted to Salivary Gland Tumor2015
- Author(s)
  Naoki KUNII
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  東京大学伊藤国際学術センター（東京都・文京区）
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 頭頸部がんに対する免疫細胞療法～iNKT細胞関連トランスレーショナルリサーチと今後の展望～2015
- Author(s)
  國井直樹
- Organizer
  第77回耳鼻咽喉科臨床学会学術講演会
- Place of Presentation
  オークラアクトシティホテル浜松（静岡県・浜松市）
- Year and Date
  2015-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K20181
[Presentation] 頭頸部がんに対する免疫細胞療法2014
- Author(s)
  國井直樹
- Organizer
  耳鼻咽喉科臨床学会学術集会
- Place of Presentation
  オークラアクトシティホテル浜松、アクトシティ浜松（浜松市中区）
- Year and Date
  2014-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] The Antigen Specific Immunotherapy Based on the Chimeric Antigen Receptor Expressing T cells Targeted to Salivary Gland Tumor2014
- Author(s)
  Naoki KUNII, Yuji MAKITA, Fumie IHARA, Ryosuke UCHIDA, Akira FUJIKAWA, Daiju Sakurai, Shinichiro MOTOHASHI, Toshinori NAKAYAMA and Yoshitaka OKAMOTO
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都市左京区）
- Year and Date
  2014-12-11
- Data Source
  KAKENHI-PROJECT-25861526
[Presentation] 唾液腺癌に対する抗原特異的T細胞の細胞傷害活性は活性化NKT細胞によって相乗的に増強する2014
- Author(s)
  蒔田勇治、國井直樹、岡本美孝
- Organizer
  日本唾液腺学会学術集会
- Place of Presentation
  文京学院大学（東京都文京区）
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-25861526

1. OKAMOTO Yoshitaka (40169157)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. MAKITA Yuji (90706722)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. SUZUKI TAKESHI (20422230)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. SAKURAI Daijyu (10375636)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YONEKURA Syuji (20400939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OKUMA Yusuke (50745825)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MORIMOTO Yuki (40802575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 伊原史英 (40779906)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 本橋新一郎 (60345022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. CARL H. June

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. June Carl H.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUSAKA Keisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. FUKUYO Masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 岡本好海

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUNII Naoki 國井 直樹

國井 直樹 クニイ ナオキ

Research Projects

Research Products

Co-Researchers

唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adoptive Immunotherapy using the Lymphocytes transduced with Chmeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of photodynamic therapy for the allergic rhinitis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adoptive Immunotherapy using the Lymphocytes transduced with Chimeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

NKT細胞免疫系と血管成熟化因子Apelinの併用による相乗的抗腫瘍効果の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Case of Oropharyngeal Squamous Cell Carcinoma who Developed Sigmoid Colon Perforation after Cetuximab Treatment2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three Cases of Neck Swelling after FNAC (fine-needle aspiration cytology)2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

KUNII Naoki 國井直樹

國井直樹クニイナオキ

[Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の有効性に関する前臨床研究2019

[Presentation] 唾液腺がん症例に対する α-galactosylceramideパルス樹状細胞の鼻粘膜下投与を用いた第Ⅰ/Ⅱ相臨床研究2016

[Presentation] Ⅳ期中下咽頭癌治療後CR例に対する NKT細胞免疫療法に関する第Ⅱ相ランダム化二重盲検試験2016