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KUNII Naoki  國井 直樹

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… Alternative Names

國井 直樹  クニイ ナオキ

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Researcher Number 00456047
Other IDs
Affiliation (based on the past Project Information) *help 2013 – 2018: 千葉大学, 医学部附属病院, 助教
2017: 千葉大学, 大学院医学研究院, 助教
2009: 千葉大, 医学(系)研究科(研究院), 助教
Review Section/Research Field
Principal Investigator
Otorhinolaryngology
Except Principal Investigator
Otorhinolaryngology
Keywords
Principal Investigator
トランスレーショナル・リサーチ / mesothelin / 免疫療法 / 唾液腺癌 / キメラ抗原受容体 / 唾液腺がん / がん免疫 / メソテリン / 標的分子 / 移植・再生医療 … More / 癌 / 免疫学 / トランスレーショナルリサーチ / NKT細胞 / 免疫細胞療法 / がん免疫療法 / 癌免疫 … More
Except Principal Investigator
光線力学治療 / アレルギー性鼻炎 / アミノレブリン酸 / 光線力学的治療 Less
  • Research Projects

    (5 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (14 People)
  •  唾液腺がんに対するCAR T細胞とNKT細胞の併用療法に関する橋渡し研究Principal Investigator

    • Principal Investigator
      國井 直樹
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Chiba University
  •  Adoptive Immunotherapy using the Lymphocytes transduced with Chmeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator

    • Principal Investigator
      KUNII Naoki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Chiba University
  •  Development of photodynamic therapy for the allergic rhinitis

    • Principal Investigator
      SUZUKI TAKESHI
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Chiba University
  •  Adoptive Immunotherapy using the Lymphocytes transduced with Chimeric Antigen Receptor against Salivary Gland TumorPrincipal Investigator

    • Principal Investigator
      KUNII Naoki
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Chiba University
  •  NKT細胞免疫系と血管成熟化因子Apelinの併用による相乗的抗腫瘍効果の検討Principal Investigator

    • Principal Investigator
      國井 直樹
    • Project Period (FY)
      2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Chiba University

All 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer2018

    • Author(s)
      Makita Yuji、Kunii Naoki、Sakurai Daiju、Ihara Fumie、Motohashi Shinichiro、Suzuki Akane、Nakayama Toshinori、Okamoto Yoshitaka
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 1254-1254

    • DOI

      10.1186/s12885-018-5179-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
  • [Journal Article] Immunosuppressive property of submandibular lymph nodes in patients with head and neck tumors: differential distribution of regulatory T cells2018

    • Author(s)
      Sakurai D, Uchida R, Ihara F, Kunii N, Nakagawa T, Chazono H, Hanazawa T, Motohashi S, Okamoto Y
    • Journal Title

      BMC Research Notes

      Volume: 11 Issue: 1 Pages: 479-479

    • DOI

      10.1186/s13104-018-3587-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05483, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-18H02892
  • [Journal Article] Frequent promoter hypermethylation associated with human papillomavirus infection in pharyngeal cancer.2017

    • Author(s)
      Nakagawa T, Matsusaka K, Misawa K, Ota S, Takane K, Fukuyo M, Rahmutulla B, Shinohara K, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Nakatani Y, Okamoto Y, Kaneda A.
    • Journal Title

      Cancer Letters

      Volume: 407 Pages: 21-31

    • DOI

      10.1016/j.canlet.2017.08.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08729, KAKENHI-PROJECT-17K01959, KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16530
  • [Journal Article] CD45RA-Foxp3high regulatory T cells have a negative impact on the clinical outcome of head and neck squamous cell carcinoma2017

    • Author(s)
      Ihara Fumie、Sakurai Daiju、Horinaka Atsushi、Makita Yuji、Fujikawa Akira、Sakurai Toshioki、Yamasaki Kazuki、Kunii Naoki、Motohashi Shinichiro、Nakayama Toshinori、Okamoto Yoshitaka
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 66 Issue: 10 Pages: 1275-1285

    • DOI

      10.1007/s00262-017-2021-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11376, KAKENHI-PROJECT-17K16892, KAKENHI-PROJECT-26221305
  • [Journal Article] A Case of Oropharyngeal Squamous Cell Carcinoma who Developed Sigmoid Colon Perforation after Cetuximab Treatment2016

    • Author(s)
      浜崎佐和子, 國井直樹, 蒔田勇治, 有本昇平, 木谷令, 鈴木猛司, 山崎一樹, 米倉修二, 茶薗英明, 櫻井大樹, 花澤豊行, 岡本美孝
    • Journal Title

      Practica Oto-Rhino-Laryngologica

      Volume: 109 Issue: 11 Pages: 803-808

    • DOI

      10.5631/jibirin.109.803

    • NAID

      130005268091

    • ISSN
      0032-6313, 1884-4545
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Journal Article] Invariant NKT cells are resistant to circulating CD15(+) myeloid-derived suppressor cells in patients with head and neck cancer.2016

    • Author(s)
      Horinaka A, Sakurai D, Ihara F, Makita Y, Kunii N, Motohashi S, Nakayama T, Okamoto Y.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 3 Pages: 207-16

    • DOI

      10.1111/cas.12866

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181
  • [Journal Article] Blockade of Programmed Death-1/Programmed Death Ligand pathway enhances the antitumor immunity of human invariant Natural Killer T cells.2016

    • Author(s)
      Kamata T, Suzuki A, Mise N, Ihara F, Takami T, Makita Y, Horinaka A, Harada K, Kunii K, Yoshida S, Yoshino I, Nakayama T, and Motohashi S.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 65 Issue: 12 Pages: 1477-1489

    • DOI

      10.1007/s00262-016-1901-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249081, KAKENHI-PROJECT-15K20181, KAKENHI-PROJECT-26861119, KAKENHI-PROJECT-16K19974
  • [Journal Article] Three Cases of Neck Swelling after FNAC (fine-needle aspiration cytology)2016

    • Author(s)
      大塚雄一郎, 根本俊光, 國井直樹, 花澤豊行, 岡本美孝
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 119 Issue: 9 Pages: 1225-1230

    • DOI

      10.3950/jibiinkoka.119.1225

    • NAID

      130005420700

    • ISSN
      0030-6622, 1883-0854
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] メソテリン特異的CART細胞と活性化NKT細胞を併用したがん免疫細胞療法の 有効性に関する前臨床研究2019

    • Author(s)
      國井直樹、伊原史英、松島可奈、飯沼智久、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
    • Organizer
      第37回日本耳鼻咽喉科免疫アレルギー学会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] The efficacy of measuring the anti-moesin antibody titer in the patients with granulomatosis with polyangiitis limited to the upper respiratory tract.2019

    • Author(s)
      Naoki Kunii, Kazuo Suzuki, Wako Yumura, Kaori Tateyama, Kan Kishibe, Yasuaki Harabuchi, Yoshitaka Okamoto
    • Organizer
      International vasculitis and ANCA workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 診断に苦慮した上気道限局型多発血管炎性肉芽腫症における抗moesin抗体価の変動2018

    • Author(s)
      國井直樹、飯沼智久、櫻井利興、大木雄示、山﨑一樹、米倉修二、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
    • Organizer
      第57回日本鼻科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] メソテリン発現唾液腺がんに対するCART細胞と活性化NKT細胞を併用した免疫細胞療法に関する前臨床研究2018

    • Author(s)
      國井直樹、茶薗英明、岡本美孝
    • Organizer
      第63回日本唾液腺学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 上気道限局型多発血管炎性肉芽腫症における抗moesin抗体価測定の意義2018

    • Author(s)
      國井直樹、鈴木和男、湯村和子、立山香織、岸部幹、原渕保明、岡本美孝
    • Organizer
      第24回MPO研究会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 上気道限局型多発血管炎性肉芽腫症の診断に抗moesin抗体価測定が有用であった1例2018

    • Author(s)
      國井直樹、飯沼智久、鈴木和男、湯村和子、立山香織、岸部幹、原渕保明、岡本美孝
    • Organizer
      第67回日本アレルギー学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] NKT細胞免疫系を利用した頭頸部扁平上皮癌患者に対する免疫細胞療法2017

    • Author(s)
      國井直樹、櫻井大樹、伊原史英、岡本美孝
    • Organizer
      第41回日本頭頸部癌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 被裂喉頭蓋ヒダ切除により経口的に切除し得た咽喉頭表在がんT2症例3例2017

    • Author(s)
      國井直樹、茶薗英明、鈴木猛司、新井智之、吉川直子、米倉修二、櫻井大樹、花澤豊行、岡本美孝
    • Organizer
      日本耳鼻咽喉科臨床学会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 唾液腺がんに対するメソテリン特異的キメラ抗原受容体導入T細胞と活性化NKT細胞を併用したがん免疫療法2017

    • Author(s)
      國井直樹、蒔田勇治、伊原史英、中川拓也、山﨑一樹、茶薗英明、櫻井大樹、花澤豊行、岡本美孝
    • Organizer
      第118回日本耳鼻咽喉科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-17K11376
  • [Presentation] 中下咽頭癌CR例に対するiNKT細胞アジュバント療法の有効性に関するランダム化試験2016

    • Author(s)
      國井直樹, 山崎一樹, 茶薗英明, 花澤豊行, 岡本美孝
    • Organizer
      日本口腔咽頭科学会
    • Place of Presentation
      松江テルサ(島根県・松江市)
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 頭頸部扁平上皮癌患者における制御性T細胞の機能的分画と臨床的意義2016

    • Author(s)
      伊原史英, 堀中敦史, 蒔田勇治, 國井直樹, 櫻井大樹, 岡本美孝
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      ソニックシティ(埼玉県・さいたま市)
    • Year and Date
      2016-06-09
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 唾液腺がん症例に対する α-galactosylceramideパルス樹状細胞の 鼻粘膜下投与を用いた第Ⅰ/Ⅱ相臨床研究2016

    • Author(s)
      國井直樹
    • Organizer
      第34回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      鳥羽国際ホテル(三重県・鳥羽市)
    • Year and Date
      2016-02-06
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] Ⅳ期中下咽頭癌治療後CR例に対する NKT細胞免疫療法に関する 第Ⅱ相ランダム化二重盲検試験2016

    • Author(s)
      國井直樹
    • Organizer
      第26回 日本頭頸部外科学会学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2016-01-28
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 制御性T細胞の機能的分類と臨床経過との関連2016

    • Author(s)
      伊原史英, 櫻井大樹, 本橋新一郎, 國井直樹, 岡本美孝
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 中咽頭癌におけるエピゲノム変化とHPV感染の検討2016

    • Author(s)
      中川拓也, 松坂恵介, 高根希世子, 福世真樹, 太田聡, 中谷行雄, 國井直樹, 櫻井大樹, 花澤豊行, 岡本美孝, 金田篤志
    • Organizer
      日本癌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] The phase I / II study about iNKT cell-mediated immunotherapy against salivary gland cancer2015

    • Author(s)
      國井直樹
    • Organizer
      第60回日本唾液腺学会学術集会
    • Place of Presentation
      文教学院大学本郷キャンパス(東京都・文京区)
    • Year and Date
      2015-12-05
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 標準治療後の進行期中・下咽頭癌症例に対するαGalCerパルス樹状細胞療法の有効性に関するランダム化二重盲検試験2015

    • Author(s)
      國井直樹、蒔田勇治、伊原史英、内田亮介、佐々原剛、藤川陽、櫻井大樹、岡本美孝
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      東武レバントホテル(東京都墨田区)
    • Year and Date
      2015-02-27
    • Data Source
      KAKENHI-PROJECT-25861526
  • [Presentation] The Antigen Specific Immunotherapy Based on Chimeric Antigen Receptor Expressing T cells Targeted to Salivary Gland Tumor2015

    • Author(s)
      Naoki KUNII
    • Organizer
      International Conference of Cancer Immunotherapy and Macrophages 2015
    • Place of Presentation
      東京大学伊藤国際学術センター(東京都・文京区)
    • Year and Date
      2015-07-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 頭頸部がんに対する免疫細胞療法 ~iNKT細胞関連トランスレーショナルリサーチと今後の展望~2015

    • Author(s)
      國井直樹
    • Organizer
      第77回耳鼻咽喉科臨床学会学術講演会
    • Place of Presentation
      オークラアクトシティホテル浜松(静岡県・浜松市)
    • Year and Date
      2015-06-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K20181
  • [Presentation] 頭頸部がんに対する免疫細胞療法2014

    • Author(s)
      國井直樹
    • Organizer
      耳鼻咽喉科臨床学会学術集会
    • Place of Presentation
      オークラアクトシティホテル浜松、アクトシティ浜松(浜松市中区)
    • Year and Date
      2014-06-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-25861526
  • [Presentation] The Antigen Specific Immunotherapy Based on the Chimeric Antigen Receptor Expressing T cells Targeted to Salivary Gland Tumor2014

    • Author(s)
      Naoki KUNII, Yuji MAKITA, Fumie IHARA, Ryosuke UCHIDA, Akira FUJIKAWA, Daiju Sakurai, Shinichiro MOTOHASHI, Toshinori NAKAYAMA and Yoshitaka OKAMOTO
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-12-11
    • Data Source
      KAKENHI-PROJECT-25861526
  • [Presentation] 唾液腺癌に対する抗原特異的T細胞の細胞傷害活性は活性化NKT細胞によって相乗的に増強する2014

    • Author(s)
      蒔田勇治、國井直樹、岡本美孝
    • Organizer
      日本唾液腺学会学術集会
    • Place of Presentation
      文京学院大学(東京都文京区)
    • Year and Date
      2014-12-06
    • Data Source
      KAKENHI-PROJECT-25861526
  • 1.  OKAMOTO Yoshitaka (40169157)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 2.  MAKITA Yuji (90706722)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  SUZUKI TAKESHI (20422230)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SAKURAI Daijyu (10375636)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  YONEKURA Syuji (20400939)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  OKUMA Yusuke (50745825)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MORIMOTO Yuki (40802575)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  伊原 史英 (40779906)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 9.  本橋 新一郎 (60345022)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  CARL H. June
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  June Carl H.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MATSUSAKA Keisuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  FUKUYO Masaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  岡本 好海
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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