Fukui Kenji 福井健二

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FUKUI Kenji 福井健二

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Researcher Number	00466038
Other IDs
Affiliation (Current)	2025: 奈良女子大学, 生活環境科学系, 准教授 2025: 大阪医科薬科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪医科薬科大学, 医学部, 助教 2014 – 2020: 大阪医科大学, 医学部, 助教 2013: 独立行政法人理化学研究所, その他部局等, 研究員 2009: The Institute of Physical and Chemical Research, 機能解析第2研究チーム, 研究員 2008: The Institute of Physical and Chemical Research, システム生物学統合研究チーム, 研究員
Review Section/Research Field	Principal Investigator Applied microbiology / Basic Section 38030:Applied biochemistry-related / Basic Section 48040:Medical biochemistry-related / Molecular biology Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43050:Genome biology-related
Keywords	Principal Investigator 高度好熱菌 / タンパク質 / PCR / ミスマッチ / 逆転写反応 / 逆転写 / DNAミスマッチ修復 / DNA修復 / X線結晶構造解析 / DNA … More / 極限環境タンパク質科学 / 極限環境生物 / 好熱菌 / 高温X線結晶構造解析 / MLH1 / PMS2 / リンチ症候群 / カドミウム / 亜鉛 / MutL / ミスマッチ修復 / 遺伝子 / 核酸 / バイオテクノロジー / 応用微生物 / 蛋白質 / X線結晶構造 / miRNA / ミスマッチ認識タンパク質 / RNA / ミスマッチ塩基対 / ミスマッチ修復系 / MutS2 / エンドヌクレアーゼ / 相同組換え / Vitamin B_1 / 酸化ストレス / 酸化傷害 / DNA切断酵素 / 相同組換え抑制 … More Except Principal Investigator ストレプトコッカス / バイオフィルム / HAG法 / トパキノン / 口腔内細菌 / クオラムセンシング / 複製エラー / 放線菌 / DNA修復 / ミスマッチ修復 / 突然変異 / DNA複製エラー / Mismatch修復 Less

High-Temperature X-ray Crystallography on the Proteins from Thermophiles, Opening the Way to Protein Science in Extreme EnvironmentsPrincipal Investigator
- Principal Investigator
  
  福井健二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析
- Principal Investigator
  
  村川武志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka Medical and Pharmaceutical University
ストレプトコッカスのバイオフィルム感染症治療に向けた研究
- Principal Investigator
  
  矢野貴人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Structural and functional characterization of DNA mismatch repair proteins for elucidation of the pathogenic mechanism of Lynch syndrome and drug discoveryPrincipal Investigator
- Principal Investigator
  
  Kenji Fukui
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Development of anti-biofilm drugs for streptococcal infection
- Principal Investigator
  
  YANO Takato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Mismatch repair system in prokaryotes lacking canonical mutS-dependent system
- Principal Investigator
  
  Takemoto Norihiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  National Center for Global Health and Medicine
Specific detection of miRNA by mismatch-binding protein-mediated reverse transcriptionPrincipal Investigator
- Principal Investigator
  
  Fukui Kenji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Osaka Medical College
Suppression of errors in reverse transcriptionPrincipal Investigator
- Principal Investigator
  
  Fukui Kenji
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Osaka Medical College
逆転写反応における非特異的増幅の抑制Principal Investigator
- Principal Investigator
  
  福井健二
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied microbiology
- Research Institution
  The Institute of Physical and Chemical Research
Structural and functional analyses on a novel mechanism of homologous recombination suppression.Principal Investigator
- Principal Investigator
  
  FUKUI Kenji
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Molecular biology
- Research Institution
  The Institute of Physical and Chemical Research

All 2020 2019 2018 2016 2010 2009 2008

All Journal Article Presentation

[Journal Article] A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL2020
- Author(s)
  Izuhara Keisuke、Fukui Kenji、Murakawa Takeshi、Baba Seiki、Kumasaka Takashi、Uchiyama Kazuhisa、Yano Takato
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 33 Pages: 11643-11655
- DOI
  10.1074/jbc.ra120.013576
- NAID
  40022734332
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07376
[Journal Article] Biochemical characterization of mismatch-binding protein MutS1 and nicking endonuclease MutL from a euryarchaeon Methanosaeta thermophila.2019
- Author(s)
  Ai Minobe, Kenji Fukui, Hitomi Yonezu, Koki Ohshita, Saki Mizobuchi, Takashi Morisawa, Yuichi Hakumai, Takato Yano, Makoto Ashiuchi, Taisuke Wakamatsu
- Journal Title
  
  DNA Repair
  
  Volume: 75 Pages: 29-38
- DOI
  10.1016/j.dnarep.2019.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K18680, KAKENHI-PROJECT-17J08400, KAKENHI-PROJECT-17H03796
[Journal Article] A novel single-stranded DNA-specific 3'-5'exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways.2010
- Author(s)
  Atsuhiro Shimada, Ryoji Masui, Yoshio Takahata, Kwang Kim, Seiki Kuramitsu, Kenji Fukui
- Journal Title
  
  Nucleic Acids Research (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20870042
[Journal Article] Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.2008
- Author(s)
  Kenji Fukui, Noriko Nakagawa, Yoshiaki Kitamura, Yuya Nishida, Ryoji Masui, Seiki Kuramitsu
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 33417-33427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20870042
[Journal Article] Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression2008
- Author(s)
  Kenji Fukui, Noriko Nakagawa, Yoshiaki Kitamura, Yuya Nishida, Ryoji Masui, Seiki Kuramitsu
- Journal Title
  
  Journal of Biological Chemistry 283
  
  Pages: 33417-33427
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Methanosaeta thermophila 由来ミスマッチ結合タンパク質 MutS1 及びニッキングヌクレアーゼ MutL 生化学的機能解析2018
- Author(s)
  美濃部亜衣、福井健二、米津ひとみ、大下紘貴、溝渕早紀、森澤高至、白米優一、矢野貴人、芦内誠、若松泰介
- Organizer
  第19回極限環境生物学会年会
- Data Source
  KAKENHI-PROJECT-16K18680
[Presentation] 高度好熱菌由来ミスマッチ認識タンパク質の核酸増幅反応への応用2016
- Author(s)
  福井健二
- Organizer
  日本農芸化学会中四国支部第22回若手研究者シンポジウム
- Place of Presentation
  高知大学
- Year and Date
  2016-04-23
- Invited
- Data Source
  KAKENHI-PROJECT-26850050
[Presentation] Thermus thermophilus HB8のDNAミスマッチ修復システム:MutLエンドヌクレアーゼの機能解析、理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」2009
- Author(s)
  福井健二、飯野均、満足美穂、Kim Kwang、高畑良雄、井上由美子、中川紀子、増井良治、倉光成紀
- Organizer
  第8回連携研究会
- Place of Presentation
  SPring-8センター
- Year and Date
  2009-08-22
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Structural Basis for Characterization of the DNA Binding Activity of the SMR in Human Bcl-3 Binding Protein(B3BP)2009
- Author(s)
  Huiping Zhang, Kenji Fukui, 他8名
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜市パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Thermus thermophilus HB8のDNAミスマッチ修復システム:MutLエンドヌクレアーゼの機能解析2009
- Author(s)
  Kenji Fukui, Hitoshi Iino, 他7名
- Organizer
  理研シンポジウム高度好熱菌丸ごと一匹プロジェクト第8回連携研究会
- Place of Presentation
  兵庫県佐用郡SPring-8
- Year and Date
  2009-08-22
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Functional differentiation of ssDNA-specific exonucleases in DNA repair pathways in Thermus thermophilus2009
- Author(s)
  島田敦広、福井健二、中川紀子、増井良治、倉光成紀
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Structural Basis for Characterization of the DNA Binding Activity of the SMR in Human Blc-3 Binding Protein (B3BP)2009
- Author(s)
  Zhang Huiping、福井健二、渡部暁、原田拓志、藤倉由紀子、小原収、木川隆則、倉光成紀、林文晶、横山茂之
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] 高度好熱菌Thermus thermophilus HB8のDNA修復系およびRNA分解系2009
- Author(s)
  増井良治、福井健二、若松泰介、石川大仁、新海暁男、中川紀子、倉光成紀
- Organizer
  第3回日本ゲノム微生物学会年会
- Place of Presentation
  中央大学後楽園キャンパス
- Year and Date
  2009-03-06
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Functional differentiation of ssDNA-specific exonucleases in DNA repair pathways in Thermus thermophilus2009
- Author(s)
  Atsuhiro Shimada, Kenji Fukui, 他3名
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜市パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Thermus thermophilus HB8のDNAミスマッチ修復システム2008
- Author(s)
  福井健二, 飯野均, 満足美穂, 中川紀子, 増井良治, 倉光成紀
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学大会(BMB2008)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] Thermus thermophilus HB8のDNAミスマッチ修復機構、理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」2008
- Author(s)
  福井健二、飯野均、満足美穂、中川紀子、増井良治、倉光成紀
- Organizer
  第7回連携研究会
- Place of Presentation
  SPring-8センター
- Year and Date
  2008-09-14
- Data Source
  KAKENHI-PROJECT-20870042
[Presentation] DNAミスマッチ修復系初期反応におけるMutLエンドヌクレアーゼ活性の制御機構2008
- Author(s)
  福井健二、飯野均、満足美穂、中川紀子、増井良治、倉光成紀
- Organizer
  第31回日本分子生物学会・第81回日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20870042

1. YANO Takato (40239827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 石井誠志 (10247851)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 馬場清喜 (00437344)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 村川武志 (90445990)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Takemoto Norihiko (40546793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 末次正幸 (00363341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Fukui Kenji 福井 健二

FUKUI Kenji 福井 健二

Research Projects

Research Products

Co-Researchers

High-Temperature X-ray Crystallography on the Proteins from Thermophiles, Opening the Way to Protein Science in Extreme EnvironmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ストレプトコッカスのバイオフィルム感染症治療に向けた研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural and functional characterization of DNA mismatch repair proteins for elucidation of the pathogenic mechanism of Lynch syndrome and drug discoveryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti-biofilm drugs for streptococcal infection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mismatch repair system in prokaryotes lacking canonical mutS-dependent system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Specific detection of miRNA by mismatch-binding protein-mediated reverse transcriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Suppression of errors in reverse transcriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

逆転写反応における非特異的増幅の抑制Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and functional analyses on a novel mechanism of homologous recombination suppression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Biochemical characterization of mismatch-binding protein MutS1 and nicking endonuclease MutL from a euryarchaeon Methanosaeta thermophila.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel single-stranded DNA-specific 3'-5'exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways.2010

Author(s)

Journal Title

Data Source

Fukui Kenji 福井健二

FUKUI Kenji 福井健二