Shimosato Takeshi 下里剛士

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SHIMOSATO Takeshi 下里剛士

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Researcher Number	00467200
Other IDs
Affiliation (Current)	2025: 信州大学, 学術研究院農学系, 教授
Affiliation (based on the past Project Information) *help	2025: 信州大学, 学術研究院農学系, 教授 2019 – 2023: 信州大学, 学術研究院農学系, 教授 2014 – 2018: 信州大学, 学術研究院農学系, 准教授 2012 – 2013: 信州大学, 農学研究科, 准教授 2008 – 2011: Shinshu University, ファイバーナノテク国際若手研究者育成拠点, 助教
Review Section/Research Field	Principal Investigator Basic Section 42010:Animal production science-related / Zootechnical science/Grassland science / Animal production science / Studies on the Super-Aging Society / Animal production science / Applied molecular and cellular biology Except Principal Investigator Basic Section 38050:Food sciences-related / Basic Section 54030:Infectious disease medicine-related / Medium-sized Section 50:Oncology and related fields / Medium-sized Section 90:Biomedical engineering and related fields / Respiratory organ internal medicine
Keywords	Principal Investigator 乳酸菌 / 経口 / プロバイオティクス / 腸管 / 免疫 / 微粒子 / オリゴDNA / ナノカプセル / 食品免疫学 / 機能強化乳酸菌 … More / Lactobacillus / CRISPR-Cas / LGG / 乳酸桿菌 / ゲノム編集 / 肺静脈心筋細胞 / 腸肺相関 / 腸管上皮 / スマート / スマート乳酸菌 / 遺伝子組換え / リボソーム工学 / 育種 / 機能強化 / 腸管粘膜 / 乳酸菌DNA微粒子 / DNA微粒子 / 経口投与 / 腸内細菌 / 喘息モデル / 肺 / 乳酸菌オリゴDNA / 免疫調節 / オリゴ核酸カプセル / マイクロカプセル / iODN / ODN / オリゴ核酸 / DNanocap / DNAナノカプセル / DNA / 機能性飼料 / 機能性食品 / オリゴヌクレオチド / 食物アレルギー / DNAワクチン … More Except Principal Investigator 経気道治療 / 遺伝子組換え乳酸菌 / 乳酸菌 / 肺がん / ナノマイクロ粒子 / 肺癌 / 腸管免疫 / 膜小胞 / 免疫 / マクロファージ / GroEL / GAPDH / グリセルアルデヒド-3-リン酸脱水素酵素 / ムーンライティングプロテイン / SARS-CoV-2 / COVID-19 / 組換え乳酸菌 / 気道粘膜ワクチン / 経気道的標的治療 / 生物資源医薬 / 免疫チェックポイント阻害 / 高分子医薬 / 経気道的治療法 / 抗体医薬 / 肺癌免疫療法 / 吸入療法 / PD-1 / 免疫チェックポイント / 吸入免疫治療 / 分子細胞呼吸器学 / 癌 / ナノ材料 / 肺癌モデル / 経気道投与 / 免疫治療 / 動物モデル / 肺気腫 / ドラッグデリバリー / ナノメディシン Less

肉用鶏由来プロバイオティクスによるカンピロバクター増殖・定着阻害機構の解明Principal Investigator
- Principal Investigator
  
  下里剛士
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Shinshu University
GAPDH及び膜小胞（MVs）に着目した乳酸菌の腸内定住戦略解明と抗炎症剤への応用
- Principal Investigator
  
  木下英樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Tokai University
Development of genetically modified lactococcus lactis-based mucosal vaccines/drugs for COVID-19
- Principal Investigator
  
  佐藤隆
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Shinshu University
Development of smart lactic acid bacteriaPrincipal Investigator
- Principal Investigator
  
  Shimosato Takeshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Shinshu University
The Optimization of Oral Lactobacillus Oligodeoxynucleotide Microparticles and the Elucidation of Immune Regulation Mechanisms via Intestinal EpitheliumPrincipal Investigator
- Principal Investigator
  
  Shimosato Takeshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42010:Animal production science-related
- Research Institution
  Shinshu University
Innovative therapy for lung cancer: prophylaxis and therapy by intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment
- Principal Investigator
  
  Sato Takashi
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Shinshu University
Development of innovative delivery systems of biologics to the lung
- Principal Investigator
  
  Sato Takashi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Shinshu University
  Yokohama City University
Development of genetic tools for the annotation in LactobacillusPrincipal Investigator
- Principal Investigator
  
  下里剛士
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Animal production science
- Research Institution
  Shinshu University
Study on the immune mechanism using oral nanocapsule with oligodeoxynucleotides from lactic acid bacteriaPrincipal Investigator
- Principal Investigator
  
  Shimosato Takeshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal production science
- Research Institution
  Shinshu University
Study of nanoparticles-incorporating immune modulating oligodeoxynucleotide for the treatment of lung diseases
- Principal Investigator
  
  SATO Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Yokohama City University
Development for novel food and feed using DNA Nanocapsules of Lactic acid bacteria as Oral Delivery DevicesPrincipal Investigator
- Principal Investigator
  
  SHIMOSATO Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Shinshu University
Development of functional foods and feeds using probiotic lactic acid bacteria DNAPrincipal Investigator
- Principal Investigator
  
  SHIMOSATO Takeshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Zootechnical science/Grassland science
- Research Institution
  Shinshu University
Study on the anti-allergic DNA vaccines with nanoparticle in gut mucosal immune systemPrincipal Investigator
- Principal Investigator
  
  SHIMOSATO Takeshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Shinshu University

[Book] A Compendium of Chronic Obstructive Pulmonary Disease-Intratracheally Therapeutic Option for COPD: A Potential Usage of the Therapeutic Microbe for Delivering Specific Protein to the Lungs2023
- Author(s)
  Sato T and Shimosato T
- Total Pages
  11
- Publisher
  IntechOpen
- ISBN
  9781803567686
- Data Source
  KAKENHI-PROJECT-19KK0208
[Book] A Compendium of Chronic Obstructive Pulmonary Disease-Intratracheally Therapeutic Option for COPD: A Potential Usage of the Therapeutic Microbe for Delivering Specific Protein to the Lungs2022
- Author(s)
  Sato T and Shimosato T
- Total Pages
  11
- Publisher
  IntechOpen
- ISBN
  9781803567679
- Data Source
  KAKENHI-PROJECT-22K08578
[Book] アジュバント開発研究の新展開第三章アジュバント各論「プロバイオティック乳酸菌を利用した経口ワクチン・アジュバント研究の新展開」2011
- Author(s)
  石井健,青枝大貴,小檜山康司,鉄谷耕平,審良静男,山西弘一,吉田裕樹,原博満,安田好文,中西憲司,竹内理,荒木幸一,黒田悦史,小山正平,藤本ゆかり,深瀬浩一,新川武,宮田健,柳義和,豊永憲司,山崎晶,下里剛士,北澤春樹, CevayirCoban, KeiichiOhata, YoshikatsuIgai, MasahiroKato, ToshihiroTsukui,望月慎一,櫻井和朗,岩田晃,前山順一,山本三郎,改正恒康,西川元也,高倉喜信,角田慎一,堤康央,吉開泰信,内田哲也,赤木隆美,明石満,長谷川秀樹,植松智,佐々木津, NathalieGarcon,瀬谷司,佐藤治子,志馬寛明,松本美佐子
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22780239
[Book] アジュバント開発研究の新展開Advanced Technologies for Adjuvant Research and Development2011
- Author(s)
  石井健, 下里剛士, 他43名
- Total Pages
  249
- Publisher
  株式会社シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22780239
[Journal Article] Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria2024
- Author(s)
  Oshima Suzuka、Namai Fu、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  Molecular Biotechnology
  
  Volume: 66 Issue: 1 Pages: 151-160
- DOI
  10.1007/s12033-023-00741-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08578, KAKENHI-PROJECT-19KK0208
[Journal Article] Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics2023
- Author(s)
  Namai Fu、Sumiya Shunsuke、Nomura Natsumi、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  AMB Express
  
  Volume: 13 Issue: 1 Pages: 4-4
- DOI
  10.1186/s13568-023-01509-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08578, KAKENHI-PROJECT-19KK0208
[Journal Article] Oral administration of <scp><i>Brevibacterium linens</i></scp> from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice2023
- Author(s)
  Murakami Aito、Toyomoto Koharu、Namai Fu、Sato Takashi、Fujii Tadashi、Tochio Takumi、Shimosato Takeshi
- Journal Title
  
  Animal Science Journal
  
  Volume: 94 Issue: 1
- DOI
  10.1111/asj.13905
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0208
[Journal Article] 機能強化乳酸菌の創製研究2022
- Author(s)
  生井楓，下里剛士
- Journal Title
  
  日本乳酸菌学会誌
  
  Volume: 33 Pages: 5-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20656
[Journal Article] Oral administration of Flavonifractor plautii, a bacteria increased with green tea consumption, promotes recovery from acute colitis in mice via suppression of IL-172021
- Author(s)
  Ayane Mikami, Tasuku Ogita, Fu Namai, Suguru Shigemori, Takashi Sato, Takeshi Shimosato
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 7 Pages: 610946-610946
- DOI
  10.3389/fnut.2020.610946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K15480, KAKENHI-PROJECT-19KK0208
[Journal Article] Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice2021
- Author(s)
  Okajima, T., Shigemori, S., Namai, F., Ogita, T., Sato, T. & Shimosato, T.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 738041-738041
- DOI
  10.3389/fimmu.2021.738041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03125, KAKENHI-PROJECT-19KK0208
[Journal Article] Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice2020
- Author(s)
  Namai Fu、Shigemori Suguru、Ogita Tasuku、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  Experimental & Molecular Medicine
  
  Volume: 52 Issue: 9 Pages: 1627-1636
- DOI
  10.1038/s12276-020-00507-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0208
[Journal Article] Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema2020
- Author(s)
  Yumoto Kentaro、Sato Takashi、Nakashima Kentaro、Namai Fu、Shigemori Suguru、Shimosato Takeshi、Kaneko Takeshi
- Journal Title
  
  Antioxidants
  
  Volume: 9 Issue: 11 Pages: 1049-1049
- DOI
  10.3390/antiox9111049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0208
[Journal Article] Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice2020
- Author(s)
  Ogita Tasuku、Yamamoto Yoshinari、Mikami Ayane、Shigemori Suguru、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 11 Pages: 379-379
- DOI
  10.3389/fimmu.2020.00379
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0208, KAKENHI-PROJECT-18K19935, KAKENHI-PROJECT-20K15480
[Journal Article] Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue2020
- Author(s)
  Ayane Mikami, Tasuku Ogita, Fu Namai, Suguru Shigemori, Takashi Sato, Takeshi Shimosato
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 47 Issue: 9 Pages: 6717-6725
- DOI
  10.1007/s11033-020-05727-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15480, KAKENHI-PROJECT-19KK0208
[Journal Article] Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable2020
- Author(s)
  Namai Fu、Shigemori Suguru、Ogita Tasuku、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 47 Issue: 9 Pages: 7039-7047
- DOI
  10.1007/s11033-020-05765-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0208
[Journal Article] Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin2020
- Author(s)
  Ishida Minori、Namai Fu、Shigemori Suguru、Kajikawa Shoko、Tsukagoshi Masami、Sato Takashi、Ogita Tasuku、Shimosato Takeshi
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 86 Issue: 20
- DOI
  10.1128/aem.01448-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0208, KAKENHI-PROJECT-19J22578
[Journal Article] Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable2020
- Author(s)
  Namai Fu、Murakami Aito、Ueda Asami、Tsukagoshi Masami、Shigemori Suguru、Ogita Tasuku、Sato Takashi、Shimosato Takeshi
- Journal Title
  
  Molecular Biotechnology
  
  Volume: 62 Issue: 11-12 Pages: 572-579
- DOI
  10.1007/s12033-020-00274-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0208
[Journal Article] Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents2019
- Author(s)
  Sato T and Shimosato T
- Journal Title
  
  Science Impact Ltd.
  
  Volume: 2019 Issue: 3 Pages: 56-58
- DOI
  10.21820/23987073.2019.3.56
- NAID
  120007180880
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19935
[Journal Article] Cooperation of Oligodeoxynucleotides and Synthetic Molecules as Enhanced Immune Modulators2019
- Author(s)
  Nigar, S. & Shimosato, T.
- Journal Title
  
  Frontiers in Nutrition
  
  Volume: 6 Pages: 140-140
- DOI
  10.3389/fnut.2019.00140
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03907
[Journal Article] Silicosis and lung cancer: current perspectives.2018
- Author(s)
  Sato T, Shimosato T, Klinman DM
- Journal Title
  
  Lung Cancer (Auckl)
  
  Volume: 9 Pages: 91-101
- DOI
  10.2147/lctt.s156376
- NAID
  120007180882
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19935
[Journal Article] Regulatory role of heme oxygenase-1 in silica-induced lung injury.2018
- Author(s)
  Nakashima K, Sato T, Shimosato T
- Journal Title
  
  Respiratory Research
  
  Volume: 19 Issue: 1 Pages: 144-144
- DOI
  10.1186/s12931-018-0852-6
- NAID
  120007180881
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19935
[Journal Article] Use of nanoparticles to deliver immunomodulatory oligonucleotides2016
- Author(s)
  Klinman DM, Sato T, Shimosato T.
- Journal Title
  
  Wiley Interdiscip Rev Nanomed Nanobiotechnol.
  
  Volume: 8 Issue: 4 Pages: 631-631
- DOI
  10.1002/wnan.1382
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09224
[Journal Article] Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice2015
- Author(s)
  Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T.
- Journal Title
  
  Molecular Therapy
  
  Volume: 23 Issue: 2 Pages: 297-309
- DOI
  10.1038/mt.2014.239
- NAID
  120007106220
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24580388
[Journal Article] Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors2015
- Author(s)
  Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman DM
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 14 Issue: 10 Pages: 2198-2205
- DOI
  10.1158/1535-7163.mct-15-0401
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09224
[Journal Article] Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice2015
- Author(s)
  Shigemori S, Watanabe T, Kudoh K, Ihara M, Nigar S, Yamamoto Y, Suda Y, Sato T, Kitazawa H, Shimosato T
- Journal Title
  
  Microbial Cell Factories
  
  Volume: 14 Issue: 1 Pages: 189-189
- DOI
  10.1186/s12934-015-0378-2
- NAID
  120007101329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09224, KAKENHI-PROJECT-14J06317
[Journal Article] Immunobiotic Lactobacillus jensenii elicit anti-inflammatory activity in porcine intestinal epithelial cells by modulating negative regulators of the toll-like receptor signaling pathway2012
- Author(s)
  Shimazu, T., H.Aso, Y.Suda, Y.Kawai, T.Saito, H.Kitazawa, et al
- Journal Title
  
  Infect.Immun.
  
  Volume: 80 Issue: 1 Pages: 276-288
- DOI
  10.1128/iai.05729-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380164, KAKENHI-PROJECT-22780239, KAKENHI-PROJECT-24380150, KAKENHI-PROJECT-24658224, KAKENHI-PROJECT-22380144
[Journal Article] Class I/II hybrid inhibitory oligodeoxynucleotides exerts Th1 and Th2 double immunosuppression2012
- Author(s)
  to Y, Shigemori S, Sato T, Shimazu T, et al
- Journal Title
  
  FEBS Open Bio
  
  Volume: (in press) Issue: 1 Pages: 41-45
- DOI
  10.1016/j.fob.2012.11.002
- NAID
  120007106173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790917, KAKENHI-PROJECT-24580388
[Journal Article] Immunobiotic lactic acid bacteria beneficially regulate immune response triggered by poly(I:C) in porcine intestinal epithelial cells2011
- Author(s)
  Hosoya, S., H.Aso, Y.Suda, Y.Kawai, T.Saito, H.Kitazawa, et al
- Journal Title
  
  Vet.Res.
  
  Volume: 42(111) Issue: 1 Pages: 1-13
- DOI
  10.1186/1297-9716-42-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380164, KAKENHI-PROJECT-21380170, KAKENHI-PROJECT-22780239
[Journal Article] Immunobiotic Lactobacillus strains augment NLRP3 expression in newborn and adult porcine gut-associated lymphoid tissues2011
- Author(s)
  Tohno, M., H.Aso, H.Kitazawa, et al
- Journal Title
  
  Vet.Immunol.Immunopathol.
  
  Volume: 144 Issue: 3-4 Pages: 410-416
- DOI
  10.1016/j.vetimm.2011.09.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380164, KAKENHI-PROJECT-22780239, KAKENHI-PROJECT-23780274
[Journal Article] Effect of Lactobacillus pentosus ONRIC b0240 on intestinal IgA production in mice fed differing levels of protein2011
- Author(s)
  Shimosato T, Tomida K, Otani H
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 59(6) Issue: 6 Pages: 2646-2651
- DOI
  10.1021/jf104240d
- Data Source
  KAKENHI-PROJECT-22780239
[Journal Article] Toll-like receptor-2 activating bifidobacteria strains differentially regulate inflammatory cytokines in porcine intestinal epithelial cell culture system : finding new anti-inflammatory immunobiotics2011
- Author(s)
  Fujie, H., H.Aso, Y.Suda, T.Saito, H.Kitazawa, et al
- Journal Title
  
  FEMS Immunol.Med.Microbiol.
  
  Volume: 63 Issue: 1 Pages: 129-139
- DOI
  10.1111/j.1574-695x.2011.00837.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380164, KAKENHI-PROJECT-21380170, KAKENHI-PROJECT-22590869, KAKENHI-PROJECT-22780239
[Journal Article] Anti-allergic effects of a mixture of Saccharomyces cerevisiae and its specific goat' s milk immunoglobulin G-rich fraction on ovalbuminsensitized BALB/c mice2011
- Author(s)
  Sekimura Y, Shimosato T, Otani H
- Journal Title
  
  Milchwissenshaft-Milk Science International
  
  Volume: 66(1) Pages: 7-10
- Data Source
  KAKENHI-PROJECT-22780239
[Journal Article] イムノジェニクスとしての免疫刺激性DNA研究の最前線2010
- Author(s)
  下里剛士, 北澤春樹
- Journal Title
  
  北信越畜産学会報
  
  Volume: 100 Pages: 1-9
- NAID
  40017293435
- Data Source
  KAKENHI-PROJECT-22780239
[Journal Article] CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9.2010
- Author(s)
  Shimosato T, Fujimoto M, Tohno M, Takashi Sato, Tateo M, Otani H, Kitazawa H
- Journal Title
  
  Biochemical and Biophysical Research Communications 394
  
  Pages: 81-86
- NAID
  120007106179
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice2010
- Author(s)
  Nagasawa C, Nishimura-Uemura J, Tohno M, Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H
- Journal Title
  
  Asian Australasian Journal ofAnimal Science 23
  
  Pages: 106-115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Oral Administration of Phosphorylated Dextran Regulates Immune Response in Ovalbumin-Immunized Mice.2010
- Author(s)
  Nagasawa C, Nishimura-Uemura J, Tohno M, Shimosato T, Kawai Y, Ikegami S, Oda M, Saito T, Kitazawa H
- Journal Title
  
  Asian-Australasian Journal of Animal Sciences 23(1)
  
  Pages: 106-115
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Accelerated Wound Healing Mediated by Activation of Toll-like Receptor 92010
- Author(s)
  Sato T, Yamamoto M, Shimosato T, KlinmanDM
- Journal Title
  
  Wound Repair and Regeneration
  
  Volume: 18(6) Issue: 6 Pages: 586-593
- DOI
  10.1111/j.1524-475x.2010.00632.x
- NAID
  10031181701
- Data Source
  KAKENHI-PROJECT-22780239
[Journal Article] CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 92010
- Author(s)
  Shimosato T, Fujimoto M, Tohno M, Takashi Sato, Tateo M, Otani H, Kitazawa H
- Journal Title
  
  Biochemical and Biophysical Research Communications 394
  
  Pages: 81-86
- NAID
  120007106179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ2009
- Author(s)
  Shimosato T, Tohno M, Sato T, Nishiura J, Kawai Y, Saito T, Kitazawa H
- Journal Title
  
  Animal Science Journal 80
  
  Pages: 597-604
- NAID
  10027887689
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Utilization of the porcine system to study lymphotoxin-βregulation in intestina lymphoid tissue2009
- Author(s)
  Shimazu T, Tohno M, Katoh S, Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H
- Journal Title
  
  Biochemical Genetics 47(1-2)
  
  Pages: 126-36
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Preparation of goat milk anti-Saccharomyces cerevisiae immunoglobulin G (IgG)-rich fraction and immunological functions of mice orally administered a mixture of the antigen and its specific IgG-rich fraction.2009
- Author(s)
  Sekimura Y, Nao Onodera, Minami Banno, Hata I, Hamano K, Shimosato T, Hajime O
- Journal Title
  
  Milk Science 58(3)
  
  Pages: 119-128
- NAID
  130003398674
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Utilization of the porcine system to study lymphotoxin-β regulation in intestina lymphoid tissue2009
- Author(s)
  Shimazu T, Tohno M, Katoh S, Shimosato T, Aso H, Kawai Y, Saito T, Kitazawa H
- Journal Title
  
  Biochemical Genetics 47
  
  Pages: 126-136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation.2008
- Author(s)
  Sato T, Shimosato T, Alvord WG, Klinman DM
- Journal Title
  
  Journal of Immunology 180(11)
  
  Pages: 7648-54
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice2008
- Author(s)
  Iliev ID, Tohno M, Kurosaki D, Shimosato T, He F, Hosoda M, Saito T.
- Journal Title
  
  Scandinavian Journal of Immunology 67
  
  Pages: 370-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20780238
[Journal Article] Immunostimulatory oligodeoxynucleotide containing TTTCGTTT motif from Lactobacillus rhamnosus GG DNA potentially suppresses OVA-specific IgE production in mice.2008
- Author(s)
  Iliev ID, Tohno M, Kurosaki D, Shimosato T, He F, Hosoda M, Saito T
- Journal Title
  
  Scandinavian Journal of Immunology 67(4)
  
  Pages: 370-6
- Data Source
  KAKENHI-PROJECT-20780238
[Patent] 医薬組成物2020
- Inventor(s)
  佐藤隆、下里剛士、森谷樹、森永匡彦、佐藤祐一、小番昭宏
- Industrial Property Rights Holder
  佐藤隆、下里剛士、森谷樹、森永匡彦、佐藤祐一、小番昭宏
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-19KK0208
[Patent] 医薬組成物2019
- Inventor(s)
  佐藤隆、下里剛士、森谷樹、森永匡彦、佐藤祐一、小番昭宏
- Industrial Property Rights Holder
  佐藤隆、下里剛士、森谷樹、森永匡彦、佐藤祐一、小番昭宏
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K19935
[Presentation] Intranasal-administrable microbial therapeutics for lung cancer based on immune- checkpoint inhibitory scFv-producing genetically modified lactic acid bacteria2023
- Author(s)
  Namai F, Sato T, Shimosato T
- Organizer
  Federation of European Microbiological Societies 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis2023
- Author(s)
  Kaho Suzuki, Fu Namai, Natsumi Nomura, Yuichi Sato, Akihiro Kotsugai, Takeshi Shimosato, Takashi Sato
- Organizer
  ATS (American Thoracic Society) 2023 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] 乳酸菌由来のムーンライティングプロテインがマクロファージの免疫応答に及ぼす影響2023
- Author(s)
  日比友之, 中島勇貴, 福地雄大, 大貫琴音, 浦上雅史, 森井大貴, 生井楓, 下里剛士, 安田伸, 米田一成, 木下英樹
- Organizer
  第60回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-23K05133
[Presentation] プロバイオティック乳酸菌の機能強化と菌体表層タンパク質と細胞外小胞による相反する免疫応答2023
- Author(s)
  Jamiyanpurev Soyolmaa、生井楓、木下英樹，下里剛士
- Organizer
  日本畜産学会第131回大会
- Data Source
  KAKENHI-PROJECT-23K05133
[Presentation] Immunomodulatory effect of moonlighting proteins of lactic acid bacteria on macrophage cells2023
- Author(s)
  Tomoyuki Hibi, Yuki Nakashima, Yudai Fukuchi, Kotone Onuki, Masafumi Urakami, Taiki Morii, Shin Yasuda, Kazunari Yoneda, Fu Namai, Takeshi Shimosato and Hideki Kinoshita
- Organizer
  The 19th Asian Agricultural Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K05133
[Presentation] Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice2023
- Author(s)
  Natsumi Nomura, Fu Namai, Takashi Sato, Takeshi Shimosato
- Organizer
  ATS (American Thoracic Society) 2023 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis2023
- Author(s)
  K. Suzuki; F. Namai; N. Nomura; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
- Organizer
  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03125
[Presentation] Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice2023
- Author(s)
  Nomura N, Namai F, Sato T, Shimosato T
- Organizer
  American Thoracic Society International Conference 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08578
[Presentation] Microbial therapeutics for lung cancer based on immune-checkpoint inhibitory scFv-producing engineered lactic acid bacteria2023
- Author(s)
  Fu Namai, Haruki Kitazawa, Takashi Sato, Takeshi Shimosato
- Organizer
  FEMS (Federation of European Microbiological Societies) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1scFv Improves Survival in Lung Cancer Model Mice2023
- Author(s)
  Nomura N, Namai F, Sato T, Shimosato T
- Organizer
  American Thoracic Society 2023 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] A breeding strategy of ribosome engineering for probiotics enhances the adhesion to human colonic mucin in Lacticaseibacillus rhamnosus GG2021
- Author(s)
  Namai Fu, Shigemori Suguru, Shimosato Takeshi
- Organizer
  日本農芸化学会 2021年度大会
- Data Source
  KAKENHI-PROJECT-20K20656
[Presentation] Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG2021
- Author(s)
  Masami Tsukagoshi, Fu Namai, Suguru Shigemori, Takeshi Shimosato
- Organizer
  The 11th Asian Conference on Lactic Acid Bacteria
- Data Source
  KAKENHI-PROJECT-20K20656
[Presentation] 機能強化乳酸菌の創製研究2021
- Author(s)
  下里剛士
- Organizer
  日本乳酸菌学会設立30周年記念シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K20656
[Presentation] 腸内常在性乳酸菌におけるイムノバイオティック機能の強化2021
- Author(s)
  金山理佐, 生井楓，重盛駿，下里剛士
- Organizer
  酪農科学シンポジウム2021
- Data Source
  KAKENHI-PROJECT-20K20656
[Presentation] 2.PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組み換え体の構築と肺がんモデルマウスを用いた検証2019
- Author(s)
  上田麻未，生井楓，村上愛斗，重盛駿，荻田佑，佐藤隆，下里剛士
- Organizer
  2019酪農科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] イムノバイオティクス由来核酸成分を用いた経口用微粒子の創製と機能性食品・飼料素材への展開2019
- Author(s)
  下里剛士
- Organizer
  日本食品科学工学会第66回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03907
[Presentation] 2.PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組み換え体の構築と肺がんモデルマウスを用いた検証2019
- Author(s)
  上田麻未，生井楓，村上愛斗，重盛駿，荻田佑，佐藤隆，下里剛士
- Organizer
  2019酪農科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K19935
[Presentation] 1.抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築2019
- Author(s)
  村上愛斗, 生井楓, 上田麻未，重盛駿, 荻田佑, 佐藤隆, 下里剛士
- Organizer
  2019酪農科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19KK0208
[Presentation] Oral delivery of probiotic ODN particles modulate the host immune system2019
- Author(s)
  Takeshi Shimosato, Suguru Shigemori, Tasuku Ogita
- Organizer
  TASP2019[The 2nd International Conference on Tropical Animal Science and Production]
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03907
[Presentation] 1.抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築2019
- Author(s)
  村上愛斗, 生井楓, 上田麻未，重盛駿, 荻田佑, 佐藤隆, 下里剛士
- Organizer
  2019酪農科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K19935
[Presentation] 敗血症の重症化を抑えるオリゴDNAのプライミング効果2019
- Author(s)
  下里剛士
- Organizer
  日本農芸化学会中部支部第186回例会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03907
[Presentation] 乳酸菌オリゴDNAを有効成分とする経口用微粒子がもたらす急性大腸炎の予防効果2019
- Author(s)
  重盛駿，荻田佑，下里剛士
- Organizer
  日本畜産学会第126回大会
- Data Source
  KAKENHI-PROJECT-17H03907
[Presentation] Free-feeding of DNA nanocapsules containing CpG oligodeoxynucleotide from Streptococcus thermophilus2017
- Author(s)
  Okajima Takuma, Yamamoto Yoshinari, Ogita Tasuku, Shimosato Takeshi
- Organizer
  IDF World Diary Summit 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03907
[Presentation] Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect on murine lung cancer2015
- Author(s)
  Sato T, Shimosato T, Klinman DM
- Organizer
  13th US-JAPAN Symposium on Drug Delivery Systems
- Place of Presentation
  Maui, HI, USA
- Year and Date
  2015-12-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09224
[Presentation] 乳酸菌オリゴDNAナノカプセルの経口投与による全身免疫系の活性化作用2015
- Author(s)
  WANG YEQIN, 山本祥也，WANG PENGFEI, 大城和士，重盛駿，下里剛士
- Organizer
  日本畜産学会第119回大会
- Place of Presentation
  宇都宮大学峰キャンパス
- Year and Date
  2015-03-29
- Data Source
  KAKENHI-PROJECT-24580388
[Presentation] 乳酸菌オリゴ核酸ナノカプセルの標的細胞の同定2014
- Author(s)
  Wang Yeqin, 山本祥也, Wang Pengfei, 重盛駿, 下里剛士
- Organizer
  平成26年度日本酪農科学シンポジウム
- Place of Presentation
  昭和女子大学グリーンホール
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-24580388
[Presentation] 乳酸菌オリゴ核酸ナノカプセルの特性解析2014
- Author(s)
  Wang Xinyu, Wang Yeqin, 大谷元, 下里剛士
- Organizer
  平成26年度日本酪農科学シンポジウム
- Place of Presentation
  昭和女子大学グリーンホール
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-24580388
[Presentation] 乳酸菌由来オリゴ核酸のマイクロカプセル化とその特性解析2013
- Author(s)
  下里剛士, 秋場菜央, 重盛駿，大谷元
- Organizer
  日本畜産学会第116回大会
- Place of Presentation
  安田女子大学
- Data Source
  KAKENHI-PROJECT-24580388
[Presentation] ビール酵母とその牛乳抗体のマウスI型アレルギーに及ぼす影響2012
- Author(s)
  森崎健太郎,松田孝裕,岡田実,堀江健二,金武祚,下里剛士,大谷元
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 乳酸菌由来オリゴヌクレオチドによる新規分泌型IL-33様タンパク質の誘導2012
- Author(s)
  下里剛士, 伊藤雄亮, 遠野雅徳, 大谷元, 北澤春樹
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  愛知県名古屋市名古屋大学東山キャンパス
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ後期初乳の新規生体防御機能の探索2012
- Author(s)
  長谷川実希,遠見和幸,内田健志,為定誠,下里剛士,大谷元
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 乳酸菌由来オリゴヌクレオチドによる新規分泌型IL-33様タンパク質の誘導2012
- Author(s)
  下里剛士,伊藤雄亮,遠野雅徳,大谷元,北澤春樹
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 乳酸菌菌体外多糖の異なるパターン認識受容体を介する免疫調節機能特性2012
- Author(s)
  室伏陽,和知俊,細矢翔一,遠野雅徳,島津朋之,下里剛士,川井泰,齋藤忠夫,橋口健司,吉田睦子,北澤春樹
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ後期初乳中の抗アレルギータンパク質の探索2012
- Author(s)
  遠見和幸,須賀正喜,内田健志,為定誠,下里剛士,大谷元
- Organizer
  日本畜産学会第115回大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Streptococcus thermophilus由来オリゴヌクレオチドにより誘導されるIL-33活性化機構の解析2011
- Author(s)
  下里剛士,伊藤雄亮,遠野雅徳,大谷元,北澤春樹
- Organizer
  平成23年度日本酪農科学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Streptococcus thermophilus由来オリゴヌクレオチドにより誘導されるIL-33活性化機構の解析2011
- Author(s)
  下里剛士, 伊藤雄亮, 遠野雅徳, 大谷元, 北澤春樹
- Organizer
  平成23年度日本酪農科学シンポジウム
- Place of Presentation
  宮城県仙台市フォレスト仙台
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ後期初乳添加飼料で飼育したマウスのアレルギー関連因子に及ぼす影響2011
- Author(s)
  遠見和幸,清水努,内田健志,為定誠,下里剛士,大谷元
- Organizer
  第60回北信越畜産学会大会
- Place of Presentation
  長野
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-cancer Drug In Human Lung Cancer Cells2011
- Author(s)
  Takahashi R, Sato S, Miyazawa N, Klinman DM, Shimosato T, Hayashi M, Yamamoto M, Tomaru K, Tsukahara T, Kaneko T, Ishigatsubo Y
- Organizer
  American Thoracic Society Annual Meeting 2011
- Place of Presentation
  Denver, CO, USA
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Streptococcus thermophilus由来オリゴヌクレオチド刺激によるIL-33の断片化解析2011
- Author(s)
  下里剛士, 伊藤雄亮, 遠野雅徳, 大谷元, 北澤春樹
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  青森県十和田市北里大学十和田キャンパス
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] αS1カゼインを発現するLactococcus lactis組み換え体の構築2011
- Author(s)
  下里剛士,重盛駿,大谷元
- Organizer
  平成23年度日本酪農科学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 腸管免疫系におけるイムノバイオティック乳酸菌によるNLRP3受容体の発現増強2011
- Author(s)
  遠野雅徳,下里剛士,麻生久,北澤春樹
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  十和田
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 生体防御に関わるペプチドグリカン認識タンパク質ファミリーの腸管における発現解析2011
- Author(s)
  遠野雅徳,植田渉,島津朋之,下里剛士,麻生久,北澤春樹
- Organizer
  平成23年度日本酪農科学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Streptococcus thermophilus由来オリゴヌクレオチド刺激によるIL-33の断片化解析2011
- Author(s)
  下里剛士,伊藤雄亮,遠野雅徳,大谷元,北澤春樹
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  十和田
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ後期初乳および常乳のマウスI型アレルギーに及ぼす影響2011
- Author(s)
  遠見和幸,清水努,内田健志,為定誠,下里剛士,大谷元
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  十和田
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] プルーン果実の免疫調節機能の探索2011
- Author(s)
  宮下亮二,唐澤幸司,下里剛士,大谷元
- Organizer
  2011年度日本栄養食糧学会大会講演要旨
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] CpG oligodeoxynucleotides promote wound healing in airway epithelial cells2011
- Author(s)
  Sato T, Miyazawa N, Klinman DM, Shimosato T, Takahashi R, Tsukahara T, Hayashi M, Yamamoto M, Tomaru K, Kaneko T, Ishigatsubo Y
- Organizer
  American Thoracic Society Annual Meeting 2011
- Place of Presentation
  Denver, CO, USA
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ビール酵母とそれに特異的な牛乳IgGのマウスI型アレルギーに及ぼす影響2011
- Author(s)
  森崎健太郎,下里剛士,大谷元
- Organizer
  第60回北信越畜産学会大会
- Place of Presentation
  長野
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ腸管上皮細胞による抗ウィルス性イムノバイオティクスの評価系構築2011
- Author(s)
  千葉絵里子,細矢翔一,高梨直也,下里剛士,遠野雅徳,麻生久,川井泰,齋藤忠夫,北澤春樹
- Organizer
  平成23年度日本酪農科学シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ウシ腸管上皮細胞による抗ウイルス性イムノバイオティクスの評価系構築2011
- Author(s)
  千葉絵里子,細矢翔一,高梨直也,下里剛士,遠野雅徳,麻生久,川井泰,齋藤忠夫,北澤春樹
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  十和田
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Toll-like receptor 4 recognizes extracellular polysaccharide from Lactococcus lactis subsp. cremoris2011
- Author(s)
  Tohno M, Shimosato T, Aso H, Kitazawa H
- Organizer
  4th congress of european microbiologists FEMS 2011
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] The novel immunostimulatory activities of CpG oligodeoxynucleotides from Streptococcus thermophilus2010
- Author(s)
  Shimosato T, Fujimoto M, Tohno M, SatoT, Otani H, Kitazawa H
- Organizer
  ADSA-PSA-AMPA-CSAS-ASAS Joint annual meeting
- Place of Presentation
  CO, USA.
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 乳酸菌由来CpG DNAによるToll様受容体9を介するIL-33の発現増強2010
- Author(s)
  下里剛士,遠野雅徳,大谷元,北澤春樹
- Organizer
  日本食品免疫学会第6回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Evaluation of Anti-Inflammatory Immunobiotics in Porcine Intesinal Epithelial Cells2010
- Author(s)
  Kitazawa H, Shimazu T, Tohno M, Villena J, Hosoya S, Fujie H, Suda Y, Shimosato T, Aso H, Makino S, Ikegami S, Kawai Y, Saito T
- Organizer
  International Scientific Conference on Probiotics and Prebiotics-IPC2010
- Place of Presentation
  Kosice, Slovakia
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Effect of immunobiotics on the immune performance and productivity of pigs2010
- Author(s)
  Suda Y, Takahashi Y, Tohno M, Villena Julio, Hosoya S, Fujie H, Shimosato T, Kobashi J, Ishida M, Aso H, Kawai Y, Saito T, Makino S, Ikegami S, Kitazawa H
- Organizer
  International Scientific Conference on Probiotics and Prebiotics-IPC2010
- Place of Presentation
  Kosice, Slovakia
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] 乳酸菌由来CpG DNAによるToll様受容体9を介するIL-33の発現増強2010
- Author(s)
  下里剛士
- Organizer
  日本食品免疫学会第6回学術大会
- Place of Presentation
  東京大学安田講堂
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ビール酵母とその牛乳IgGの急性毒性に関する検討2010
- Author(s)
  須賀正喜, 荻田佑, 下里剛士, 大谷元
- Organizer
  日本畜産学会第112回大会
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] Streptococcus thermophilus由来DNAによる抗炎症免疫応答の誘導2010
- Author(s)
  下里剛士, 藤本恵, 遠野雅徳, 大谷元, 北澤春樹
- Organizer
  日本畜産学会第112回大会
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide2010
- Author(s)
  Sato T, Shimosato T, Klinman DM
- Organizer
  97th AAI Annual Meeting, IMMUNOLOGY 2010
- Place of Presentation
  Baltimore, MD, USA
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] Streptococcusthermophilus由来CpG DNAが誘導するIL-33の機能性解析2010
- Author(s)
  下里剛士,畑野木の実,藤本恵,遠野雅徳,大谷元,北澤春樹
- Organizer
  平成22年度日本酪農科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-22780239
[Presentation] ブタ腸管上皮細胞におけるイムノバイオティクスの抗炎症機構2009
- Author(s)
  島津朋之, 遠野雅徳, 下里剛士, 麻生久, 川井泰, 齋藤忠夫, 北澤春樹
- Organizer
  日本畜産学会第110回大会
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] Streptococcus thermophilus lacZからの強免疫刺激性DNAモチーフの発見2009
- Author(s)
  下里剛士, 遠野雅徳, 西村順子, 川井泰, 齋藤忠夫, 北澤春樹
- Organizer
  日本畜産学会第110回大会
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] ブタNOD1および2を介する可溶性ペプチドグリカンフラグメントの免疫刺激活性とそのリガンド構造特性2009
- Author(s)
  遠野雅徳, 島津朋之, 下里剛士, 麻生久, 齋藤忠夫, 北澤春樹
- Organizer
  日本畜産学会第110回大会
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] Streptococcus thermophilus由来DNA刺激によるサイトカイン遺伝子の発現特性2009
- Author(s)
  下里剛士, 舘尾万里子, 遠野雅徳, 大谷元, 北澤春樹
- Organizer
  日本畜産学会第111回大会
- Year and Date
  2009-09-27
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] βラクトグロブリン遺伝子をコードしたDNAワクチンの構築とその機能解析2009
- Author(s)
  下里剛士, 藤本恵, 大谷元, 北澤春樹
- Organizer
  平成21年度日本酪農科学シンポジウム
- Year and Date
  2009-08-31
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] プロバイオティック乳酸菌由来ATオリゴヌクレオチドの2次構造特性とTLR9結合領域の解明2008
- Author(s)
  下里剛士
- Organizer
  日本食品免疫学会第4回学術大会
- Place of Presentation
  東京
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] プロバイオティック乳酸菌由来ATオリゴヌクレオチドの2次構造特性とTLR9結合領域の解明2008
- Author(s)
  下里剛士, 遠野雅徳, 川井泰, 齋藤忠夫, 北澤春樹
- Organizer
  日本食品免疫学会第4回学術集会
- Year and Date
  2008-05-13
- Data Source
  KAKENHI-PROJECT-20780238
[Presentation] 乳酸菌由来CpGオリゴ核酸カプセルの経口投与によるアトピー性皮膚炎症状に及ぼす影響
- Author(s)
  下里剛士，王叶沁，重盛駿，大谷元
- Organizer
  日本畜産学会第117回大会
- Place of Presentation
  新潟大学五十嵐キャンパス
- Data Source
  KAKENHI-PROJECT-24580388
[Presentation] 乳酸菌由来オリゴ核酸のナノ粒子包摂体を用いた経口デリバリーシステムの構築
- Author(s)
  WANG YEQIN, 重盛駿，大谷元, 下里剛士
- Organizer
  日本畜産学会第118回大会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-24580388

1. SATO Takashi (70510436)

# of Collaborated Projects: 7 results

# of Collaborated Products: 36 results
2. 荻田佑 (50738010)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. 重盛駿 (90803487)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. YONEKURA Shinichi (40443113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 渡邉敬文 (50598216)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 生井楓 (60893857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. 木下英樹 (50533288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. Klinman Dennis

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. VANDENHEUVEL DIETER

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 齋藤忠夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
11. 麻生久

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. 北澤春樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 川井泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shimosato Takeshi 下里 剛士

SHIMOSATO Takeshi 下里 剛士

Research Projects

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Co-Researchers

肉用鶏由来プロバイオティクスによるカンピロバクター増殖・定着阻害機構の解明Principal Investigator

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GAPDH及び膜小胞（MVs）に着目した乳酸菌の腸内定住戦略解明と抗炎症剤への応用

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Development of genetically modified lactococcus lactis-based mucosal vaccines/drugs for COVID-19

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Development of smart lactic acid bacteriaPrincipal Investigator

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The Optimization of Oral Lactobacillus Oligodeoxynucleotide Microparticles and the Elucidation of Immune Regulation Mechanisms via Intestinal EpitheliumPrincipal Investigator

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Innovative therapy for lung cancer: prophylaxis and therapy by intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment

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Development of innovative delivery systems of biologics to the lung

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Development of genetic tools for the annotation in LactobacillusPrincipal Investigator

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Study on the immune mechanism using oral nanocapsule with oligodeoxynucleotides from lactic acid bacteriaPrincipal Investigator

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Study of nanoparticles-incorporating immune modulating oligodeoxynucleotide for the treatment of lung diseases

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Development for novel food and feed using DNA Nanocapsules of Lactic acid bacteria as Oral Delivery DevicesPrincipal Investigator

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Development of functional foods and feeds using probiotic lactic acid bacteria DNAPrincipal Investigator

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Study on the anti-allergic DNA vaccines with nanoparticle in gut mucosal immune systemPrincipal Investigator

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Shimosato Takeshi 下里剛士

SHIMOSATO Takeshi 下里剛士