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Kojima Karin  小島 華林

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小島 華林  コジマ カリン

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Researcher Number 00468331
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2022 – 2023: 自治医科大学, 医学部, 准教授
2016 – 2021: 自治医科大学, 医学部, 講師
2015: 自治医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics
Keywords
Principal Investigator
遺伝子治療 / MECP2 / AAV / Rett症候群 / 大脳皮質オルガノイド / AAVベクター / 小児神経 / CRSPR-dCas / Gaucher病 / iPS … More / スクリーニング / AADC欠損症 / micro RNA / 発現調整 / microRNA / small RNA / miRNA / シナプス機能 / SCTR / 自閉性障害 / シナプスバランス / ノックインマウス / CADM1 / ER stress / 小胞体ストレス / 自閉症スペクトラム障害 Less
  • Research Projects

    (4 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (1 People)
  •  Rett症候群・MECP2重複症候群に対する発現量調整可能なAAV遺伝子治療開発Principal Investigator

    • Principal Investigator
      小島 華林
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jichi Medical University
  •  Research on the Development of Gene Therapy for Neurological Diseases Using AAV Vectors and Small RNAsPrincipal Investigator

    • Principal Investigator
      Kojima Karin
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jichi Medical University
  •  Development of Gene Therapy for Pediatric Neurological Diseases Using Adeno-Associated Virus VectorsPrincipal Investigator

    • Principal Investigator
      Kojima Karin
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jichi Medical University
  •  Analysis of the influence of autism spectrum disorder related gene mutations on synaptic function and endoplasmic reticulum stressPrincipal Investigator

    • Principal Investigator
      Kojima Karin
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jichi Medical University

All 2022 2021 2020 2019 2018 2017 2015

All Journal Article Presentation

  • [Journal Article] The ATRX splicing variant c.21-1G>A is asymptomatic2022

    • Author(s)
      Kojima Karin、Wada Takahito、Shimbo Hiroko、Ikeda Takahiro、Jimbo Eriko F.、Saitsu Hirotomo、Matsumoto Naomichi、Yamagata Takanori
    • Journal Title

      Human Genome Variation

      Volume: 9 Issue: 1 Pages: 33-33

    • DOI

      10.1038/s41439-022-00212-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08258, KAKENHI-PROJECT-18KK0465
  • [Journal Article] 芳香族Lアミノ酸脱炭酸酵素(AADC)欠損症診断のための乾燥血液濾紙によるスクリーニング検査法と血漿 AADC酵素活性測定系の開発.2021

    • Author(s)
      渡邉知佳, 小島華林, 黒川愛恵・他
    • Journal Title

      日本マススクリーニング学会誌

      Volume: 31 Pages: 27-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Journal Article] 【小児遺伝子疾患事典】代謝疾患 DDC(関連疾患:芳香族L-アミノ酸脱炭酸酵素<AADC>欠損症).2021

    • Author(s)
      小島華林
    • Journal Title

      小児科診療

      Volume: 84 Pages: 1520-1523

    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Journal Article] 芳香族Lアミノ酸脱炭酸酵素(AADC)欠損症診断のための乾燥血液濾紙によるスクリーニング検査法と血漿AADC酵素活性測定系の開発.2021

    • Author(s)
      渡邉知佳, 小島華林, 黒川愛恵・他
    • Journal Title

      日本マススクリーニング学会誌

      Volume: 31 Pages: 27-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18KK0465
  • [Journal Article] 【小児遺伝子疾患事典】代謝疾患 DDC(関連疾患:芳香族L-アミノ酸脱炭酸酵素<AADC>欠損症).2021

    • Author(s)
      小島華林
    • Journal Title

      小児科診療

      Volume: 84 Pages: 1520-1523

    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0465
  • [Journal Article] MiR-302 Regulates Glycolysis to Control Cell-Cycle during Neural Tube Closure2020

    • Author(s)
      Keuls Rachel A.、Kojima Karin、Lozzi Brittney、Steele John W.、Chen Qiuying、Gross Steven S.、 Finnell Richard H.、Parchem Ronald J.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 20 Pages: 7534-7534

    • DOI

      10.3390/ijms21207534

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15685, KAKENHI-PROJECT-18KK0465
  • [Journal Article] Gene therapy improves motor and mental function of aromatic l-amino acid decarboxylase deficiency2019

    • Author(s)
      Karin Kojima Takeshi Nakajima Naoyuki Taga Akihiko Miyauchi Mitsuhiro Kato Ayumi Matsumoto Takahiro Ikeda Kazuyuki Nakamura Tetsuo Kubota Hiroaki Mizukami Sayaka Ono Yoshiyuki Onuki Toshihiko Sato Hitoshi Osaka Shin-ichi Muramatsu Takanori Yamagata
    • Journal Title

      Brain

      Volume: 142 Issue: 2 Pages: 322-333

    • DOI

      10.1093/brain/awy331

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] Gene therapy for aromatic L-amino acid decarboxylase deficiency in Japan improved the motor and mental function of patients with various phenotypes.2022

    • Author(s)
      Karin Kojima
    • Organizer
      12th International Collaborative Forum of Human Gene Therapy for Genetic Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18KK0465
  • [Presentation] Gene therapy for aromatic L-amino acid decarboxylase deficiency in Japan improved the motor and mental function of patients with various phenotypes.2022

    • Author(s)
      Karin Kojima
    • Organizer
      12th International Collaborative Forum of Human Gene Therapy for Genetic Diseases
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] AADC欠損症遺伝子治療の長期効果2022

    • Author(s)
      小島 華林、宮内 彰彦、池田 尚広、黒川 愛恵、大貫 良幸、中嶋 剛、平井 真洋、村松 一洋、小坂 仁、村松 慎一、山形 崇倫
    • Organizer
      第64回日本小児神経学会学術集会
    • Data Source
      KAKENHI-PROJECT-18KK0465
  • [Presentation] AADC欠損症に対する遺伝子治療の効果: 運動・認知機能の改善.2018

    • Author(s)
      小島華林、平井 真洋、中嶋 剛、多賀直行、宮内彰彦、小坂 仁、村松慎一、山形崇倫
    • Organizer
      第33回日本大脳基底核研究会:シンポジウム.
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] Gene therapy for AADC deficiency, AADC 欠損症に対する遺伝子治療臨床研究の成果と他疾患への応用.2018

    • Author(s)
      小島 華林、山形 崇倫.
    • Organizer
      第60回日本小児神経学会学術集会:シンポジウム.
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] Gene therapy for child neurological diseases: Effective for AADC deficiency, new challenges for Glut1-deficiency syndrome and potential for other diseases.2018

    • Author(s)
      Karin Kojima, Takanori Yamagata.
    • Organizer
      The 24th Annual Meeting of the American Society of gene and cell therapy (JSGCT2018): Symposium.
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] Improvement of Motor and Cognitive Function by Gene Therapy for Patients with AADC Deficiency2018

    • Author(s)
      Karin Kojima, Takeshi Nakajima, Naoyuki Taga, Hitoshi Osaka, Shin-ichi Muramatsu, Takanori Yamagata
    • Organizer
      American society of gene and cell therapy the 21st annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K15685
  • [Presentation] CADM1 mutation knock-in mice as mice model of ASD showing abnormal excitatory-inhibitory synaptic balance.2017

    • Author(s)
      Karin Kojima, Eriko F. Jimbo, Takanori Yamagata, Takashi Momoi, Mariko Y. Momoi
    • Organizer
      International Society for Autism Research 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19628
  • [Presentation] Relationship Between ASD Candidate Gene Mutations And Endoplasmic Reticulum Stress2015

    • Author(s)
      Karin Kojima, Eriko F. Jimbo, Takanori Yamagata
    • Organizer
      13th Asian and Oceania Congress of Child Neurology 2015 (AOCCN 2015)
    • Place of Presentation
      Taipei International Convention Center
    • Year and Date
      2015-05-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19628
  • 1.  山形 崇倫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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