UI Ayako 宇井彩子

Researcher Number	00469967
Other IDs
Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 東北大学, 加齢医学研究所, 准教授 2016 – 2018: 東京工科大学, 応用生物学部, 准教授 2014 – 2015: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 2012 – 2013: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Tumor biology and related fields / Risk sciences of radiation and chemicals / Risk sciences of radiation/Chemicals Except Principal Investigator Basic Section 63020:Radiation influence-related
Keywords	Principal Investigator がん / 転写 / ATM / DSB修復 / ＤＮＡ修復 / ユビキチン / PRC1 / DSB / ゲノム安定性 / Polycomb … More / MLLT1 / ENL / ポリコーム / DNA修復 / DNA二本鎖修復 / 癌治療 / 細胞がん化 / SWi/SNF / SWI/SNF / AMPK2 / クロマチンリモデリング / LKB1 … More Except Principal Investigator 相同組換 / 相同染色体 / CRISPR/Cas9 / 相同組換え / 遺伝子治療 / 複製 / 相同染色体間組換 / ニック / ゲノム編集 / DNA1本鎖切断 / ユビキチン化 / DNA損傷応答 / RNF8 / ユビキチン / DNA修復 / DNA修復選択 / PARP阻害剤 / DNA損傷 / DNA2本鎖切断 Less

Mechanism for Multiplex Nicks-induced interhomolog homologous recombination
- Principal Investigator
  
  中田慎一郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Osaka University
Elucidation of Ubiquitin-Dependent DNA Damage Response as the Core Mechanism for Double-Strand Break Repair
- Principal Investigator
  
  Shinichiro Nakada
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Osaka University
Investigation of the mechanism underlying the association between DSB repair and TranscriptionPrincipal Investigator
- Principal Investigator
  
  UI Ayako
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Tumor biology and related fields
- Research Institution
  Tokyo University of Technology
Function of MLL fusion partner ENL in DSB repairPrincipal Investigator
- Principal Investigator
  
  UI Ayako
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Tokyo University of Technology
  St. Marianna University School of Medicine
LKB1-AMPK2 signaling promotes non-homologous end joining by regulating SWI/SNF chromatin remodelingPrincipal Investigator
- Principal Investigator
  
  UI Ayako
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites2018
- Author(s)
  Yasuda Takeshi、Kagawa Wataru、Tajima Katsushi
- Journal Title
  
  PLOS Genetics
  
  Volume: 14 Issue: 3 Pages: 1007277-1007277
- DOI
  10.1371/journal.pgen.1007277
- NAID
  120006459820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10376, KAKENHI-PROJECT-15H05333, KAKENHI-PROJECT-26281026, KAKENHI-PUBLICLY-16H01316, KAKENHI-PROJECT-17H00783, KAKENHI-PROJECT-15K14953, KAKENHI-PROJECT-17K16332, KAKENHI-PROJECT-18J13707, KAKENHI-PROJECT-16K10377, KAKENHI-PROJECT-17K19615, KAKENHI-PROJECT-15H04646, KAKENHI-PROJECT-17H01877
[Journal Article] Nucleosome remodelling, DNA repair and transcriptional regulation build negative feedback loops in cancer and cellular ageing2017
- Author(s)
  Watanabe Reiko、Kanno Shin-ichiro、Mohammadi Roushandeh Amaneh、Ui Ayako、Yasui Akira
- Journal Title
  
  Philos Trans R Soc Lond B Biol Sci
  
  Volume: 372 Issue: 1731 Pages: 0473-0473
- DOI
  10.1098/rstb.2016.0473
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19615, KAKENHI-PROJECT-15H01737
[Journal Article] Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair2017
- Author(s)
  Niida, H., Matsunuma, R., Horiguchi, R., Uchida, C., Nakazawa, Y., Motegi, A., Nishimoto, K., Sakai, S., Ohhata, T., Kitagawa, K., Moriwaki, S., Nishitani, H., Ui, A., Ogi, T. and Kitagawa, M.
- Journal Title
  
  Nature Communications
  
  Volume: 8 Issue: 1 Pages: 16102-16102
- DOI
  10.1038/ncomms16102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06994, KAKENHI-PROJECT-16K08580, KAKENHI-PROJECT-17K00548, KAKENHI-PROJECT-17K19615
[Journal Article] Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity2016
- Author(s)
  Ui A and Yasui A
- Journal Title
  
  Nucleus
  
  Volume: 7 Issue: 2 Pages: 138-145
- DOI
  10.1080/19491034.2016.1177681
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H01737, KAKENHI-PROJECT-26740016
[Journal Article] Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair2015
- Author(s)
  Ui A, Nagaura Y, Yasui A
- Journal Title
  
  Molecular Cell
  
  Volume: ５８ Issue: 3 Pages: 468-482
- DOI
  10.1016/j.molcel.2015.03.023
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26740016, KAKENHI-PROJECT-15H01737
[Journal Article] Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair2015
- Author(s)
  Ayako Ui, Yuko Nagaura, Akira Yasui
- Journal Title
  
  Molecular Cell
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26740016
[Journal Article] Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice2014
- Author(s)
  Kato K, Nakajima K, Ui A, Muto-Terao Y, Ogiwara H, Nakada S
- Journal Title
  
  Mol Cell
  
  Volume: 53(4) Issue: 4 Pages: 617-30
- DOI
  10.1016/j.molcel.2014.01.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300358, KAKENHI-PROJECT-23310040, KAKENHI-PROJECT-24710057, KAKENHI-PUBLICLY-25131708, KAKENHI-PROJECT-26830122
[Journal Article] Possible involvement of LKB1-AMPK signaling in non-homologous end joining.2014
- Author(s)
  Ui A, Ogiwara H, Nakajima S, Kanno S-I, Watanabe R, Harata M, Okayama H, Harris CC, Yokota J, Yasui A and Kohno T
- Journal Title
  
  Oncogene
  
  Volume: 33 Issue: 13 Pages: 1640-1648
- DOI
  10.1038/onc.2013.125
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131005, KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23510059, KAKENHI-PROJECT-23658281, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-24380183, KAKENHI-PROJECT-24710057, KAKENHI-PLANNED-25116009, KAKENHI-PUBLICLY-25118503, KAKENHI-PUBLICLY-25125703, KAKENHI-PROJECT-25660286, KAKENHI-PROJECT-26830122
[Journal Article] クロマチンリモデリングとDNA二重鎖切断・細胞がん化2013
- Author(s)
  宇井彩子
- Journal Title
  
  放射線生物研究
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24710057
[Journal Article] Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.2013
- Author(s)
  Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T
- Journal Title
  
  Carcinogenesis
  
  Volume: 34 Issue: 11 Pages: 2486-2497
- DOI
  10.1093/carcin/bgt240
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131006, KAKENHI-PROJECT-23701110, KAKENHI-PROJECT-24310037, KAKENHI-PROJECT-24710057, KAKENHI-PROJECT-25701005
[Presentation] DSB修復におけるヒストンメチル化H3K4の機能2018
- Author(s)
  宇井彩子
- Organizer
  日本遺伝学会　ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17K19615
[Presentation] DSBシグナル伝達と修復におけるヒストン修飾因子とクロマチンリモデリング複合体の機能解析2018
- Author(s)
  宇井彩子
- Organizer
  日本放射線影響学会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K19615
[Presentation] DSBシグナル伝達と修復におけるPRC1とヒストンユビキチン化に関する分子機能解析2018
- Author(s)
  宇井彩子
- Organizer
  日本分子生物学会　ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-17K19615
[Presentation] 新規Ubiquitin E3-ligaseのDSB修復を介した染色体安定機構2017
- Author(s)
  宇井彩子
- Organizer
  染色体ワークショップ
- Place of Presentation
  かずさアカデミアホール(千葉県木更津市)
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ゲノム安定性におけるDSB修復と蛋白質恒常性維持機構の共役2017
- Author(s)
  宇井彩子
- Organizer
  DNA損傷応答ワークショップ
- Data Source
  KAKENHI-PROJECT-17K19615
[Presentation] DSB修復に関与する新規Ubiquitin E3-ligaseの機能解析2016
- Author(s)
  宇井彩子
- Organizer
  パシフィコ横浜（神奈川県横浜市）
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATMによる転写とDSB修復の制御2016
- Author(s)
  宇井彩子
- Organizer
  染色体ワークショップ
- Place of Presentation
  宮城県仙台市　松島一の坊
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] エストロゲン依存的なユビキチン化制御機構の解2016
- Author(s)
  宇井彩子
- Organizer
  第2回Neo Vitamin D Workshop 学術集会
- Place of Presentation
  TKPガーデンシティ品川（東京都品川区）
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATMによる転写とDSB修復の制御2016
- Author(s)
  宇井彩子
- Organizer
  転写サイクル「冬の若手ワークショップ2016」
- Place of Presentation
  山梨県南都留郡　ホテルマウント富士入口
- Year and Date
  2016-02-04
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] DNA損傷修復と転写の共役機構と染色体安定性2016
- Author(s)
  宇井彩子
- Organizer
  第9回Symphony
- Place of Presentation
  ホテルメトロポリタンエドモンド(東京都千代田区）
- Year and Date
  2016-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] DSB修復に関与する新規Ubiquitin E3-ligaseの機能解析2016
- Author(s)
  宇井彩子
- Organizer
  生物ゲノム安定維持の分子機構
- Place of Presentation
  国立遺伝学研究所（静岡県三島市）
- Year and Date
  2016-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] Chromatin remodeling complexes belonging to ISWI and SWI/SNF families cooperatively promote DSB repair to prevent genome instability.2016
- Author(s)
  宇井彩子
- Organizer
  3R symposium
- Place of Presentation
  ホテル一畑（島根県松江市）
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ユビキチンを介したDSB依存的な転写と修復の共役機構2015
- Author(s)
  宇井彩子
- Organizer
  新学術領域研究領域「ユビキチンネオバイオロジー」平成27年度領域班会議
- Place of Presentation
  千葉県南房総市　富浦ロイヤルホテル
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] DSB修復と転写におけるヒストン修飾とクロマチンリモデリング2015
- Author(s)
  宇井彩子
- Organizer
  遺伝研研究会
- Place of Presentation
  静岡県三島市　国立遺伝研究所
- Year and Date
  2015-10-01
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATMは転写部位の近傍でDSBが生じると、転写促進因子のENLをリン酸化して、転写抑制因子のポリコームを呼び込み、転写を抑制する2015
- Author(s)
  宇井彩子
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市　ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATMによる転写とDSB修復の制御2015
- Author(s)
  宇井彩子
- Organizer
  放射線医学総合研究所セミナー
- Place of Presentation
  千葉県千葉市　放射線医学総合研究所
- Year and Date
  2015-12-18
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] Phosphorylation of transcriptional elongation factor ENL by ATM turns off the transcription by recruiting Polycomb for DSB repair2015
- Author(s)
  Ayako Ui
- Organizer
  第74回日本癌学会
- Place of Presentation
  愛知県名古屋市　名古屋国際会議場
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATMは転写因子をリン酸化し、制御することにより、転写を抑制し、DSB修復を促進する2015
- Author(s)
  宇井彩子
- Organizer
  第23回DNA複製・組換え・修復ワークショップ
- Place of Presentation
  静岡県焼津市　焼津グランドホテル
- Year and Date
  2015-10-19
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] DNA二重鎖切断修復と転写におけるMLL融合遺伝子、ENLの機能2013
- Author(s)
  宇井彩子
- Organizer
  遺伝研研究会
- Place of Presentation
  三島
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] ENL, partner of MLL, has novel functions that regulate chromatin modifications and remodeling, and promotes DSB repair2013
- Author(s)
  Ayako Ui, Reiko Watanabe, Mikiko Hoshi, Shinichiro Kanno, Akira Yasui
- Organizer
  Ｋｅｙｓｔｏｎｅ　Ｓｙｍｐｏｓｉａｓ　2013
- Place of Presentation
  カナダ、バンフ
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] MLL融合遺伝子ENLは転写抑制とDSB修復の制御に関与する2013
- Author(s)
  宇井彩子
- Organizer
  3R
- Place of Presentation
  仙台秋保
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] MLL融合遺伝子ENLは転写抑制とDSB修復の制御に関与する2013
- Author(s)
  宇井彩子
- Organizer
  染色体ワークショップ
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] DNA修復とクロマチンリモデリング2013
- Author(s)
  宇井彩子
- Organizer
  第二回DNA損傷応答ワークショップ
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] DSB修復とクロマチンリモデリング2013
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  第二回DNA損傷応答ワークショップ
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] Mixed lineage leukemia (MLL) 融合遺伝子ENL (MLLT1)は、転写抑制とDSB修復の制御に関与する2013
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  染色体ワークショップ
- Place of Presentation
  箱根
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] Mixed lineage leukemia (MLL) 融合遺伝子ENL (MLLT1)は、転写抑制とDSB修復の制御に関与する2013
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  3R
- Place of Presentation
  仙台秋保
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] DNA二重鎖切断修復・クロマチンリモデリングにおける、白血病MLL融合遺伝子、ENLの新規機能2012
- Author(s)
  宇井彩子、渡邉怜子、保志美季子、菅野新一郎、安井明
- Organizer
  分子生物学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] ENL, partner of MLL, has novel functions that regulate chromatin modifications and remodeling, and promotes DSB repair.2012
- Author(s)
  Ayako Ui, Reiko Watanabe, Mikiko Hoshi, Shinichiro Kanno, Akira Yasui
- Organizer
  3R; The 8th 3R Symposium
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] ENL, partner of MLL, has novel functions that regulate chromatin modifications and remodeling, and promotes DSB repair.2012
- Author(s)
  Ayako Ui, Reiko Watanabe, Mikiko Hoshi, Shinichiro Kanno, Akira Yasui
- Organizer
  28th RBC-NIRS INTERNATIONAL SYMPOSIUM; Radiation-associated Repair Proteins and DNA Repair Network
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24710057
[Presentation] ATMは、転写因子ENL/MLLT1とPolycombに作用して、DSB近傍の転写とDSB修復を制御する
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  染色体ワークショップ
- Place of Presentation
  安芸グランドホテル　（広島県　廿日市市）
- Year and Date
  2014-12-15 – 2014-12-17
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] ATM は転写因子Polycomb とENL/MLT1 に作用してDSB 近傍の転写とDSB 修復を制御する
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  遺伝研集会
- Place of Presentation
  国立遺伝研究所（静岡県　三島市）
- Year and Date
  2014-11-06 – 2014-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-26740016
[Presentation] DSBに応答して、ENL/MLLT1はPolycombと共に転写の抑制を制御する
- Author(s)
  宇井彩子、永浦裕子、安井明
- Organizer
  分子生物学会
- Place of Presentation
  パシフィコ横浜　（神奈川県　横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26740016

1. Shinichiro Nakada (70548528)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Kitagawa Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 安井明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 荻原秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 河野隆志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 安田武嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 田嶋克史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 北川恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UI Ayako 宇井 彩子

Research Projects

Research Products

Co-Researchers

Mechanism for Multiplex Nicks-induced interhomolog homologous recombination

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Ubiquitin-Dependent DNA Damage Response as the Core Mechanism for Double-Strand Break Repair

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the mechanism underlying the association between DSB repair and TranscriptionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Function of MLL fusion partner ENL in DSB repairPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

LKB1-AMPK2 signaling promotes non-homologous end joining by regulating SWI/SNF chromatin remodelingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Nucleosome remodelling, DNA repair and transcriptional regulation build negative feedback loops in cancer and cellular ageing2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair2017

Author(s)

Journal Title

DOI

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[Journal Article] Collaboration of MLLT1/ENL, Polycomb and ATM for transcription and genome integrity2016

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[Journal Article] Transcriptional elongation factor ENL phosphorylated by ATM recruits polycomb and switches off transcription for DSB repair2015

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[Journal Article] Transcriptional Elongation Factor ENL Phosphorylated by ATM Recruits Polycomb and Switches Off Transcription for DSB Repair2015

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[Journal Article] Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice2014

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[Journal Article] Possible involvement of LKB1-AMPK signaling in non-homologous end joining.2014

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[Journal Article] クロマチンリモデリングとDNA二重鎖切断・細胞がん化2013

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[Journal Article] Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor.2013

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UI Ayako 宇井彩子