Nokihara Hiroshi 軒原浩

Researcher Number	00505919
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療センター, 医長
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人国立国際医療研究センター, センター病院, 呼吸器内科医長 2019 – 2021: 徳島大学, 大学院医歯薬学研究部(医学域), 准教授
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 間質性肺炎 / 非小細胞肺癌 / PD-L1抗体 / 血管新生阻害薬 / CXCLケモカイン / 薬剤耐性 / ケモカイン / 免疫チェックポイント / 血管新生 / 線維細胞 … More Except Principal Investigator … More 樹状細胞 / 骨髄由来抑制細胞 / 線維細胞 / がん免疫療法 / 肺がん Less

Development of biomarkers related to drug resistance of angiogenesis inhibitorsPrincipal Investigator
- Principal Investigator
  
  Nokihara Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  National Center for Global Health and Medicine
  The University of Tokushima
Development of novel combination immunotherapy against lung cancer and mesothelioma: establishment of immunological basis for clinic
- Principal Investigator
  
  NISHIOKA Yasuhiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  The University of Tokushima

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade2023
- Author(s)
  Mitsuhashi Atsushi、Koyama Kazuya、Ogino Hirokazu、Afroj Tania、Nguyen Na Thi、Yoneda Hiroto、Otsuka Kenji、Sugimoto Masamichi、Kondoh Osamu、Nokihara Hiroshi、Hanibuchi Masaki、Takizawa Hiromitsu、Shinohara Tsutomu、Nishioka Yasuhiko
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 3 Pages: 112162-112162
- DOI
  10.1016/j.celrep.2023.112162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08542, KAKENHI-PROJECT-23K24340, KAKENHI-PROJECT-22K16302
[Journal Article] Efficacy and safety of second‐line chemotherapy for patients with advanced non‐small cell lung cancer complicated by interstitial lung disease2022
- Author(s)
  Otsuka Kenji、Nokihara Hiroshi、Mitsuhashi Atsushi、Ozaki Ryohiko、Yabuki Yohei、Yoneda Hiroto、Ogino Hirokazu、Nishioka Yasuhiko
- Journal Title
  
  Thoracic Cancer
  
  Volume: 13 Issue: 21 Pages: 2978-2984
- DOI
  10.1111/1759-7714.14645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08542
[Journal Article] Radiation-associated Angiosarcoma Presenting as Massive Pleural Effusion2022
- Author(s)
  Ogino Hirokazu, Tobiume Makoto, Kagawa Kozo, Kawano Hiroshi, Sakaguchi Satoshi, Saijo Atsuro, Matsumoto Daisuke, Takizawa Hiromitsu, Morikawa Yuriko, Bando Yoshimi, Goto Hisatsugu, Nokihara Hiroshi, Nishioka Yasuhiko
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 9 Pages: 1393-1397
- DOI
  10.2169/internalmedicine.8195-21
- NAID
  130008103336
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-05-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] S‐1 eliminates <scp>MDSCs</scp> and enhances the efficacy of <scp>PD</scp> ‐1 blockade via regulation of tumor‐derived Bv8 and <scp>S100A8</scp> in thoracic tumor2022
- Author(s)
  Nguyen Na T.、Mitsuhashi Atsushi、Ogino Hirokazu、Kozai Hiroyuki、Yoneda Hiroto、Afroj Tania、Sato Seidai、Nokihara Hiroshi、Shinohara Tsutomu、Nishioka Yasuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 2 Pages: 384-398
- DOI
  10.1111/cas.15620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08542, KAKENHI-PROJECT-23K24340
[Journal Article] Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma2021
- Author(s)
  Yoneda Hiroto, Nokihara Hiroshi, Mitsuhashi Atsushi, Ozaki Ryohiko, Yabuki Yohei, Ogino Hirokazu, Otsuka Kenji, Nishioka Yasuhiko
- Journal Title
  
  BMC Pulmonary Medicine
  
  Volume: 21 Issue: 1
- DOI
  10.1186/s12890-021-01746-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes2021
- Author(s)
  Afroj Tania、Mitsuhashi Atsushi、Ogino Hirokazu、Saijo Atsuro、Otsuka Kenji、Yoneda Hiroto、Tobiume Makoto、Nguyen Na Thi、Goto Hisatsugu、Koyama Kazuya、Sugimoto Masamichi、Kondoh Osamu、Nokihara Hiroshi、Nishioka Yasuhiko
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 6 Pages: 1204-1214
- DOI
  10.4049/jimmunol.2000909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] Multidisciplinary treatment of skeletal muscle metastasis from lung cancer: A case of triceps muscle metastasis of lung squamous cell cancer2021
- Author(s)
  Haji Keiko, Sato Seidai, Yoneda Hiroto, Nisisho Toshihiko, Nokihara Hiroshi, Nishioka Yasuhiko
- Journal Title
  
  Respiratory Medicine Case Reports
  
  Volume: 33 Pages: 101470-101470
- DOI
  10.1016/j.rmcr.2021.101470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] Programmed death (PD)‐1/PD‐ligand 1 blockade mediates antiangiogenic effects by tumor‐derived CXCL10/11 as a potential predictive biomarker2021
- Author(s)
  Mitsuhashi Atsushi、Kondoh Kensuke、Horikawa Kazuki、Koyama Kazuya、Nguyen Na Thi、Afroj Tania、Yoneda Hiroto、Otsuka Kenji、Ogino Hirokazu、Nokihara Hiroshi、Shinohara Tsutomu、Nishioka Yasuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 12 Pages: 4853-4866
- DOI
  10.1111/cas.15161
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05415, KAKENHI-PROJECT-19H03668, KAKENHI-PROJECT-20K08542, KAKENHI-PROJECT-21K15488
[Journal Article] 間質性肺炎合併非小細胞肺癌の治療戦略2020
- Author(s)
  軒原浩、西岡安彦
- Journal Title
  
  肺癌
  
  Volume: 60 Pages: 74-80
- NAID
  130007840510
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] Paclitaxel for relapsed small-cell lung cancer patients with idiopathic interstitial pneumonias.2019
- Author(s)
  Atsuro Saijo, Masaki Hanibuchi, Hirokazu Ogino, Kenji Otsuka, Hisatsugu Goto, Hiroshi Nokihara, Yasuhiko Nishioka
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 10 Pages: 541-546
- DOI
  10.3892/mco.2019.1828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-19H03668
[Journal Article] The clinical features of older patients with lung cancer in comparison with their younger counterparts2019
- Author(s)
  Ogino Hirokazu、Hanibuchi Masaki、Sakaguchi Satoshi、Toyoda Yuko、Tezuka Toshifumi、Kawano Hiroshi、Kakiuchi Soji、Otsuka Kenji、Saijo Atsuro、Azuma Masahiko、Nokihara Hiroshi、Goto Hisatsugu、Nishioka Yasuhiko
- Journal Title
  
  Respiratory Investigation
  
  Volume: 57 Issue: 1 Pages: 40-48
- DOI
  10.1016/j.resinv.2018.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] 免疫チェックポイント阻害薬の効果を増強する併用療法2019
- Author(s)
  三橋　惇志、軒原　浩
- Journal Title
  
  分子呼吸器病
  
  Volume: 23 Pages: 49-53
- Data Source
  KAKENHI-PROJECT-19H03668
[Journal Article] Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA2019
- Author(s)
  Hanibuchi Masaki、Kanoh Akira、Kuramoto Takuya、Saito Tatsuro、Tobiume Makoto、Saijo Atsuro、Kozai Hiroyuki、Kondo Mayo、Morizumi Shun、Yoneda Hiroto、Kagawa Kozo、Ogino Hirokazu、Sato Seidai、Kawano Hiroshi、Otsuka Kenji、Toyoda Yuko、Nokihara Hiroshi、Goto Hisatsugu、Nishioka Yasuhiko
- Journal Title
  
  Oncotarget
  
  Volume: 10 Issue: 38 Pages: 3654-3666
- DOI
  10.18632/oncotarget.26951
- NAID
  120007120175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] The examination of the second-line chemotherapy in SCLC patients with interstitial lung disease2022
- Author(s)
  Ryohiko Ozaki, Hiroshi Nokihara, Youhei Yabuki, Atsushi Mitsuhashi, Hiroto Yoneda, Kenji Otsuka, Hirokazu Ogino, Yasuhiko Nishioka
- Organizer
  ERS International Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08542
[Presentation] Second-line chemotherapy for extensive-disease small cell lung cancer with interstitial lung disease2022
- Author(s)
  Ryohiko Ozaki, Hiroshi Nokihara, Yohei Yabuki, Atsushi Mitsuhashi, Hiroto Yoneda, Kenji Otsuka, Hirokazu Ogino, Yasuhiko Nishioka
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] PD-1/PD-L1 blockade mediates antiangiogenic effects by tumorderived CXCL10/11 as a potential predictive biomarker2022
- Author(s)
  Atsushi Mitsuhashi, Hirokazu Ogino, Hiroshi Nokihara, Yasuhika Nishioka
- Organizer
  第81回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08542
[Presentation] 免疫チェックポイント阻害薬および血管新生阻害薬併用療法におけるfibrocyteの役割2021
- Author(s)
  三橋惇志, 荻野広和, 西條敦郎，大塚憲司, 杉本正道，軒原浩, 西岡安彦
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] S-1 reduces myeloid-derived suppressor cells in murine mesothelioma model and enhances the anti-tumor activity of anti-PD-1 antibody.2021
- Author(s)
  Thi Na Nguyen, Atsushi Mitsuhashi, Hirokazu Ogino, Hiroyuki Kozai, Hiroto Yoneda, Tania Afroj, Kenji Otsuka, Hiroshi Nokihara, Yasuhiko Nishioka
- Organizer
  APSR 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] Antigen-presenting capacity of fibrocytes and its regulation by anti-PD-1/PD-L1 antibodies2021
- Author(s)
  Hirokazu Ogino, Tania Afroj, Atsushi Mitsuhashi, Atsuro Saijo, Kenji Otsuka, Hiroto Yoneda, Na Thi Nguyen, Kazuya Koyama, Masamichi Sugimoto, Osamu Kondoh, Hiroshi Nokihara, Yasuhiko Nishioka
- Organizer
  APSR 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 抗PD-1/PD-L1抗体による腫瘍血管新生抑制メカニズムの解析と治療効果予測バイオマーカーとしての応用2021
- Author(s)
  三橋惇志, Tania Afroj, Nguyen Thi Na, 荻野広和, 米田浩人, 大塚憲司, 軒原浩, 西岡安彦
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 肺がん肝転移におけるspheroid形成がん幹細胞様分画の役割2021
- Author(s)
  三橋惇志, 荻野広和, 米田浩人, 大塚憲司, 軒原浩, 西岡安彦
- Organizer
  第30回日本がん転移学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] Association of immune-related adverse events with therapeutic response to Nivolumab in patients with malignant pleural mesothelioma2021
- Author(s)
  Hiroto Yoneda, Hiroshi Nokihara, Atsushi Mitsuhashi, Ryohiko Ozaki, Yohei Yabuki, Hirokazu Ogino, Kenji Otsuka, Yasuhiko Nishioka
- Organizer
  APSR 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 抗PD-1/PD-L1抗体による血管新生制御メカニズムの解析と治療効果予測バイオマーカーとしての応用2021
- Author(s)
  三橋惇志, 荻野広和, 米田浩人, 大塚憲司, 軒原浩, 西岡安彦
- Organizer
  第62回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] TS-1による腫瘍関連骨髄由来抑制細胞の制御を介した免疫チェックポイント阻害剤との併用効果の検討2021
- Author(s)
  Nguyen Thi Na, 三橋惇志, 香西博之, 米田浩人, Tania Afroj, 大塚憲司, 軒原浩, 西岡安彦
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 進展型小細胞肺癌における予後規定因子2021
- Author(s)
  大塚憲司, 三橋惇志, 尾崎領彦, 矢葺洋平, 米田浩人, 荻野広和, 軒原浩, 竹内栄治, 杉浦八十生, 知花賢治, 田村厚久, 安宅信二, 西岡安彦
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 悪性胸膜中皮腫患者におけるニボルマブの免疫関連有害事象と治療効果の相関性2021
- Author(s)
  米田浩人, 軒原浩, 三橋惇志, 尾崎領彦, 矢葺洋平, 荻野広和, 大塚憲司, 西岡安彦
- Organizer
  第59回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 進展型小細胞肺癌の予後規定因子の検討2020
- Author(s)
  大塚憲司、三橋惇志、米田浩人、軒原浩、竹内栄治、知花賢治、安宅信二、田村厚久、西岡安彦
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 免疫チェックポイント阻害薬および血管新生阻害薬併用療法における腫瘍内 fibrocyte-like cell の機能解析2020
- Author(s)
  三橋惇志、Tania Afroj、荻野広和、Nguyen Thi Na、米田浩人、香西博之、大塚憲司、杉本正道、根東攝、軒原浩、西岡安彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 肺癌において細胞障害性抗癌剤が免疫原性細胞死に与える影響についての検討2020
- Author(s)
  香西博之、三橋惇志、Nguyen Thi Na、Tania Afroj、米田浩人、大塚憲司、軒原浩、西岡安彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 非小細胞肺癌における免疫チェックポイント阻害剤の予後予測因子の検討2020
- Author(s)
  近藤健介、軒原浩、三橋惇志、米田浩人、香西博之、大塚憲司、西岡安彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 腫瘍免疫における線維細胞の免疫調節機能の検討2020
- Author(s)
  Tania Afroj、荻野広和、三橋惇志、米田浩人、香西博之、大塚憲司、軒原浩、安倍正博、西岡安彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] マウス中皮腫細胞株皮下移植モデルにおける細胞障害性抗癌剤の腫瘍関連骨髄由来抑制細胞への影響2020
- Author(s)
  Nguyen Thi Na、三橋惇志、Tania Afroj、米田浩人、香西博之、大塚憲司、軒原浩、西岡安彦
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 細胞障害性抗がん剤による腫瘍免疫原性細胞死誘導能の検討2020
- Author(s)
  香西博之、三橋惇志、米田浩人、大塚憲司、軒原浩、西岡安彦
- Organizer
  第58回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] ペメトレキセド投与後の皮疹に対する低用量デキサメタゾン予防効果の検討2020
- Author(s)
  三橋惇志、櫻田巧、合田光寬、座間味義人、米田浩人、大塚憲司、軒原浩、石澤啓介、西岡安彦
- Organizer
  第61回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] The role of fibrocyte-like cells in combination treatment of immune checkpoint inhibitor with antiangiogenic agents2020
- Author(s)
  Atsushi Mitsuhashi、Tania Afroj、Atsuro Saijo、Kenji Otsuka、Hiroto Yoneda、Kazuya Koyama、Masamichi Sugimoto、Osamu Kondoh、Hiroshi Nokihara、Yasuhiko Nishioka
- Organizer
  ERS International Congress 2020 Virtual
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03668
[Presentation] 免疫チェックポイント阻害薬および血管新生阻害薬による複合がん免疫療法における腫瘍内fibrocytelike cellの機能解析2019
- Author(s)
  三橋　惇志、荻野　広和、木宿　昌俊、大塚　憲司、軒原　浩、西岡　安彦
- Organizer
  第32回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-19H03668

1. 三橋惇志 (00833732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
2. NISHIOKA Yasuhiko (70274199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 28 results
3. 佐藤正大 (80530899)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 大塚憲司 (70776856)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. GOTO Hisatsugu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. HORIKAWA Kazuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 埴淵昌毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 荻野広和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 西條敦郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nokihara Hiroshi 軒原 浩

Research Projects

Research Products

Co-Researchers

Development of biomarkers related to drug resistance of angiogenesis inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel combination immunotherapy against lung cancer and mesothelioma: establishment of immunological basis for clinic

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy and safety of second‐line chemotherapy for patients with advanced non‐small cell lung cancer complicated by interstitial lung disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiation-associated Angiosarcoma Presenting as Massive Pleural Effusion2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] S‐1 eliminates <scp>MDSCs</scp> and enhances the efficacy of <scp>PD</scp> ‐1 blockade via regulation of tumor‐derived Bv8 and <scp>S100A8</scp> in thoracic tumor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correlation between immune-related adverse events and therapeutic effects of nivolumab in patients with malignant pleural mesothelioma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blockade of PD-1/PD-L1 Pathway Enhances the Antigen-Presenting Capacity of Fibrocytes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Multidisciplinary treatment of skeletal muscle metastasis from lung cancer: A case of triceps muscle metastasis of lung squamous cell cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Programmed death (PD)‐1/PD‐ligand 1 blockade mediates antiangiogenic effects by tumor‐derived CXCL10/11 as a potential predictive biomarker2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 間質性肺炎合併非小細胞肺癌の治療戦略2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Paclitaxel for relapsed small-cell lung cancer patients with idiopathic interstitial pneumonias.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The clinical features of older patients with lung cancer in comparison with their younger counterparts2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 免疫チェックポイント阻害薬の効果を増強する併用療法2019

Author(s)

Journal Title

Data Source

[Journal Article] Development, validation, and comparison of gene analysis methods for detecting EGFR mutation from non-small cell lung cancer patients-derived circulating free DNA2019

Nokihara Hiroshi 軒原浩