Hegab Ahmed ヒガブ中井アハマド

… Alternative Names

Hegab Ahmed E ヒガブ中井アハマド

HEGAB Ahmed ヒガブアハマド

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Researcher Number	00507915
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 総合教育センター, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2022: 慶應義塾大学, 医学部(信濃町), 共同研究員 2016 – 2020: 慶應義塾大学, 医学部(信濃町), 特任講師 2015: 慶應義塾大学, 医学部, 講師 2013 – 2015: 慶應義塾大学, 医学部, 特任講師 2008 – 2009: Tohoku University, 大学院・医学系研究科, 産学官連携研究員
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 53030:Respiratory medicine-related / Applied pharmacology Except Principal Investigator Respiratory organ internal medicine
Keywords	Principal Investigator lung stem cells / Calorie restriction / mitochondria / lung / alveolar type-2 cells / fibrosis / fatty a. oxidation / Alveolar type-2 cells / bronchioalveolar cells / Fibrosis … More / Fatty acids / High fat diet / high fat diet / lung fibrosis / 分子細胞呼吸器学 / 呼吸器内科学 / 内科 / rachea stem cells / Aging / colony-forming assay / calorie restriction / aging / stem cells / stem cell / aldehyde / ALDH2 / 自然気胸 / 肺線維症 / COPD / 細胞培養 / 肺細胞 / 呼吸器病学 … More Except Principal Investigator マクロファージ / 線維芽細胞増殖因子 / FGF / 肺癌 / stem cell / ニッチ / 線維芽細胞 / 肺上皮幹細胞 / 再生医療 Less

The interaction between High Fat Diet, lung stem cells, and lung fibrosisPrincipal Investigator
- Principal Investigator
  
  Hegab Ahmed E
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Keio University
Aging deteriorates the function of lung stem cells, but it can be restored by calorie restriction.Principal Investigator
- Principal Investigator
  
  Hegab Ahmed E
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Approaches to mimic lung tissue stem cell nichies
- Principal Investigator
  
  Betsuyaku Tomoko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
肺癌における線維芽細胞増殖因子の多機能性とその制御に向けた新展開
- Principal Investigator
  
  別役智子
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
Characterization of the role of aldehyde dehydrogensase-2 (ALDH2) and the effect of its human mutant allele (ALDH2*2) on airway stem cells function and predisposition to lung diseasesPrincipal Investigator
- Principal Investigator
  
  Hegab Ahmed
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Keio University
ヒト疾患肺細胞を用いた創薬システムの開発Principal Investigator
- Principal Investigator
  
  HEGAB Ahmed
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Applied pharmacology
- Research Institution
  Tohoku University

All 2022 2021 2019 2018 2017 2016 2015 2014 2013 2008

All Journal Article Presentation

[Journal Article] Effect of High Fat Diet on the Severity and Repair of Lung Fibrosis in Mice2022
- Author(s)
  Hegab Ahmed E.、Ozaki Mari、Kagawa Shizuko、Fukunaga Koichi
- Journal Title
  
  Stem Cells and Development
  
  Volume: 30 Issue: 18 Pages: 908-921
- DOI
  10.1089/scd.2021.0050
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08548
[Journal Article] Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes2019
- Author(s)
  Hegab Ahmed E.、Ozaki Mari、Meligy Fatma Y.、Nishino Makoto、Kagawa Shizuko、Ishii Makoto、Betsuyaku Tomoko
- Journal Title
  
  Journal of Tissue Engineering and Regenerative Medicine
  
  Volume: 13 Issue: 2 Pages: 295-308
- DOI
  10.1002/term.2792
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09666, KAKENHI-PROJECT-18K19566
[Journal Article] Intermittent Exposure to Cigarette　Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous　Exposure.2018
- Author(s)
  Kameyama N, Chubachi S, Hegab AE, Yasuda H, Kagawa S, Tsutsumi A, Fukunaga K, Shimoda M, Kanai Y, Soejima K, Betsuyaku T.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: Epub ahead of print Issue: 2 Pages: 179-188
- DOI
  10.1165/rcmb.2017-0375oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09667, KAKENHI-PROJECT-15H04833, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-17K16063
[Journal Article] Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.2018
- Author(s)
  Hegab AE, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, Soejima K, Yin Y, Kinoshita T, Yaguchi T, Kawakami Y, Ornitz DM, Betsuyaku T.
- Journal Title
  
  Lung Cancer.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04833
[Journal Article] Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer.2016
- Author(s)
  Hegab AE, Kameyama N, Kuroda A, Kagawa S, Yin Y, Ornitz D, Betsuyaku T.
- Journal Title
  
  J Vis Exp
  
  Volume: 20 Issue: 111 Pages: 111-111
- DOI
  10.3791/53904
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04833, KAKENHI-PROJECT-15K15323
[Journal Article] Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior2015
- Author(s)
  Hegab AE, Arai D, Gao J, Kuroda A, Yasuda H, Ishii M, Naoki K, Soejima K, Betsuyaku T
- Journal Title
  
  Stem Cell Res
  
  Volume: 15 Issue: 1 Pages: 109-121
- DOI
  10.1016/j.scr.2015.05.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15K15323, KAKENHI-PROJECT-15H04833
[Journal Article] Characterization of the cell of origin　and propagation potential of the fibroblast growth factor 9-induced mouse model　of lung adenocarcinoma2014
- Author(s)
  Arai D, Hegab AE, Soejima K, Kuroda A, Ishioka K, Yasuda H, Naoki K, KagawaS, Hamamoto J, Yin Y, Ornitz DM, Betsuyaku T S,
- Journal Title
  
  J Pathol
  
  Volume: 235 Issue: 4 Pages: 593-605
- DOI
  10.1002/path.4486
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23390218, KAKENHI-PROJECT-15K09229, KAKENHI-PROJECT-15H04833
[Journal Article] Lung Natural Killer Cells Play a Major Counter-Regulatory Role in Pulmonary Vascular Hyperpermeability After Myocardial Infarction.2013
- Author(s)
  Yan X, Hegab AE, Endo J, Anzai A, Matsuhashi T, Katsumata Y, Ito K, Yamamoto T, Betsuyaku T, Shinmura K, Shen W, Vivier E, Fukuda K, Sano M.
- Journal Title
  
  Circ Res
  
  Volume: 114(4) Pages: 637-649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461196
[Journal Article] Intranasal HGF administration ameliorates the physiologic and morphologic changes in lung emphysema2008
- Author(s)
  Hegab AE, et.al.
- Journal Title
  
  Mol. Ther 16
  
  Pages: 1417-1426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890015
[Presentation] Enhanced fatty-acid oxidation slows the contribution of AT2 stem cells in the lung repair process after a fibrosis-inducing injury2022
- Author(s)
  Ahmed E Hegab
- Organizer
  American Thoracic Society annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08548
[Presentation] Enhanced fatty-acid oxidation slows the contribution of AT2 stem cells in the lung repair process after a fibrosis-inducing injury2022
- Author(s)
  Ahmed E Hegab
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology (APSR 2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08548
[Presentation] Effect of high fat diet on the severity and repair of lung fibrosis in mice2021
- Author(s)
  Ahmed E. hegab
- Organizer
  The 25th Congress of the Asian Pacific Society of Respirology (APSR 2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08548
[Presentation] Effect of diet on lung stem and epithelial cells, and its interaction with aging2019
- Author(s)
  Hegab AE
- Organizer
  日本呼吸器内科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] Calorie Restriction Can Reverse Several Of The Aging, And HFD-Induced Changes, In Lung Epithelial Stem Cells2019
- Author(s)
  Ahmed E Hegab
- Organizer
  The 60th Annual Meeting of the Japanese Respiratory Society, April 2019
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] Calorie restriction can reverse several of the aging and HFD-induced changes in lung epithelial stem cells2019
- Author(s)
  Ahmed E Hegab
- Organizer
  The 17th Annual Meeting of the International Society for Stem cells Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] EFFECT OF DIET ON LUNG STEM AND EPITHELIAL CELLS, AND ITS INTERACTION WITH AGING2019
- Author(s)
  Ahmed E Hegab
- Organizer
  The 60th Annual Meeting of the Japanese Respiratory Society
- Invited
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] The influence of intermittent smoking exposure for the lung tumorigenesis in the murine model2018
- Author(s)
  Naofumi Kameyama1, Shotaro Chubachi1, Hidehiro Irie1, Akihiro Tsutsumi1, Hiroyuki Yasuda1, Ichiro Kawada1, Ahmed Hegab1, Masahiro Shimoda2, Tomoko Betsuyaku1
- Organizer
  American Thoracic Soceity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04833
[Presentation] Effect of caalorie restriction on lung epithelial stem cells and its interaction with aging2017
- Author(s)
  ヒガブ　アハマド
- Organizer
  呼吸器内科学会
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] Effect of caalorie restriction on lung epithelial stem cells and its interaction with aging2017
- Author(s)
  ヒガブ　アハマド
- Organizer
  アメリカ呼吸器内科学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09666
[Presentation] Dependence of lung epithelial stem cell proliferation and differentiation on fibroblast-specific FGF2 signaling2016
- Author(s)
  Mari Ozaki, Ahmed E. Hegab, Robert D. Guzy, David M. Ornitz, Tomoko Betsuyaku
- Organizer
  American Thoracic Society annual meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04833
[Presentation] Characterizing the role of immune cells in the FGF9-induced lung adenocarcinoma mouse model2016
- Author(s)
  Ahmed E. Hegab, Tomonari Kinoshita, Tomonori Yaguchi, Yutaka Kawakami, Tomoko Betsuyaku
- Organizer
  American Thoracic Society annual meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04833
[Presentation] Dependence of lung epithelial stem cell proliferation and differentiation on fibroblast-specific FGF2 signaling2016
- Author(s)
  Mari Ozaki, Ahmed E. Hegab, Robert D. Guzy, David M. Ornitz, Tomoko Betsuyaku
- Organizer
  American Thoracic Society annual meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15323
[Presentation] Effects of fibroblast growth factor (FGF) 9 on mouse tracheal stem cells2013
- Author(s)
  Hegab AE
- Organizer
  The 11th Annual Meeting of the International Society for Stem cells Research (ISSCR); June 13-16 2013
- Place of Presentation
  ボストン（アメリカ）
- Data Source
  KAKENHI-PROJECT-25461196
[Presentation] Effects of fibroblast growth factor (FGF) 9 on mouse tracheal stem cells2013
- Author(s)
  Hegab AE
- Organizer
  The Annual International Conference of the American Thoracic Society (ATS)
- Place of Presentation
  フィラデルフィア（アメリカ）
- Data Source
  KAKENHI-PROJECT-25461196
[Presentation] New Advances in lung stem cell and cancer stem cell fields.2013
- Author(s)
  Hegab AE4
- Organizer
  The 18th Congress of the Asian Pacific Society of Respirology (APSR)
- Place of Presentation
  横浜(パシフィコ横浜)
- Invited
- Data Source
  KAKENHI-PROJECT-25461196
[Presentation] Effects of fibroblast growth factor (FGF) 9 on mouse tracheal stem cells2013
- Author(s)
  Hegab AE
- Organizer
  The 54th Annual Meeting of the Japanese Respiratory Society (JRS)
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-25461196

1. Betsuyaku Tomoko (60333605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 副島研造 (30236145)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 安田浩之 (70365261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Hegab Ahmed ヒガブ中井 アハマド

Hegab Ahmed E ヒガブ中井 アハマド

HEGAB Ahmed ヒガブ アハマド

Research Projects

Research Products

Co-Researchers

The interaction between High Fat Diet, lung stem cells, and lung fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Aging deteriorates the function of lung stem cells, but it can be restored by calorie restriction.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Approaches to mimic lung tissue stem cell nichies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肺癌における線維芽細胞増殖因子の多機能性とその制御に向けた新展開

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Characterization of the role of aldehyde dehydrogensase-2 (ALDH2) and the effect of its human mutant allele (ALDH2*2) on airway stem cells function and predisposition to lung diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト疾患肺細胞を用いた創薬システムの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effect of High Fat Diet on the Severity and Repair of Lung Fibrosis in Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intermittent Exposure to Cigarette Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous Exposure.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms.2018

Author(s)

Journal Title

Data Source

[Journal Article] Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mimicking the niche of lung epithelial stem cells and characterization of several effectors of their in vitro behavior2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of the cell of origin and propagation potential of the fibroblast growth factor 9-induced mouse model of lung adenocarcinoma2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lung Natural Killer Cells Play a Major Counter-Regulatory Role in Pulmonary Vascular Hyperpermeability After Myocardial Infarction.2013

Author(s)

Journal Title

Data Source

Hegab Ahmed ヒガブ中井アハマド

Hegab Ahmed E ヒガブ中井アハマド

HEGAB Ahmed ヒガブアハマド

[Journal Article] Intermittent Exposure to Cigarette　Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous　Exposure.2018

[Journal Article] Characterization of the cell of origin　and propagation potential of the fibroblast growth factor 9-induced mouse model　of lung adenocarcinoma2014