Yasumi Takahiro 八角高裕

… Alternative Names

YASUMI Takahiro 八角高裕

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Researcher Number	00511891
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定教授
Affiliation (based on the past Project Information) *help	2024: 京都大学, 医学研究科, 特定教授 2021 – 2024: 京都大学, 医学研究科, 准教授 2016 – 2018: 京都大学, 医学研究科, 講師 2012 – 2016: 京都大学, 医学(系)研究科(研究院), 講師 2015: 京都大学, 大学院医学研究科発達小児科学, 講師 … More 2011 – 2014: 京都大学, 医学研究科, 講師 2012: 京都大学, 大学院・医学研究科, 講師 2010 – 2011: 京都大学, 医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 迅速診断 / 迅速診断法 / 原発性免疫不全症 / イメージング / 時空間ダイナミクス / pyrinインフラマソーム / 乾燥ろ紙血 / プロテオミクス / 乾燥ろ紙 / 発症前診断 … More / 新生児スクリーニング / 機能病態解析 / 病態解析 / 迅速スクリーニング / バイオマーカー検索 / 細胞ライブラリー / 機能解析系の確立 / 機能解析 / 分子病態解析 / 血球貪食性リンパ組織球症 / iPS細胞 / 家族性血球貪食症候群 / 家族性血球貪食性リンパ組織球症 … More Except Principal Investigator 自己炎症性疾患 / CAPS / インフラマソーム / iPS細胞 / 自然免疫 / NLRP3 / 全エクソーム解析 / 炎症 / 自己炎症疾患 / 軟骨細胞 / 次世代シークエンサー / モザイシズム / 新生児スクリーニング / プロテオーム解析 / 乾燥ろ紙血 / 病態解析 / 低分子蛍光センサー / 蛋白質会合蛍光センサー / MAFB / 遺伝子改変マウス / 遺伝子異常 / 遺伝性炎症性疾患 / NLRC4 / 遺伝子探索 / IFIH1 / deep intron変異 / PCYT1A / 原発性免疫不全症 / 炎症性疾患 / Aicardi-Goutieres症候群 / メバロン酸キナーゼ欠損症 / FLNA異常症 / NLRC4異常症 / 単球、マクロファージ / 単球・マクロファージ / 病態解明 / 細胞障害性T細胞 / NK細胞 / 血球貪食症候群 / FHL / 創薬基盤開発 / 機能解析 / 免疫調節異常症 / 血球貪食性リンパ組織球症 / 単細胞解析 / 軟骨分化 / 体細胞モザイク / 遺伝子診断 / 自己炎症 / ELISA / SOX9 / FilaminA / FilaminA異常症 / 不明熱 / 軟骨 / メンデル遺伝疾患 / 自己炎症性症候群 / mevalonate kinase / インフラマゾーム / 高IgD症候群 Less

時空間ダイナミクス・高次構造解析によるパイリンインフラマソーム活性化機構の解明Principal Investigator
- Principal Investigator
  
  八角高裕
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
Development of an automated method for extraction of comprehensive disease causing proteins from dried blood spots
- Principal Investigator
  
  中島大輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kazusa DNA Research Institute
Development of newborn screening method for primary immunodeficiency disorders using dried blood spot proteomicsPrincipal Investigator
- Principal Investigator
  
  Yasumi Takahiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyoto University
Elucidating the mechanism of NLRP3 inflammasome activation using fluorescence and light emission protein-interaction sensors
- Principal Investigator
  
  Heike Toshio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation
- Principal Investigator
  
  Ryuta Nishikomori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders
- Principal Investigator
  
  Heike Toshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishing an innovative platform for the analysis of hemophagocytic lymphohistiocytosisPrincipal Investigator
- Principal Investigator
  
  Yasumi Takahiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishing the research basis for innovative medical care of familial hemophagocytic lymphohistiocytosis.
- Principal Investigator
  
  HEIKE Toshio
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering
- Principal Investigator
  
  NISHIKOMORI Ryuta
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Analysis and development of medical treatment for autoinflammatory diseases
- Principal Investigator
  
  HEIKE TOSHIO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University
Establishing rapid diagnostic method and unraveling the pathogenesis offamilial hemophagocytic lymphohistiocytosisPrincipal Investigator
- Principal Investigator
  
  YASUMI Takahiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kyoto University

All 2024 2023 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Book

[Book] 自己炎症性疾患・自然免疫不全症とその周辺疾患2012
- Author(s)
  八角高裕
- Total Pages
  279
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-22591159
[Journal Article] Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq2017
- Author(s)
  Nakayama Manabu、Oda Hirotsugu、Nakagawa Kenji、Yasumi Takahiro、Kawai Tomoki、Izawa Kazushi、Nishikomori Ryuta、Heike Toshio、Ohara Osamu
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 9 Pages: 146-152
- DOI
  10.1016/j.bbrep.2016.12.002
- NAID
  120006355733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
[Journal Article] A CD57+ CTL degranulation assay effectively identifies familial hemophagocytic lymphohistiocytosis type 3 patients2017
- Author(s)
  Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, Eitaro Hiejima, Hirotsugu Oda, Kazushi Izawa, Tomoki Kawai, Masataka Ishimura, Naoko Nakano, Ryutaro Shirakawa, Ryuta Nishikomori, Hidetoshi Takada, Satoshi Morita, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, and Toshio Heike
- Journal Title
  
  Journal of Clinical Immunology
  
  Volume: 37 Issue: 1 Pages: 92-99
- DOI
  10.1007/s10875-016-0357-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-15K19623, KAKENHI-PROJECT-16K08574, KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-15K09655
[Journal Article] Fever of unknown origin with rashes in early infancy is indicative of adenosine deaminase type 2 deficiency2017
- Author(s)
  Nihira H、Nakagawa K、Izawa K、Kawai T、Yasumi T、Nishikomori R、Nambu M、Miyagawa-Hayashino A、Nomura T、Kabashima K、Ito M、Iwaki-Egawa S、Sasahara Y、Nakayama M、Heike T
- Journal Title
  
  Scandinavian Journal of Rheumatology
  
  Volume: 47 Issue: 2 Pages: 170-172
- DOI
  10.1080/03009742.2017.1324912
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
[Journal Article] Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway2015
- Author(s)
  Yokoyama, K. Ikeya, M. Umeda, K. Oda, H. Nodomi, S. Nasu, A. Matsumoto, Y. Izawa, K. Horigome, K. Kusaka, T. Tanaka, T. Saito, M. K. Yasumi, T. Nishikomori, R. Ohara, O. Nakayama, N. Nakahata, T. Heike, T. Toguchida, J.
- Journal Title
  
  Arthritis Rheumatol
  
  Volume: 67 Issue: 1 Pages: 302-314
- DOI
  10.1002/art.38912
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24591507, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-15K15549
[Journal Article] Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis2015
- Author(s)
  Yasumi T, Hori M, Hiejima E, Shibata H, Izawa K, Oda H, Yoshioka K, Nakagawa K, Kawai T, Nishikomori R, Ohara O, Heike T
- Journal Title
  
  British Journal of Haematology
  
  Volume: 170 Issue: 4 Pages: 532-538
- DOI
  10.1111/bjh.13461
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-25670475
[Journal Article] Heterogeneity of HLH pathophysiology and treatment strategies2015
- Author(s)
  八角高裕、柴田洋史、下寺佐栄子、平家俊男
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 56 Issue: 10 Pages: 2248-2257
- DOI
  10.11406/rinketsu.56.2248
- NAID
  130005103313
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-25670475
[Journal Article] Familial Hemophagocytic Lymphohistiocytosis Presenting as Hydrops Fetalis2015
- Author(s)
  Iwatani S, Uemura K, Mizobuchi M, Yoshimoto S, Kawasaki K, Kosaka Y, Hori M, Yasumi T, Nakao H
- Journal Title
  
  AM J Perinatol Rep
  
  Volume: 5 Issue: 01 Pages: e022-e024
- DOI
  10.1055/s-0034-1544110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461582
[Journal Article] 血球貪食性リンパ組織球症と免疫不全症2014
- Author(s)
  八角高裕
- Journal Title
  
  小児内科
  
  Volume: 46 Pages: 1513-1517
- Data Source
  KAKENHI-PROJECT-26461582
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2014
- Author(s)
  Nakagawa K, Kawai T, Umebayashi H, Takei S, Kobayashi N, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI et al.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: in press Issue: 3 Pages: 1-8
- DOI
  10.1136/annrheumdis-2013-204361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23249056, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590681, KAKENHI-PROJECT-25460838, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062
[Journal Article] Aicardi-Goutières syndrome is caused by IFIH1 mutations.2014
- Author(s)
  Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., Heike, T.
- Journal Title
  
  America Journal of Human Genetics
  
  Volume: 95 Issue: 1 Pages: 121-125
- DOI
  10.1016/j.ajhg.2014.06.007
- NAID
  120005460706
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25670474
[Journal Article] A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.2014
- Author(s)
  Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, Awaya T, Kawai T, Yasumi T, Toyoshima I, Hasegawa K, Ohshima Y, Hiragi T, Sasahara Y, Suzuki Y, Kikuchi M, Osaka H, Ohya T, Ninomiya S, Fujikawa S, Akasaka M, Iwata N, Kawakita A, Funatsuka M, Shintaku H, Ohara O, Ichinose H, Heike T.
- Journal Title
  
  Rheumatology
  
  Volume: 53 Issue: 3 Pages: 448-458
- DOI
  10.1093/rheumatology/ket372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2013
- Author(s)
  Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI
- Journal Title
  
  Ann Rheum Dis
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] 家族性血球貪食症候群のスクリーニング検査2013
- Author(s)
  八角高裕
- Journal Title
  
  血液フロンティア
  
  Volume: 23 Pages: 27-32
- Data Source
  KAKENHI-PROJECT-22591159
[Journal Article] Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell- free conditions.2013
- Author(s)
  Yanagimachi MD, Niwa A, Tanaka T, Ozaki F, Nishimoto S, Murata Y, Yasumi T, Ito J, Tomida S, Oshima K, Asaka I, Goto H, Heike T, Nakahata T, Saito MK
- Journal Title
  
  PLoS ONE
  
  Volume: 8(4) Issue: 4 Pages: e59243-e59243
- DOI
  10.1371/journal.pone.0059243
- NAID
  120005244458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22591159, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24659496, KAKENHI-PROJECT-24790997, KAKENHI-PROJECT-25461591
[Journal Article] Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99. 9% statistical confidence by massively parallel sequencing2012
- Author(s)
  Izawa K, Hijikata A, Tanaka N, Kawai T, Saito MK, Goldbach-Mansky R, Aksentijevich I, Yasumi T, Nakahata T, Heike T, Nishikomori R, Ohara O
- Journal Title
  
  DNA Res
  
  Volume: 19 Pages: 143-152
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with> 99. 9% Statistical Confidence by Massively Parallel Sequencing2012
- Author(s)
  Izawa, K., A. Hijikata, N. Tanaka, T. Kawai, M. K. Saito, R. Goldbach-Mansky, I. Aksentijevich, T. Yasumi, T. Nakahata, T. Heike, R. Nishikomori, and O. Ohara
- Journal Title
  
  DNA Res
  
  Volume: 19 Issue: 2 Pages: 143-52
- DOI
  10.1093/dnares/dsr047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390310, KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24659496
[Journal Article] Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis2012
- Author(s)
  Nishi M, Nishimura R, Suzuki N, Sawada A, Okamura T, Fujita N, Kanai R, Yano J, Adachi S, Yasumi T, Sato E, Yasutomo K, Ishii E, Ohga S
- Journal Title
  
  Am J Hematol
  
  Volume: 87(6):637-9 Issue: 6 Pages: 637-639
- DOI
  10.1002/ajh.23190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591159, KAKENHI-PROJECT-24591577
[Journal Article] Rapid diagnosis of familial hemophagocytic lymphohistiocytosis type 3 (FHL3) by flow cytometric detection of intraplatelet Munc 13-4 protein.2011
- Author(s)
  Murata Y., Yasumi T., Shirakawa R., Izawa K., Sakai H., Abe J., Tanaka N., Kawai T., Oshima K., Saito M., Nishikomori R., Ohara O.、Ishii E., Nakahata T., Horiuchi H., Heike T.
- Journal Title
  
  Blood
  
  Volume: 118 Issue: 5 Pages: 1225-1230
- DOI
  10.1182/blood-2011-01-329540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-22591159, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503
[Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011
- Author(s)
  Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Aróstegui JI, Yagüe J, Merino R, Ibañez M, Pontillo A, Takada H, Imagawa T, Kawai T, Yasumi T, Nakahata T, Heike T
- Journal Title
  
  International Multicenter Collaborative Study
  
  Volume: 63 Pages: 3625-3632
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011
- Author(s)
  Ohta H, Miyashita E, Hirata I, Matsumura R, Yoshida H, Hashii Y, Higashiura T, Yasumi T, Murata Y, Heike T, Yang X, Kanegane H, Ohara O, Ozono K
- Journal Title
  
  Int J Hematol
  
  Volume: 94(3):285-90 Issue: 3 Pages: 285-290
- DOI
  10.1007/s12185-011-0916-6
- NAID
  10029694397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591159
[Journal Article] Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation2011
- Author(s)
  Tahara M, Sakai H, Nishikomori R, Yasumi T, Heike T, Nagata I, Inui A, Fujisawa T, Shigematsu Y, Nishijima K, Kuwakado K, Watabe S, Kameyama J
- Journal Title
  
  Mod Rheumatol
  
  Volume: 21 Pages: 641-645
- NAID
  10030206205
- Data Source
  KAKENHI-PROJECT-23249056
[Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.2010
- Author(s)
  Nagai, N., Yamamoto, K., Fujiwara, H., An, J., Ochi, T., Suemori, K., Yasumi, T., Tauchi, H., Koh, K., Sato, M., Morimoto, A., Heike, T., Ishii, E., Yasukawa, M.
- Journal Title
  
  PloS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591159
[Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes2010
- Author(s)
  Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, Ishii E, Yasukawa M
- Journal Title
  
  PLoS One
  
  Volume: 5(11):e14173 Issue: 11 Pages: e14173-e14173
- DOI
  10.1371/journal.pone.0014173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] プロテオーム解析による新たな新生児スクリーニング法開発2024
- Author(s)
  八角高裕
- Organizer
  第7回日本免疫不全・自己炎症学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07795
[Presentation] ろ紙血プロテオームを用いた先天性免疫異常症に於ける新規バイオマーカー2023
- Author(s)
  仁平寛士，川島祐介，大西秀典，小原收，八角高裕，他
- Organizer
  第6回日本免疫不全・自己炎症学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K07795
[Presentation] PFAPAの臨床像で発症し、長期経過後に腸管炎症、陰部潰瘍を合併したため診断に至った孤発性のTNFA1P3異常症の1例2016
- Author(s)
  本田吉孝, 河合朋樹, 西小森隆太, 八角高裕, 井澤和司, 日衛嶋栄太郎, 中川権史, 柴田洋史, 下寺佐栄子, 大音泰介, 芝剛, 仁平寛士, 小田紘嗣, 小原收, 平家俊男
- Organizer
  小児リウマチ学会
- Place of Presentation
  千葉
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-15H04876
[Presentation] 家族性血球貪食症候群（FHL）3型における迅速診断系・機能解析系の確立2016
- Author(s)
  柴田洋史、八角高裕、日衛嶋栄太郎、中川権二、井澤和司、河合朋樹、小原收、平家俊男
- Organizer
  第44回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-26461582
[Presentation] 本邦でのメバロン酸キナーゼ欠損症のまとめ2016
- Author(s)
  田中孝之, 西小森隆太, 中川権史, 井澤和司, 河合朋樹, 八角高裕, 平家俊男
- Organizer
  日本リウマチ学会
- Place of Presentation
  横浜
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15H04876
[Presentation] HLH病態の多様性と治療戦略の展望2015
- Author(s)
  八角高裕
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ANAクラウンプラザホテル金沢
- Year and Date
  2015-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26461582
[Presentation] 本邦でのメバロン酸キナーゼ欠損症のまとめ2015
- Author(s)
  田中孝之, 吉岡耕平, 酒井秀政, 西小森隆太, 阿部純也, 日衛嶋栄太郎, 小原收, 河合朋樹, 八角高裕, 平家俊男
- Organizer
  日本小児リウマチ学会総会
- Place of Presentation
  金沢
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15H04876
[Presentation] CD57+ CTL degranulation and Munc13-4 protein expression assays are sensitive and reliable screening methods for FHL32015
- Author(s)
  Kikuya A, Hori M, Yasumi T, Hiejima E, Shibata H, Izawa K, Oda H, Nishikomori R, Ohara O, Heike T
- Organizer
  第11回アジア小児研究学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2015-04-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670475
[Presentation] Understanding the pathophysiology of NOMID arthropathy for drug discovery by iPSCs technology.2015
- Author(s)
  Nakagawa K., Okuno Y., Nishikomori R., Yokoyama K., Tanaka T., Kawai T., Yasumi T., Umeda K., Nakayama N., Toguchida J., Hagiwara M., Heike T.
- Organizer
  8th International Society of Systemic Autoinflammatory Diseases Meeting 2015 (2015)
- Place of Presentation
  Dresden, Germany
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04876
[Presentation] HLH病態の多様性と治療戦略の展望2015
- Author(s)
  八角高裕
- Organizer
  第77回日本血液学会
- Place of Presentation
  ANAクラウンプラザホテル金沢
- Year and Date
  2015-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25670475
[Presentation] Aicardi-Goutieres syndrome is caused by IFIH1 mutations2014
- Author(s)
  Oda, H. Nakagawa, K. Abe, J. Awaya, T. Funabiki, M. Hijikata, A. Nishikomori, R. Funatsuka, M. Ohshima, Y. Sugawara, Y. Yasumi, T. Kato, H. Shirai, T. Ohara, O. Fujita, T. Heike, T.
- Organizer
  American Society of Human Genetics
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-10-09
- Data Source
  KAKENHI-PROJECT-24390263
[Presentation] Late-onset FHL3: 2症例の検討2013
- Author(s)
  堀雅之、八角高裕
- Organizer
  第8回血球貪食症候群研究会
- Place of Presentation
  ベルサール八重洲
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] 一般検査から見たFHL/二次性HLHの特徴と病態の考察2013
- Author(s)
  八角高裕
- Organizer
  第8回血球貪食症候群研究会
- Place of Presentation
  ベルサール八重洲
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討2013
- Author(s)
  中川権史、西小森隆太、井澤和司、河合朋樹、八角高裕、河合利尚、梅林宏明、武井修治、小林法元、小原收、Eva Gonzalez-Roca、Juan I. Arostegui、平家俊男
- Organizer
  第23回日本小児リウマチ学会総会
- Place of Presentation
  大宮
- Data Source
  KAKENHI-PROJECT-24390263
[Presentation] 一般検査から見た FHL/二次性 HLH の特徴と病態の考察2013
- Author(s)
  八角高裕
- Organizer
  第8回血球貪食症候群研究会
- Place of Presentation
  東京
- Year and Date
  2013-03-16
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] 血球貪食性リンパ組織球症の病態解明に向けて2013
- Author(s)
  八角高裕
- Organizer
  第116回日本小児科学会学術集会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] Familial Hemophagocytic Lymphohistiocytosis may Present with Atypical Features in Adolescence and Adulthood2013
- Author(s)
  YASUMI T
- Organizer
  The 4thJSH International Symposium
- Place of Presentation
  Matsuyama
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] 血球貪食性リンパ組織球症の病態解明に向けて2013
- Author(s)
  八角高裕
- Organizer
  第116回日本小児科学会学術集会
- Place of Presentation
  広島市文化交流会館
- Invited
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] Diagnosing FHLs among HLHs: Current status and future direction2012
- Author(s)
  八角高裕
- Organizer
  第54回日本小児血液・がん学会
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] Cryopyrin-associated periodic syndromeの治療本邦におけるcanakinumab臨床試験及びアナキンラ疫学調査について2012
- Author(s)
  酉小森隆太、井澤和司、河合朋樹、八角高裕、平家俊男
- Organizer
  第40回日本臨床免疫学会
- Place of Presentation
  東京
- Year and Date
  2012-09-28
- Data Source
  KAKENHI-PROJECT-24390263
[Presentation] Current status and future direction2012
- Author(s)
  YASUMI T. Diagnosing FHLs among HLHs
- Organizer
  第54回日本小児血液・がん学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] フローサイトメトリーを用いた家族性血球貪食症候群Type3(FHL3)の迅速診断2010
- Author(s)
  八角高裕
- Organizer
  第113回日本小児科学会総会
- Place of Presentation
  岩手県民情報交流センター(盛岡)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22591159
[Presentation] 次世代シーケンサーを用いた“変異陰性TRAPS”における体細胞モザイクの検索
- Author(s)
  19.中川権史、西小森隆太、河合朋樹、八角高裕、平家俊男
- Organizer
  第117回日本小児科学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26253062
[Presentation] アナキンラをもちいて治療をおこなった高IgD症候群の2例
- Author(s)
  下寺佐栄子、西小森隆太、吉岡耕平、河合朋樹、八角高裕、平家俊男
- Organizer
  第24回小児リウマチ学会
- Place of Presentation
  仙台
- Year and Date
  2014-10-03 – 2014-10-05
- Data Source
  KAKENHI-PROJECT-24390263
[Presentation] 次世代シークエンサーを用いた“変異陰性TRAPS”における体細胞モザイクの検索
- Author(s)
  中川権史、西小森隆太、河合朋樹、八角高裕、平家俊男
- Organizer
  第117回日本小児科学会
- Place of Presentation
  名古屋
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-24390263
[Presentation] 当科におけるFHL(家族性血球貪食性リンパ組織球症)スクリーニングの現状
- Author(s)
  堀雅之、八角高裕、西小森隆太、平家俊男
- Organizer
  第117回日本小児科学会学術集会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-26461582

1. HEIKE Toshio (90190173)

# of Collaborated Projects: 8 results

# of Collaborated Products: 26 results
2. NISHIKOMORI Ryuta (70359800)

# of Collaborated Projects: 6 results

# of Collaborated Products: 20 results
3. OHARA Osamu (20370926)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
4. SAITO Megumu (90535486)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. TOGUCHIDA Junya (40273502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIMODERA Saeko

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. KAMBE Naotomo (50335254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. IZAWA Kazushi (90634931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. FUJITA Takashi (10156870)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KATO Hiroki (10597173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 河合朋樹 (20631568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 田口友彦 (10300881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中島大輔 (30370935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 川島祐介 (30588124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HORI Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. HIEJIMA Eitaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. SHIBATA Hirofumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. TANAKA Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. NAKAGAWA Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. HONDA Yoshitaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. OHTO Taisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. ODA Hirotsugu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. OSHIMA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. NIWA Akira

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 戸田口淳也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 中畑龍俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Yasumi Takahiro 八角 高裕

YASUMI Takahiro 八角 高裕

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時空間ダイナミクス・高次構造解析によるパイリンインフラマソーム活性化機構の解明Principal Investigator

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Development of an automated method for extraction of comprehensive disease causing proteins from dried blood spots

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Development of newborn screening method for primary immunodeficiency disorders using dried blood spot proteomicsPrincipal Investigator

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Elucidating the mechanism of NLRP3 inflammasome activation using fluorescence and light emission protein-interaction sensors

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Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation

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Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disorders

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Establishing an innovative platform for the analysis of hemophagocytic lymphohistiocytosisPrincipal Investigator

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Establishing the research basis for innovative medical care of familial hemophagocytic lymphohistiocytosis.

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Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering

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Analysis and development of medical treatment for autoinflammatory diseases

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Establishing rapid diagnostic method and unraveling the pathogenesis offamilial hemophagocytic lymphohistiocytosisPrincipal Investigator

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[Book] 自己炎症性疾患・自然免疫不全症とその周辺疾患2012

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[Journal Article] Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq2017

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Yasumi Takahiro 八角高裕

YASUMI Takahiro 八角高裕