Abe Yuichi 阿部雄一

Researcher Number	00529092
Other IDs
Affiliation (Current)	2025: 崇城大学, 生物生命学部, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 崇城大学, 生物生命学部, 准教授 2019 – 2021: 九州大学, 基幹教育院, 学術研究員 2017 – 2018: 九州大学, 生体防御医学研究所, 学術研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry
Keywords	Principal Investigator ペルオキシソーム / BDNF / 分裂異常 / 中枢神経 / メタボローム / 分裂障害 / Pex16 / グリア細胞 / 中枢神経系異常 / 生理活性脂質 … More / 大脳皮質 / NADH / グルタチオン / カタラーゼ / 記憶障害 / TrkB-T1 / Pex2 / 中枢神経系障害 / 還元化 / 海馬 / オルガネラ / 脳神経疾患 / 転写調節 / 代謝障害 / プルキンエ細胞 / 小脳 / ペルオキシソーム形成異常症 Less

ペルオキシソーム形成障害および形態形成異常が及ぼす中枢神経系障害の分子機構解明Principal Investigator
- Principal Investigator
  
  阿部雄一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Sojo University
Metabolic abnormality and pathogenesis of peroxisome biogenesis deficiencyPrincipal Investigator
- Principal Investigator
  
  Abe Yuichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyushu University
Defect of peroxisome metabolism impairs development of central nervous systemPrincipal Investigator
- Principal Investigator
  
  Abe Yuichi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases,2020
- Author(s)
  Abe, Y., Tamura, S., Honsho, M., and *Fujiki, Y.
- Publisher
  Springer Nature, Berlin Heidelberg New York.
- Data Source
  KAKENHI-PROJECT-19K07386
[Journal Article] Genetic defects in peroxisome morphogenesis (Pex11β, dynamin‐like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid‐phospholipid metabolism2023
- Author(s)
  Abe Yuichi、Wanders Ronald J. A.、Waterham Hans R.、Mandel Hanna、Falik‐Zaccai Tzipora C.、Ishihara Naotada、Fujiki Yukio
- Journal Title
  
  Journal of Inherited Metabolic Disease
  
  Volume: 46 Issue: 2 Pages: 273-285
- DOI
  10.1002/jimd.12582
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06912
[Journal Article] Recent advances in research on the dynamics and functional regulation of peroxisome2023
- Author(s)
  奥本寛治、阿部雄一、藤木幸夫
- Journal Title
  
  生化学
  
  Volume: 95 Issue: 6 Pages: 719-729
- DOI
  10.14952/SEIKAGAKU.2024.950719
- ISSN
  0037-1017
- Year and Date
  2023-12-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06912
[Journal Article] Alterations in ether lipid metabolism and the consequences for the mouse lipidome2023
- Author(s)
  Lackner Katharina、Sailer Sabrina、van Klinken Jan-Bert、Wever Eric、Pras-Raves Mia L.、Dane Adrie D.、Honsho Masanori、Abe Yuichi、Keller Markus A.、Golderer Georg、Werner-Felmayer Gabriele、Fujiki Yukio、Vaz Fr?d?ric M.、Werner Ernst R.、Watschinger Katrin
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1868 Issue: 4 Pages: 159285-159285
- DOI
  10.1016/j.bbalip.2023.159285
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06839, KAKENHI-PROJECT-22K06912
[Journal Article] Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders2022
- Author(s)
  Fujiki Yukio、Okumoto Kanji、Honsho Masanori、Abe Yuichi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1869 Issue: 11 Pages: 119330-119330
- DOI
  10.1016/j.bbamcr.2022.119330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06155, KAKENHI-PROJECT-21K06839, KAKENHI-PROJECT-22K06912
[Journal Article] <i>De novo</i> formation and maintenance of mammalian peroxisomes in the absence of PEX162022
- Author(s)
  Yagita Yuichi、Abe Yuichi、Fujiki Yukio
- Journal Title
  
  Journal of Cell Science
  
  Volume: -
- DOI
  10.1242/jcs.258377
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07386, KAKENHI-PROJECT-22K06912
[Journal Article] Identification of a Homozygous PEX26 Mutation in a Heimler Syndrome Patient2021
- Author(s)
  Kim Youn Jung、Abe Yuichi、Kim Young-Jae、Fujiki Yukio、Kim Jung-Wook
- Journal Title
  
  Genes
  
  Volume: 12 Issue: 5 Pages: 646-646
- DOI
  10.3390/genes12050646
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07386
[Journal Article] A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway2020
- Author(s)
  Abe Yuichi、Honsho Masanori、Kawaguchi Ryoko、Matsuzaki Takashi、Ichiki Yayoi、Fujitani Masashi、Fujiwara Kazushirou、Hirokane Masaaki、Oku Masahide、Sakai Yasuyoshi、Yamashita Toshihide、Fujiki Yukio
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: - Issue: 16 Pages: 5321-5334
- DOI
  10.1074/jbc.ra119.011989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07386, KAKENHI-PLANNED-19H05709, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K07337, KAKENHI-PROJECT-20K05838, KAKENHI-PROJECT-18K06474
[Journal Article] Recent insights into peroxisome biogenesis and associated diseases2020
- Author(s)
  *Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A.J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W.K., and Kuroiwa, T.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 133 Issue: 9 Pages: 236943-236943
- DOI
  10.1242/jcs.236943
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K07337, KAKENHI-PROJECT-19K06567, KAKENHI-PROJECT-19K07386, KAKENHI-PROJECT-20K06643, KAKENHI-PROJECT-19H03260
[Journal Article] Peroxisome deficiency impairs BDNF signaling and memory.2020
- Author(s)
  Abe, Y., Nishimura, Y., Nakamura, K., Tamura, S., Honsho, M., Udo, H., Yamashita, T., and Fujiki, Y.
- Journal Title
  
  Front. Cell Dev. Biol.
  
  Volume: 8 Pages: 567017-567017
- DOI
  10.3389/fcell.2020.567017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06567, KAKENHI-PROJECT-19K07386
[Journal Article] Mammalian Homologue NME3 of DYNAMO1 Regulates Peroxisome Division2020
- Author(s)
  Honsho Masanori、Abe Yuichi、Imoto Yuuta、Chang Zee-Fen、Mandel Hanna、Falik-Zaccai Tzipora C.、Fujiki Yukio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 21 Pages: 8040-8040
- DOI
  10.3390/ijms21218040
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07386
[Journal Article] A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.2019
- Author(s)
  Tanaka, A. J., Okumoto, K., Tamura, S., Abe, Y., Hirsch, Y., Deng, L., Ekstein, J., Chung, W. K., and Fujiki Y.
- Journal Title
  
  Cold Spring Harb. Mol. Case Stud.
  
  Volume: 5 Issue: 1 Pages: 1-16
- DOI
  10.1101/mcs.a003483
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07310, KAKENHI-INTERNATIONAL-15K21743, KAKENHI-PLANNED-26116007, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-16K07275, KAKENHI-PROJECT-17K15621, KAKENHI-PROJECT-19K06567
[Journal Article] Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum2019
- Author(s)
  Honsho Masanori、Dorninger Fabian、Abe Yuichi、Setoyama Daiki、Ohgi Ryohei、Uchiumi Takeshi、Kang Dongchon、Berger Johannes、Fujiki Yukio
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 166 Issue: 4 Pages: 353-361
- DOI
  10.1093/jb/mvz043
- NAID
  40022023663
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07386, KAKENHI-PROJECT-17H01550, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K07337, KAKENHI-INTERNATIONAL-15K21743
[Journal Article] Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of <i>Cyanidioschyzon merolae</i>2019
- Author(s)
  Imoto, Y., Abe, Y., Okumoto, K., Ohnuma, M., Kuroiwa, H., Kuroiwa, T., and Fujiki, Y.
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 95 Issue: 2 Pages: 75-85
- DOI
  10.2183/pjab.95.007
- NAID
  130007591938
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2019-02-08
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07310, KAKENHI-INTERNATIONAL-15K21743, KAKENHI-PLANNED-26116007, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K15621, KAKENHI-PROJECT-19H03260
[Journal Article] Plasmalogen mediates integration of adherens junction2019
- Author(s)
  Takahashi Takanori、Honsho Masanori、Abe Yuichi、Fujiki Yukio
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 166 Issue: 5 Pages: 423-432
- DOI
  10.1093/jb/mvz049
- NAID
  40022069621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07386, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K07337
[Journal Article] Onsite GTP fuelling via DYNAMO1 drives division of mitochondria and peroxisomes2018
- Author(s)
  Imoto Yuuta、Abe Yuichi、Honsho Masanori、Okumoto Kanji、Ohnuma Mio、Kuroiwa Haruko、Kuroiwa Tsuneyoshi、Fujiki Yukio
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41467-018-07009-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00676, KAKENHI-PROJECT-17K07310, KAKENHI-PROJECT-17K07337, KAKENHI-INTERNATIONAL-15K21743, KAKENHI-PLANNED-26116007, KAKENHI-PROJECT-16H04813, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17K15621
[Journal Article] Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum2018
- Author(s)
  Abe Yuichi、Honsho Masanori、Itoh Ryota、Kawaguchi Ryoko、Fujitani Masashi、Fujiwara Kazushirou、Hirokane Masaaki、Matsuzaki Takashi、Nakayama Keiko、Ohgi Ryohei、Marutani Toshihiro、Nakayama Keiichi I、Yamashita Toshihide、Fujiki Yukio
- Journal Title
  
  Life Science Alliance
  
  Volume: 1 Issue: 6 Pages: 1-17
- DOI
  10.26508/lsa.201800062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07337, KAKENHI-PROJECT-18K19281, KAKENHI-INTERNATIONAL-15K21743, KAKENHI-PROJECT-18H05215, KAKENHI-PUBLICLY-18H04795, KAKENHI-PLANNED-26116007, KAKENHI-PROJECT-17H03675, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-16K07275, KAKENHI-PROJECT-17K15621
[Presentation] ペルオキシソームの形態形成・分裂障害はリン脂質代謝異常をきたす2021
- Author(s)
  阿部雄一、藤木幸夫
- Organizer
  第44回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K07386
[Presentation] Pathogenesis mechanism of peroxisome biogenesis disorders2019
- Author(s)
  Yuichi Abe, Masanori Honsho, Ryota Itoh, Ryoko Kawaguchi, Masashi Fujitani, Kazushirou Fujiwara, Masaaki Hirokane, Takashi Matsuzaki, Keiko Nakayama, Ryohei Ohgi, Toshihiro Marutani, Keiichi I. Nakayama, Toshihide Yamashita, and Yukio Fujiki
- Organizer
  EMBO Workshop “Current advances in protein translocation across membranes”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15621
[Presentation] ペルオキシソーム欠損性アストロサイトにおける代謝障害とBDNF異常発現2019
- Author(s)
  阿部雄一, 本庄雅則, 藤木幸夫
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07386
[Presentation] ペルオキシソーム形成異常による小脳形態形成障害の病態発症機構2019
- Author(s)
  阿部雄一、本庄雅則、伊藤竜太、藤谷昌司、中山啓子、大城遼平、中山敬一、山下俊英、藤木幸夫
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07386
[Presentation] Pex14欠損マウスにおける小脳形態異常の分子機構2018
- Author(s)
  阿部雄一, 本庄雅則, 藤木幸夫
- Organizer
  平成30年度日本生化学会九州支部例会
- Data Source
  KAKENHI-PROJECT-17K15621
[Presentation] PEX14障害マウスにおける小脳形態異常2017
- Author(s)
  阿部雄一、本庄雅則、大城遼平、藤木幸夫
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K15621

1. Fujiki Yukio

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. Honsho Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. Yamashita Toshihide

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Ohgi Ryohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 奥本寛治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 田村茂彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 大沼みお

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abe Yuichi 阿部 雄一

Research Projects

Research Products

Co-Researchers

ペルオキシソーム形成障害および形態形成異常が及ぼす中枢神経系障害の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Metabolic abnormality and pathogenesis of peroxisome biogenesis deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Defect of peroxisome metabolism impairs development of central nervous systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders. In: Lizard, G. (ed.) Peroxisomes in Neurodegenerative Diseases,2020

Author(s)

Publisher

Data Source

[Journal Article] Genetic defects in peroxisome morphogenesis (Pex11β, dynamin‐like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid‐phospholipid metabolism2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent advances in research on the dynamics and functional regulation of peroxisome2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Alterations in ether lipid metabolism and the consequences for the mouse lipidome2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>De novo</i> formation and maintenance of mammalian peroxisomes in the absence of PEX162022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a Homozygous PEX26 Mutation in a Heimler Syndrome Patient2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A peroxisome deficiency-induced reductive cytosol state up-regulates the brain-derived neurotrophic factor pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recent insights into peroxisome biogenesis and associated diseases2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Peroxisome deficiency impairs BDNF signaling and memory.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mammalian Homologue NME3 of DYNAMO1 Regulates Peroxisome Division2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.2019

Abe Yuichi 阿部雄一

[Presentation] ペルオキシソームの形態形成・分裂障害はリン脂質代謝異常をきたす2021