TSUKAHARA, Tamotsu 塚原完

… Alternative Names

Researcher Number	00529943
Other IDs	https://orcid.org/0000-0001-6469-920X
Affiliation (Current)	2021: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授
Affiliation (based on the past Project Information) *help	2014 – 2020: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2015: 長崎大学, 医歯(薬)学総合研究科, 准教授 2013: 金沢医科大学, 医学部, 特定講師 2013: 金沢医科大学, 医学部, 講師 2010 – 2012: 信州大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Digestive surgery / General surgery / Basic Section 48030:Pharmacology-related Except Principal Investigator Orthopaedic surgery / Urology / Biomedical engineering/Biomaterial science and engineering / Anesthesiology / Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 核内受容体 / リゾリン脂質 / 生理活性脂質 / 大腸癌 / 大腸がん / ハイドロゲル / 動脈硬化 / 内膜肥厚 / 血管内膜肥厚 / 動脈硬化症 … More Except Principal Investigator カーボンナノチューブ / 脊髄損傷 / 前立腺癌 / ホルモン抵抗性 / 肥満 / レプチン / cDNAマイクロアレイ法 / 治療標的分子 / 生体物性 / ナノマテリアル / エンドサイトーシス / 骨・軟骨代謝学 / バイオマテリアル / 骨芽細胞 / 生理活性物質 / リン脂質 / 脊椎損傷 / 線維筋痛症 / 神経障害性疼痛 / リゾホスファチジン酸 / 脳画像解析 / 創薬 / 慢性疼痛 / 質量顕微鏡 / PET解析 / eRNA-CAGE解析 / 痛みメモリー / in vivoイメージング / Centralized Pain / Empathy / LPA受容体 / 脳卒中後慢性疼痛 / Imaging MS解析 / リゾリン脂質 / ニューロン / グリア細胞 / 脂肪酸 Less

脊髄損傷性運動麻痺の機能回復におけるリゾリン脂質の役割とそのメカニズムOngoing
- Principal Investigator
  
  羽二生久夫
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Shinshu University
Developing novel therapeutic strategies for cerebrovascular disease by delayed neuronal death inhibitionPrincipal InvestigatorOngoing
- Principal Investigator
  
  塚原完
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Nagasaki University
LPA signaling molecules and basic diagnostic and therapeutic studies on chronic painOngoing
- Principal Investigator
  
  植田弘師
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Anesthesiology
- Research Institution
  Kyoto University
  Nagasaki University
Development of the therapeutic drug for the spinal cord injury with the bioactive substance derived from porcine liver decomposition
- Principal Investigator
  
  Haniu Hisao
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
The effect of cPA on carotid intimate-media thickness progression in animal model with atherosclerosisPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tamotsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Nagasaki University
  Kanazawa Medical University
Identification of the specific receptors for the nanomaterials
- Principal Investigator
  
  USUI Yuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shinshu University
Elucidation of the calcified promotion mechanism of osteoblasts by the carbon nanotubes
- Principal Investigator
  
  HANIU Hisao
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
Elucidation of the anticancer mechanism of the lysophospholid through the nuclear receptorPrincipal Investigator
- Principal Investigator
  
  TSUKAHARA Tamotsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Shinshu University
アディポカインシグナル伝達に基づくホルモン抵抗性前立腺癌の新規治療標的分子の同定
- Principal Investigator
  
  岩本芳樹
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Shinshu University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010

All Journal Article Presentation Book Patent

[Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry (edited by Jerold Chun) John Wiley book (ISBN: 978-0-470-56905-4)2013
- Author(s)
  Ryoko Tsukahara, Tamotsu Tsukahara, Gabor Tigyi
- Total Pages
  808
- Data Source
  KAKENHI-PROJECT-22591482
[Book] Regulation of the Nuclear Hormone Receptor PPAR_Y by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors2012
- Author(s)
  Ryoko Tsukahara, Tamotsu Tsukahahara, Gabor Tigyi
- Total Pages
  750
- Publisher
  John Wiley Book
- Data Source
  KAKENHI-PROJECT-22591482
[Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry2012
- Author(s)
  Ryoko Tsukahara
- Publisher
  John Wiley book
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro2020
- Author(s)
  Tamotsu Tsukahara, Hisao Haniu, Takeshi Uemura, Yoshikazu Matsuda
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Pages: 3748-3748
- DOI
  10.1038/s41598-020-60781-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07322
[Journal Article] 1-O-alkyl glycerophosphate-induced CD36 expression drives oxidative stress in microglial cells2019
- Author(s)
  Tamotsu Tsukahara
- Journal Title
  
  Cellular Signalling
  
  Volume: 65 Pages: 109459-109459
- DOI
  10.1016/j.cellsig.2019.109459
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07322
[Journal Article] LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.2018
- Author(s)
  Tsukahara, R., Yamamoto, S., Yoshikawa, K., Gotoh, M., Tsukahara, T., Neyama, H., Ishii, S., Akahoshi, N., Yanagida, K., Sumida, H., Araki, M., Araki, K., Yamamura, K. I., Murakami-Murofushi, K., Ueda, H.
- Journal Title
  
  J. Pharmacol. Sci.
  
  Volume: 136 Pages: 93-96
- DOI
  10.1016/j.jphs.2018.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07093, KAKENHI-PROJECT-17K08287, KAKENHI-PROJECT-17K19918, KAKENHI-PROJECT-17H01586, KAKENHI-PROJECT-16H05136, KAKENHI-PROJECT-26860144, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K21229
[Journal Article] Tyrosyl-tRNA synthetase: a potential kyotorphin synthetase in mammals.2018
- Author(s)
  Tsukahara T, Yamagishi S, Neyama H, Ueda H
- Journal Title
  
  Peptides
  
  Volume: 101 Pages: 60-68
- DOI
  10.1016/j.peptides.2017.12.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01586
[Journal Article] Lysophospholipid-Related Diseases and PPARγ Signaling Pathway2017
- Author(s)
  Tsukahara Tamotsu、Matsuda Yoshikazu、Haniu Hisao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Pages: 2730-2730
- DOI
  10.3390/ijms18122730
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15660
[Journal Article] Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons2017
- Author(s)
  Tsukahara Tamotsu、Yamagishi Shuhei、Matsuda Yoshikazu、Haniu Hisao
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 491 Pages: 223-227
- DOI
  10.1016/j.bbrc.2017.07.082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15660
[Journal Article] Short-term treatment with a 2-carba analog of cyclic phosphatidic acid induces lowering of plasma cholesterol levels2016
- Author(s)
  Tamotsu Tsukahara, Hisao Haniu, Yoshikazu Matsuda, and Kimiko Murakami-Murofushi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 473 Pages: 107-113
- DOI
  10.1016/j.bbrc.2016.03.060
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293274
[Journal Article] ブタ肝臓分解物のヒト認知機能改善効果2016
- Author(s)
  松田佳和, 羽二生久夫, 塚原完, 井上俊夫, 佐古兼一, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
- Journal Title
  
  医学と薬学
  
  Volume: 73 Pages: 1057-1066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15660
[Journal Article] ラットの空間認知記憶に及ぼすコリン塩化物長期摂取の影響2016
- Author(s)
  井上俊夫, 松田佳和, 佐藤卓美, 櫻田誓, 羽二生久夫, 塚原完, 杉田和夫, 馬渕知子, 江水保, 佐藤和三郎.
- Journal Title
  
  医学と薬学
  
  Volume: 73 Pages: 1009-1016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15660
[Journal Article] Cyclic Phosphatidic Acid inhibits the Secretion of Vascular Endothelial Growth Factor from Diabetic Human Coronary Artery Endothelial Cells through Peroxisome Proliferator-activated Receptor Gamma2015
- Author(s)
  Tamotsu Tsukahara, Ryoko Tsukahara, Hisao Haniu Yoshikazu Matsuda, and Kimiko Murakami-Murofushi
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 412 Pages: 320-329
- DOI
  10.1016/j.mce.2015.05.021
- NAID
  120005661526
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293274
[Journal Article] The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells.2015
- Author(s)
  Tsukahara T, Matsuda Y, Haniu H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16 Pages: 40-48
- DOI
  10.3390/ijms16010040
- NAID
  120005527913
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
[Journal Article] Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells.2015
- Author(s)
  Maruyama K, Haniu　H, Saito　N, Matsuda Y, Tsukahara T, Kobayashi S, Nomura H, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H.
- Journal Title
  
  BioMed Res Int.
  
  Volume: 2015 Pages: 793186-793186
- NAID
  120005621900
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350524
[Journal Article] Cyclic Phosphatidic Acid Inhibits Alkyl-Glycerophosphate- Induced Downregulation of Histone Deacetylase 2 Expression and Suppresses the Inflammatory Response in Human Coronary Artery Endothelial Cells2014
- Author(s)
  Tamotsu Tsukahara, Hisao Haniu, and Yoshikazu Matsuda
- Journal Title
  
  International Journal of Medical Sciences
  
  Volume: 11 Pages: 955-961
- DOI
  10.7150/ijms.9316
- NAID
  120005526782
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293274
[Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014
- Author(s)
  Haniu　H, Saito　N, Matsuda Y, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H.
- Journal Title
  
  Int J Nanomedicine.
  
  Volume: 9 Pages: 1979-90
- NAID
  120005456106
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25350524
[Journal Article] Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells.2014
- Author(s)
  Ryoko Tsukahara, Hisao Haniu, Yoshikazu Matsuda, Tamotsu Tsukahara
- Journal Title
  
  FEBS OPEN BIO
  
  Volume: 4 Pages: 947-51
- DOI
  10.1016/j.fob.2014.10.014
- NAID
  120005526780
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293274
[Journal Article] The Role of Autophagy as a Mechanism of Toxicity Induced by Multi-Walled Carbon Nanotubes in Human Lung Cells.2014
- Author(s)
  Tsukahara T, Matsuda Y, Usui Y, Haniu H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16 Pages: 40-48
- NAID
  120005527913
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25350524
[Journal Article] PPARγ Networks in Cell Signaling: Update and Impact of Cyclic Phosphatidic Acid2013
- Author(s)
  Tamotsu Tsukahara
- Journal Title
  
  Journal of Lipids
  
  Pages: 1-6
- URL
  http://dx.DOI:.org/10.1155/2013/246597
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Cyclic Phosphatidic Acid: An Endogenous Antagonist of PPARγ2013
- Author(s)
  Tamotsu Tsukahara, Yoshikazu Matsuda, Hisao Haniu and Kimiko Murakami- Murofushi
- Journal Title
  
  Journal of Endocrinology, Diabetes & Obesity
  
  Volume: 1 Pages: 1005-1005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293274
[Journal Article] Highly purified, multi-wall carbon nanotubes induce light-chain 3B expression in human lung cells.2013
- Author(s)
  Tsukahara T, Matsuda Y, Usui Y, Haniu H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440 Pages: 348-53
- DOI
  10.1016/j.bbrc.2013.09.089
- NAID
  120006651225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
[Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response.2013
- Author(s)
  Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H
- Journal Title
  
  Toxicol In Vitro.
  
  Volume: 27 Pages: 1679-1685
- DOI
  10.1016/j.tiv.2013.04.012
- NAID
  120005248282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670, KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
[Journal Article] PTB-Associated Splicing Factor (PSF) is a PPAR gamma-Binding Protein and Growth Regulator of Colon Cancer Cells2013
- Author(s)
  Tamotsu Tsukahara, Hisao Haniu and Yoshikazu Matsuda
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0058749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Lysophosphatidic Acid Stimulates MCP-1 Secretion from C2C12 Myoblast2012
- Author(s)
  Tamotsu Tsukahara and Hisao Haniu
- Journal Title
  
  ISRN Inflammation
  
  Volume: 2012 Pages: 1-6
- DOI
  10.5402/2012/983420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] The Role of PPAR_Y in the Transcriptional Control by Agonists and Antagonists2012
- Author(s)
  Tamotsu Tsukahara
- Journal Title
  
  PPAR research
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Peroxisome Proliferator-Activated Receptor gamma Overexpression Suppresses Proliferation of Human Colon Cancer Cells2012
- Author(s)
  Tamotsu Tsukahara and Hisao Haniu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 424 Pages: 524-529
- URL
  http://dx.DOI:.org/10.1016/j.bbrc.2012.06.149
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists2012
- Author(s)
  Tamotsu Tsukahara
- Journal Title
  
  PPAR research
  
  Volume: 2012 Pages: 1-9
- DOI
  10.1155/2012/362361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Murofushi Release of cyclic phosphatidic acid from a gelatin-based hydrogel inhibits colon cancer cell growth and migration2012
- Author(s)
  Tamotsu Tsukahara and Kimiko Murakami
- Journal Title
  
  Scientific Reports
  
  Volume: 687 Pages: 1-7
- DOI
  10.1038/srep00687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Cyclic Phosphatidic Acid Influences the Expression and Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 cells2011
- Author(s)
  Tamotsu Tsukahara, Shuwa Hanazawa, Kimiko Murofushi-Murakami
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 404 Pages: 109-114
- NAID
  120005247546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Phospholipase A_1 Activity of Lysophospholipase A-I Links Platelet Activation to LPA Production During Blood Coagulation2011
- Author(s)
  Alyssa L.Bolen, Anjapravanda P.Naren, Sunitha, Tamotsu Tsukahara, Gabor Tigyi
- Journal Title
  
  Journal of Lip id Research
  
  Volume: 52 Pages: 958-970
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid2010
- Author(s)
  Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, Juming Yue, Yunhui Cheng, Huazhan Guo, Alyssa Bolen, Chhunxiang Zhang, Louis Balazs, Fabio Re, Guangwei Du, Michael A Frohman, Daniel L. Baker, Abby.L. Parrill, Ayako Uchiyama, Tetsuyuki Kobayashi, Kimiko-Murofushi, and Gabor Tigyi
- Journal Title
  
  Molecular Cell
  
  Volume: 39 Pages: 421-432
- URL
  http://dx.DOI:.org/10.1016/j.molcel.2010.07.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Cyclic Phosphatidic Acid Decreases Proliferation and Survival of Colon Cancer Cells through Inhibition of Peroxisome Proliferator-Activated Receptor γ2010
- Author(s)
  Tamotsu Tsukahara, Shuwa Hanazawa, Tetsuyuki Kobayashi and Kimiko Murofusi-Murakami
- Journal Title
  
  Prostaglandins and Other Lipid Mediators
  
  Volume: 93 Pages: 126-133
- URL
  http://dx.DOI:.org/10.1016/j.prostaglandins.2010.09.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Cyclic phosphatidic acid decreases proliferation and survival of colon cancer cells through inhibition of peroxisome proliferator-activated recentor gamma2010
- Author(s)
  Tamotsu Tsukahara, Shuwa Ha nazawa, et al.
- Journal Title
  
  Prostaglandins and Other Lipid Mediators
  
  Volume: 93 Pages: 126-133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Journal Article] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPAR by cyclic nhosphatidic acid2010
- Author(s)
  Tamotsu Tsukahara, Ryoko Tsukahara, Yuko Fujiwara, et al.
- Journal Title
  
  Molecular Cell
  
  Volume: 39 Pages: 421-432
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591482
[Patent] 神経機能再生促進剤2019
- Inventor(s)
  井上俊夫、植村健、塚原完、羽二生久夫、松田佳和、佐藤和三郎
- Industrial Property Rights Holder
  佐藤和三郎
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K15660
[Presentation] 長谷川式認知症スケールに対するブタ肝臓分解物の効果2020
- Author(s)
  石田季子 , 羽二生久夫 , 塚原完 , 植村健 , 佐藤和三郎 , 佐古兼一 , 井上俊夫 , 松田佳和
- Organizer
  日本薬学会第140年会 (京都)
- Data Source
  KAKENHI-PROJECT-19K07322
[Presentation] ミクログリア細胞における2ccPA結合タンパク質の同定と細胞死制御作用2020
- Author(s)
  佐原慈佳 , 塚原完
- Organizer
  第93回日本薬理学会年会 (横浜) 誌上開催
- Data Source
  KAKENHI-PROJECT-19K07322
[Presentation] 脊髄損傷モデルラットにおけるブタ肝臓分解物の治癒効果の検討2018
- Author(s)
  上田勝也, 鎌仲貴之, 滝沢崇, 黒田千佳, 石田悠, 塚本圭祐, 佐藤和三郎, 塚原完, 松田佳和, 齋藤直人, 羽二生久夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15660
[Presentation] 摘出リンパ管を用いた薬物評価システムの開発2017
- Author(s)
  黒田千佳、安嶋久美子、羽二生久夫、塚原完、松田佳和、青木薫、加藤博之、齋藤直人
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市，長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K15660
[Presentation] リゾリン脂質を介した新生内膜形成と動脈硬化症2016
- Author(s)
  塚原　完
- Organizer
  第25回神経行動薬理若手研究者の集いシンポジウム：健康寿命の延伸を受けた新たなアプローチ
- Place of Presentation
  埼玉県さいたま市ソニックシティビル公益財団法人埼玉県産業文化センター
- Year and Date
  2016-03-08
- Invited
- Data Source
  KAKENHI-PROJECT-25293274
[Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013
- Author(s)
  Hisao Haniu, Naoto Saito, Yoshikazu Matsuda, Kayo Maruyama, Tamotsu Tsukahara, Yuki Usui, Kaoru Aoki, Seiji Takanashi, Shinsuke Kobayashi, Hiroki Nomura, Masanori Okamoto, Masayuki Shimizu, Hiroyuki Kato.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-25350524
[Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013
- Author(s)
  Hisao Haniu, Naoto Saito, Yoshikazu Matsuda, Kayo Maruyama, Tamotsu Tsukahara, Yuki Usui, Kaoru Aoki, Seiji Takanashi, Shinsuke Kobayashi, Hiroki Nomura, Masanori Okamoto, Masayuki Shimizu, Hiroyuki Kato.
- Organizer
  6th International Symposium on Nanotechnology, Occupational and Environmental Health
- Place of Presentation
  愛知県名古屋市
- Data Source
  KAKENHI-PROJECT-25462365
[Presentation] Release of Cyclic Phosphatidic Acid from a Gelatin-Based Hydrogel Inhibits Colon Cancer Cell Growth and MigrationAnnual Meeting of the Japanese Biochemical Society2012
- Author(s)
  Tamotsu Tsukahara and Kimiko Murakami-Murofushi
- Organizer
  Japanese Biochemical Society
- Place of Presentation
  Fukuoka, Kyushu, Japan
- Year and Date
  2012-12-15
- Data Source
  KAKENHI-PROJECT-22591482
[Presentation] Release of Cyclic Phosphatidic Acid from a Gelatin-Based Hydrogel Inhibits Colon Cancer Cell Growth and Migration2012
- Author(s)
  Tamotsu Tsukahara
- Organizer
  Annual Meeting of the Japanese Biochemical Society, Japanese Biochemical Society
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22591482
[Presentation] Cyclic phosphatidic acid inhibits colon cancer cell proliferation through suppression of peroxisome proliferator-activated receptor gamma2011
- Author(s)
  Tamotsu Tsukahara and Kimiko Murakami-Murofushi
- Organizer
  ASBMB Annual Meeting
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22591482
[Presentation] Cyclic phosphatidic acid inhibits colon cancer cell proliferation through suppression of peroxisome proliferator-activated receptor gamma2011
- Author(s)
  Tamotsu Tsukahara, Kimiko Murakami-Murofushi
- Organizer
  ASBMB Annual Meeting 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-22591482
[Presentation] Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARga mma by Cyclic Phosnhatidic Acid2010
- Author(s)
  Tamotsu Tsukahara
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22591482
[Presentation] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid2010
- Author(s)
  Tamotsu Tsukahara and Gabor Tigyi
- Organizer
  The 83nd Annual Meeting of the Japanese Biochemical Society
- Place of Presentation
  Kobe, Hyogo, Japan
- Data Source
  KAKENHI-PROJECT-22591482

1. HANIU Hisao (30252050)

# of Collaborated Projects: 6 results

# of Collaborated Products: 21 results
2. MATSUDA Yoshikazu (20377633)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. USUI Yuki (00467169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. SAITO Naoto (80283258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 高橋淳 (60345741)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. MUROFUSHI Kimiko (00103557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. KOBAYASHI Shinsuke (40624705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. NOMURA Hiroki (40646543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 岩本芳樹 (30569314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤井千文 (10361982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 植田弘師 (00145674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 金子周司 (60177516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 崔翼龍 (60312229)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 酒井佑宜 (70588095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 藤田和歌子 (30382328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 植村健 (00372368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKIZAWA Takashi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. KAMANAKA Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. KATSUYA Ueda

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. AKAHOSHI Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. GOTOH Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. YAMAMOTO Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. HARA Kazuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. TAKANASHI Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. SHIMIZU Masayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. AOKI Kaoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. OKAMOTO Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 斎藤直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
29. 荒木正健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 荒木喜美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 石井聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 伊川正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 加藤博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUKAHARA, Tamotsu 塚原 完

TSUKAHARA Tamotsu 塚原 完

Research Projects

Research Products

Co-Researchers

脊髄損傷性運動麻痺の機能回復におけるリゾリン脂質の役割とそのメカニズムOngoing

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Developing novel therapeutic strategies for cerebrovascular disease by delayed neuronal death inhibitionPrincipal InvestigatorOngoing

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Review Section

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LPA signaling molecules and basic diagnostic and therapeutic studies on chronic painOngoing

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Development of the therapeutic drug for the spinal cord injury with the bioactive substance derived from porcine liver decomposition

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The effect of cPA on carotid intimate-media thickness progression in animal model with atherosclerosisPrincipal Investigator

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Identification of the specific receptors for the nanomaterials

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Elucidation of the calcified promotion mechanism of osteoblasts by the carbon nanotubes

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Elucidation of the anticancer mechanism of the lysophospholid through the nuclear receptorPrincipal Investigator

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アディポカインシグナル伝達に基づくホルモン抵抗性前立腺癌の新規治療標的分子の同定

Principal Investigator

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[Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry (edited by Jerold Chun) John Wiley book (ISBN: 978-0-470-56905-4)2013

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Data Source

[Book] Regulation of the Nuclear Hormone Receptor PPAR_Y by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors2012

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Data Source

[Book] Regulation of the Nuclear Hormone Receptor PPARγ by Endogenous Lysophosphatidic Acids. Lysophospholipid Receptors: Signaling and Biochemistry2012

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[Journal Article] Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro2020

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Data Source

[Journal Article] 1-O-alkyl glycerophosphate-induced CD36 expression drives oxidative stress in microglial cells2019

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TSUKAHARA, Tamotsu 塚原完

TSUKAHARA Tamotsu 塚原完