ogawa yasuhiro 小川泰弘

… Alternative Names

Ogawa Yasuhiro 小川泰弘

OGAWA Yasuhiro 小川泰弘

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Researcher Number	00531948
Other IDs
Affiliation (Current)	2025: 明治薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2022: 明治薬科大学, 薬学部, 准教授 2016 – 2022: 明治薬科大学, 薬学部, 講師 2013: 明治薬科大学, 薬学部, 講師 2009 – 2012: Meiji Pharmaceutical University, 薬学部, 助教
Review Section/Research Field	Principal Investigator General physiology / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Pharmacology in pharmacy
Keywords	Principal Investigator アストロサイト / 脳・神経 / 神経科学 / リソソーム病 / 脳炎症 / 活性化アストロサイト / ザンドホッフ病 / イオンチャネル / グリア細胞 / シナプス / ニューロン―グリア相互作用 / 分子・細胞生理学 / 遺伝子 … More Except Principal Investigator … More 脳神経疾患 / 分化 / アストログリオーシス / 逆行性輸送 / iPS細胞 / 神経分化 / リソソーム病 Less

Creation of Novel Therapeutics Targeting Astrocytes in Sandhoff's DiseasePrincipal Investigator
- Principal Investigator
  
  Ogawa Yasuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Meiji Pharmaceutical University
Molecular mechanisms underlying differentiation and developmental abnormalities of the nervous system that occurs during the asymptomatic phase of Sandhoff's disease and application to drug discovery
- Principal Investigator
  
  Oishi Kazuhiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Meiji Pharmaceutical University
The involvement of astrocytes in the synaptic formationPrincipal Investigator
- Principal Investigator
  
  OGAWA YASUHIRO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Meiji Pharmaceutical University
ADAM22 localization mechanism and myelin formation at the Axon.Principal Investigator
- Principal Investigator
  
  OGAWA Yasuhiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  General physiology
- Research Institution
  Meiji Pharmaceutical University

All 2023 2022 2020 2019 2018 2017 2016 2014 2013 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Interaction of Astrocytes and Microglia in Sandhoff disease2023
- Author(s)
  Yasuhiro Ogawa, Shotaro Michinaga, Hitoshi Sakuraba, Shigeru Hishinuma
- Journal Title
  
  Bio Clinica
  
  Volume: 38 Pages: 60-63
- Data Source
  KAKENHI-PROJECT-19K06914
[Journal Article] ザンドホッフ病での治療標的としてのアストロサイト2022
- Author(s)
  小川泰弘、道永昌太郎、櫻庭均、菱沼滋
- Journal Title
  
  Medical Science Digest
  
  Volume: 48 Pages: 48-50
- Data Source
  KAKENHI-PROJECT-19K06914
[Journal Article] Improvement in dysmyelination by the inhibition of microglial activation in a mouse model of Sandhoff disease2018
- Author(s)
  Ogawa Y, Irisa M, Sano T, Yanagi Y, Furusawa E, Saito T, Yamanaka S, Itoh K, Sakuraba H, Oishi K
- Journal Title
  
  Neuroreport
  
  Volume: 29 Issue: 11 Pages: 962-967
- DOI
  10.1097/wnr.0000000000001060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10057, KAKENHI-PROJECT-17H04102, KAKENHI-PROJECT-16K08281
[Journal Article] Inhibition of astrocytic adenosine receptor A 2A attenuates microglial activation in a mouse model of Sandhoff disease2018
- Author(s)
  Ogawa Yasuhiro、Furusawa Eiri、Saitoh Takahiro、Sugimoto Hiroki、Omori Takumi、Shimizu Shinya、Kondo Hisatsugu、Yamazaki Mika、Sakuraba Hitoshi、Oishi Kazuhiko
- Journal Title
  
  Neurobiology of Disease
  
  Volume: 118 Pages: 142-154
- DOI
  10.1016/j.nbd.2018.07.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08281
[Journal Article] Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage2017
- Author(s)
  Ogawa Yasuhiro、Kaizu Katsutoshi、Yanagi Yusuke、Takada Subaru、Sakuraba Hitoshi、Oishi Kazuhiko
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 6 Pages: e0178978-e0178978
- DOI
  10.1371/journal.pone.0178978
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08281
[Journal Article] FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.2017
- Author(s)
  Ogawa Y, Sano T, Irisa M, Kodama T, Saito T, Furusawa E, Kaizu K, Yanagi Y, Tsukimura T, Togawa T, Yamanaka S, Itoh K, Sakuraba H, Oishi K
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 40518-40518
- DOI
  10.1038/srep40518
- NAID
  120006535048
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08281, KAKENHI-PROJECT-17K10057
[Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier2013
- Author(s)
  Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN
- Journal Title
  
  Neuron
  
  Volume: 78 Pages: 469-482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257
[Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.2013
- Author(s)
  Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 1 Pages: e55856-e55856
- DOI
  10.1371/journal.pone.0055856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257, KAKENHI-PROJECT-24590218, KAKENHI-PROJECT-25461702
[Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier.2013
- Author(s)
  Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN.
- Journal Title
  
  Neuron
  
  Volume: 78 Issue: 3 Pages: 469-482
- DOI
  10.1016/j.neuron.2013.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257, KAKENHI-PUBLICLY-24110509
[Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease2013
- Author(s)
  Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257
[Journal Article] A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.2012
- Author(s)
  Galiano MR, Jha S, Ho TS, Zhang C, Ogawa Y, Chang KJ, Stankewich MC, Mohler PJ, Rasband MN.
- Journal Title
  
  Cell
  
  Volume: 149 Issue: 5 Pages: 1125-1139
- DOI
  10.1016/j.cell.2012.03.039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257
[Journal Article] A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly2012
- Author(s)
  Galiano MR, Jha S, Ho TS, Zhang C, Ogawa Y, Chang KJ, Stankewich MC, Mohler PJ, Rasband MN
- Journal Title
  
  Cell
  
  Volume: 149 Pages: 1125-1139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257
[Journal Article] Schwann cell spectrins modulate peripheral nerve myelination2011
- Author(s)
  Susuki K, Raphael AR, Ogawa Y, Stankewich MC, Peles E, Talbot WS, Rasband MN
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 108 Pages: 8009-8014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790257
[Journal Article] ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.2010
- Author(s)
  Ogawa Y., Oses-Prieto J., Kim M.Y., Horresh I., Peles E., Burlingame A.L., Trimmer J.S., Meijer D., Rasband M.N.
- Journal Title
  
  Journal of Neuroscience 30
  
  Pages: 1038-1048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Journal Article] ADAM22, aKv1channel-itneracting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons.2010
- Author(s)
  Ogawa Y, et al.
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 30 Pages: 1038-1048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Journal Article] ADAM22, aKvlchannel-itneracting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons2010
- Author(s)
  Ogawa Y, et al.
- Journal Title
  
  Journal of Neuroscience 30
  
  Pages: 1038-1048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.2009
- Author(s)
  Ogawa Y, Rasband MN.
- Journal Title
  
  Journal of Neuroscience Research 87
  
  Pages: 3502-3510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.2009
- Author(s)
  Ogawa Y, et al.
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 87 Pages: 3502-3510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Journal Article] Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins2009
- Author(s)
  Ogawa Y, et al.
- Journal Title
  
  Jurnal of Neuroscience Reserach 87
  
  Pages: 3502-3510
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890269
[Presentation] Sandhoff病の病態とグリア細胞、その創薬薬理2020
- Author(s)
  小川泰弘
- Organizer
  第93回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06914
[Presentation] 1.ザンドホッフ病モデルマウスでのアストロサイトに発現するA2A受容体の抑制はミクログリアの活性化を抑制する2019
- Author(s)
  小川泰弘
- Organizer
  NEURO2019（第42回日本神経科学大会、第62回日本神経化学会大会）
- Data Source
  KAKENHI-PROJECT-19K06914
[Presentation] LPS誘導性脳炎症モデルマウスにおけるA2A受容体のグリア細胞での発現変化2017
- Author(s)
  山崎美香、清水伸弥、小川泰弘、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウスから樹立したiPS細胞の神経系への分化異常2017
- Author(s)
  宇野可奈子、小川泰弘、櫻庭均、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] 多能性幹細胞の神経堤系譜への分化におけるFGF/ERKシグナル伝達経路の関与2017
- Author(s)
  青野大輝、多田朋香、大上望、小川泰弘、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] レトロマー複合体の安定化はザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常を改善する2017
- Author(s)
  原佑太、小川泰弘、柳勇介、櫻庭均、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウスにおける脳炎症の長期的な抑制による治療効果2017
- Author(s)
  設楽修平、齊藤貴洋、小川泰弘、櫻庭均、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常はザンドホッフ病の病態を反映している2017
- Author(s)
  秋山裕理、小川泰弘、海津勝俊、櫻庭均、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウス由来iPS細胞の神経系への分化異常に対するレトロマー構成因子VPS35の効果2017
- Author(s)
  柳勇介、海津勝俊、原佑太、櫻庭均、小川泰弘、大石一彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病でのグリア細胞を標的とした治療薬の効果2017
- Author(s)
  小川泰弘、櫻庭均、大石一彦
- Organizer
  第19回応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウスにおいて活性化アストロサイトはA2A受容体を発現する2016
- Author(s)
  古澤栄梨、齊藤貴洋、小川泰弘、大石一彦
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内北キャンパス（仙台）
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] ザンドホッフ病モデルマウスでの運動機能障害に対する早期免疫抑制剤による効果2016
- Author(s)
  齊藤貴洋、古澤栄梨、小川泰弘、大石一彦
- Organizer
  生体機能と創薬シンポジウム2016
- Place of Presentation
  東北大学川内北キャンパス（仙台）
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-16K08281
[Presentation] Astrogliosis begins at presymptomatic stages in a mouse model of Sandhoff di sease2014
- Author(s)
  Sano T, Ogawa Y, Sakuraba H, Oishi K.
- Organizer
  薬理学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] P0-Cre x Z/EGトランスジェニックマウスから作製したiPS細胞2014
- Author(s)
  江東洗、小川泰弘、大石一彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] ザンドホッフ病モデルマウスにおいてグリオーシスが発症前に起きている2014
- Author(s)
  佐野貴文、小川泰弘、棲庭均、大石一彦
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] ザンドホッフ病モデルマウスから作製したiPS細胞2014
- Author(s)
  田中真、小川泰弘、鈴木俊宏、兎川忠靖、棲庭均、大石一彦
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] ザンドホッフ病モデルマウス脳の早期異常を見つけました2014
- Author(s)
  小川泰弘、大石一彦
- Organizer
  臨床遺伝学公開シンポジウム
- Place of Presentation
  明治薬科大学総合教育研究棟フロネシス
- Year and Date
  2014-03-14
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] Induced pluripotent stem cells generated from P0-Cre x Z/EG transgenic mice2014
- Author(s)
  Eto A, Ogawa Y, Oishi K.
- Organizer
  薬理学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] ザンドホッフ病モデルマウス由来iPS細胞はニューロンに分化しにくいことを見つけました2013
- Author(s)
  高田昂、小川泰弘、大石一彦
- Organizer
  臨床遺伝学公開シンポジウム
- Place of Presentation
  明治薬科大学総合教育研究棟フロネシス
- Year and Date
  2013-03-05
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] ザンドホッフ病モデルマウス由来iPS細胞から神経系細胞を作りました2012
- Author(s)
  小川泰弘、大石一彦
- Place of Presentation
  明治薬科大学総合教育研究棟フロネシス
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-23790257
[Presentation] Kv1チャネルと結合するADAM22はジャクスタパラノードにMAGUKsタンパク質を局在させる2010
- Author(s)
  小川泰弘(代表)
- Organizer
  Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21890269

1. Oishi Kazuhiko (80203701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
2. Sakuraba Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
3. Togawa Tadayasu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Kanekura Takuro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kaizu Katsutoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Irisa Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 山中正二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ogawa yasuhiro 小川 泰弘

Ogawa Yasuhiro 小川 泰弘

OGAWA Yasuhiro 小川 泰弘

Research Projects

Research Products

Co-Researchers

Creation of Novel Therapeutics Targeting Astrocytes in Sandhoff's DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms underlying differentiation and developmental abnormalities of the nervous system that occurs during the asymptomatic phase of Sandhoff's disease and application to drug discovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The involvement of astrocytes in the synaptic formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ADAM22 localization mechanism and myelin formation at the Axon.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction of Astrocytes and Microglia in Sandhoff disease2023

Author(s)

Journal Title

Data Source

[Journal Article] ザンドホッフ病での治療標的としてのアストロサイト2022

Author(s)

Journal Title

Data Source

[Journal Article] Improvement in dysmyelination by the inhibition of microglial activation in a mouse model of Sandhoff disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of astrocytic adenosine receptor A 2A attenuates microglial activation in a mouse model of Sandhoff disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier2013

Author(s)

Journal Title

Data Source

[Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three mechanisms assemble central nervous system nodes of Ranvier.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease2013

Author(s)

Journal Title

Data Source

[Journal Article] A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.2012

Author(s)

Journal Title

ogawa yasuhiro 小川泰弘

Ogawa Yasuhiro 小川泰弘

OGAWA Yasuhiro 小川泰弘