HARA Kazuo 原一生

Researcher Number	00532045
Affiliation (based on the past Project Information) *help	2016: 信州大学, 医学部附属病院, 医員 2009: 信州大学, 医学部附属病院, 医員
Review Section/Research Field	Except Principal Investigator Nanomaterials/Nanobioscience
Keywords	Except Principal Investigator カーボンナノチューブ / 生体材料 / ナノ粒子チューブ / ナノ粒子ナノチューブ / ナノ材料 / scaffold / 生体安全性 / 生体界面 / DDS / Scafford … More / ナノチューブ / ナノ粒子 / ナノ機能材料 / カーボン / 人工関節 / 複合体 / セラミックス Less

Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Shinshu University
Development of carbon nanotube/ceramic composites as new biomaterials for artificial joint
- Principal Investigator
  
  SAITO Naoto
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Nanomaterials/Nanobioscience
- Research Institution
  Shinshu University

All 2016 2015 2014 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Book

[Book] カーボンナノチューブ・グラフェンの応用研究最前線－製造・分離・分散・評価から半導体デバイス・複合材料の開発、リスク管理まで2016
- Author(s)
  青木薫, 齋藤直人, 樽田誠一, 荻原伸英, 西村直之
- Total Pages
  480
- Publisher
  株式会社エヌ・ティー・エス
- Data Source
  KAKENHI-PROJECT-24241045
[Book] Thin carbon fiber web that functions as a scaffold for tissue regeneration. In: Columbus NG (ed), Tissue regeneration and repair: procedures, clinical implications and applications, Nova Science Publishers2010
- Author(s)
  Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Hanyiu H, Kim C, Taruta S, Kim YA, Endo M
- Publisher
  Nova Science Publishers, Inc. (in press)
- Data Source
  KAKENHI-PROJECT-18201021
[Book] Application of carbon nanotubes on scaffolds for bone tissue regeneration. In: Legard V, Schluter R (eds), Bone regeneration: growth factors, augmentation procedures and tissue engineering applications, Nova Science Publishers2010
- Author(s)
  Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M
- Publisher
  Nova Science Publishers, Inc. (in press)
- Data Source
  KAKENHI-PROJECT-18201021
[Journal Article] The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.2016
- Author(s)
  Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.
- Journal Title
  
  Nanomaterials-Basel
  
  Volume: 6 Issue: 11 Pages: 219-219
- DOI
  10.3390/nano6110219
- NAID
  120007100160
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-16K21065
[Journal Article] Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells2015
- Author(s)
  Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H
- Journal Title
  
  Biomed Res Int
  
  Volume: 2015 Pages: 793186-793186
- DOI
  10.1155/2015/793186
- NAID
  120007110651
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24241045
[Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014
- Author(s)
  Haniu H, Saito N, Matsuda N, Tsukahara T, Usui Y, Maruyama K, Takanashi S, Aoki K, Kobayashi S, Nomura H, Tanaka M, Okamoto M, Kato H
- Journal Title
  
  Int J Nanomed
  
  Volume: ９ Pages: 1979-1989
- DOI
  10.2147/ijn.s58661
- NAID
  120007110603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670
[Journal Article] Safe clinical use of carbon nanotubes as innovative biomaterials2014
- Author(s)
  Saito N, Haniu H, Usui Y, Aoki K, Hara K, Takanashi S, Shimizu M, Narita N, Okamoto M, Kobayashi S, Nomura H, Kato H, Nishimura N, Taruta S, Endo M
- Journal Title
  
  Chem Rev
  
  Volume: 114 Issue: 11 Pages: 6040-6079
- DOI
  10.1021/cr400341h
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670
[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014
- Author(s)
  Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
- Journal Title
  
  Sci. report
  
  Volume: 4 Issue: 1 Pages: 4493-4493
- DOI
  10.1038/srep04493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23112007, KAKENHI-PROJECT-23593054, KAKENHI-PROJECT-23791668, KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24390080, KAKENHI-PROJECT-24390417, KAKENHI-PROJECT-24592821, KAKENHI-PROJECT-24659833, KAKENHI-PROJECT-25221310, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25462385, KAKENHI-PROJECT-25462904, KAKENHI-PROJECT-25462905, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25670793, KAKENHI-PROJECT-26462825, KAKENHI-PROJECT-26670814
[Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response2013
- Author(s)
  Haniu H, Saito N, Matsuda Y, Tsukahara T, Maruyama K, Usui Y, Aoki K, Takanashi S, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H
- Journal Title
  
  Toxicol in Vitro
  
  Volume: 27 Issue: 6 Pages: 1679-1685
- DOI
  10.1016/j.tiv.2013.04.012
- NAID
  120007110519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240076, KAKENHI-PROJECT-24241045, KAKENHI-PROJECT-24659670, KAKENHI-PROJECT-25350524, KAKENHI-PROJECT-25462365
[Journal Article] Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice2012
- Author(s)
  Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K Saito N
- Journal Title
  
  Sci Rep
  
  Volume: 2 Issue: 1 Pages: 498-498
- DOI
  10.1038/srep00498
- NAID
  120007110636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24241045
[Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009
- Author(s)
  Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Shimizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
- Journal Title
  
  Nano Lett 9(4)
  
  Pages: 1406-1413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201021
[Journal Article] Carbon nanotubes: biomaterial applications.2009
- Author(s)
  Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Taruta S, Endo M.
- Journal Title
  
  Chem Soc Rev 38(7)
  
  Pages: 1897-1903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201021
[Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function2009
- Author(s)
  Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N
- Journal Title
  
  Nano Lett 9(4)
  
  Pages: 1406-1413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201021
[Journal Article] Carbon nanotubes : Biomaterial applications
- Author(s)
  Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Taruta S,Endo M.
- Journal Title
  
  Chem Soc Rev (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] Endocytosis of MWCNT in BEAS-2B cells are affected by the culture medium type.2013
- Author(s)
  Haniu H, Saito N, Matsuda N, Maruyama K, Tsukahara T, Usui Y, Takanashi S, Aoki K, Kobayashi S, Nomura H, Okamoto M, Shimizu M, Kato H.
- Organizer
  The 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
- Place of Presentation
  Nagoya, Japan.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Wnt5a enhances Wnt/ß-catenin signaling through the up-regulation of Lrp5/6 during osteogenesis.(President’s Poster Competition Award)2013
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y.
- Organizer
  ASBMR 2013 Annual Meeting.
- Place of Presentation
  Baltimore, Maryland, USA.
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブは骨芽細胞との双方向性の相互作用により骨の石灰化を促進する2012
- Author(s)
  清水政幸, 青木薫, 成田伸代, 原一生, 羽二生久夫, 岡本正則, 高梨誠司, 加藤博之, 小林泰浩, 中村浩彰, 川原一郎, 宇田川信之, 高橋直之, 小澤英浩, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブを複合した新規アルミナセラミックスの開発2012
- Author(s)
  齋藤直人, 荻原伸英, 樽田誠一,薄井雄企, 加藤博之, 西村直之
- Organizer
  第118回中部日本整形外科災害外科学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブ複合超高分子量ポリエチレンの機械的特性と骨組織親和性2012
- Author(s)
  青木薫, 荻原伸英, 石垣範雄, 中村恒一, 清水政幸, 薄井雄企, 加藤博之, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Peapod-CNTによるカーボンナノチューブの体内動態評価方法の開発2012
- Author(s)
  小林伸輔, 高梨誠司, 羽二生久夫, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一, 　加藤博之, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] カーボンナノチューブに対する細胞反応の定量的評価法の開発: ONE TO ONE法2012
- Author(s)
  高梨誠司, 羽二生久夫, 石垣範雄, 荻原伸英, 青木薫, 清水政幸, 岡本正則, 小林伸輔, 野村博紀, 加藤博之, 薄井雄企, 齋藤直人
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Mechanical property and bone tissue compatibility of MWCNT (multi-walled carbon nanotube)-polyethylene complex2012
- Author(s)
  Aoki K, Ogihara N, Ishigaki N, Nakamura K, Shimizu M, Haniu H, Kato H, Usui Y, Nishi K, Noguchi T, Nishimura N, Saito N
- Organizer
  6th International Conference on Nanotoxicology
- Place of Presentation
  Beijing
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Biocompatibility of thin carbon fiber web as a scaffold for bone regeneration.2009
- Author(s)
  Aoki K, Usui Y, Hara K, Narita N, Shimizu M, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Taruta S, Kim YA, Endo M, Saito N.
- Organizer
  4th International Conference on Nanotechnology-Occupational and Environmental Health
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] Bone Tissue Compatibility of Carbon Nanotubes.2009
- Author(s)
  Aoki K, Usui Y, Hara K, Narita N, Simizu M, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Kim YA, Taruta S, Endo M, Kobayashi Y, Saito N.
- Organizer
  2nd International Workshop on CNT's Toxicology and Safety (IWCTS)
- Place of Presentation
  Nagano(Workshop)
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] Mechanidal Properties and Bone Tissue Compatibility of Polyethylene / Multi-Walled Carbon Nanotube Composite.2009
- Author(s)
  Aoki K, Hara K, Narita N, Usui Y, Shimizu M, Ogiwara N, Ishigaki N, Nakamura K, Kato H, Todoroki H, Ito I, Endo M, Saito N.
- Organizer
  22nd European Conference on Biomaterials, (ESB2009)
- Place of Presentation
  Lausanne, Switzerland
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2008
- Author(s)
  Narita N, Usui Y, Aoki K, Simizu M, Kato H, Saito N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Ozawa H, Udagawa N, Takahashi N, Endo M.
- Organizer
  NanoEurope 2008
- Place of Presentation
  St. Gallen, Switzerland
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2008
- Author(s)
  Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Simizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N.
- Organizer
  Carbon 2008
- Place of Presentation
  Nagano
- Data Source
  KAKENHI-PROJECT-18201021
[Presentation] カーボンナノチューブの細胞毒性：形とタイプの影響
- Author(s)
  羽二生久夫, 齋藤直人, 松田佳和, 薄井雄企, 高梨誠司, 小林伸輔, 岡本正則, 清水政幸, 荻原伸英, 石垣範雄, 中村恒一, 加藤博之
- Organizer
  第39回日本毒性学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Wnt5a up-regulated the expression of Lrp5/6 during osteoblastogenesis.
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Kato H, Saito N, Takahashi N, Kobayashi Y.
- Organizer
  5th International Conference on Osteoimmunology
- Place of Presentation
  Kos, Greece
- Year and Date
  2014-06-15 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Noncanonical Wnt5a enhances Wnt/b-catenin signaling through the up-regulation of Lrp5/6 during osteoblastogenesis.
- Author(s)
  Okamoto M, Udagawa N, Yamashita T, Uehara S, Aoki K, Haniu H, Kato H, Saito N, Takahashi N, Kobayashi Y.
- Organizer
  ANZBMS Annual Scientific Meeting
- Place of Presentation
  Queenstown, New Zealand
- Year and Date
  2014-09-07 – 2014-09-10
- Data Source
  KAKENHI-PROJECT-24241045
[Presentation] Study of the manufacturing process of multi-walled carbon nanotubes for improving biocompatibility
- Author(s)
  Haniu H, Saito N, Matsuda Y, Usui Y, Takanashi S, Kobayashi S, Okamoto M, Shimizu M, Ogihara N, Ishigaki N, Nakamura K, Kato H.
- Organizer
  The 6th International Congress of Asian Society of Toxicology
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-24241045

1. SAITO Naoto (80283258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. ENDO Morinobu (10021015)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. TARUTA Seiichi (00217209)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. KATO Hiroyuki (40204490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 27 results
5. ISHIGAKI Norio (20447725)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. USUI Yuki (00467169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
7. AOKI Kaoru (30467170)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
8. SHIMIZU Masayuki (40467171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
9. HORIUCHI Hiroshi (80377639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TENSHO Keiji (20419378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAKAMURA Kouichi (80419382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
12. KAWAKUBO Yoichi (40313829)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OGIWARA Nobuhide (40447727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
14. HANIU Hisao (30252050)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
15. TAKANASHI Seiji (70596783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
16. OKAMOTO Masanori (50596781)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
17. KOBAYASHI Shinsuke (40624705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
18. NOMURA Hiroki (40646543)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
19. TANAKA Manabu (30723069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
20. AJIMA Kumiko (70584051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. TAKIZAWA Takashi (40748109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SOBAJIMA Atsushi (00770760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. KAMANAKA Takayuki (30791884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 佐々木克典 (30170666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 宇田川信之 (70245801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
26. KIM YOONG AHM (70362100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 斎藤直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 30 results
28. 南康博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA Kazuo 原 一生

Research Projects

Research Products

Co-Researchers

Establishment and safety evaluation of carbon nanotube (CNT) bio-interface technology for developing high-function biomaterials using CNTs

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of carbon nanotube/ceramic composites as new biomaterials for artificial joint

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] カーボンナノチューブ・グラフェンの応用研究最前線－製造・分離・分散・評価から半導体デバイス・複合材料の開発、リスク管理まで2016

Author(s)

Total Pages

Publisher

Data Source

[Book] Thin carbon fiber web that functions as a scaffold for tissue regeneration. In: Columbus NG (ed), Tissue regeneration and repair: procedures, clinical implications and applications, Nova Science Publishers2010

Author(s)

Publisher

Data Source

[Book] Application of carbon nanotubes on scaffolds for bone tissue regeneration. In: Legard V, Schluter R (eds), Bone regeneration: growth factors, augmentation procedures and tissue engineering applications, Nova Science Publishers2010

Author(s)

Publisher

Data Source

[Journal Article] The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Endocytosis of multiwalled carbon nanotubes in bronchial epithelial and mesothelial cells2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells2014

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Safe clinical use of carbon nanotubes as innovative biomaterials2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncanonical Wnt5a enhances Wnt/&#61538;-catenin signaling during osteogenesis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response2013

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function.2009

Author(s)

Journal Title

Data Source

[Journal Article] Carbon nanotubes: biomaterial applications.2009

Author(s)

Journal Title

Data Source

[Journal Article] Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function2009

Author(s)

Journal Title

HARA Kazuo 原一生

[Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis.2014