ISODA KIKUO 磯田菊生

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Isoda Kikuo 磯田菊生

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Researcher Number	00532475
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 先任准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 順天堂大学, 大学院医学研究科, 先任准教授 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授 2016 – 2018: 順天堂大学, 医学(系)研究科(研究院), 准教授 2014 – 2015: 順天堂大学, 医学部, 准教授 2013: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院, 講師
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 炎症 / サイトカイン / 動脈瘤 / 動脈硬化 / 時計遺伝子 / IL-1 / 高血圧 / アンジオテンシンII / 炎症性サイトカイン / 慢性炎症 … More / 新生内膜肥厚 / 内膜肥厚 / 血管傷害 / NK細胞 / 血管障害 / 新生内膜 / 腎障害 / E4BP４ / 分子血管学 / 循環器・高血圧 / IL-1受容体アンタゴニスト / IL-1β / IL-6 / 抗サイトカイン療法 / 大動脈瘤 / IL-6受容体拮抗薬 / IL-1β中和抗体 / アンジオテンシン / 炎症細胞 / 抗炎症性サイトカイン / DPP-４阻害薬 / DPP-4阻害 / 骨髄 … More Except Principal Investigator 酸化ストレス / 老化 / 動脈硬化 / ORAIP Less

E4BP4制御による動脈硬化および動脈瘤進行抑制効果の実証Principal Investigator
- Principal Investigator
  
  磯田菊生
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
酸化ストレス応答アポトーシス誘導蛋白ORAIPが動脈硬化・老化に果たす役割
- Principal Investigator
  
  世古義規
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
Elucidation of the effect of E4BP4 on the development of atherosclerosisPrincipal Investigator
- Principal Investigator
  
  Isoda Kikuo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Juntendo University
Validation of efficiency of anti-cytokine therapy for suppression of hypertension and organ damagePrincipal Investigator
- Principal Investigator
  
  Isoda Kikuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Juntendo University
Elucidation of the mechanism of development of different types of aneurysmPrincipal Investigator
- Principal Investigator
  
  Isoda Kikuo
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Juntendo University
  National Defense Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Successful healing of aneurysmal false lumen using a second-generation drug-eluting stent in spontaneous coronary artery dissection: a case report2024
- Author(s)
  Niida Tomiharu、Isoda Kikuo、Tada Miho、Kitahara Satoshi、Fujino Yusuke
- Journal Title
  
  The Egyptian Heart Journal
  
  Volume: 76 Issue: 1 Pages: 13-13
- DOI
  10.1186/s43044-024-00447-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Gastric emphysema with massive hepatic portal venous gas2024
- Author(s)
  Niida Tomiharu、Takeuchi Mitsuhiro、Kataoka Kosuke、Isoda Kikuo
- Journal Title
  
  BMJ Case Reports
  
  Volume: 17 Issue: 4 Pages: e259865-e259865
- DOI
  10.1136/bcr-2024-259865
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Left ventricular apical aneurysm caused by takotsubo cardiomyopathy2024
- Author(s)
  Hiki Masaru、Ajima Tomohi、Takeuchi Mitsuhiro、Isoda Kikuo
- Journal Title
  
  Journal of Cardiology Cases
  
  Volume: 29 Issue: 3 Pages: 144-147
- DOI
  10.1016/j.jccase.2023.11.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Pacemaker Implantation with Absent Right Superior Vena Cava2023
- Author(s)
  Kunimoto Mitsuhiro, Tabuchi Haruna, Isoda Kikuo
- Journal Title
  
  Annals of Case Reports
  
  Volume: 8 Issue: 3 Pages: 1300-1300
- DOI
  10.29011/2574-7754.101300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Capture of Part of a Vessel Wall by a Coronary Orbital Atherectomy System2022
- Author(s)
  Yasuda Hidetoshi、Isoda Kikuo、Okazaki Shinya、Minamino Tohru
- Journal Title
  
  CJC Open
  
  Volume: 4 Issue: 11 Pages: 994-995
- DOI
  10.1016/j.cjco.2022.09.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Horrifying shift of a giant thrombus during coronary intervention2022
- Author(s)
  Fukuda Kentaro、Funamizu Takehiro、Tamura Hiroshi、Isoda Kikuo
- Journal Title
  
  European Heart Journal - Case Reports
  
  Volume: 6 Issue: 5 Pages: 1-2
- DOI
  10.1093/ehjcr/ytac177
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433
[Journal Article] Blocking of interleukin-1 suppresses angiotensin II-induced renal injury2021
- Author(s)
  Akita Koji、Isoda Kikuo、Ohtomo Fumie、Isobe Sarasa、Niida Tomiharu、Sato-Okabayashi Yayoi、Sano Motoaki、Shimada Kazunori、Iwakura Yoichiro、Minamino Tohru
- Journal Title
  
  Clinical Science
  
  Volume: 135 Issue: 17 Pages: 2035-2048
- DOI
  10.1042/cs20201406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-17K01470, KAKENHI-PROJECT-20K08433
[Journal Article] Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis2020
- Author(s)
  Sato-Okabayashi Yayoi、Isoda Kikuo、Heissig Beate、Kadoguchi Tomoyasu、Akita Koji、Kitamura Kenichi、Shimada Kazunori、Hattori Koichi、Daida Hiroyuki
- Journal Title
  
  IJC Heart & Vasculature
  
  Volume: 28 Pages: 100529-100529
- DOI
  10.1016/j.ijcha.2020.100529
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08433, KAKENHI-PROJECT-18K17935
[Journal Article] Lack of IκBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice2019
- Author(s)
  Kitamura Kenichi、Isoda Kikuo、Akita Koji、Miyosawa Katsutoshi、Kadoguchi Tomoyasu、Shimada Kazunori、Daida Hiroyuki
- Journal Title
  
  IJC Heart & Vasculature
  
  Volume: 23 Pages: 100344-100344
- DOI
  10.1016/j.ijcha.2019.03.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09522, KAKENHI-PROJECT-17K01470
[Journal Article] Inhibition of interleukin-1 suppresses angiotensin II-induced aortic inflammation and aneurysm formation.2018
- Author(s)
  Isoda K, Akita K, Kitamura K, Sato-Okabayashi Y, Kadoguchi T, Isobe S, Ohtomo F, Sano M, Shimada K, Iwakura Y, Daida H
- Journal Title
  
  Int J Cardiol
  
  Volume: 270 Pages: 221-227
- DOI
  10.1016/j.ijcard.2018.05.072
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K17935, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-16K09522, KAKENHI-PROJECT-16K16607
[Journal Article] An Interleukin-6 Receptor Antibody Suppresses Atherosclerosis in Atherogenic Mice.2017
- Author(s)
  Akita K, Isoda K, Sato-Okabayashi Y, Kadoguchi T, Kitamura K, Ohtomo F, Shimada K, Daida H.
- Journal Title
  
  Front Cardiovasc Med
  
  Volume: 4 Pages: 84-91
- DOI
  10.3389/fcvm.2017.00084
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09522, KAKENHI-PROJECT-16K16607
[Journal Article] Lack of IkBNS accelerates atheroclerosis in LDL receptor-deficient mice via increased interleukin-6 production2016
- Author(s)
  Akita K, Isoda K, Okabayasi Y, Shimada K, Daida H
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 211 Pages: 61-63
- DOI
  10.1016/j.ijcard.2016.02.142
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461142
[Journal Article] Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice.2015
- Author(s)
  Akita K, Isoda K, Shimada K, Daida H
- Journal Title
  
  J Am Heart Assoc
  
  Volume: 4 Issue: 3
- DOI
  10.1161/jaha.114.001469
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461142
[Journal Article] Interleukin-1 Receptor Antagonist Originating from Bone Marrowderived Cells and Non-bone Marrow-derived Cells Helps to Suppress Arterial Inflammation and Reduce Neointimal Formation after Injury2014
- Author(s)
  Isoda K, Akita K, Isobe S, Niida T, Adachi T, Iwakura Y, Daida H
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 21 Issue: 11 Pages: 1208-1218
- DOI
  10.5551/jat.25668
- NAID
  130004690941
- ISSN
  1340-3478, 1880-3873
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] The Effect of Endothelin-1 on Angiotensin II-Induced Renal Injury.2023
- Author(s)
  Niida Tomiharu, Isoda Kikuo, Ohtomo Fumie, Akita Koji, Kitamura Kenichi, Kadoguchi Tomoyasu, Minamino Tohru
- Organizer
  American Heart Association’s annual Scientific Sessions 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08433
[Presentation] Inhibition of　Endothelin-1 Suppresses Both Angiotensin II-induced Renal Inflammation and Hypertension.2023
- Author(s)
  Niida Tomiharu, Isoda Kikuo, Otomo Fumie, Akita Koji, Kitamura Kenichi, Kadoguchi Tomoyasu, Minamino Tohru.
- Organizer
  第87 回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08433
[Presentation] Inhibition of interleukin-1 suppresses both angiotensin II-induced hypertension and renal injury2021
- Author(s)
  Ohtomo F, Isoda K, Niida T, Kitamura K, Okabayashi Y, Kadoguchi T, Shimada K, Minamino T
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08433
[Presentation] Blocking of interleukin-1 suppresses both angiotensin II-induced renal inflammation and hypertension2020
- Author(s)
  1.Niida T, Isoda K, Kitamura K, Okabayashi Y, Kadoguchi T, Ohtomo F, Shimada K.
- Organizer
  ESC Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08433
[Presentation] アンジオテンシンII誘導の高血圧と腹部大動脈瘤に対するIL-1抑制効果の検討2019
- Author(s)
  喜多村健一、磯田　菊生、秋田　耕嗣、門口智泰、三代沢勝利、島田和典、代田　浩之
- Organizer
  第53回日本成人病(生活習慣病)学会
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] Suppression of IL-1 Inhibited Both Angiotensin II-induced Hypertension and Aortic Aneurysm2018
- Author(s)
  喜多村健一、磯田菊生、秋田耕嗣、岡林弥生、島田和典、代田浩之
- Organizer
  The 81th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] Deficiency of Interleukin-1 receptor antagonist continues angiotensin II induced aortic inflammation and promotes aneurysm formation after the cesation of its infusion2018
- Author(s)
  Kai Ishii, Kikuo Isoda, Kenichi Kitamura, Koji Akita, Yayoi Okabayashi, Tomoyasu Kadoguchi, Fumie Ohtomo, Kazunori Shimada, Hiroyuki Daida
- Organizer
  ESC congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] An anti-Interleukin-1beta antibody suppresses both angiotensin II-induced hypertension and aortic aneurysm2017
- Author(s)
  Kitamura Kitamura, Kikuo Isoda, Koji Akita, Yayoi Okabayashi, Kazunori Shimada, Hiroyuki Daida
- Organizer
  ESC congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] An Anti-Interleukin-1β Antibody Suppresses Both Angiotensin II-induced Renal Inflammation and Hypertension2017
- Author(s)
  Kikuo Isoda, Kenichi Kitamura, Koji Akita, Yayoi Okabayashi, Tomoyasu Kadoguchi, Kazunori Shimada, Hiroyuki Daida
- Organizer
  AHA Scientific Sessions 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] インターロイキン1受容体アンタゴニストはアンジオテンシンII投与で喚起される動脈の炎症及び瘤形成を抑制する2016
- Author(s)
  秋田　耕嗣、磯田　菊生、代田　浩之
- Organizer
  第64回日本心臓病学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-09-23
- Data Source
  KAKENHI-PROJECT-16K09522
[Presentation] インターロイキン1受容体アンタゴニストはアンジオテンシンII投与によって誘導された動脈の炎症及び瘤形成を抑制する2015
- Author(s)
  秋田耕嗣、磯田菊生、代田浩之
- Organizer
  第47回日本動脈硬化学会
- Place of Presentation
  仙台
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] The Role of Interleukin-1 Receptor Antagonist in the Suppresion of Aortic Inflammation and Aneurysm after Angiotensin II Infusion2015
- Author(s)
  Koji Akita, Kikuo Isoda, Hiroyuki Daida
- Organizer
  The 79th Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  大阪
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Interleukin-1receptor antagonist contributes to the suppression of both angiotensin II-induced hypertention and organ damage.2015
- Author(s)
  Koji Akita, Kikuo Isoda, Hiroyuki Daida
- Organizer
  ESC congress 2015
- Place of Presentation
  London
- Year and Date
  2015-08-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Interleukin-1 receptor antagonist from both bone marrow-derived cells and non-bone marrow cells helps suppress arterial inflammation after injury2014
- Author(s)
  磯田菊生
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] The role of interleukin-1 receptor antagonist in angiotensin II-induced hypertension and renal damages2014
- Author(s)
  磯部更紗、磯田菊生
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京国際フォーラム（東京）
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Interleukin-1 receptor antagonist in bone marrow-derived cells helps suppress arterial inflammation and reduces neointimal formation after injury2013
- Author(s)
  磯田菊生
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル（新宿）
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Interleukin-1 receptor antagonist deficiency promotes angiotensin II-induced hypertension and renal damage2013
- Author(s)
  磯部更紗、磯田菊生
- Organizer
  American Heart Association Scientific Sessions 2013
- Place of Presentation
  Dallas Convention Center (Dallas, USA)
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Alogliptin, a dipeptidyl peptidase-4 inhibitor, suppresses arterial inflammation and neointimal formation after injury2013
- Author(s)
  秋田耕嗣、磯田菊生
- Organizer
  第45回日本動脈硬化学会総会・学術集会
- Place of Presentation
  京王プラザホテル（新宿）
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] Deficiency of Interleukin-1 Receptor Antagonist Promotes Angiotensin II-induced Aortic Inflammation and Aneurysm
- Author(s)
  Koji Akita, Kikuo Isoda, Hiroyuki Daida
- Organizer
  AHA Scientific Session 2014
- Place of Presentation
  Chicago
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25461142
[Presentation] The Effect of Interleukin-1 Receptor Antagonist from both Bone Marrow-Derived Cells and Non-bone Marrow Cells in Arterial Inflammation and Neointimal Formation after Injury
- Author(s)
  Kikuo Isoda, Koji Akita, Manabu Kitagaki, Sarasa Isobe, Tomiharu Niida, Takeshi Adachi
- Organizer
  The 78th Annual Scientific Meeting of the Japanese Atherosclerosis Society
- Place of Presentation
  東京、京王プラザホテル
- Year and Date
  2014-07-10 – 2014-07-11
- Data Source
  KAKENHI-PROJECT-25461142

1. 世古義規 (30240708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 門口智泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISODA KIKUO 磯田 菊生

Isoda Kikuo 磯田 菊生

Research Projects

Research Products

Co-Researchers

E4BP4制御による動脈硬化および動脈瘤進行抑制効果の実証Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸化ストレス応答アポトーシス誘導蛋白ORAIPが動脈硬化・老化に果たす役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the effect of E4BP4 on the development of atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Validation of efficiency of anti-cytokine therapy for suppression of hypertension and organ damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of development of different types of aneurysmPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Successful healing of aneurysmal false lumen using a second-generation drug-eluting stent in spontaneous coronary artery dissection: a case report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gastric emphysema with massive hepatic portal venous gas2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Left ventricular apical aneurysm caused by takotsubo cardiomyopathy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pacemaker Implantation with Absent Right Superior Vena Cava2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Capture of Part of a Vessel Wall by a Coronary Orbital Atherectomy System2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Horrifying shift of a giant thrombus during coronary intervention2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blocking of interleukin-1 suppresses angiotensin II-induced renal injury2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low-dose oral cyclophosphamide therapy reduces atherosclerosis progression by decreasing inflammatory cells in a murine model of atherosclerosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lack of IκBNS promotes cholate-containing high-fat diet-induced inflammation and atherogenesis in low-density lipoprotein (LDL) receptor-deficient mice2019

Author(s)

Journal Title

DOI

Data Source

ISODA KIKUO 磯田菊生

Isoda Kikuo 磯田菊生

[Presentation] Inhibition of　Endothelin-1 Suppresses Both Angiotensin II-induced Renal Inflammation and Hypertension.2023