TENO naoki 手納直規

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TENO Naoki 手納直規

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Researcher Number	00535586
Other IDs
Affiliation (based on the past Project Information) *help	2018: 広島国際大学, 医療栄養学部, 教授 2014: 広島国際大学, 医療栄養学部, 教授 2012 – 2013: 広島国際大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator Drug development chemistry
Keywords	Principal Investigator 構造活性相関 / ニトリル / Scaffold / Warhead / scaffold / ヒダントイン / ピロロピリミジン / プラスミン阻害剤 Except Principal Investigator 臨床応用 / P1’ 残基 … More / プラスミン / 阻害剤 / 活性部位指向型 / 分子設計 / プラスミン阻害剤 / 炎症性疾患治療薬 / 活性中心指向型 Less

Design of the active site-directed plasmin inhibitor oriented to the clinical applications
- Principal Investigator
  
  Tsuda Yuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Kobe Gakuin University
Novel type of plasmin inhibitors: providing insight into P1 moietyPrincipal Investigator
- Principal Investigator
  
  TENO Naoki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima International University

All 2019 2018 2017 2016 2015 2014 2012 Other

All Journal Article Presentation

[Journal Article] Exploration of active site-directed plasmin inhibitors2019
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Peptide Science
  
  Volume: 2018 Pages: 97-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Journal Title
  
  Proceedings of 35th European Peptide Symposium
  
  Volume: 2017 Pages: 171-172
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Structure-based design of plasmin inhibitors with novel P1’moiety2017
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Peptide Science 2016
  
  Volume: - Pages: 89-90
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity2016
- Author(s)
  Naoki Teno, Keigo Gohda, Yukoko Yamashita, Tadamune Otsubo, Masafumi Yamaguchi, Keiko Wanaka, Yuko Tsuda
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Issue: 9 Pages: 2259-2261
- DOI
  10.1016/j.bmcl.2016.03.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08333
[Journal Article] Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine2015
- Author(s)
  Naoki Teno, Keigo Gohda, Keiko Wanaka, Yuko Tsuda, Maiko Akagawa, Eriko Akiduki, Mitsuhito Araki, Arisa Masuda, Tadamune Otsubo, Yukiko Yamashita
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590154
[Journal Article] Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin2014
- Author(s)
  Naoki Teno, Keigo Gohda, Keiko Wanaka, Yuko Tsuda, Takuya Sueda, Yukiko Yamashita, Tadamune Otsubo
- Journal Title
  
  Bioorganic Medicinal Chemistry.
  
  Volume: 22 Pages: 2339-2352
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590154
[Journal Article] Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin2014
- Author(s)
  Naoki Teno, Keigo Gohda, Keiko Wanaka, Yuko Tsuda, Takuya Sueda, Yukiko Yamashita, Tadamune Otsubo
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 7 Pages: 2339-2352
- DOI
  10.1016/j.bmc.2014.02.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590154
[Journal Article] Synthesis and evaluation of tripepetidic plasmin inhibitors with nitrile as warhead2012
- Author(s)
  Teno Naoki
- Journal Title
  
  J. Peptide Sci.
  
  Volume: 18 Issue: 10 Pages: 620-625
- DOI
  10.1002/psc.2442
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590111, KAKENHI-PROJECT-24590154, KAKENHI-PROJECT-24590155
[Presentation] 活性中心指向型プラスミン阻害剤のヒト結腸癌細胞(HCT116)への影響2019
- Author(s)
  後藤光香子, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] ベンズイミダゾール骨格を有するプラスミン阻害剤の設計と活性の検討2019
- Author(s)
  川神千昂, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子, 津田裕子
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design of new cyclic plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S2’サブサイトを標的としたプラスミン阻害剤の設計と活性の検討2018
- Author(s)
  杉浦成香、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  日本薬学会138年会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S1ポケットにおける相互作用を標的としたプラスミン阻害剤の分子設計2018
- Author(s)
  津田裕子, 児嶋基樹, 近藤めぐみ, 日高興士, 北條恵子, 合田圭吾, 手納直規, 和中敬子
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Exploration of Active site-directed plasmin inhibitors2018
- Author(s)
  Yuko Tsuda, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka
- Organizer
  The 10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017
- Author(s)
  Seika Sugiura, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 54th Japanese Peptide Symposium
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] X線構造解析に基づくプラスミン阻害剤の設計2017
- Author(s)
  桝田昂志、久野元嗣、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第67回日本薬学会近畿支部大会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] P1残基を修飾したプラスミン阻害剤の分子設計2017
- Author(s)
  園田浩士、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第22回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Plasmin specific inhibitors: Optimization of the P2 and P1’ residues2016
- Author(s)
  Naomichi Iwasa, Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  34th European Peptide Symposium
- Place of Presentation
  ライプツィッヒ、ドイツ
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] 疎水性アミノ酸をリンカーとして導入した新規プラスミン阻害剤の合成と構造活性相関の検討2016
- Author(s)
  山下ユキコ、手納直規、合田圭吾、大坪忠宗、山口雅史、和中敬子、津田裕子
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Structure-based design of plasmin inhibitors with novel P1’ moiety2016
- Author(s)
  Takashi Masuda, Mototsugu Kuno, Koushi Hidaka, Keiko Hojo, Keigo Gohda, Naoki Teno, Keiko Wanaka, Yuko Tsuda
- Organizer
  The 53rd Japanese Peptide Symposium
- Place of Presentation
  Ｋｙｏｔｏ
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] S1ポケットにおける相互作用を利用したプラスミン阻害剤の分子設計2016
- Author(s)
  園田浩士、桝田昂志、日高興士、北條恵子、合田圭吾、手納直規、和中敬子、津田裕子
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  吹田
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-16K08333
[Presentation] Pyrrolopyrimidine scaffold上にP1, P4部を有するプラスミン阻害剤のデザインと合成
- Author(s)
  山下ユキコ, 合田圭吾, 大坪忠宗, 和中敬子, 津田裕子, 手納直規
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-24590154

1. Tsuda Yuko (10098478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
2. HATTORI kouichi (10360116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 北條恵子 (20289028)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
4. 日高興士 (30445960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
5. GOHDA keigo

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
6. WANAKA keiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
7. LAW ruby

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TENO naoki 手納 直規

TENO Naoki 手納 直規

Research Projects

Research Products

Co-Researchers

Design of the active site-directed plasmin inhibitor oriented to the clinical applications

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel type of plasmin inhibitors: providing insight into P1 moietyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Exploration of active site-directed plasmin inhibitors2019

Author(s)

Journal Title

Data Source

[Journal Article] Design of new cyclic plasmin inhibitors2018

Author(s)

Journal Title

Data Source

[Journal Article] Structure-based design of plasmin inhibitors with novel P1’moiety2017

Author(s)

Journal Title

Data Source

[Journal Article] Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine2015

Author(s)

Journal Title

Data Source

[Journal Article] Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin2014

Author(s)

Journal Title

Data Source

[Journal Article] Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and evaluation of tripepetidic plasmin inhibitors with nitrile as warhead2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] 活性中心指向型プラスミン阻害剤のヒト結腸癌細胞(HCT116)への影響2019

Author(s)

Organizer

Data Source

[Presentation] ベンズイミダゾール骨格を有するプラスミン阻害剤の設計と活性の検討2019

Author(s)

Organizer

Data Source

[Presentation] Design of new cyclic plasmin inhibitors2018

Author(s)

Organizer

Data Source

[Presentation] S2’サブサイトを標的としたプラスミン阻害剤の設計と活性の検討2018

Author(s)

Organizer

Data Source

[Presentation] S1ポケットにおける相互作用を標的としたプラスミン阻害剤の分子設計2018

Author(s)

Organizer

Data Source

[Presentation] Exploration of Active site-directed plasmin inhibitors2018

Author(s)

Organizer

Data Source

[Presentation] Design of plasmin inhibitors with targeting the S2’ subsite2017

Author(s)

Organizer

Data Source

TENO naoki 手納直規

TENO Naoki 手納直規