Wachino Junichi 和知野純一

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WACHINO Jun-ichi 和知野純一

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Researcher Number	00535651
Other IDs
Affiliation (Current)	2025: 藤田医科大学, 医療科学部, 教授
Affiliation (based on the past Project Information) *help	2024: 藤田医科大学, 医療科学部, 教授 2021 – 2023: 修文大学, 医療科学部, 准教授 2015 – 2020: 名古屋大学, 医学系研究科, 講師 2016 – 2017: 名古屋大学, 大学院医学系研究科, 講師 2015: 名古屋大学, 医学(系)研究科(研究院), 特任講師 … More 2015: 名古屋大学, 大学院医学系研究科, 特任講師 2012 – 2014: 名古屋大学, 医学(系)研究科(研究院), 助教 2010: National Institute of Infectious Diseases, 細菌第二部, 主任研究官 2009 – 2010: 国立感染症研究所, 細菌第二部, 研究員 2009: National Institute of Infectious Diseases, 厚生労働技官 2009: 国立感染症研究所, 細菌第2部, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Infectious disease medicine / Laboratory medicine / Bacteriology (including Mycology) Except Principal Investigator Infectious disease medicine / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / Physical pharmacy / Bacteriology (including mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator メタロβ-ラクタマーゼ / 阻害剤 / メタロ-β-ラクタマーゼ / 薬剤耐性菌 / 薬剤耐性 / メタロベータラクタマーゼ / カルバペネム耐性 / β-ラクタマーゼ / 金属親和性天然物 / 腸内細菌目細菌 … More / 競合阻害 / カルバペネマーゼ / X線結晶構造解析 / カルバペネム / 化合物合成 / カルバペネム耐性腸内細菌科細菌 / 蛋白結晶 / in silico screening / 16S rRNA MTase / ハイスループット / メロペネム / セフタジジム / ニトロセフィン / 16S rRNA メチルトランスフェラーゼ / D-captopril / SMB-1 / クラリスロマイシン / ミコール酸 / 非結核性抗酸菌 … More Except Principal Investigator 阻害剤 / 薬剤耐性菌 / カルバペネマーゼ / IMP-1 / 抗生物質 / ベタラクタマーゼ / 細菌感染症 / カルバぺネム系抗菌薬 / ベータラクタマーゼ / メタロベータラクタマーゼ / X線小角散乱 / Zn酵素 / 触媒機構 / 基質認識 / 亜鉛酵素 / 加水分解機構 / β-ラクタム剤 / 高触媒活性 / メタロ－β－ラクタマーゼ / 速度論的解析 / 溶液構造 / 結晶構造 / Zn(II)イオン / メタロ-β-ラクタマーゼ / 加水分解酵素 / 低感受性 / 耐性 / カルバペネム系薬 / ベータラクタム系薬 / インフルエンザ桿菌 / PBP / Haemophilus influenzae / ペニシリン結合タンパク / インフルエンザ菌 / 薬剤耐性 / 阻害薬 / メタロβ-ラクタマーゼ / ニトロセフィン / ハイスループット / 既承認薬 / 薬剤耐性遺伝子伝達 / メンブレンベシクル / Acinetobacter baumannii / 水平伝播 / 薬剤耐性遺伝子 / vanA / VRE / AAC(6')-Ib / IntI3 / Klebsiella pneumoniae / Serratia marcescens / 再配列 / インテグラーゼ / 耐性遺伝子 / カルバペネム耐性 / OXA型β-ラクタマーゼ / アシネトバクター / クラス3インテグロン / 遺伝子転位機構 Less

金属親和性天然物のスリム化と再構築による薬剤耐性阻害剤の開発Principal Investigator
- Principal Investigator
  
  和知野純一
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Fujita Health University
セリン-とメタロ-カルパぺネマーゼを同時に阻害する二元型化合物の分子設計と探索
- Principal Investigator
  
  金万春
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kinjo Gakuin University
細菌性薬剤耐性タンパク質を標的としたデュアルターゲット型治療薬の開発研究Principal Investigator
- Principal Investigator
  
  和知野純一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Shubun University
Development of antibacterial auxiliary agents targeted for metallo-beta-lactamasesPrincipal Investigator
- Principal Investigator
  
  Wachino Jun-ichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Nagoya University
Screening for carbapenemase inhibitors among approved drug compounds
- Principal Investigator
  
  Arakawa Yoshichika
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Development of atomic structural platform for controlling multi-drug resistant bacteriaPrincipal Investigator
- Principal Investigator
  
  Wachino Jun-ichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Characterization of IMP-1, a major carbapenem resistance factor in bacteria
- Principal Investigator
  
  Arakawa Yoshichika
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Horizontal transfer of antibiotic resistance genes through outer membrane vesicles
- Principal Investigator
  
  Arakawa Yoshichika
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Nagoya University
Analysis of Haemophilus influenzae with reduced carbapenem susceptibility
- Principal Investigator
  
  Kimura Kouji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Nagoya University
Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibiotics
- Principal Investigator
  
  Yamaguchi Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Structure-based discovery of metallo-type carbapenemase inhibitor and application to bacteriological examinationPrincipal Investigator
- Principal Investigator
  
  WACHINO Jun-ichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya University
Molecular characterization of antibiotic resistance mechanism in nontuberculous mycobacteria.Principal Investigator
- Principal Investigator
  
  WACHINO Jun-Ichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases
Molecular mechanism of accumulation and rearrangement of antibiotic resistance gene in bacteria.
- Principal Investigator
  
  ARAKAWA Yoshichika
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases

[Journal Article] Bird's-eye MApping of plasmids (BeMAp) for visualization and comparison of genomic structures of different plasmids by mapping antimicrobial resistance genes on spreadsheets2023
- Author(s)
  Tsuda Yusuke、Suzuki Masahiro、Wachino Jun-ichi、Kimura Kouji、Arakawa Yoshichika
- Journal Title
  
  Journal of Microbiological Methods
  
  Volume: 204 Pages: 106645-106645
- DOI
  10.1016/j.mimet.2022.106645
- Data Source
  KAKENHI-PROJECT-21H02967
[Journal Article] Improved disk diffusion method for simple detection of group B streptococci with reduced penicillin susceptibility (PRGBS)2023
- Author(s)
  Goto Rikuko、Jin Wanchun、Wachino Jun-ichi、Arakawa Yoshichika、Kimura Kouji
- Journal Title
  
  Diagnostic Microbiology and Infectious Disease
  
  Volume: 105 Issue: 3 Pages: 115881-115881
- DOI
  10.1016/j.diagmicrobio.2022.115881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02967
[Journal Article] Difference in the Inhibitory Effect of Thiol Compounds and Demetallation Rates from the Zn(II) Active Site of Metallo-β-lactamases (IMP-1 and IMP-6) Associated with a Single Amino Acid Substitution2022
- Author(s)
  Yamaguchi Yoshihiro、Kato Koichi、Ichimaru Yoshimi、Uenosono Yuya、Tawara Sakiko、Ito Rio、Matsuse Natsuki、Wachino Jun-ichi、Toma-Fukai Sachiko、Jin Wanchun、Arakawa Yoshichika、Otsuka Masami、Fujita Mikako、Fukuishi Nobuyuki、Sugiura Kirara、Imai Masanori、Kurosaki Hiromasa
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: 9 Issue: 1 Pages: 65-78
- DOI
  10.1021/acsinfecdis.2c00395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06500, KAKENHI-PROJECT-21K15244, KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-17K08376
[Journal Article] Dissecting the clonality of I1 plasmids using ORF-based binarized structure network analysis of plasmids (OSNAp)2022
- Author(s)
  Suzuki Masahiro、Norizuki Chihiro、Wachino Jun-ichi、Kawamura Kumiko、Nagano Noriyuki、Nagano Yukiko、Hayashi Wataru、Kimura Kouji、Doi Yohei、Arakawa Yoshichika
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 28 Issue: 4 Pages: 473-479
- DOI
  10.1016/j.jiac.2021.12.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-20K08819, KAKENHI-PROJECT-20K10457
[Journal Article] Crystal Structures of Metallo-β-Lactamase (IMP-1) and Its D120E Mutant in Complexes with Citrate and the Inhibitory Effect of the Benzyl Group in Citrate Monobenzyl Ester2021
- Author(s)
  Yamaguchi Yoshihiro、Kato Koichi、Ichimaru Yoshimi、Jin Wanchun、Sakai Misa、Abe Miki、Wachino Jun-ichi、Arakawa Yoshichika、Miyagi Yukina、Imai Masanori、Fukuishi Nobuyuki、Yamagata Yuriko、Otsuka Masami、Fujita Mikako、Kurosaki Hiromasa
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 14 Pages: 10019-10026
- DOI
  10.1021/acs.jmedchem.1c00308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-17K08376
[Journal Article] Practical Agar-Based Disk Diffusion Tests Using Sulfamoyl Heteroarylcarboxylic Acids for Identification of Subclass B1 Metallo-β-Lactamase-Producing Enterobacterales2021
- Author(s)
 Norizuki Chihiro、Wachino Jun-ichi、Jin Wanchun、Kimura Kouji、Kawamura Kumiko、Nagano Noriyuki、Arakawa Yoshichika
- Journal Title
 
 Journal of Clinical Microbiology
 
 Volume: 59 Issue: 10
- DOI
 10.1128/jcm.00761-21
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-21H02967, KAKENHI-PROJECT-20K08819
[Journal Article] Daptomycin Susceptibility of Group B Streptococcus 2021
- Author(s)
 Takumi Ushino, Wanchun Jin, Jun-Ichi Wachino, Yoshichika Arakawa, Kouji Kimura
- Journal Title
 
 Jpn J Infect Dis
 
 Volume: 74 Issue: 3 Pages: 233-235
- DOI
 10.7883/yoken.JJID.2020.371
- NAID
 130008041995
- ISSN
 1344-6304, 1884-2836
- Year and Date
 2021-05-31
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-18K08430
[Journal Article] Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance2020
- Author(s)
  Wachino Jun-ichi、Jin Wanchun、Kimura Kouji、Kurosaki Hiromasa、Sato Ayato、Arakawa Yoshichika
- Journal Title
  
  mBio
  
  Volume: 11 Issue: 2
- DOI
  10.1128/mbio.03144-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08430
[Journal Article] Characterization of blaCTX-M-27/F1:A2:B20 Plasmids Harbored by Escherichia coli ST131 Sublineage C1/H30R Isolates Spreading among Elderly Japanese in Non-acute Care Settings2020
- Author(s)
  Matsuo Nao、Nonogaki Rina、Hayashi Michiko、Wachino Jun-ichi、Suzuki Masahiro、Arakawa Yoshichika、Kawamura Kumiko
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 64 Issue: 5
- DOI
  10.1128/aac.00202-20
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08430, KAKENHI-PROJECT-20K08819
[Journal Article] Aminoglycoside Resistance: Updates with a Focus on Acquired 16S Ribosomal RNA Methyltransferases2020
- Author(s)
  Jun-ichi Wachino, Yohei Doi, Yoshichika Arakawa
- Journal Title
  
  Infectious disease clinics of North America
  
  Volume: 34(4) Issue: 4 Pages: 887-902
- DOI
  10.1016/j.idc.2020.06.002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08430
[Journal Article] Erythromycin-Susceptible but Clindamycin-Resistant Phenotype of Clinical ermB-PCR-Positive Group B Streptococci Isolates with IS1216E-Inserted ermB2019
- Author(s)
 Moroi Hiroaki、Kimura Kouji、Ido Ayaka、Banno Hirotsugu、Jin Wanchun、Wachino Jun-ichi、Yamada Keiko、Kikkawa Fumitaka、Park Yeon-Joon、Arakawa Yoshichika
- Journal Title
 
 Jpn J Infect Dis
 
 Volume: 72 Issue: 6 Pages: 420-422
- DOI
 10.7883/yoken.JJID.2019.015
- NAID
 130007749434
- ISSN
 1344-6304, 1884-2836
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18K08430, KAKENHI-PROJECT-19H05462
[Journal Article] Intercellular Transfer of Chromosomal Antimicrobial Resistance Genes between Acinetobacter baumannii Strains Mediated by Prophages2019
- Author(s)
  Wachino Jun-ichi、Jin Wanchun、Kimura Kouji、Arakawa Yoshichika
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 63 Issue: 8
- DOI
  10.1128/aac.00334-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08430
[Journal Article] 4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-β-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-β-Lactamase Subclasses2019
- Author(s)
  Wachino Jun-ichi、Kanechi Reo、Nishino Erina、Mochizuki Marie、Jin Wanchun、Kimura Kouji、Kurosaki Hiromasa、Arakawa Yoshichika
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 63 Issue: 10
- DOI
  10.1128/aac.01197-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08430
[Journal Article] Detection of Escherichia coli Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 20162018
- Author(s)
 Chihiro Norizuki, Kumiko Kawamura, Jun-ichi Wachino, Masahiro Suzuki, Noriyuki Nagano, Takaaki Kondo, Yoshichika Arakawa.
- Journal Title
 
 Jpn J Infect Dis
 
 Volume: 71 Issue: 1 Pages: 33-38
- DOI
 10.7883/yoken.JJID.2017.206
- NAID
 130006317356
- ISSN
 1344-6304, 1884-2836
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08966, KAKENHI-PROJECT-15H04868
[Journal Article] Predominance of Serogroup 19 CC320/271 among Penicillin-Nonsusceptible Streptococcus pneumoniae Isolates after Introduction of the PCV7 Vaccine in Several Regions of Japan2018
- Author(s)
 Mitsuru Oodate, Kouji Kimura, Hirotsugu Banno, Satoru Yokoyama, Wanchun Jin, Jun-ichi Wachino, Yoshinori Hasegawa, Yoshichika Arakawa
- Journal Title
 
 Jpn J Infect Dis
 
 Volume: 71 Issue: 1 Pages: 14-20
- DOI
 10.7883/yoken.JJID.2017.236
- NAID
 130006317355
- ISSN
 1344-6304, 1884-2836
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-15H04868
[Journal Article] Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies.2017
- Author(s)
  Hirotsugu Banno, Kouji Kimura , Yosuke Tanaka, Tsuyoshi Sekizuka, Makoto Kuroda, Wanchun Jin, Jun-ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa
- Journal Title
  
  PLOS one
  
  Volume: 12(8) Issue: 8 Pages: e0183453-e0183453
- DOI
  10.1371/journal.pone.0183453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04868
[Journal Article] Recurrence of Escherichia coli meningitis in a preterm infant and co-infection of echovirus 18.2017
- Author(s)
  Kentaro Kato, Hiroshi Mizumoto, Kousaku Matsubara, Atsuko Hata, Jun-ichi Wachino, Yoshichika Arakawa, and Daisuke Hata
- Journal Title
  
  IDCases
  
  Volume: 10 Pages: 135-137
- DOI
  10.1016/j.idcr.2017.11.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04868
[Journal Article] Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP05952017
- Author(s)
  Wanchun Jin, Jun-ichi Wachino, Yoshihiro Yamaguchi, Kouji Kimura, Anupriya Kumar, Mototsugu Yamada, Akihiro Morinaka, Yoshiaki Sakamaki, Minoru Yonezawa, Hiromasa Kurosaki and Yoshichika Arakawa
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 61(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04868
[Journal Article] Specific blaCTX-M-8/IncI1 Plasmid Transfer among Genetically Diverse Escherichia coli Isolates between Humans and Chickens2017
- Author(s)
  Norizuki C, Wachino JI, Suzuki M, Kawamura K, Nagano N, Kimura K, Arakawa Y.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 61
- Data Source
  KAKENHI-PROJECT-15H05672
[Journal Article] Structural Insights into the TLA-3 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam and OP05952017
- Author(s)
  Jin W, Wachino JI, Yamaguchi Y, Kimura K, Kumar A, Yamada M, Morinaka A, Sakamaki Y, Yonezawa M, Kurosaki H, Arakawa Y
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05672
[Journal Article] Structural Insights into Recognition of Hydrolyzed Carbapenems and Inhibitors by Subclass B3 Metallo-β-Lactamase SMB-12016
- Author(s)
  Wachino J, Yamaguchi Y, Mori S, Jin W, Kimura K, Kurosaki H, Arakawa Y.
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 60 Issue: 7 Pages: 4274-4282
- DOI
  10.1128/aac.03108-15
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05672
[Journal Article] Comparison of Active-Site Loop Structures between IMP-1 and IMP-22015
- Author(s)
  Yamaguchi Y., Matsueda S., Matsunaga K., Takashio N., Toma-Fukai S., Yamagata Y., Shibata N., Wachino J., Shibayama K., Arakawa Y. & Kurosaki H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 1 Pages: 96-101
- DOI
  10.1248/bpb.b14-00594
- NAID
  130004872220
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131007, KAKENHI-PROJECT-26460037
[Journal Article] Practical Agar-Based Disk Potentiation Test to Detect Fosfomycin-Non-Susceptible Escherichia coli Clinical Isolates Producing Glutathione S-Transferases2014
- Author(s)
  G. Nakamura, J. Wachino, N. Sato, K. Kimura, K. Yamada, W. Jin, K. Shibayama, T. Yagi, K. Kawamura, Y. Arakawa
- Journal Title
  
  Journal Clinical Microbiology
  
  Volume: 52 Issue: 9 Pages: 3175-3179
- DOI
  10.1128/jcm.01094-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790551, KAKENHI-PROJECT-24790570
[Journal Article] Evaluation of a double-disk synergy test with a common metallo-β-lactamase inhibitor, mercaptoacetate, for detecting NDM-1-producing Enterobacteriaceae and Acinetobacter baumannii2014
- Author(s)
  Wachino J, Matsui M, Tran HH, Suzuki M, Suzuki S, Shibayama K
- Journal Title
  
  Japanese Journal of Infectious Diseases
  
  Volume: 67 Pages: 66-68
- NAID
  130003399237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] Invasive infection caused by carbapenem-resistant Acinetobacter soli, Japan.2014
- Author(s)
  Kitanaka H, Sasano MA, Yokoyama S, Suzuki M, Jin W, Inayoshi M, Hori M, Wachino J, Kimura K, Yamada K, Arakawa Y.
- Journal Title
  
  Emerg Infect Dis
  
  Volume: 20 Issue: 9 Pages: 1574-6
- DOI
  10.3201/eid2009.140117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] Evaluation of Disk Potentiation Test Using KB Disks Containing High Dosage Fosfomycin and Glucose-6-Phosphate to Detect the Production of Glutathione S-Transferase Responsible For Fosfomycin Resistance2014
- Author(s)
  J. Wachino, K. Kimura, K. Yamada, W. Jin, Y. Arakawa
- Journal Title
  
  Journal Clinical Microbiology
  
  Volume: 52 Issue: 10 Pages: 3827-3828
- DOI
  10.1128/jcm.01805-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790551, KAKENHI-PROJECT-24790570
[Journal Article] Novel integron-mediated fosfomycin resistance gene fosK2014
- Author(s)
  Kitanaka H, Wachino J, Jin W, Yokoyama S, Sasano MA, Hori M, Yamada K, Kimura K, Arakawa Y
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 8 Pages: 4978-9
- DOI
  10.1128/aac.03131-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] Ability of the VITEK(R) 2 system to detect group B streptococci with reduced penicillin susceptibility (PRGBS)2013
- Author(s)
  Kimura K, Nagano N, Nagano Y, Wachino J, Shibayama K, Arakawa Y.
- Journal Title
  
  Journal of Antimicrobial Chemotherapy
  
  Volume: 68 Pages: 1442-1444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] First detection of fosfomycin resistance gene fosA3 in CTX-M-producing Escherichia coli isolates from healthy individuals in Japan2013
- Author(s)
  Sato N, Kawamura K, Nakane K, Wachino J, Arakawa Y
- Journal Title
  
  Microbial Drug Resistance
  
  Volume: 19 Issue: 6 Pages: 477-482
- DOI
  10.1089/mdr.2013.0061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] Rapid and reliable loop-mediated isothermal amplification method for detecting Streptococcus agalactiae2013
- Author(s)
  Kimura K, Yanagisawa H, Wachino J, Shibayama K, Arakawa Y
- Journal Title
  
  Japanese Journal of Infectious Diseases
  
  Volume: 66 Pages: 546-548
- NAID
  130003390340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] High cephalosporin resistance due to amino acid substitutions in PBP1A and PBP2X in a clinical isolate of group B Streptococcus2013
- Author(s)
  Kimura K, Wachino J, Kurokawa H, Matsui M, Suzuki S, Yamane K, Nagano N, Shibayama K, Arakawa Y.
- Journal Title
  
  Journal of Antimicrobial Chemotherapy
  
  Volume: 68 Issue: 7 Pages: 1533-1536
- DOI
  10.1093/jac/dkt060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570, KAKENHI-PROJECT-24791020
[Journal Article] Screening for group B streptococci with reduced penicillin susceptibility in clinical isolates obtained between 1977 and 20052013
- Author(s)
  Kimura K, Nishiyama Y, Shimizu S, Wachino J, Matsui M, Suzuki S, Yamane K, Shibayama K, Arakawa Y
- Journal Title
  
  Japanese Journal of Infectious Diseases
  
  Volume: 66 Pages: 222-225
- NAID
  130003381675
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790570
[Journal Article] Structural Insights into the Subclass B3 Metallo-β-Lactamase SMB-1 and the Mode of Inhibition by the Common Metallo-β-Lactamase Inhibitor Mercaptoacetate2012
- Author(s)
  Jun-ichi Wachino, Yoshihiro Yamaguchi, Shigetarou Mori, Hiromasa Kurosaki, Yoshichika Arakawa, Keigo Shibayama
- Journal Title
  
  Antimicrob. Agents Chemother.
  
  Volume: 57 Issue: 1 Pages: 101-109
- DOI
  10.1128/aac.01264-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790045, KAKENHI-PROJECT-24790570
[Journal Article] Structural Insights into the Novel Diadenosine 5',5'''-P(1),P(4)-Tetraphosphate Phosphorylase from Mycobacterium tuberculosis H37Rv.2011
- Author(s)
  Mori Shigetarou, Shibayama Keigo, Wachino Jun-ichi, Arakawa Yoshichika
- Journal Title
  
  J Mol Biol. 410(1)
  
  Pages: 93-104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890309
[Journal Article] Purification and molecular characterization of a novel diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.2010
- Author(s)
  Mori Shigetarou, Shibayama Keigo, Wachino Jun-ichi, Arakawa Yoshichika
- Journal Title
  
  Protein Expr Purif. 9(1)
  
  Pages: 99-105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890309
[Journal Article] Crystallization and preliminary X-ray analysis of the diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37Rv.2010
- Author(s)
  Mori Shigetarou, Shibayama Keigo, Wachino Jun-ichi, Arakawa Yoshichika
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun 66(Pt3)
  
  Pages: 279-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21890309
[Patent] ホスホマイシン不活化酵素産生菌の検出2014
- Inventor(s)
  和知野純一、荒川宜親
- Industrial Property Rights Holder
  名古屋大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-04-15
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] Sulfamoyl heterarylcarboxylic acids as promising metallo-beta-lactamase inhibitors for controlling bacterial carbapenem resistance2020
- Author(s)
  Jun-ichi Wachino, Wanchun Jin, Kouji Kimura, Hiromasa Kurosaki, Ayato Sato, Yoshichika Arakawa
- Organizer
  ASM Microbe, Chicago, 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08430
[Presentation] 薬剤耐性機構とその制御に資する創薬研究2020
- Author(s)
  和知野純一、荒川宜親
- Organizer
  日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08430
[Presentation] Emergence of New Metallo-beta-lactamase and Spread of ESBL-producers in Japan2019
- Author(s)
  Jun-ichi Wachino
- Organizer
  The 30th annual meeting of Japanese society for clinical microbiology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08430
[Presentation] メタロ-β-ラクタマーゼ阻害剤開発の試み2018
- Author(s)
  和知野純一、金万春、木村幸司、荒川宜親
- Organizer
  日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-18K08430
[Presentation] メタロ-β-ラクタマーゼ阻害剤開発の試み（第一報）2018
- Author(s)
  和知野純一、金万春、木村幸司、荒川宜親
- Organizer
  日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-18K08430
[Presentation] Avibactam-, OP0595-TLA-3 ベータラクタマーゼ複合体のX線結晶構造解析2018
- Author(s)
  Wanchun Jin, 和知野純一, 木村幸司, 荒川宜親
- Organizer
  第91回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-15H04868
[Presentation] Characterization of Group B Streptococci with Reduced Penicillin Susceptibility Forming Small Less-beta-Hemolytic Colonies on Sheep Blood Agar2017
- Author(s)
  坂野弘嗣、木村幸司、田中洋輔、関塚剛史、黒田誠、和知野純一、山田景子、柴山恵吾、荒川宜親
- Organizer
  第54回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-15H04868
[Presentation] Novel Insertion in Penicillin-Binding Protein 3 of Carbapenem-Resistant Haemophilus influenzae2017
- Author(s)
  北岡一樹、木村幸司、坂野弘嗣、金万春、和知野純一、荒川宜親
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Data Source
  KAKENHI-PROJECT-26461501
[Presentation] Carbapenem Resistance due to Amino Acid Insertion in Penicillin-Binding Protein of 3 of beta-Lactamase-Negative Ampicillin-Resistant Haemophilus Influenzae2017
- Author(s)
  Kazuki Kitaoka, Kouji Kimura, Hirotsugu Banno, Wanchun Jin, Jun-ichi Wachino, and Yoshichika Arakawa
- Organizer
  第54回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-15H04868
[Presentation] メタロベータラクタマーゼVIM-2の精製と阻害剤探索2017
- Author(s)
  仲崇天、和知野純一、木村幸司、荒川宜親
- Organizer
  第54回日本細菌学会中部支部総会
- Data Source
  KAKENHI-PROJECT-15H04868
[Presentation] Genetic, biochemical and structural analyses of a subclass B3 metallo-β-lactamase SMB-1 from a Serratia marcescens clinical isolate2013
- Author(s)
  Jun-ichi Wachino, Yoshichika Arakawa
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] 多剤耐性を引き起こすカルバペネマーゼに関する最新の知見2013
- Author(s)
  和知野純一、荒川宜親
- Organizer
  第61回日本化学療法学会西日本支部総会
- Place of Presentation
  大阪国際会議場（大阪市）
- Invited
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] アミノグリコシド、フルオロキノロン、ホスホマイシン耐性メカニズムの新知見2013
- Author(s)
  和知野純一、荒川宜親
- Organizer
  第61回日本化学療法学会総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] メタロ-β-ラクタマーゼSMB-1の構造機能解析2013
- Author(s)
  和知野純一、森茂太郎、柴山恵吾、荒川宜親
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] 結核菌由来新規diadenosine 5',5'''-P1,P4-tetraphosphate加リン酸分解酵素の結晶構造解析2010
- Author(s)
  森茂太郎、柴山恵吾、和知野純一、荒川宜親
- Organizer
  日本農芸化学会2010年度大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21890309
[Presentation] 結核菌由来新規diadenosine 5',5'''-P1,P4-tetraphosphate加リン酸分解酵素の機能構造解析2010
- Author(s)
  森茂太郎、柴山恵吾、和知野純一、荒川宜親
- Organizer
  日本生物工学会2010年度大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21890309
[Presentation] CREが産生するカルバペネマーゼの種類と CREの疫学
- Author(s)
  和知野純一、荒川宜親
- Organizer
  第26回日本臨床微生物学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-02-01 – 2015-02-02
- Invited
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] メルカプト酢酸ナトリウム(SMA）を用いたNDM型メタロβ-ラクタマーゼ産生株検出法の評価
- Author(s)
  和知野純一、荒川宜親
- Organizer
  第６２回日本化学療法学会総会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡市）
- Year and Date
  2014-06-18 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-24790570
[Presentation] ESBL産生大腸菌における新型ホスホマイシン耐性機構の出現とその簡易識別法の開発
- Author(s)
  和知野純一、木村幸司、荒川宜親
- Organizer
  第61日本化学療法学会東日本支部総会
- Place of Presentation
  東京ドームホテル（東京都文京区）
- Year and Date
  2014-10-29 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-24790570

1. ARAKAWA Yoshichika (10212622)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. KIMURA Kouji (50425675)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
3. 黒崎博雅 (70234599)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. 金万春 (30868807)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. KANECHI Leo

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KANAYAMA Takato

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. KITAOKA Kazuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. SHIBAYAMA Keigo (50283437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MORI Shigetarou (60425676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMANE Kunikazu (00356247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SUZUKI Satowa (30373400)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MATSUI Mari (50555761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Yamaguchi Yoshihiro (10363524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 柴田尚宏 (50311402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YOKOYAMA Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KIRIKAE Teruo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FUJITA Mikako

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SHIMIZU Nobutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAMAGATA Yuriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. BANNO Hirotsugu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
21. Kumar Anupuriya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. ANUPRIYA Kumar

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 山田景子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Wachino Junichi 和知野 純一

WACHINO Jun-ichi 和知野 純一

Research Projects

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Co-Researchers

金属親和性天然物のスリム化と再構築による薬剤耐性阻害剤の開発Principal Investigator

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セリン-とメタロ-カルパぺネマーゼを同時に阻害する二元型化合物の分子設計と探索

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細菌性薬剤耐性タンパク質を標的としたデュアルターゲット型治療薬の開発研究Principal Investigator

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Development of antibacterial auxiliary agents targeted for metallo-beta-lactamasesPrincipal Investigator

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Screening for carbapenemase inhibitors among approved drug compounds

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Development of atomic structural platform for controlling multi-drug resistant bacteriaPrincipal Investigator

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Characterization of IMP-1, a major carbapenem resistance factor in bacteria

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Horizontal transfer of antibiotic resistance genes through outer membrane vesicles

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Analysis of Haemophilus influenzae with reduced carbapenem susceptibility

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Physicochemical analysis of metallo-beta-lactamase with improved catalytic efficiency for cephem antibiotics

Principal Investigator

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Structure-based discovery of metallo-type carbapenemase inhibitor and application to bacteriological examinationPrincipal Investigator

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Molecular characterization of antibiotic resistance mechanism in nontuberculous mycobacteria.Principal Investigator

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Molecular mechanism of accumulation and rearrangement of antibiotic resistance gene in bacteria.

Principal Investigator

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Wachino Junichi 和知野純一

WACHINO Jun-ichi 和知野純一