Nakazawa Soken 中沢宗健

Researcher Number	00535958
Affiliation (based on the past Project Information) *help	2015 – 2016: 大阪大学, 産業科学研究所, 招へい准教授 2013 – 2014: 大阪大学, 工学(系)研究科(研究院), 准教授
Review Section/Research Field	Principal Investigator Hematology
Keywords	Principal Investigator TNFα / 関節リウマチ / ヘプシジン / 炎症性貧血 / IL-6阻害 / ヘプシジン(hepcidin) / トシリズマブ / BMP / tocilizumab / TNFa … More / リウマチ / TNF-a / フェロポルチン / IL-6 Less

IL-6阻害によるヘプシジン発現抑制による炎症性貧血改善機構の解明と臨床応用探索Principal Investigator
- Principal Investigator
  
  中沢宗健
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
The elucidation and clinical application of the hepcidin-ferroportin regulation mechanism in inflammatory anemiaPrincipal Investigator
- Principal Investigator
  
  Nakazawa Soken
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Osaka University

All 2016 2015 2013 Other

All Journal Article Presentation

[Journal Article] Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases2016
- Author(s)
  Soken-Nakazawa J Song and Kazuyuki Yoshizaki
- Journal Title
  
  Journal of Alcoholism & Drug Dependence
  
  Volume: 4 Issue: 3 Pages: 1-4
- DOI
  10.4172/2329-6488.1000239
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09873, KAKENHI-PROJECT-15K09524
[Journal Article] Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy2015
- Author(s)
  Soken-Nakazawa J Song and Kazuyuki Yoshizaki
- Journal Title
  
  Expert Opin Drug Metab Toxicol.
  
  Volume: 11(2) Issue: 2 Pages: 307-316
- DOI
  10.1517/17425255.2015.992779
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461452
[Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.2013
- Author(s)
  Tomoyasu Isobe, Soken-Nakazawa J. Song, Prabha Tiwari, et al.
- Journal Title
  
  FEBS Lett.
  
  Volume: 587 Pages: 2487-2492
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461452
[Journal Article] Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid A gene promoter.2013
- Author(s)
  Prabha Tiwari, Lokesh P. Tripathi, Teppei Nishikawa, Shandar Ahmadb, Soken-Nakazawa J. Song, et al.
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1830 Pages: 3650-3655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461452
[Journal Article] Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients2013
- Author(s)
  Soken-Nakazawa J Song, Mitsuhiro Iwahashi, Naohisa Tomosugi, Kazuko Uno, Jiro Yamana, Seizou Yamana,Tomoyasu Isobe, Hiroki Ito, Hiroshi Kawabata, Kazuyuki Yoshizaki
- Journal Title
  
  Arthritis Research & Therapy
  
  Volume: 15 Issue: 5 Pages: 1-10
- DOI
  10.1186/ar4323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460784, KAKENHI-PROJECT-25461452
[Presentation] The inhibitory effect of soluble form of gp130, sgp130, on the regulation of inflammatory status in rheumatoid arthritis2016
- Author(s)
  K. Yoshizaki, JS. Soken-Nakazawa, K. Uno
- Organizer
  The 8th International Forum on Rheumatoid Arthritis
- Place of Presentation
  日本、東京（品川プリンスホテル）
- Year and Date
  2016-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09873
[Presentation] Soluble form of gp130 molecular, an IL-6 inhibitor, contributes the efficacy on RA to tocilizumab (an anti-IL-6 receptor antibody) therapy2016
- Author(s)
  K. Yoshizaki, JS. Soken-Nakazawa, H. Ito, M. Iwahashi, K. Uno
- Organizer
  Annual European Congress of Rheumatology EULAR 2016
- Place of Presentation
  London, UK
- Year and Date
  2016-06-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09873
[Presentation] Opposite role of Soluble Forms of IL-6 Receptor, SIL-6R and sgp130, on the Regulation of Inflammatory Status in Rheumatoid Arthritis2015
- Author(s)
  Yoshizaki K, Soken-Nakazawa J Song and Uno K
- Organizer
  12th World Congress on Inflammation
- Place of Presentation
  Boston, USA
- Year and Date
  2015-08-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Two Soluble Forms of IL-6 Receptor, sIL-6R and sgp130, Regulate Physiological Status and Affect Inflammatory Status Pathologically.2015
- Author(s)
  Kazuyuki Yoshizaki, Soken Nakazawa and Kazuko Uno.
- Organizer
  FOCIS2015
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2015-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Different mechanism of anemia in chronic inflammatory disease and improvement of anemia by IL-6 blocking therapy.2013
- Author(s)
  Kazuyuki Yoshizaki and Soken-Nakazawa J Song
- Organizer
  The Federation of Clinical Immunology Societies (FOCIS)
- Place of Presentation
  Boston. USA
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Analysis of the Molecular Mechanisms Leading to Significantly Higher Serum Hepcidin and More Severe Anemia in Multicentric Castleman’s Disease (MCD) Patients Than in Rheumatoid Arthritis (RA) Patients.2013
- Author(s)
  Soken-Nakazawa J. Song, H Kawabata and K Yoshizaki.
- Organizer
  The American Society of Hematology（ASH）
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] ヘプシジンを介する炎症性貧血のサイトカイン制御機構2013
- Author(s)
  吉崎和幸、中沢宗健
- Organizer
  第3４回日本炎症再生学会
- Place of Presentation
  京都（国際会館）
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Mechanism of IL-6 induced SAA production and amyloid A deposition in AA Amyloidosis patients with RA
- Author(s)
  Kazuyuki Yoshizaki and Soken-Nakazawa J Song
- Organizer
  XIVth International Symposium on Amyloidosis
- Place of Presentation
  Indianapolis, Indiana, USA.
- Year and Date
  2014-04-27 – 2014-05-01
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Suppressing Hepcidin by Tocilizumab Effectively Improve Anemia in Inflammatory Diseases: Clinical Evidence and Basic Mechanisms
- Author(s)
  Kazuyuki Yoshizaki、Soken-Nakazawa J. Song　and Hiroshi Kawabata
- Organizer
  The 56th American Society of Hematology (ASH)
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25461452
[Presentation] Tocilizumab is More Effective than Tumor Necrosis Factor-a Inhibitors for Improving Anemia in Rheumatoid Arthritis by Inhibiting Hepcidin Production
- Author(s)
  Soken-Nakazawa J. Song and Kazuyuki Yoshizaki
- Organizer
  MidTerm Conference of ICIS, Interleukin 6 Biology-Pathophysiology-Therapy.
- Place of Presentation
  Kiel, Germany.
- Year and Date
  2014-05-14 – 2014-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-25461452

1. Yoshizaki Kazuyuki (90144485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
2. Tomosugi Naohisa (80155580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kawabata Hiroshi (10329401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. Uno Kazuko (50211082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Ito Hiroki (60590635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TANIGAWA Miki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nakazawa Soken 中沢 宗健

Research Projects

Research Products

Co-Researchers

IL-6阻害によるヘプシジン発現抑制による炎症性貧血改善機構の解明と臨床応用探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation and clinical application of the hepcidin-ferroportin regulation mechanism in inflammatory anemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mechanism and Clinical Significance of IL-6 Combined with TNF-α or IL-1 for the Induction of Acute Phase Proteins SAA and CRP in Chronic Inflammatory Diseases2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tocilizumab for treating rheumatoid arthritis: an evaluation of pharmacokinetics/pharmacodynamics and clinical efficacy2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation-induced cytidine deaminase auto-activates and triggers aberrant gene expression.2013

Author(s)

Journal Title

Data Source

[Journal Article] Prediction and experimental validation of a putative non-consensus binding site for transcription factor STAT3 in serum amyloid A gene promoter.2013

Author(s)

Journal Title

Data Source

[Journal Article] Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin, anemia response and disease activity in rheumatoid arthritis patients2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] The inhibitory effect of soluble form of gp130, sgp130, on the regulation of inflammatory status in rheumatoid arthritis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Soluble form of gp130 molecular, an IL-6 inhibitor, contributes the efficacy on RA to tocilizumab (an anti-IL-6 receptor antibody) therapy2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Opposite role of Soluble Forms of IL-6 Receptor, SIL-6R and sgp130, on the Regulation of Inflammatory Status in Rheumatoid Arthritis2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Two Soluble Forms of IL-6 Receptor, sIL-6R and sgp130, Regulate Physiological Status and Affect Inflammatory Status Pathologically.2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Different mechanism of anemia in chronic inflammatory disease and improvement of anemia by IL-6 blocking therapy.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Analysis of the Molecular Mechanisms Leading to Significantly Higher Serum Hepcidin and More Severe Anemia in Multicentric Castleman’s Disease (MCD) Patients Than in Rheumatoid Arthritis (RA) Patients.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ヘプシジンを介する炎症性貧血のサイトカイン制御機構2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Mechanism of IL-6 induced SAA production and amyloid A deposition in AA Amyloidosis patients with RA

Author(s)

Nakazawa Soken 中沢宗健