Hara Susumu 原進

Researcher Number	00536956
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 助教 2022 – 2023: 大阪大学, 大学院医学系研究科, 助教 2020: 大阪大学, 医学系研究科, 助教 2015 – 2019: 大阪大学, 医学系研究科, 寄附講座助教
Review Section/Research Field	Principal Investigator Basic Section 56060:Ophthalmology-related / Ophthalmology Except Principal Investigator Basic Section 90120:Biomaterials-related
Keywords	Principal Investigator 転写制御 / 転写因子 / 角膜内皮 / 角膜 / TFAP2B / 強膜 / 線維柱帯 / 前眼部形成 / 眼周囲間充織 / 発現制御 … More / TFAP2ファミリー / ZO-1 / バリア機能 / STAT3 / スプライシングバリアント / 選択的スプライシング / SLC4A11 / 再生医学 / 発生・分化 / マウス発生 / 再生医療 … More Except Principal Investigator 水晶体 / ヒトiPS細胞 / オルガノイド / 眼科再生医療 / ヒトiPS / ナノ結晶製剤 / 薬物療法 / 白内障 Less

Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment
- Principal Investigator
  
  馬場耕一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  The University of Osaka
眼周囲間充織由来眼組織の分化制御機構の解明Principal Investigator
- Principal Investigator
  
  原進
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Osaka University
眼オルガノイド白内障モデルを用いた白内障治療薬ナノ結晶点眼液の有効性検証
- Principal Investigator
  
  馬場耕一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka University
Unraveling the Transcriptional Control Mechanisms of the SLC4A11 Gene Toward Understanding Corneal Endothelial Disease PathogenesisPrincipal Investigator
- Principal Investigator
  
  Hara Susumu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Osaka University
Physiological regulation of the transcription factor TFAP2B in corneal endothelial cellsPrincipal Investigator
- Principal Investigator
  
  Hara Susumu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka University
Analysis of corneal endotheliual differentiational mechanism using corneal endothelial progenitor cells.Principal Investigator
- Principal Investigator
  
  Hara Susumu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka University

All 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation2019
- Author(s)
  Hara Susumu、Tsujikawa Motokazu、Kawasaki Satoshi、Nishida Kohji
- Journal Title
  
  Experimental Eye Research
  
  Volume: 188 Pages: 107782-107782
- DOI
  10.1016/j.exer.2019.107782
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-18K09446, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
[Journal Article] STAT3 signaling maintains homeostasis through a barrier function and cell survival in corneal endothelial cells2019
- Author(s)
  Hara Susumu、Tsujikawa Motokazu、Maruyama Kazuichi、Nishida Kohji
- Journal Title
  
  Experimental Eye Research
  
  Volume: 179 Pages: 132-141
- DOI
  10.1016/j.exer.2018.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K11475, KAKENHI-PROJECT-17K16968
[Journal Article] KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression2019
- Author(s)
  Fujimoto Satoko、Hayashi Ryuhei、Hara Susumu、Sasamoto Yuzuru、Harrington Jodie、Tsujikawa Motokazu、Nishida Kohji
- Journal Title
  
  Regenerative Therapy
  
  Volume: 11 Pages: 249-257
- DOI
  10.1016/j.reth.2019.08.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K11480, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
[Journal Article] Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells2019
- Author(s)
  Hara Susumu、Tsujikawa Motokazu、Nishida Kohji
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 514 Issue: 3 Pages: 580-585
- DOI
  10.1016/j.bbrc.2019.04.178
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
[Journal Article] Transcription factor TFAP2B up-regulates human corneal endothelial cell?specific genes during corneal development and maintenance2018
- Author(s)
  Hara Susumu、Kawasaki Satoshi、Yoshihara Masahito、Winegarner Andrew、Busch Caleb、Tsujikawa Motokazu、Nishida Kohji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 7 Pages: 2460-2469
- DOI
  10.1074/jbc.ra118.005527
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K16968
[Journal Article] Restricted Presence of POU6F2 in Human Corneal Endothelial Cells Uncovered by Extension of the Promoter-level Expression Atlas2017
- Author(s)
  Yoshihara Masahito、Hara Susumu、Tsujikawa Motokazu、Kawasaki Satoshi、Hayashizaki Yoshihide、Itoh Masayoshi、Kawaji Hideya、Nishida Kohji
- Journal Title
  
  EBioMedicine
  
  Volume: 25 Pages: 175-186
- DOI
  10.1016/j.ebiom.2017.10.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16968, KAKENHI-PROJECT-17K11448
[Patent] 角膜内皮細胞マーカー2017
- Inventor(s)
  西田幸二、辻川元一、原進、川崎諭、吉原正仁、伊藤昌可、川路英哉
- Industrial Property Rights Holder
  西田幸二、辻川元一、原進、川崎諭、吉原正仁、伊藤昌可、川路英哉
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-17K16968
[Presentation] 角膜内皮における転写因子STAT3を介したバリア機能の制御2019
- Author(s)
  原　進、辻川元一、丸山和一、西田幸二
- Organizer
  角膜カンファランス2019
- Data Source
  KAKENHI-PROJECT-17K16968
[Presentation] KLF4 Prevents Epithelial-to-Mesenchymal Transition in Human Corneal Epithelia via SMAD2/3 Nuclear Translocation Inhibition of the TGF-β Signaling Pathway2019
- Author(s)
  Satoko Fujimoto; Ryuhei Hayashi; Yuzuru Sasamoto; Susumu Hara; Jodie Harrington; Motokazu Tsujikawa; Kohji Nishida
- Organizer
  ARVO2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16968
[Presentation] In vitroでの発生系譜解析を可能にするiPS細胞ラインの作製2019
- Author(s)
  小林礼子、上野博夫、小林由紀、佐々本弦、原　進、林竜平、辻川元一、西田幸二
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-17K16968
[Presentation] FANTOM5データベースを活用した新規角膜内皮細胞特異的マーカーの同定2017
- Author(s)
  吉原正仁, 大宮寛子, 原進, 川崎諭, 林崎良英, 伊藤昌可, 川路英哉, 辻川元一, 西田幸二
- Organizer
  第6回わかもと先進眼科医療研究会
- Data Source
  KAKENHI-PROJECT-17K16968
[Presentation] 転写因子AP-2betaにおける角膜内皮マーカーの発現制御2017
- Author(s)
  原進、川崎諭、吉原正仁、辻川元一、西田幸二
- Organizer
  第16回日本再生医療学会総会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-15K20259
[Presentation] 角膜内皮における転写因子AP-2betaの解析2017
- Author(s)
  原進、川崎諭、吉原正仁、辻川元一、西田幸二
- Organizer
  角膜カンファランス2017
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-15K20259
[Presentation] FANTOM5データベースを活用した新規角膜内皮細胞特異的マーカーの同定2016
- Author(s)
  吉原正仁、大宮寛子、原進、川崎諭、林崎良英、伊藤昌可、川路英哉、辻川元一、西田幸二
- Organizer
  第15回日本再生医療学会
- Place of Presentation
  大阪府
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-15K20259
[Presentation] 角膜内皮・角膜内皮前駆細胞の表面マーカーの探索2016
- Author(s)
  木村恵利香、原進、川崎諭、林竜平、谷脇勇輝、高田裕香、辻川元一
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪府
- Year and Date
  2016-03-19
- Data Source
  KAKENHI-PROJECT-15K20259
[Presentation] 新規角膜内皮前駆細胞の解析2015
- Author(s)
  原　進
- Organizer
  第69回日本臨床眼科学会
- Place of Presentation
  愛知県
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K20259

1. 馬場耕一 (00436172)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 西田幸二 (40244610)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 吉原正仁 (70807065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TSUJIKAWA Motokazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Hara Susumu 原 進

Research Projects

Research Products

Co-Researchers

Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

眼周囲間充織由来眼組織の分化制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

眼オルガノイド白内障モデルを用いた白内障治療薬ナノ結晶点眼液の有効性検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Unraveling the Transcriptional Control Mechanisms of the SLC4A11 Gene Toward Understanding Corneal Endothelial Disease PathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Physiological regulation of the transcription factor TFAP2B in corneal endothelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of corneal endotheliual differentiational mechanism using corneal endothelial progenitor cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] STAT3 signaling maintains homeostasis through a barrier function and cell survival in corneal endothelial cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcription factor TFAP2B up-regulates human corneal endothelial cell?specific genes during corneal development and maintenance2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Restricted Presence of POU6F2 in Human Corneal Endothelial Cells Uncovered by Extension of the Promoter-level Expression Atlas2017

Author(s)

Journal Title

DOI

Data Source

[Patent] 角膜内皮細胞マーカー2017

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 角膜内皮における転写因子STAT3を介したバリア機能の制御2019

Author(s)

Organizer

Data Source

Hara Susumu 原進