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Hara Susumu  原 進

ORCIDConnect your ORCID iD *help
Researcher Number 00536956
Other IDs
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help 2025: 大阪大学, 大学院医学系研究科, 助教
2022 – 2023: 大阪大学, 大学院医学系研究科, 助教
2020: 大阪大学, 医学系研究科, 助教
2015 – 2019: 大阪大学, 医学系研究科, 寄附講座助教
Review Section/Research Field
Principal Investigator
Basic Section 56060:Ophthalmology-related / Ophthalmology
Except Principal Investigator
Basic Section 90120:Biomaterials-related
Keywords
Principal Investigator
転写制御 / 転写因子 / 角膜内皮 / 角膜 / TFAP2B / 強膜 / 線維柱帯 / 前眼部形成 / 眼周囲間充織 / 発現制御 … More / TFAP2ファミリー / ZO-1 / バリア機能 / STAT3 / スプライシングバリアント / 選択的スプライシング / SLC4A11 / 再生医学 / 発生・分化 / マウス発生 / 再生医療 … More
Except Principal Investigator
水晶体 / ヒトiPS細胞 / オルガノイド / 眼科再生医療 / ヒトiPS / ナノ結晶製剤 / 薬物療法 / 白内障 Less
  • Research Projects

    (6 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (4 People)
  •  Development of in vivo lens regeneration technology using lens stem cells for next-generation cataract treatment

    • Principal Investigator
      馬場 耕一
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      The University of Osaka
  •  眼周囲間充織由来眼組織の分化制御機構の解明Principal Investigator

    • Principal Investigator
      原 進
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Osaka University
  •  眼オルガノイド白内障モデルを用いた白内障治療薬ナノ結晶点眼液の有効性検証

    • Principal Investigator
      馬場 耕一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      Osaka University
  •  Unraveling the Transcriptional Control Mechanisms of the SLC4A11 Gene Toward Understanding Corneal Endothelial Disease PathogenesisPrincipal Investigator

    • Principal Investigator
      Hara Susumu
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Osaka University
  •  Physiological regulation of the transcription factor TFAP2B in corneal endothelial cellsPrincipal Investigator

    • Principal Investigator
      Hara Susumu
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Osaka University
  •  Analysis of corneal endotheliual differentiational mechanism using corneal endothelial progenitor cells.Principal Investigator

    • Principal Investigator
      Hara Susumu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Osaka University

All 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

  • [Journal Article] Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation2019

    • Author(s)
      Hara Susumu、Tsujikawa Motokazu、Kawasaki Satoshi、Nishida Kohji
    • Journal Title

      Experimental Eye Research

      Volume: 188 Pages: 107782-107782

    • DOI

      10.1016/j.exer.2019.107782

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-18K09446, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
  • [Journal Article] STAT3 signaling maintains homeostasis through a barrier function and cell survival in corneal endothelial cells2019

    • Author(s)
      Hara Susumu、Tsujikawa Motokazu、Maruyama Kazuichi、Nishida Kohji
    • Journal Title

      Experimental Eye Research

      Volume: 179 Pages: 132-141

    • DOI

      10.1016/j.exer.2018.11.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K11475, KAKENHI-PROJECT-17K16968
  • [Journal Article] KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression2019

    • Author(s)
      Fujimoto Satoko、Hayashi Ryuhei、Hara Susumu、Sasamoto Yuzuru、Harrington Jodie、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 249-257

    • DOI

      10.1016/j.reth.2019.08.003

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K11480, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
  • [Journal Article] Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells2019

    • Author(s)
      Hara Susumu、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 514 Issue: 3 Pages: 580-585

    • DOI

      10.1016/j.bbrc.2019.04.178

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-19H01063, KAKENHI-PROJECT-17K16968
  • [Journal Article] Transcription factor TFAP2B up-regulates human corneal endothelial cell?specific genes during corneal development and maintenance2018

    • Author(s)
      Hara Susumu、Kawasaki Satoshi、Yoshihara Masahito、Winegarner Andrew、Busch Caleb、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 7 Pages: 2460-2469

    • DOI

      10.1074/jbc.ra118.005527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K11448, KAKENHI-PROJECT-17K16968
  • [Journal Article] Restricted Presence of POU6F2 in Human Corneal Endothelial Cells Uncovered by Extension of the Promoter-level Expression Atlas2017

    • Author(s)
      Yoshihara Masahito、Hara Susumu、Tsujikawa Motokazu、Kawasaki Satoshi、Hayashizaki Yoshihide、Itoh Masayoshi、Kawaji Hideya、Nishida Kohji
    • Journal Title

      EBioMedicine

      Volume: 25 Pages: 175-186

    • DOI

      10.1016/j.ebiom.2017.10.024

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16968, KAKENHI-PROJECT-17K11448
  • [Patent] 角膜内皮細胞マーカー2017

    • Inventor(s)
      西田幸二、辻川元一、原進、川崎諭、吉原正仁、伊藤昌可、川路英哉
    • Industrial Property Rights Holder
      西田幸二、辻川元一、原進、川崎諭、吉原正仁、伊藤昌可、川路英哉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-17K16968
  • [Presentation] 角膜内皮における転写因子STAT3を介したバリア機能の制御2019

    • Author(s)
      原 進、辻川元一、丸山和一、西田幸二
    • Organizer
      角膜カンファランス2019
    • Data Source
      KAKENHI-PROJECT-17K16968
  • [Presentation] KLF4 Prevents Epithelial-to-Mesenchymal Transition in Human Corneal Epithelia via SMAD2/3 Nuclear Translocation Inhibition of the TGF-β Signaling Pathway2019

    • Author(s)
      Satoko Fujimoto; Ryuhei Hayashi; Yuzuru Sasamoto; Susumu Hara; Jodie Harrington; Motokazu Tsujikawa; Kohji Nishida
    • Organizer
      ARVO2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16968
  • [Presentation] In vitroでの発生系譜解析を可能にするiPS細胞ラインの作製2019

    • Author(s)
      小林礼子、上野博夫、小林由紀、佐々本弦、原 進、林竜平、辻川元一、西田幸二
    • Organizer
      第18回日本再生医療学会総会
    • Data Source
      KAKENHI-PROJECT-17K16968
  • [Presentation] FANTOM5データベースを活用した新規角膜内皮細胞特異的マーカーの同定2017

    • Author(s)
      吉原正仁, 大宮寛子, 原進, 川崎諭, 林崎良英, 伊藤昌可, 川路英哉, 辻川元一, 西田幸二
    • Organizer
      第6回わかもと先進眼科医療研究会
    • Data Source
      KAKENHI-PROJECT-17K16968
  • [Presentation] 転写因子AP-2betaにおける角膜内皮マーカーの発現制御2017

    • Author(s)
      原進、川崎諭、吉原正仁、辻川元一、西田幸二
    • Organizer
      第16回日本再生医療学会総会
    • Place of Presentation
      仙台市
    • Data Source
      KAKENHI-PROJECT-15K20259
  • [Presentation] 角膜内皮における転写因子AP-2betaの解析2017

    • Author(s)
      原進、川崎諭、吉原正仁、辻川元一、西田幸二
    • Organizer
      角膜カンファランス2017
    • Place of Presentation
      福岡市
    • Data Source
      KAKENHI-PROJECT-15K20259
  • [Presentation] FANTOM5データベースを活用した新規角膜内皮細胞特異的マーカーの同定2016

    • Author(s)
      吉原 正仁、大宮 寛子、原 進、川崎 諭、林崎 良英、伊藤 昌可、川路 英哉、辻川 元一、西田 幸二
    • Organizer
      第15回日本再生医療学会
    • Place of Presentation
      大阪府
    • Year and Date
      2016-03-17
    • Data Source
      KAKENHI-PROJECT-15K20259
  • [Presentation] 角膜内皮・角膜内皮前駆細胞の表面マーカーの探索2016

    • Author(s)
      木村 恵利香、原 進、川崎 諭、林 竜平、谷脇 勇輝、高田 裕香、辻川 元一
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪府
    • Year and Date
      2016-03-19
    • Data Source
      KAKENHI-PROJECT-15K20259
  • [Presentation] 新規角膜内皮前駆細胞の解析2015

    • Author(s)
      原 進
    • Organizer
      第69回日本臨床眼科学会
    • Place of Presentation
      愛知県
    • Year and Date
      2015-10-22
    • Data Source
      KAKENHI-PROJECT-15K20259
  • 1.  馬場 耕一 (00436172)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  西田 幸二 (40244610)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  吉原 正仁 (70807065)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TSUJIKAWA Motokazu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results

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